788 results about "Skin Injury" patented technology

The present invention provides cystine derivatives, which may be in a free form, a salt form, a solvate form. The cystine derivatives of the present invention may be used to suppress activation of inflammatory factors. Accordingly, the present invention provides: compositions containing the cystine derivatives; a method for suppressing the activation of inflammatory factors by administering the composition; a method for preventing, ameliorating and / or therapeutically treating diseases, skin injuries or disorders involved in the activation of inflammatory factors by administering the composition; a method for preventing, delaying, ameliorating and / or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors by administering the composition; and pharmaceutical agents containing the cystine derivatives.

The present invention describes breathable multilayered adhesive structures that can be used as adhesives to mount devices onto the skin. The breathable multilayered adhesive structures can comprise moisture-wicking layers adhered to the skin by a porous adhesion layer. The pores allow moisture released from the skin to be transferred away through the moisture-wicking layer. The adhesive structures permit the devices to be skin-mounted for an extended period of time (e.g., a few hours or days) without causing moisture-associated skin injuries such as erythema, maceration, and irritation or inflammation.

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for fighting bacterium, diminishing inflammation, removing putrefaction and promoting tissue regeneration such as angelica, Szechuan lovage rhizome, salvia root and the like which are prepared into a plurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, and has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn / scald,bedsore, chronic leg ulcer, diabetic foot or cancerous ulcer and the like.

The invention belongs to the technical field of molecular biology and relates to application of an exosome derived from human mesenchymal stem cells to preparation of medicines for antagonizing scars or tissue and organ fibrosis. According to the application, the high-purity and high-bioactivity exosome is obtained by subjecting healthy human umbilical cords to primary in-vitro culture, collecting liquid supernatant after amplification, performing low-temperature ultracentrifugation, purifying and the like; the exosome is used individually or added into medicines, health care products and cosmetics according to a proportion to be developed into a product with a bioactivity function, thereby being capable of regulating organism cell signal transduction effectively, inhibiting fibrocyte differentiation and then antagonizing the tissue and organ fibrosis and scar forming. Through experimental verification, the exosome can play a remarkable role in repairing promotion in hypertrophic scar after skin injury, particularly pathological fibrosis proliferation such as scar contracture of the joint parts, hepatic fibrosis and cardiac fibrosis, and is high in safety, little in toxicity and convenient to storage and transport, thereby being wide in application prospect.

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for clearing heat and releasing toxin such as coptis root, golden cypress bark, rhubarb, giant knotweed rhizome, honeysuckle flower, forsythia fruit and the like which are prepared into aplurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior common preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn / scald, bedsore,chronic leg ulcer, diabetic foot or cancerous ulcer and the like, and can greatly shorten the required time for wound healing and tissue repair.

A method and composition for reducing or eliminating stinging that may accompany application of topical solution of a skin-compatible polymeric material to a skin wound, abrasion, burn or other skin injury. The topical solution may contain one or more skin-irritating chemicals, such as diethyl ether, ethanol, ethyl acetate, methyl acetate, acetone, methyl ethyl ketone and combinations thereof. The method includes: (i) providing a composition that contains between 1% and 10% by weight of the skin-compatible polymeric material dissolved in a liquid medium suitable for human topical use in which the liquid medium includes less than 20% combined weight of skin-irritating chemicals, and at least 45% combined weight of at least one volatile solvent and / or volatile co-solvent, in which the molecules constituting this 45% combined weight portion of the liquid medium contain at least 5 carbon atoms, and the liquid medium has an initial boiling point at 1 atmosphere of greater than 35° C. and less than 150° C., and causes little or no stinging when applied to a skin injury, and (ii) applying the composition to the skin of a patient at the site of the skin injury.

