This invention relates to the field of
biomedical technology and discloses a method for preparing and applying
copper-
manganese coordinated
taurine-
Schiff base nanopolymers. The preparation method includes: dissolving
taurine and an equimolar amount of
sodium hydroxide in
anhydrous ethanol, heating under
reflux, and adding
protocatechuic aldehyde dissolved in
anhydrous ethanol dropwise while stirring; heating under
reflux and stirring; a yellow
solid precipitates from the reaction solution, which is then transferred to a refrigerator to further precipitate the
solid, and collected to obtain
taurine-
Schiff base; dissolving
copper chloride and
manganese chloride in an
aqueous solution of
polyvinylpyrrolidone, adding taurine-
Schiff base while stirring, adjusting the pH of the reaction solution to alkaline with an alkaline solution, stirring, and collecting to obtain
copper-
manganese coordinated taurine-Schiff base nanopolymers; ultrasonically dispersing the nanopolymer in
ultrapure water, adding an anti-angiogenic
drug, stirring, and collecting to obtain
drug-loaded copper-manganese coordinated taurine-Schiff base nanopolymers. This invention achieves effective local treatment and
immune system activation, while improving treatment safety.