9 results about "Traumatic wound" patented technology

The invention relates to a high-efficiency hemostatic antibacterial gel dressing, which is prepared from the following raw materials: 4-carboxyphenylboronic acid-based chitosan, drug aldehyde, methacrylic acid esterified gelatin and tranexamic acid, wherein the 4-carboxyphenylboronic acid-based chitosan and the methacrylic acid esterified gelatin are dissolved in water to form a solution A; protocatechuic aldehyde and tranexamic acid are dissolved in water to form a solution B, the solution A and the solution B are rapidly and uniformly mixed to form a pre-injection solution before treatment, the pre-injection solution is injected to the surface of a wound surface so that the dressing can be cured and formed in situ, after forming, the dressing can effectively adhere to the skin and release drugs, rapid hemostasis and antibiosis are achieved, and the dressing can be degraded in about 10 days in a physiological solution environment; the gel dressing can be widely applied to treatment of different trauma wounds.

The invention discloses a nano-enzyme cross-linked polylipoic acid-based hydrogel adhesive and preparation and application thereof.The preparation method comprises the following steps that caffeic acid is dissolved in ethyl alcohol to obtain a caffeic acid solution, an AgNO3 solution is added into the caffeic acid solution, stirring reaction is conducted, and caffeic acid-silver nano-enzyme is prepared; the preparation method comprises the following steps: sequentially adding lipoic acid and sericin into an aqueous solution of lithium hydroxide, then adding caffeic acid-silver nano-enzyme into the mixed solution, stirring and mixing until gel is formed, and cooling to obtain the hydrogel adhesive. The hydrogel provided by the invention has excellent wet adhesion performance, remarkable antibacterial property, good mechanical property and biocompatibility, and due to the characteristics, the hydrogel can provide a good repairing environment for wounds and provide effective antibacterial treatment, so that the rapid healing of traumatic wounds is facilitated, and the wound healing effect is improved. The method has a very good application prospect in the field of wound repair.

The present invention relates to a mechanical wound cleansing device comprising a carrier layer and an abrasive loop system arranged above the carrier layer, whereby the loop system is an intermeshed fiber system which is intermeshed above the carrier layer and / or a loop system comprising highly and softly abrasive loops. The present invention further relates to a method of producing said mechanical wound cleansing device. The present invention finally relates to the use of said wound cleansing device for the abrasive removal of and cleansing of wounds, especially for venous leg ulcers, diabetic foot ulcers (neuropathic and neuro-ischemic), arterial ulcers, mixed etiology ulcers, pressure ulcers or traumatic wounds.

The present application belongs to the technical field of external preparations of traditional Chinese medicine, and relates to a cream containing imperatorin and capable of promoting skin wound healing and a preparation method thereof. The cream takes imperatorin and puerarin as core effective components, magnesium lithium silicate and sodium hyaluronate as synergistic repair components, sorbitan oleate and lanolin as emulsifiers, refined sesame oil, squalane and white petrolatum as oil phase matrix, and further includes glycerol, and the rest is deionized water. Animal experiment results show that the cream can promote collagen fiber generation of granulation tissue, promote polarization of repair type macrophages, significantly optimize repair quality and reduce scar formation while improving wound healing rate, and has good safety. The preparation process is stable and controllable, and is suitable for industrial production. The cream can be used for I and II degree mild burn and scald, skin abrasion and other traumatic wounds, and is also suitable for skin problems such as postoperative wound repair of medical beauty and hand and foot chapped skin, has wide clinical application range, and has good application prospect and popularization value.

A method of promoting healing of a wound generally includes administering to the wound an amount of a PEP exosome preparation effective to promote healing of the wound. In one or more embodiments, the PEP exosome preparation includes a tissue sealant or surgical glue. In one or more embodiments, the wound is an ischemic wound, a puncture wound, a laceration, an abrasion, a surgical wound, a skin graft, or a traumatic wound.

A selectively transparent wound therapy dressing, system, and method of use are provided. The dressing may include conformable foam and drape layers, wherein the drape layer has a refractive index substantially within a range of a disclosing liquid. When the disclosing liquid is applied to the drape layer, the drape layer may switch from opaque to transparent. Subsequent evaporation of the disclosing liquid may return the drape layer to an opaque state. Some embodiments provide for paired use with a negative pressure source input device. The method of use provides selective visibility of a treatment site, and reduces the amount of time in which a patient views an acute or traumatic wound or injury.

The present invention relates to the field of biomedical materials, regenerative medicine and biotechnology, specifically to a method for producing a type I collagen solution from collagen-containing natural raw materials, and also to a method for producing a wound dressing based on type I collagen. The method for producing a type I collagen solution from collagen-containing natural raw materials does not require the use of complex equipment (in particular, centrifuges) and is therefore technologically simpler and requires less time and labor to produce type I collagen from collagen-containing natural raw materials. Moreover, said method is characterized by the short duration of the collagen extraction stage (with no need to perform a re-extraction step), as well as a high collagen yield. In addition, the type-I-collagen-based wound dressing produced using the method according to the invention is non-toxic and holds promise for the topical treatment of human skin defects, as well as for use in the case of second- and third-degree burns, and for the treatment of slow-healing shallow granulating wounds in the regeneration stage, post-traumatic wounds, trophic ulcers of any etiology or localization, bedsores, epidermolysis bullosa, and various types of pemphigus.

The dressing change device comprises a supporting frame, a grip is arranged on one side of the supporting frame, the other side of the supporting frame is sleeved with a rolling wheel in a rolling mode through a rotating shaft, flexible sponge is fixedly pasted to the bottom end of the supporting frame, the side, facing the rolling wheel, of the flexible sponge is distributed in an inclined mode, and the flexible sponge comprises a fixing base; and an inclined end is integrally formed on one side of the fixed seat. By arranging the roller, the flexible sponge and the support frame, an operator controls and pushes the roller to roll along the upper part of the dressing, so that the dressing is opened by using an adhesive layer on the roller, and the dressing is gradually adhered to the roller, and when the roller rolls, the dressing is prevented from falling off. The inclined end at the front end of the flexible sponge can smear liquid infiltrating the interior of the flexible sponge on the contact face of the dressing and the skin in real time, so that the contact face of the dressing is wetted, excessive adhesion between the dressing and the skin wound is prevented, and then the discomfort of a patient is relieved when the dressing is replaced.

The application discloses a nano-enzyme cross-linked polysulfooxynic acid-based hydrogel adhesive as well as a preparation method and application thereof, wherein the preparation method comprises the following steps: dissolving caffeic acid in ethanol to obtain a caffeic acid solution, adding an AgNO3 solution into the caffeic acid solution, and stirring and reacting to prepare caffeic acid-silver nano-enzymes; adding sulfooxynic acid and silk fibroin into an aqueous solution of lithium hydroxide in sequence, and then adding the caffeic acid-silver nano-enzymes into the mixture, stirring and mixing to form a gel, and obtaining the hydrogel adhesive after cooling. The hydrogel provided by the application has excellent wet adhesion, remarkable antibacterial property, good mechanical property and biocompatibility, these properties enable the hydrogel to provide a good repair environment for a wound and provide effective antibacterial treatment, thereby being beneficial to the rapid healing of a traumatic wound, and having a very good application prospect in the field of wound repair.