Medicinal composition for treating skin injury and ulcer and application thereof

A composition and drug technology, applied in skin diseases, drug combinations, metabolic diseases, etc., can solve the problems of slow onset, limited clinical promotion and application, and long course of disease, so as to accelerate regeneration, promote wound healing and tissue repair, The effect of promoting blood circulation

Inactive Publication Date: 2010-02-17
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used external preparations of traditional Chinese medicine in clinical practice, such as powder, lotion, pla

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take the newly slaughtered beef Achilles tendon, soak it with 2mol / L hydrochloric acid for 48 hours at room temperature, take it out, wash it with distilled water, neutralize it with 0.5mol / L sodium hydroxide solution, and then soak it in 0.1% pepsin at 20°C Put it in the solution for 12 hours, take it out, wash it with water, cut it into small pieces of 0.05-0.5 cm, pickle and enzymatically hydrolyze once under the same conditions as above, and dry it at 60°C-70°C to obtain collagen.

Embodiment 2

[0027] Take fresh pigskin, wash, remove hair and fat, cut into small pieces, add 50 times the amount of 0.45mol / L sodium chloride-trishydroxymethylaminomethane-hydrochloric acid buffer solution (pH7.5), the condition of 4 ℃ Freeze for 48 hours, stir once every 8 hours, 5 minutes each time, centrifuge (3000r / min) for 15 minutes, take the supernatant and store it at 4°C, repeat the above operation for the precipitate, and take the supernatant and store it at 4°C. Combine the obtained supernatants, add glacial acetic acid under the condition of stirring, make the solution contain 0.5mol / L of glacial acetic acid, pH2.5~3, then add sodium chloride under the condition of stirring, make the whole solution contain 1mol of sodium chloride / L, stirred at 60r / min for 12 hours at 4°C, centrifuged, discarded the supernatant, collected the precipitate, added 50 times of 0.5mol / L glacial acetic acid solution to dissolve, centrifuged, collected the supernatant , add the calculated amount of 0...

Embodiment 3

[0029] Take fresh pigskin, wash, remove hair and fat, grind it, add water at a concentration of 60g / L, transfer it into a fermenter, stir, heat up to 90°C, keep it for 5 minutes, then cool down to 37°C, add 1% pepsin enzyme Decompose for 2 hours, heat up to 60°C, add 2% trypsin for 12 hours, heat up to 90°C, inactivate for 5 minutes, pass through a 10kD ultrafiltration membrane, and spray dry to obtain collagen with a molecular weight of less than 40kD.

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PUM

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Abstract

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for clearing heat and releasing toxin such as coptis root, golden cypress bark, rhubarb, giant knotweed rhizome, honeysuckle flower, forsythia fruit and the like which are prepared into aplurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior common preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn/scald, bedsore,chronic leg ulcer, diabetic foot or cancerous ulcer and the like, and can greatly shorten the required time for wound healing and tissue repair.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating various skin damage and ulcer diseases and application thereof. The composition is composed of collagen and heat-clearing and detoxifying traditional Chinese medicine, and belongs to the field of traditional Chinese medicine. Background technique [0002] Various diseases characterized by skin damage or ulcers mainly include various types of mechanical trauma, burns, decubitus ulcers, chronic lower ulcers, diabetic foot, cancerous ulcers, etc., because these diseases often cause skin surface defects, resulting in Skin lesions that reach deep into the dermis or deeper are often lingering and difficult to heal, and the course of the disease is long. It is a refractory disease recognized by doctors, and there is no ideal treatment plan at present. [0003] The external treatment method of traditional Chinese medicine emphasizes that "surgical treatment should focus on external treatment" a...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K38/39A61P17/02A61P3/10A61P35/00
Inventor 武建卓柴金苗
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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