86 results about "Traumatic wound" patented technology

An apparatus, system, and method are disclosed for protection, depressurization, and treatment of a traumatic wound. The disclosed apparatus comprises a flexible patch with an elevated portion configured to accommodate multiple connectors at least one of which is configured to interface with a two-way valve.

Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.

The invention herein encompasses methods effective to stimulate epithelial cell proliferation and / or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of beta -glucosidase activity or beta -glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions. The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of beta -glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.

The invention discloses application of ozonized oil to preparation of raw materials of medical health-care products and belongs to the field of medical health care. In particular, the ozonized oil is applied to preparation of toothpaste for preventing and treating saprodontia and oral diseases, preparation of cosmetics for preventing all the skin infectious diseases, preparation of medical dressing for externally applying to surgical wounds and skin diseases and preparation of ointment applied to burnt wound surfaces and traumatic wound surfaces. The ozonized oil has unmatched effect on daily sterilization compared with any other bactericide and does not have toxicity and medicament tolerance.

The present invention relates to a bendable bone plate for external fixation, comprising a main body made of flexible materials, wherein the end of the main body has a larger surface area. There are several perforations running the length of the bone plate body and more located on the larger proximal end. The characteristics of the present invention, a bendable bone plate for external fixation, deal with remote end fracture, proximal end fracture, central fracture or comminuted fracture of an upper limb long bone. Furthermore, the bendable bone plate for external fixation can be manipulated for averting the nerve plexus and traumatic wounds, allowing for external fixation surgery.

The invention relates to a hydrogel dressing, comprising a non-woven fabric layer and a hydrogel layer arranged thereon. The hydrogel is poured on the non-woven fabric and cross-linked by an electron accelerator with an irradiation dose of 15-90 kGy; The hydrogel of the adhesive layer contains water-soluble polymers and monomers and water-soluble chitosan derivatives, the mass percentage of water-soluble polymers and monomers is 15-30%, and the mass percentage of water-soluble chitosan derivatives The percentage content is 0.5-3%; the water-soluble polymer and monomer are one or more of polyvinyl alcohol, hydroxyethyl methacrylate, sodium polyacrylate and gelatin, and the water-soluble chitosan derivative is the shell Polysaccharide hydrochloride. The hydrogel dressing has excellent water absorption performance and good air permeability, and has the functions of antibacterial, anti-inflammatory and promoting wound healing, and is suitable for wound protection and treatment of burns, scalds and traumatic wounds.

Some embodiments of the invention provide an apparatus for achieving hemostasis in a puncture tract in a patient (e.g., a human or animal). Such a tract might have been created during a medical procedure or operation. Alternatively, the tract might be a result of a traumatic injury (e.g., injury that occurred outside of a hospital) that created a traumatic wound, such as a bullet wound, shrapnel or knife puncture. The puncture typically extends from the epidermis to the vasculature and / or internal organs in a living organism. In some embodiments, the apparatus includes (1) a bandage for inserting at least partially into a puncture tract to achieve hemostasis, and (2) a strap for maintaining the bandage on a part of a patient (e.g., a part of a human or animal such as appendage, torso, extremity, etc.). The strap maintains the bandage within the puncture tract at a particular pressure in some embodiments. The bandage and strap are removed from the patient after a time period (e.g., once hemostasis is achieved).

The invention provides a medical adhesive prepared by adopting skin mucus of giant salamander as a raw material and a preparation method, relating to the medical field. The medical adhesive is prepared by adopting the skin mucus of giant salamander as the raw material. The preparation method comprises the following steps: A, carrying out quick-freezing, B, carrying out low-temperature sterilizing, C, carrying out low-temperature grinding, D, carrying out dehydrating, and E, forming styptic medicinal powder. The second-level bleeding-stopping and adhering functions of the skin mucus of giant salamander are utilized, so that the rapid bleeding stopping and adhering functions for the wound are realized; during the whole process of preparing the adhesive, the physical methods are only adopted, and the raw materials are pure natural biological materials, so that no toxic and side effects are caused; the prepared adhesive is wide in applicable people, realizes the second-level bleeding-stopping and adhering functions, and is good in effect, the pain of patients is alleviated, and the medical adhesive can be widely applied to the medical fields of surgical operation, traumatic wound healing, feature beautifying, and the like. In addition, for the adult giant salamander, 0.3-0.6 kg of skin mucus can be obtained from each adult giant salamander each month, and with the prepared medical adhesive, the additional value for culturing giant salamander can be greatly improved.

