61 results about "Smart hydrogels" patented technology

The invention relates to the technical field of degreasing agents, in particular to a high-efficiency energy-saving degreasing agent and a preparation method thereof, and the high-efficiency energy-saving degreasing agent comprises the following components in parts by weight: 6-9 parts of recombinant thermostable lipase; 4-7 parts of alkaline protease; 1.5 to 2.5 parts of nano silver particles wrapped by chitosan; 0.8 to 1.8 parts of beta-cyclodextrin modified carbon quantum dots; 12 to 18 parts of sodium alginate based intelligent hydrogel microspheres; 18 to 22 parts of lauryl glucoside; 12 to 18 parts of coconut oil-based betaine; 6 to 9 parts of propylene glycol; 4 to 7 parts of d-limonene; 10 to 14 parts of polyethylene glycol 400; 2 to 4 parts of dipotassium phosphate; according to the modified recombinant thermostable lipase, the low-temperature activity and the pH adaptability are remarkably improved while the high catalytic efficiency is maintained, and the antibacterial performance is enhanced by combining the nano-silver particles wrapped by the chitosan with the beta-cyclodextrin modified carbon quantum dots.

The invention discloses a preparation method of an intelligent driving material based on natural rubber-hydrogel, and a heterogeneous interpenetrating network intelligent driving material containing a gel network and a rubber network is obtained by compounding super-hydrophilic natural rubber latex and poly (N-isopropylacrylamide) and introducing single-sheet-layer MXene at the same time. The material disclosed by the invention not only has excellent mechanical properties (the tensile strength is 1.7 MPa, which is enhanced by 50 times or more than that of blank intelligent hydrogel) and super-tensile properties (the elongation at break can reach 1500% or more) which are far better than those of common intelligent driving hydrogel, but also keeps high photo-thermal conversion efficiency and good intelligent driving performance, can realize remote controllable near-infrared light driving, and has wide application prospects. Therefore, the method has a wide application prospect in the fields of miniature soft robots, artificial muscles, biomedicine and the like.

The invention discloses an intelligent hydrogel pH sensor based on a fiber bragg grating and a preparation method of the intelligent hydrogel pH sensor, and belongs to the technical field of optical fiber sensing. The preparation method comprises the following steps: by taking acrylic acid as a monomer, hydroxyethyl methylacrylate as a comonomer, ethylene glycol methacrylate as a cross-linking agent and benzoin dimethyl ether as a photoinitiator, mixing citric acid and adding graphene, thereby obtaining the pH value sensitive hydrogel. The pH response sensitivity of the sensor can be greatly improved; meanwhile, by adding citric acid, the number of carboxyl groups is increased, the cross-linking speed is increased and enhanced, and the response range of the sensor to pH is enlarged. The intelligent hydrogel pH sensor adopts a fiber bragg grating sensing method, signal transmission of the intelligent hydrogel pH sensor is an optical signal, the intelligent hydrogel pH sensor is not easily interfered by a surrounding electromagnetic field, and due to the fact that circuit elements do not exist, the working stability can be shown under the special complex environments such as fishing-light complementation and the like.

The invention discloses a method for detecting miRNA-21 based on a paper base-friction power generation sensing chip of intelligent DNA hydrogel and application. The method comprises the following steps: preparing Pt-Ni NPs; the preparation method comprises the following steps: preparing hydrogel embedded with Pt-Ni NPs; designing a paper-based micro-fluidic chip; the miRNA-21 is recognized through a CRISPR-Cas12a system, the gel is cut, internal Pt-Ni NPs signal molecules are released, and a blue strip is displayed on the paper-based micro-fluidic chip; a nano generator is connected with the chip to prepare a paper base-friction power generation sensing chip; along with the change of the concentration of the miRNA-21, the gel releases Pt-Ni NPs with different concentrations to cause the voltage change on the paper-based friction power generation sensing chip, and the change value is in direct proportion to the concentration of the miRNA-21. The chip is used for detecting miRNA-21 and has the advantages of simplicity in operation, small size, portability, high sensitivity, good specificity and short detection period.

