7 results about "Protocatechuic aldehyde" patented technology

The invention discloses construction and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum for integrally controlling a multi-component material basis of a traumatic injury bone-growing capsule, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and neochlorogenic acid, protocatechuic aldehyde, cryptochlorogenic acid, vanillic acid, rosmarinic acid, alkannic acid, berberine hydrochloride and salvianolic acid B are taken as reference substances; the fingerprint spectrum is successfully constructed by detecting different batches of traumatic injury bone-growing capsules. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least eight components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be carried out on a plurality of characteristic components of the traumatic injury bone-growing capsule accurately, rapidly and simultaneously, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the traumatic injury bone-growing capsule.

The invention relates to the technical field of intelligent hydrogel dressings, in particular to a preparation method and application of a chitosan-based hydrogel wound dressing, and the preparation method comprises the following steps: integrating sulfydryl chitosan (CS-SH), carbon nanotubes (CNTs) and protocatechualdehyde (PA), and forming the chitosan-based hydrogel wound dressing through a crosslinking effect. The chitosan-based hydrogel wound dressing disclosed by the invention has the characteristics of photo-thermal performance, excellent antibacterial activity, excellent electrical conductivity, sensing performance and the like. The hydrogel wound dressing has great potential in the aspects of infectious wound treatment and real-time body action monitoring, and a new design thought is provided for developing an intelligent wound management system with specific adaptability to patients.

The invention relates to a high-efficiency hemostatic antibacterial gel dressing, which is prepared from the following raw materials: 4-carboxyphenylboronic acid-based chitosan, drug aldehyde, methacrylic acid esterified gelatin and tranexamic acid, wherein the 4-carboxyphenylboronic acid-based chitosan and the methacrylic acid esterified gelatin are dissolved in water to form a solution A; protocatechuic aldehyde and tranexamic acid are dissolved in water to form a solution B, the solution A and the solution B are rapidly and uniformly mixed to form a pre-injection solution before treatment, the pre-injection solution is injected to the surface of a wound surface so that the dressing can be cured and formed in situ, after forming, the dressing can effectively adhere to the skin and release drugs, rapid hemostasis and antibiosis are achieved, and the dressing can be degraded in about 10 days in a physiological solution environment; the gel dressing can be widely applied to treatment of different trauma wounds.

This invention relates to the field of biomedical technology and discloses a method for preparing and applying copper-manganese coordinated taurine-Schiff base nanopolymers. The preparation method includes: dissolving taurine and an equimolar amount of sodium hydroxide in anhydrous ethanol, heating under reflux, and adding protocatechuic aldehyde dissolved in anhydrous ethanol dropwise while stirring; heating under reflux and stirring; a yellow solid precipitates from the reaction solution, which is then transferred to a refrigerator to further precipitate the solid, and collected to obtain taurine-Schiff base; dissolving copper chloride and manganese chloride in an aqueous solution of polyvinylpyrrolidone, adding taurine-Schiff base while stirring, adjusting the pH of the reaction solution to alkaline with an alkaline solution, stirring, and collecting to obtain copper-manganese coordinated taurine-Schiff base nanopolymers; ultrasonically dispersing the nanopolymer in ultrapure water, adding an anti-angiogenic drug, stirring, and collecting to obtain drug-loaded copper-manganese coordinated taurine-Schiff base nanopolymers. This invention achieves effective local treatment and immune system activation, while improving treatment safety.

The invention relates to multifunctional composite hydrogel and a preparation method and application thereof.The multifunctional composite hydrogel is prepared from raw materials including the following components through a cross-linking reaction: a conductive and photo-thermal functional unit which is a carboxylated single-walled carbon nanotube grafted by epsilon-poly-L-lysine and polyethylene glycol diamine, recording as epsilon-PL-CNT-PEG (Polyethylene Glycol); the dynamic cross-linked network unit comprises hydrazide chondroitin sulfate and a protocatechuic aldehyde-iron complex, the hydrazide chondroitin sulfate is marked as CS-ADH, and the protocatechuic aldehyde-iron complex is marked as PA at Fe. The multifunctional composite hydrogel disclosed by the invention can realize electric conduction, photo-thermal antibiosis, oxidation resistance, self-healing, adhesion and pH response degradation in the same system.

The application discloses a method for extracting phenolic active substances from Phellinus baumii fruiting bodies by adopting a series extraction and purification method and application of the phenolic active substances in uric acid regulation, and belongs to the technical field of deep processing of edible fungi. The method is as follows: after the Phellinus baumii fruiting bodies are soaked in an acetone solution, a crude acetone extract is obtained by using a multi-frequency ultrasonic device, then the crude acetone extract is dissolved in ethanol, and a HPD-826 macroporous resin filler and a LX-17 macroporous resin filler are connected in series to carry out adsorption and elution, so that a pure Phellinus baumii polyphenol extract is obtained. The polyphenol content of the phenolic active substances prepared from the Phellinus baumii fruiting bodies is as high as 80% or more, main active substances are protocatechuic acid, protocatechuic aldehyde, coffee acid, p-coumaric acid, dihydroquercetin, Hispidin and the like, and the phenolic active substances can be prepared into medicines for regulating intestinal flora structure and uric acid metabolism.

The present application relates to ascorbate peroxidase and its coding gene and application. The ascorbate peroxidase of Fritillariae Pallidicaulis Herb is disclosed for the first time, which has the ability of synthesizing protocatechuic aldehyde and can catalyze p-hydroxybenzaldehyde to generate protocatechuic aldehyde. The present application also discloses polynucleotide coding the ascorbate peroxidase, vector and host cell expressing the ascorbate peroxidase, and method for producing protocatechuic aldehyde.