The invention discloses a drug for mainly treating leg ulcer. The drug is characterized by being made from the following parts of raw materials by weight: 25-35 parts of yellow lead, 17-23 parts of dragon blood, 13-17 parts of camphor, 17-23 parts of calamine, 13-17 parts of dried alum, 13-17 parts of calcined gypsum, 13-17 parts of ginseng, 13-17 parts of astragalus root, 13-17 parts of Chinese goldthread, 13-17 parts of Chinese teasel root, 13-17 parts of dahurian angelica root, 13-17 parts of manyleaf paris rhizome, 13-17 parts of honeysuckle, 13-17 parts of anomalous wormwood, 13-17 partsof panicled swallowwort root, 17-23 parts of pearl, 17-23 parts of poppy shell, 17-23 parts of pseudo-ginseng, 17-23 parts of cnidium fruit, 17-23 parts of climbing groundsel, 17-23 parts of Chinese lobelia, 17-23 parts of borneol, 17-23 parts of natural indigo and 17-23 parts of leaf of Chinese ilex. The drug has the beneficial effects of good curative effect, convenient use, and simple preparation, and can activate blood circulation to dissipate blood stasis, eliminate necrotic tissues and promote granulation, improve the blood supply of wound surface, cause the granulation to regenerate tissue while expelling rotten materials, and can improve conditions for accelerated wound healing, and has instant effect.