The invention relates to the technical field of burn and scald treatment, in particular to an intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release. The dressing comprises a core-shell microsphere drug loading system used for realizing physical segmentation of a functional area; the dual-release system is used for realizing surface adsorption of quick-release drug nanoparticles and internal wrapping of sustained-release microspheres; a hydrogel matrix for forming a nanofiber network; and the magnetic control regulator is magnetic nanoparticles dispersed in the hydrogel matrix, and regulates the aperture of the hydrogel network through the action of an external magnetic field. According to the intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release, the Mongolian medicine compound intelligent hydrogel dressing is developed on the basis of a TRIZ innovative method; through a core-shell microsphere drug loading system and a dual release design, high drug loading capacity and accurate drug release control are synchronously realized.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

The invention provides super-stretched liquid metal-natural rubber composite hydrogel as well as a preparation method and driving-sensing synergistic bionic application thereof, liquid metal eutectic gallium indium is crushed into nano-particles, and then the nano-particles are combined with natural rubber latex to be compounded with poly (N-isopropylacrylamide), so that the super-stretched liquid metal-natural rubber composite hydrogel is prepared. The liquid metal-natural rubber composite intelligent hydrogel driving-sensing dual-function synergistic double-layer structure biomimetic material can be obtained. The material has the super-tensile property (the tensile rate is 1300%) and has the high deformation speed (the bending speed can reach 62 degrees / s) under photo-thermal driving. As the hydrogel contains liquid metal, the hydrogel has excellent conductivity (the conductivity can reach 5532 [mu] S / cm), and an electric signal can be monitored in real time in a photoresponse bending process, so that the hydrogel has an application prospect in the field of photothermal driving-self-sensing dual-function synergistic materials.

The present invention relates to a reprogramming responsive intelligent hydrogel material and a preparation method and application thereof. The hydrogel material provided by the present invention uses alginate as a skeleton, and uses RGD series polypeptides and polyglutamic acid to modify the skeleton respectively. The iPS cell line obtained by using the hydrogel material provided by the present invention to mediate somatic cell reprogramming is similar to embryonic stem cells, showing high expression of pluripotency-related genes at the transcriptional level and translational level, strong positive staining of alkaline phosphatase, and demethylation patterns of promoter regions of endogenous pluripotency-related genes Oct4 and Nanog. The hydrogel material provided by the present invention can quickly and efficiently obtain individual-specific induced pluripotent stem cells, laying a foundation for the acquisition of individual-specific induced pluripotent stem cells and their wide application in the fields of regenerative medicine, disease simulation and drug screening.

The invention relates to the technical field of intelligent hydrogel dressings, in particular to a preparation method and application of a chitosan-based hydrogel wound dressing, and the preparation method comprises the following steps: integrating sulfydryl chitosan (CS-SH), carbon nanotubes (CNTs) and protocatechualdehyde (PA), and forming the chitosan-based hydrogel wound dressing through a crosslinking effect. The chitosan-based hydrogel wound dressing disclosed by the invention has the characteristics of photo-thermal performance, excellent antibacterial activity, excellent electrical conductivity, sensing performance and the like. The hydrogel wound dressing has great potential in the aspects of infectious wound treatment and real-time body action monitoring, and a new design thought is provided for developing an intelligent wound management system with specific adaptability to patients.

The invention discloses a pH-responsive HG type pectin hydrogel based on Schiff base reaction and a preparation method and application thereof, the pH-responsive HG type pectin hydrogel has a structural formula as shown in the following formula I. According to the pH-responsive HG type pectin hydrogel, functional characteristics of HG type pectin, biological activity of oleanolic acid, 3, 4, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3- The intelligent hydrogel system with ROS / pH dual response characteristics is successfully constructed through the redox responsiveness of oleanolic acid, 3, 3 '-dithiodipropionic acid and the pH responsiveness of Schiff base reaction, and the system can effectively protect the activity of oleanolic acid and can be used for preparing drugs for improving alcoholic liver injury.

This invention belongs to the field of DNA hydrogel technology, specifically relating to a VEGF-responsive, on-demand release smart DNA hydrogel of glycyrrhizin, its preparation method, and its applications. This invention constructs a VEGF-responsive smart DNA hydrogel, efficiently encapsulating glycyrrhizin within a three-dimensional gel network, utilizing the high expression of VEGF in the tumor microenvironment to trigger on-demand drug release. This invention achieves precise on-demand release of glycyrrhizin, significantly improving drug utilization efficiency and reducing systemic toxicity. Simultaneously, the VEGF aptamer introduced into the system can specifically bind to and neutralize free VEGF, blocking angiogenesis, cutting off tumor nutrient supply, and further inhibiting tumor proliferation and progression, achieving a synergistic effect of intelligent drug delivery and anti-angiogenesis.