The invention discloses OCT-based in-situ three-dimensional printing skin repairing equipment and an implementation method thereof. The implementation method comprises the following steps: scanning a skin injury region by adopting an OCT technology to acquire a high-resolution three-dimensional skin injury OCT image; carrying out three-dimensional bionic structural design and modeling on the skin injury part based on the OCT image so as to ensure the reconstruction requirements of skin repair to layered interfaces and vascular networks in tissues; and then, transmitting the modeled skin injury repair model data to a 3D biological printer to carry out model layering and printing, thereby implementing quick, accurate and in-situ repair on the injured part. The OCT-based in-situ three-dimensional printing skin repairing equipment has the advantages of no contact, no injury and real-time imaging, meets the requirement of skin in-situ printing on high-resolution imaging of internal micro-structures, and can acquire distribution and density information of blood vessels in the skin corium layer so as to be convenient for constructing a three-dimensional model closer to real skin structures and functions.

The invention provides an application of a human umbilical cord mesenchymal stem cell complex cell factor in preparing a biological agent for repairing skin injury. The skin injury includes laser burn, thermal burn, cold injury or common trauma skin physical and chemical injury. According to the application, an umbilical cord stem cell complex growth factor is firstly used for the treatment of human skin laser injury; the human umbilical cord mesenchymal stem cell complex cell factor can be preserved in maximal activity and plays a maximal role of injury repair and treatment under a certain preservation condition.

The invention relates to a method for preparing a multi-layer composite functional surgical dressing. The method comprises the following steps: respectively and independently carding the fiber layers comprising a functional layer which is formed by mixing chitosan fiber or chitosan fiber and viscose and is directly contacted with the skin, a water-absorbing layer which is made of viscose and has high liquid absorption performance and a protective layer which is formed by mixing the viscose and polyester fiber and has the supporting and protecting functions so as to form a net, manufacturing a three-layer laminate with an upper functional layer, a middle water-absorbing layer and a lower protective layer by employing a water jet strengthening technology, coating a waterproof agent on the protective layer of the three-layer laminate to form a waterproof layer, and finally rolling to obtain the surgical dressing. The product has high biocompatibility and promotes healing, the antibacterial rate is up to 96.7 percent, the liquid absorption rate is 1259 percent, the waterproofing grade is up to level 5, and the surgical dressing can be used for clinical repair for operative incision, burn, scald, ulcer and other skin injury and is simple in production process, low in cost and environmentally-friendly.

The invention discloses an antibacterial adhesion injectable hydrogel dressing, a preparation method and applications thereof, and belongs to the technical field of biodegradable biomedical materials.According to the method, 2,3-epoxypropyltrimethylammonium chloride (GTMAC) is grafted onto chitosan to obtain a quaternized chitosan polymer (QCS) as the main raw material of a hydrogel, p-carboxybenzaldehyde is grafted onto a triblock copolymer Pluronic< >F127 to obtain an aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) as the cross-linking agent of the gel, and the aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) and the quaternized chitosan polymer (QCS) are subjected to a cross-linking reaction under a physiological environment to obtain the antibacterial adhesion injectable hydrogel dressing (QCS / PF) with advantages of rapid self-healing, easy extending and easy compression. According to the present invention, the method has advantages of simple process, wide raw material source and low preparation cost; and the hydrogel dressing prepared by using the method has advantages of good adhesion, good pH responsiveness, good mechanical property, good self-healing property, good bleeding stopping property and good antibacterial property so as to be used in the field of skin injury treatment drugs.

The invention discloses a multi-effect skin caring and smoothening traditional Chinese medicine lotion which is characterized by comprising, by weight, 35-45 parts of lightyellow sophora root, 35-45 parts of common cnidium fruit, 28-33 parts of Chinese gall, 35-45 parts of baical skullcap root, 18-22 parts of cattail pollen, 75-85 parts of ganoderma lucidum, 110-130 parts of cortex mori, 35-45 parts of milkvetch root, 35-45 parts of radix rehmanniae, 35-45 parts of oat, and glycerin which is 0.5-0.56 times of the aforementioned materials by weight, with the balance being clean water for extraction. The multi-effect skin caring and smoothening traditional Chinese medicine lotion made from natural and environment-friendly materials has stable and reliable effect and wide application range, especially has good effects in removing freckle, wrinkle and acne, whitening, moisturizing and healing skin injury, and can not only be used to delay aging of skin and repair injury to skin caused by some hormone drugs and cosmetics but also reduce and even remove face splash, acne and wrinkle to make skin smooth, bright and elastic.