The invention relates to a medical protecting irrigation solution. The irrigation solution comprises the following components in percentage by weight: 0.5-5 percent of carboxymethyl chitosan, 0.70-0.9 percent of sodium chloride and the balance of water, wherein the weight-average molecular weight of the carboxymethyl chitosan is 5000-80000. The medical protecting irrigation solution can play roles in irrigating and cleaning a traumatic wound, and has the effects of keeping the wound wet and smooth, preventing adhesion of a wound and generation of a scar, inhibiting bacteria on the wound from growing, and the like; furthermore, the process is simple, and the irrigation solution can be stored stably and has less possibility of being degraded.

The invention provides a hydrogel active dressing with antibacterial and anti-inflammatory functions, and belongs to the field of medical hydrogel dressings. The dressing is prepared by the followingsteps: taking 2-vinyl-4, 6-diamino-1, 3, 5-triazine and hydroxyethyl acrylate as monomers, preparing a linear copolymer by adopting a chemical polymerization method, blending with amyloid protein fibers, generating a loose cross-linked network under the action of a cross-linking agent to form a first gel product, introducing a mixture of carboxymethyl chitosan and a water-soluble polyphenol compound into the loose first gel product, performing freeze-thaw cycle treatment under the combined action of the cross-linking agent in the first gel product, and performing secondary gelation to form cross-linked hydrogel which is mainly subjected to physical cross-linking and is assisted by chemical cross-linking. The mechanical property of the hydrogel dressing is greatly improved, and the hydrogeldressing has good antibacterial, anti-inflammatory and self-recovery functions and is suitable for wound protection and treatment of burns, scalds and traumatic wounds.

The invention relates to a first-aid dressing used for traumatic wounds in a cold area and a preparation method of the dressing. The first-aid dressing comprises a medicinal film protective layer, a medicinal film layer, a heating layer, a back lining layer and a heating protective layer which are arranged in sequence; and the first-aid dressing can reach a heating temperature of 28 to 38 DEG C within 1-2 hours and can heat continuously for 4-6 hours. The first-aid dressing is prepared by the following steps: 1, preparing traditional Chinese extract and a matrix, and mixing to obtain a medicinal film plaster; 2, preparing heating material, bagging to obtain the heating layer; 3, preparing the heating protective layer and the back lining layer; and 4, preparing the first-aid dressing, packaging and disinfecting. The first-aid dressing can be used for pre-hospital first aid of a wounded person, can cover and protect the wound from further being infected, can enable the medicinal layer to reach a higher temperature through the internal heating material even in a cold area with a lower temperature, has a long time of curative effect, greatly reduces the dressing change frequency and shortens treatment cycle, facilitates disinfection and sterilization more, and alleviates the pains of the wounded person.

The invention relates to a hyaluronic acid-nano silver-based dressing and a preparation method thereof. The hyaluronic acid-nano silver-based dressing comprises therapeutic drugs, nano silver, hyaluronic acid and degradable synthetic high polymers. The method mainly utilizes an electrostatic spinning technique to proportionally mix a solution containing nano silver and hyaluronic acid with a solution containing therapeutic drugs and synthetic high polymers and process the nano fiber nonwoven fabric. The obtained hyaluronic acid-nano silver-based dressing has the characteristics of favorable uniformity, high porosity, favorable air permeability and favorable biocompatibility. In the hyaluronic acid-nano silver-based dressing preparation process, water is used as the solvent, so no organic solvent residue exists. The method has the advantage of simple technique and low cost. The prepared hyaluronic acid-nano silver-based dressing has wide application range, and can be used for various surgical cuts, burn and scald surfaces, various traumatic wound surfaces, peripheral ulcer surfaces and various non-healing chronic ulcer wound surfaces.

The medical dressing consists of solid component and water, and features that the solid component contains quasi-cationic water soluble chitin derivative in 5-100 wt%. The production process of the medical dressing is to dissolve quasi-cationic water soluble chitin derivative in pure water to form water solution. Owing to that the quasi-cationic water soluble chitin derivative is water soluble, water maintainable, antibiotic, biocompatible and biodegradable and can promote heal of wound, it is easy to change without adhesion, less likely to form scar, high in antiseptic and antiphlogistic effect and high in promoting heal. The medical dressing has obvious curative effect on cut, burn and scald wound, traumatic wound, external ulcer surface, etc.