The present invention relates to the technical field of medical materials, and provides a smart hydrogel, a preparation method thereof, and an application thereof. The present invention introduces dopamine on the surface of TEMPO-oxidized nanocellulose, introduces 3-aminophenylboronic acid on the surface of oxidized dextran, and combines chitosan with polyvinyl alcohol to construct a hydrogel structure with a double cross-linked network based on Schiff base bonds and borate bonds. The present invention utilizes the characteristics of Schiff base bonds and borate bonds to enhance the mechanical properties of the hydrogel system; and due to the reversibility of Schiff base bonds and borate bonds, the smart hydrogel prepared by the present invention exhibits good self-repairing properties, further increasing the service life of the hydrogel; in addition, the smart hydrogel prepared by the present invention exhibits excellent antibacterial properties due to the presence of chitosan, which helps prevent bacterial infection at the wound site, thereby promoting wound repair, and has broad application prospects in the field of wound dressings.

The present invention provides a hydrogel for comprising a biodegradable polyphosphazene polymer, a radiation-sensitive diselenide cross-linker; and one or more payloads releasably loaded within the hydrogel. The present invention further provides methods for radiosensitizing target tissues such as tumors and providing sustained delivery of therapeutics triggered by irradiation. In another aspect, the present invention provides a method that includes: introducing the hydrogel, as describes herein, adjacent to malignant or marginal tissue; and administering radiation to the hydrogel, thereby disrupting the selenocystamine cross-linkers and releasing the one or more payloads.

The application provides a preparation method and application of tremella polysaccharide intelligent hydrogel for inhibiting ferroptosis, and relates to the technical field of biomaterial preparation, wherein the tremella polysaccharide intelligent hydrogel for inhibiting ferroptosis is prepared from methacrylated tremella polysaccharide TrepMA, oxidized tremella polysaccharide O-Trep and ketone thioalcohol diamine TK-NH2. The tremella polysaccharide intelligent hydrogel prepared by the method has a three-dimensional network structure, good mechanical properties and can load growth factors or active molecules to accelerate bone regeneration. In addition, the tremella polysaccharide intelligent hydrogel can inhibit ferroptosis and promote bone defect healing with osteoporosis. The tremella polysaccharide intelligent hydrogel prepared by the method has multiple biological activities, can not only provide certain support for bone regeneration, but also can inhibit ferroptosis, improve local osteoporosis, has antioxidant / anti-inflammatory and osteogenic differentiation induction effects through excellent biocompatibility, biological activity and drug controlled release effect, and can effectively promote bone tissue regeneration.

This invention belongs to the field of intelligent hydrogel preparation technology, and relates to a hydrogel coating constructed on the surface of titanium alloy and its preparation method. The method for constructing a hydrogel coating on the surface of titanium alloy includes the following steps: (1) preparing hydroxyapatite-coated MXene; (2) adding polyvinyl alcohol and polyacrylic acid to the hydroxyapatite-coated MXene to prepare a sol; (3) spin-coating the sol obtained in step (2) onto the surface of titanium alloy, and performing cyclic freeze-thaw operations, thereby constructing a hydrogel coating on the surface of titanium alloy. Compared with the prior art, this invention improves the tribological properties of the hydrogel coating on the surface of titanium alloy by adding MXene, and the overall process is simple and the effect is outstanding.

The invention relates to a preparation method of quick response hydrogel sensitive to pH and ROS, and belongs to the technical field of hydrogel. In order to solve the problems of easy infection, difficult healing, lack of a specific drug sustained release system for a wound and the like in an emergency, the multi-stimulation response hydrogel can better adapt to the change of the environment in a human body, and can accelerate the wound healing process. And the sustained release of specific drugs can be realized, and the common infection problem and the difficult problem of slow healing in the wound healing process can be solved. The rapid response hydrogel sensitive to pH and ROS can perform specific drug release aiming at wounds, is beneficial to improvement of treatment efficiency and reduction of pain of patients and treatment cost, and is a novel material with a potential wide application prospect. By means of the continuous drug release function of the intelligent hydrogel, rapid healing of wounds can be promoted, the infection risk is reduced, and the treatment success rate is increased.