The invention discloses a human-derived adipose tissue-derived stem cell factor, a preparation method and application thereof, and particularly discloses a method for culturing a human-derived adipose tissue-derived stem cell factor. The method comprises the following steps: culturing human adipose tissue-derived stem cells in a high-coenzyme serum-free culture medium until the cell confluence is 75-85 percent, and collecting supernatant. The invention further discloses a method for preparing human-derived adipose tissue-derived stem cell factor concentrated solution, the concentrated solution prepared by the method, further application of the concentrated solution, a cell factor concentrate prepared by the method, cosmetics and medicines prepared from the cell factor concentrate. The concentrated solution prepared by the method has high content of adipose tissue-derived stem cell factors and stable quality, and a product prepared by combining the concentrated solution with other materials in a specific ratio has a good effect of repairing skin injury; and the method is simple and feasible, is suitable for large-scale production, and has excellent market prospect.

The invention relates to a gel preparation for maintaining the activity of cryopreserved cells and a stem cell gel preparation containing stem cells. The gel preparation comprises the following components by the mass percentage: 1-3% of sodium alginate, 1-5% of dimethyl sulfoxide, 1-5% of propylene glycol, 1-5% of epigallocatechin gallate, 2-10% of dextran, 1-5% of human blood albumin, and water or a phosphate solution added to make the total amount be 100%. The gel preparation has the advantages of good biocompatibility and simple operation, can maintain high activity of cells, can be directly used for low temperature preservation, and has no need of traditional liquid nitrogen cryopreservation; the cell gel preparation after resuscitation can still maintain high activity of the cells and dryness of the cells, and can be applied for treatment of skin injury or mucosal injury.

The invention discloses scald and burn dressing prepared by a coaxial electrostatic spinning method. The scald and burn dressing is a nanofiber membrane with a core / shell structure, wherein the shell is made of a natural biological high molecular material and the core is a degradable synthetic high molecular material loaded with astragaloside. The mass ratio of astragaloside to the degradable synthetic high molecular material is 1:(2-50). The invention further discloses a preparation method of the scald and burn dressing. The raw materials are easy to get and cheap, and the preparation process is simple, easy to operate and control and can be easily put into large-scale industrial production. The prepared scald and burn dressing has good flexibility and high mechanical strength, and can form a protective fiber felt on the surface of the wound to promote growth of normal skin tissues and reduce formation of scar tissues, thereby curing skin injury.

The present invention relates to novel methods of growing or otherwise producing unpassaged or minimally-passaged dermal cells from a small biopsy specimen for treating skin injuries significantly larger than the biopsy.

The invention provides an Acetobacter xylinum Y05 strain and a method for preparing nanometer cellulose skin tissue repairing material with the same. The preparation method comprises the following steps that: Acetobacter xylinum Y05 (CCTCC M 207163) preserved on an inclined plane is made into a shake-flask seed and cultivated statically to obtain a nanometer cellulose membrane; and the well-cultivated membrane is separated, purified and then compounded with natural polysaccharide (chitosan, etc.) and protein (collagen, silk fibroin, etc.), so as to prepare the repairing material. The nanometer repairing material has good biocompatibility, flexibility and strength which are similar to human skin, as well as good plasticity and elasticity, can be suitable for various irregular wound surfaces, can keep moisture for a long time, and can be used as a skin substitute and medical dressings for burns, chronic skin ulcers and other skin injuries or defects in clinical practice.