The invention discloses a Chinese medicament for traumatic wound, which belongs to the technical field of Chinese medicaments. The Chinese medicament is characterized by taking 40g of platycladus orientalis, 15g of elephant hide, 40g of rhubarb, 9g of trogopterus dung, 10g of amur corktree bark, 9g of myrrh, 10g of cattail pollen, 15g of rhizoma corydalis, 5g of pyrolusite, 10g of panax notoginseng and 6g of common jujube bark, mixing and crushing the mixture to 200 meshes, then placing the mixture into a pressure cooker, adding 350g of water, then boiling for 5 to 8min under the pressure of 70Pa and taking out; and adding 60g of honey and 6g of borneol when the temperature is reduced to 30 DEG C or so. The traumatized wound is externally applied with the medicament, which can maintain the favorable environment of the wound, is not dry, is favorable for the falling of necrotic tissues, maintains the cleanliness of a wound substrate, reduces infection hazard, protects wound surfaces and promotes the healing.

Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.

The invention provides an externally applied Chinese herb medicine conditioner which can relax tendons and activate collaterals as well as expel the wind and eliminate the stasis, and a preparation method thereof. The Chinese herb medicine conditioner comprises the following effective constituents in percentage by weight: 28.5-36.1 percent of peppermint oil, 25.2-32.5 percent of wintergreen oil, 7.2-15.5 percent of eucalyptus oil, 8-12 percent of wormwood essential oil, 7.0-12.0 percent of white camphor oil and 4-7 percent of clove oil. The preparation method comprises the following steps of: weighing each raw material with designated weight proportion for later use; placing the peppermint oil, the wintergreen oil, the eucalyptus oil and the white camphor oil into an oil mixing tank for stirring for 6-8 hours; and adding the wormwood essential oil and the clove oil into the tank for stirring for 1-3 hours to obtain the Chinese medicine herbal conditioner. The invention can relax the tendon and invigorate the circulation of the blood, remove the stasis and relieve the pain, and prevent and treat diseases of rheumatism ostealgia, muscles and bones pain, pelvic bone sharp pain, old traumatic wounds and the like.

The invention discloses a nano-silver composite antibacterial cellulose membrane, and a preparation method and an application thereof. The preparation method comprises the following steps: (1) a cellulose membrane is prepared with uniformly dispersed nano / micron cellulose; (2) a silver nitrate solution is uniformly sprayed onto a membrane substrate, and the membrane substrate is wetted until saturated; (3) water in the wetted and saturated membrane substrate is removed with a physical method, wherein the membrane substrate is not completely dried; (4) a reducing agent solution is sprayed onto the membrane substrate obtained in the step (3), until the membrane substrate is completely impregnated; and (5) when color is completely changed, the membrane substrate is taken out; the taken-out membrane substrate is washed and the washed membrane substrate is dried, such that the nano-silver composite antibacterial cellulose membrane is obtained. The preparation method provided by the invention is simple. With the method, nano-silver loading amount and distribution are easy to control. The nano-silver has the advantages of small size, uniform dispersion, good antibacterial effects, good bonding strength, and high stability. The original quality of the nano or micron cellulose is not influenced. The prepared membrane is suitable to be applied in the fields such as traumatic wound, medical care and antibacterial packaging.

The invention discloses a rhubarb ultramicro powder-containing film spraying agent for traumatic wounds and a preparation method thereof. Specifically, the rhubarb ultramicro powder-containing film spraying agent for traumatic wounds adopts rhubarb made into ultramicro powder as the raw material, the prepared rhubarb ultramicro powder has a particle size of 75microm or below. The preparation method of the rhubarb ultramicro powder-containing film spraying agent for traumatic wounds includes the following process steps: (1) subjecting rhubarb herb material to preliminary crushing to obtain rhubarb crude powder, then conducting ultramicro pulverization on the rhubarb crude powder to obtain rhubarb ultramicro powder; (2) dissolving chitosan hydrochloride in deionized water, adding a modifier, and performing stirring till complete dissolution; (3) dissolving povidone K30 in anhydrous ethanol, then adding the rhubarb ultramicro powder obtained in step (1), and mixing the substances evenly;and (4) mixing the solution obtained in step (2) and the solution obtained in step (3) to obtain the rhubarb ultramicro powder-containing film spraying agent for traumatic wounds. The rhubarb ultramicro powder-containing film spraying agent for traumatic wounds provided by the invention can effectively treat various skin injured traumas, and has the characteristics of protecting wounds, absorbingwound exuded liquid, promoting tissue repair and regeneration, accelerating wound healing and the like.

The invention provides a preparation method of carboxymethylcellulose porous hemostatic microspheres. The preparation method comprises the following steps: adding sodium chloroacetate into a celluloseaqueous solution and reacting at 8 DEG C to obtain a carboxymethylcellulose aqueous solution; and spraying the reaction liquid into solidification liquid by an electrostatic spraying method, regenerating and molding, washing and performing supercritical carbon dioxide drying to obtain the carboxymethylcellulose porous hemostatic microspheres, wherein the carboxymethylcellulose aqueous solution contains cellulose, urea and lithium hydroxide. The preparation method has the following beneficial effects: 1. the reaction liquid is directly subjected to electrostatic spraying, the preparation speedis high, environmental friendliness is achieved, and the particle size is uniform and controllable; and 2. the carboxymethylcellulose microspheres have porous structure characteristic, the porosity is 30 to 60 percent, the water-absorbing rate is up to 300 to 600 percent and the specific surface area is 100 to 250 m<2> / g. The carboxymethylcellulose porous hemostatic microspheres provided by the invention can serve as rapid hemostatic for hemorrhagic traumatic wound.

The invention relates to a burn dressing applicable to department of burn and having an antibacterial effect, and belongs to the technical field of medical dressings. The burn dressing is mainly prepared by the following steps: preparing a mixed solution which consists of algin acid, vitamin E, sodium ascorbyl phosphate, sodium polyacrylate and glycerol; preparing extracting solutions of herba portulacae, radix astragali and honeysuckle flower; and conducting a cross-linking reaction by virtue of a water-soluble polymer, starch, modified microcrystalline cellulose, water, an antibacterial agent and a cross-linking agent, so that the dressing is prepared. According to the burn dressing disclosed by the invention, the radix astragali has functions of replenishing qi to strengthen superficial body resistance, inducing diuresis and draining toxins, expelling pus, healing sores and promoting generation of fresh tissue. Astragaloside, as a main active ingredient in the radix astragali, has a certain effect on promoting healing of traumatic wounds; the herba portulacae is effective on promoting wound recovery and enhancing the antibacterial effect; the algin acid is capable of promoting absorption of medicines and improving a recovery effect; and the burn dressing, in the dosage form of a hydrogel, has a good effect on the recovery of burns.

The invention provides a preparation method of a chitin porous hemostatic microsphere. The method comprises the following steps of spraying a chitin-sodium hydroxide-urea water solution into a solidification liquid through an electrostatic spraying method; carrying out solidification regeneration molding; and carrying out washing and supercritical CO2 drying to obtain the chitin porous hemostatic microsphere, wherein the electrostatic spraying voltage is 5-20kV. Compared with the prior art, the method has the beneficial effects that (1) an organic solvent is not needed, and the method is high in preparation speed, green, environment-friendly and uniform in particle size; and (2) the chitin microsphere has porous structure characteristics, the porosity is 40-60%, the water absorption rate can reach 900-2300%, the specific surface area is 50-130m<2> / g, and the chitin porous hemostatic microsphere can be taken as a fast hemostatic for massive hemorrhage traumatic wounds.

The invention provides a hemostatic disinfectant. The solution of the hemostatic disinfectant comprises 0.1 to 50 mu m / ml hemostatic biological enzyme, a disinfectant of which the concentration can achieve sterilization and disinfection effects and 1 to 100 mg / ml protein protective agent. The hemostatic disinfectant is more suitable for cleaning and disinfecting the wound surface of skin, a mucous membrane or a tissue in surgical operation, stopping bleeding for a traumatic wound and disinfecting the traumatic wound. The invention also provides a method for preparing the hemostatic disinfectant. The preparation method comprises the following step of: preparing the solution of the hemostatic disinfectant which comprises 0.1 to 50 mu m / ml hemostatic biological enzyme, the disinfectant of which the concentration can achieve the sterilization and disinfection effects and 1 to 100 mg / ml protein protective agent.

The drug of the present invention is a traditional Chinese medicine preparation for treating bruises and sprains, and the present invention is developed and aims at solving the problem that although the treatment methods for the common diseases, the bruises, sprains and traumatic wounds, in both traditional Chinese medicine and the western medicine, are numerous, the effects are still unsatisfactory. The drug is scatter, so the drug thereof is called as: Jinchuang San. The present invention takes the secret recipe of Guan clan as the recipe and is based on a plurality of clinical practices of the recipe, and the invention is prepared by adopting the modern biopharmaceutical process, thus having significant cure effect.