The invention discloses a firming and repairing fair mask product which is prepared by soaking mask paper with the liquid prepared from the following raw materials in parts by weight: 0.1-3 parts of hyaluronic acid oligomer, 0.1-2.5 parts of hyaluronic acid, 0.7-30 parts of synthetic egg white powder, 1-7 parts of an aloe extract, 0.7-9 parts of propylene glycol, 5-50 parts of 1,2-butylene glycol, 5-30 parts of glycerol, 40-80 parts of a ginseng extract, 10-50 parts of a milkvetch root extract, 20-50 parts of a baical skullcap root extract, 20-80 parts of a small cucumber extract, 0.1-1 part of a licorice extract, 0.3-2 parts of arbutin, 1-10 parts of superoxide dismutase, 1-10 parts of a coenzyme q10, 0.1-5 parts of beta-glucan, and the balance of water which is added until the total amount is 1000 parts. The mask product can reduce skin injuries, repair damaged cells, delay skin wrinkling, relieve the generation of facial dark stains and replenish and lock water, and is antiallergic.

The invention discloses application of a mesenchymal stem cell culture from a human umbilical cord or a supernatant of the mesenchymal stem cell culture. The invention provides the application of themesenchymal stem cell culture from the human umbilical cord or the supernatant of the mesenchymal stem cell culture in preparing drugs for promoting skin injury repair, promoting vascular growth, diminishing inflammation and promoting collagen fiber accumulation. The mesenchymal stem cells are derived from umbilical cord tissues and do not need to be cultured under hypoxia and other conditions, and only normal cell culture and regulation are needed; the passage number of cells is relatively-low and the cells are P3 and P4 generation cells which do not affect the dryness of the mesenchymal stemcells. Therefore, mesenchymal stem cell culture supernatant components disclosed by the application are closer to natural growth metabolic components of MSC, purer and better in treatment effect.

The invention discloses an extraction method of natural high-purity tea saponin. The extraction method includes: degreasing tea meal, using an eutectic reagent combined with ultrasonic waves to treat the tea meal, and filtering; adding methanol into filtrate to recycle the eutectic reagent while dissolving tea saponin; loading a sample of an extracted tea saponin solution into a chromatographic column made of macroporous resin, sequentially adopting 10%, 20%, 30%, 40% and 50% alcohol-water solution for elution, collecting eluate of 40% alcohol-water, and drying the eluate to obtain white tea saponin powder higher than 98% in purity. By adopting the method to extract tea saponin from the tea meal, extraction efficiency of tea saponin is improved while consumption of organic solvent is reduced. Tea saponin obtained by the method can be applied in daily chemical products like shampoo, shower gel and facial cleansing milk to enable the products to efficiently remove stain without causing skin injury.

Aspects of the invention relate to methods and devices for evaluating tissue injuries. In some embodiments, the invention provides methods and devices for evaluating tissue injuries based on infrared emission spectra and / or emission levels from injured tissue. In some embodiments, the invention provides methods and devices for evaluating skin injuries (e.g., skin burns) and for targeting treatment delivery to injuries including skin injuries.

The invention relates to the field of daily cosmetics, and particularly relates to a mild type Chinese medicinal herb hand sanitizer with bacteriostatic, antibacterial and skin moisturizing effects, including a Chinese medicinal herb composition and an extraction process thereof and a preparation method of the hand sanitizer. A Forsythia suspensa leaf hand sanitizer comprises a functional component, a surfactant, a thickener, a humectant, a pH regulator, an anti-hard water agent, an aromatic, a pigment, a pearling agent and deionized water, wherein the functional component is Forsythia suspensa leaf extract, traditional Chinese medicine mixed extract, and Dioscorea opposita powder, and the traditional Chinese medicine mixed extract is mixed extract of Scutellaria baicalensis, Astragalus membranaceus and Asparagus cochinchinensis. The hand sanitizer provided by the invention has cleaning and antibacterial, skin moisturizing and skin caring effects, and does not cause dry hand skin, skin injury and other adverse effects even after frequent hand cleaning.

The present invention includes compositions and methods for treating skin conditions, and more particularly, a medicinal progression of anti-oxy-vitamins to treat one or more skin conditions in a patient selected from at least one of acne, skin discoloration, comedo presence, foci of inflammation, hyper-keratinosis, enlarged sebum vessels, pores enlargement, scars or piling centers.

The invention relates to an antibacterial biological activity stent and a preparation method thereof. The method comprises the steps that gelatin microspheres are prepared; porous gelatin microspheres are prepared; gelatin microspheres carried with active factors are obtained; an antibacterial stent is prepared, wherein the preparation of the antibacterial stent comprises the steps that at least one of collagen, chitosan and silk fibroin and nano-silver grains are added to acetic acid or malonic acid to prepare a mixed solution, the mixed solution is poured into a die which is horizontally paved with the solid gelatin microspheres, the die is rapidly placed in an ultra cold refrigerator for freezing treatment, and the die is frozen and dried to obtain the antibacterial stent; and the antibacterial biological activity stent is prepared by the steps that the gelatin microspheres carried with the active factors are placed into normal saline to prepare a suspension liquid, and the suspension liquid is poured into the antibacterial stent to obtain the antibacterial biological activity stent after dried at the room temperature. According to the antibacterial biological activity stent and the preparation method thereof, pure natural polymers are taken as raw materials, the nano-silver grains and the bioactive factors are compounded to prepare the stent, so that the stent has the biological activity and antibacterial capacity, can effectively promote vascularization of cambium and can be used for skin injury healing.

The invention provides an ultraviolet radiation damage resistant complex of marine oligosaccharides and collagen peptides, which is prepared from marine oligosaccharides with antioxidant activity and tilapia mossambica fishskin collagen peptides with molecular weight of between 2,800 and 3,000 Da through compatibility. Chemical and pharmacological experiments prove that: compared with single components subjected to compatibility, the complex can inhibit the generation of oxygen radicals caused by ultraviolet radiation obviously and can enter skin cell mitochondria in a targeting mode to a greater degree to inhibit light aging, and has the obvious protective effect on skin injury caused by the ultraviolet radiation. The complex provides theoretic support for the development of natural oligosaccharide-peptide complex uvioresistant and mitochondrion targeting medicaments and the high-value utilization of mariculture industry.

Provided is a new bionic skin material with multiple functions and a high efficacy. With a compound microporous fibre net structure, the material imitates a skin barrier function, has anti-fouling properties, hygroscopic properties, moisture retention properties, air permeability, flexibility and adhesiveness, and can effectively absorb wound exudate and residues for rapid painless autolysis and debridement, ensure sufficient drainage by bidirectional regulation, maintain a semi-closed, local physiological wet environment favorable for the reparative metabolism and physiological healing of a wound, inhibit inflammation, reduce exudation, benefit the response inside and outside of cells, promote the migration of fibroblasts and epithelial cells of the body itself and the regeneration of granulation tissue and epithelial cells of the wound, accelerate the physiological healing and recovery of the wound, and reduce recurrences. It has been clinically proved that the dressing material can accelerate the healing of acute skin injuries and chronic ulcer wounds, achieve a high healing quality, avoid or reduce traumatic skin grafting to the greatest extent, reduce the pain of patients and the production of scars, and restore the physiological function and appearance of the body.

The invention relates to a preparation of anti-coagulation dermis scaffold which is used for skin injury repair and has good three-dimensional porous structure. The scaffold preparation uses three natural biologicals of regeneration silk fibroin, chitosan and heparin as raw materials, wherein, heparin has outstanding anti-coagulation property. The dermis scaffold has high porosity and aperture size appropriate for dermal cells to grow; the scaffold has better mechanical property and good hydrophily; the artificial dermis scaffold has heparin slow release function, so that the protrombin time, partial thromboplastin time and thrombin time thereof can be obviously prolonged, thus proving that the dermis scaffold has excellent anti-coagulation property.

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for activating blood and dissolving stasis such as angelica, Szechuan lovage rhizome, salvia root and the like which are prepared into a plurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior common preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn / scald, bedsore, chronic leg ulcer, diabetic foot or cancerous ulcerand the like, and can greatly shorten the required time for wound healing and tissue repair and relieve pains of patients.