The invention relates to an application of a hypertonic solution composition in the preparation of the drugs for promoting wound healing during the perioperative period, the composition is composed of 1.5 to 6.9 percent (w / v) one or more substances of sodium chloride, sodium bicarbonate, potassium chlorine, magnesium sulfate, calcium chloride and calcium gluconate, 3 to 18 percent (w / v) one or more substances of hydroxyethyl starch, dextran, carboxymethyl starch, polyvinyl pyrrolidone and gelatin derivatives and the rest amount of conventional injection liquid; the conditions are that the sodium chloride in the composition is not less than 1.5 percent (w / v), and the concentration of the sodium ions is not more than the concentration of the sodium ions in the 6.9 percent (w / v) of sodium chloride. The hypertonic solution composition can be dropped as the injection before, during and after the operation, the dosage is 100 to 1500ml per person per day, the invention can promote the wound healing after usage and has the advantages that the usage is safe and convenient, and the invention can be widely used in various types of surgical wounds or traumatic wounds (surfaces) and anastomosis, etc.

The invention belongs to the field of hygienic products, and particularly relates to a preparation method of a 3D printed wound customized adhesive bandage matched with the size, the shape and the injured part of a trauma wound through 3D printing. The wound customization program comprises image information acquisition of a wound shape and an injured part, computer image recognition and modeling to generate a model file to match the shape, the size and the injured part of the wound; and performing 3D printing on the model file to generate the adhesive bandage base material. The adhesive bandage base material can integrate one or more functions of antibiosis, blood coagulation, moisturizing, ventilation, inflammation diminishing and the like so as to accelerate wound healing. The 3D printedwound customized adhesive bandage provided by the invention can be attached to different injured parts, and can be matched with the outline and the size of a wound. The adhesive bandage is adjustablein shape, accurate in medicine application, simple to manufacture, convenient and rapid, and particularly suitable for accurate treatment of traumatic wounds of different shapes and different parts.

The invention relates to a traditional Chinese medicine for treating fractures and traumatic wounds, which effectively solves the problem that an existing medicine for treating fractures and traumatic wounds takes effect slowly, is poor in effect, high in cost and causes serious toxic and side effects after being taken for a long period of time. The traditional Chinese medicine comprises the following medicinal raw materials by weight: 0.01-0.03g of artificial tiger bone powder, 8-13g of peccary skin, 18-23g of native copper, 0.47-0.55g of semen strychni, 39.5-44.5g of acacia catechu and 8-13g of dragon's blood. The traditional Chinese medicine is prepared by the following steps: respectively grinding peccary skin, native copper, semen strychni, acacia catechu and dragon's blood into powder; mixing with artificial tiger bone powder evenly to obtain traditional Chinese medicine powder for treating traumatic wounds; and adding a dried body of ground beetle which is ground into powder, and mixing evenly, so as to obtain the traditional Chinese medicine powder for treating fractures. The traditional Chinese medicine is scientific in compatibility, simple in method, short in treatment period, high in cure rate, good in effect, small in side effect, low in cost, and free of relapse, and is capable of effectively promoting healing of the wounds, and is a great creation in traditional Chinese medicine.

The invention provides mobile nursing equipment suitable for traumatic wound nursing, and relates to the technical field of medical nursing. The mobile nursing equipment comprises a main body box, a nursing mechanism and a recycling mechanism; a servo motor is mounted at the top of the main body box, a connecting plate is fixedly connected to the tail end of a rotating shaft, and a water tank is mounted at the left end of the top of the connecting plate; the water pipe is communicated with the bottom of the water tank, the output pipe is communicated with the bottom of the medicament box, the dispersion disc is mounted at the tail end of the output pipe, a mounting plate is arranged at the position, close to the output pipe, of the bottom of the connecting plate, and the fan is fixedly connected to the mounting plate. A connecting plate is adjusted to rotate through a servo motor, so a series of operations such as cleaning, wiping and medicine applying can be performed on a hand extending into a nursing inlet to be placed on an elastic belt, binding can be directly performed after completion, the nursing efficiency is effectively improved, the whole device can be moved through moving wheels, convenience and rapidness are achieved, and the use in a medical care room is convenient.

The invention discloses a pediatric trauma spray and a preparation method thereof. The pediatric trauma spray is prepared from 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborocyclopentadien-1-ol, borneol, octyl 4-methoxycinnamate, isopropanol, methyl ethyl ketone, Tween 80, disodium edetate and purified water, is in a solution form, and has an excellent function of promoting healing of traumatic wounds of children, especially hemorrhagic traumatic wounds.