The invention belongs to the technical field of 3D printing materials, and particularly discloses intelligent hydrogel with an active shrinkage function and a preparation method and application thereof.The preparation method comprises the following steps that S1, 3-acrylamidophenylboronic acid is added into deionized water, and a 3-acrylamidophenylboronic acid solution is obtained; s2, tannic acid is added into the 3-acrylamido phenylboronic acid solution, and a tannic acid 3-acrylamido phenylboronic acid solution is obtained; s3, phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate and guar gum are sequentially added into the tannic acid 3-acrylamide phenylboronic acid solution, and the intelligent hydrogel with the active shrinkage function is obtained. According to the intelligent hydrogel with the active contraction function as well as the preparation method and the application, the problems of insufficient forming precision and structural resolution in an existing extrusion type 3D printing technology are solved, and a new technical path is provided for in-vitro bionic construction of fine tissues such as capillary networks and nerve microcatheters.

The invention discloses a dual response type intelligent hydrogel drug carrier, and relates to the technical field of biological medicine, the preparation method comprises the following steps: raw material pretreatment, preparation of a shell pH response prepolymerization solution, preparation of a transition layer solution and preparation of a core enzyme response dispersion solution, coaxial electrospray molding, multi-stage cross-linking solidification and post-treatment purification, and construction of a core-shell structure by using specific raw materials. The preparation method has the advantages that a core-shell structure is constructed, the cyclodextrin modified hyaluronic acid forms a shell layer, the adamantane modified polylactic acid-glycolic acid copolymer forms an inner core, pH and an enzyme response unit are physically isolated, mechanism conflicts are avoided, and the stability of the enzyme is improved; then through multistage crosslinking, sequential control of a shell layer is achieved, pre-enrichment is completed through pH response adaptive lesion edge microenvironment gradient, and after a transition layer is degraded, an inner core is adaptive to a lesion core gradient through enzyme response to release drugs; the defect of early drug release or delayed drug release caused by the fact that an existing dual-response carrier cannot adapt to the focus microenvironment gradient due to response mechanism conflicts is overcome.

The invention discloses environment response type hydrogel and a preparation method and application thereof, and belongs to the technical field of intelligent hydrogel and microchannel control. Stimuli response type hydrogel monomers and a water-phase dispersing agent are used as raw materials, a linear molecular chain is formed under the action of a free radical thermal initiator, and then the environment response type hydrogel is prepared. After the water-phase dispersing agent generates free radicals, graft polymerization is carried out on molecules of the stimuli-responsive hydrogel monomer under the action of the cross-linking agent, in the polymerization process, carbon-carbon double bonds of the cross-linking agent are broken and react with the water-phase dispersing agent and the stimuli-responsive hydrogel monomer, a cross-linked structure is formed, and the environment-responsive hydrogel is obtained. The environment response type hydrogel prepared by the invention has a tri-crosslinked network structure, has a pH and temperature dual-response function, is high in response speed and high in accuracy, and shows hysteresis in the response process.

The invention relates to the related technical field of medical auxiliary instruments, in particular to an intelligent hydrogel injection system capable of being used for a limited abdominal aortic dissection, which comprises an external pipe fitting, and further comprises a stable auxiliary mechanism arranged on the external pipe fitting and capable of executing an expansion action on the outer wall of the external pipe fitting to limit the external pipe fitting, and a hydrogel injection mechanism arranged on the external pipe fitting and capable of executing an expansion action on the outer wall of the stable auxiliary mechanism, the assembling structure is arranged in a columnar shape and is located in the external pipe fitting; the puncture assembly is arranged in the assembly structure and matched with the assembly structure, the puncture assembly can be used for filling two kinds of colloids and mixing the two kinds of colloids at the conveying tail end, and during specific operation, medical staff can control the stable auxiliary mechanism, so that the stability of the stable auxiliary mechanism is improved. The stabilizing auxiliary mechanism is driven to execute the expansion action on the outer wall of the external pipe fitting, so that the external pipe fitting is limited, the stabilizing auxiliary function is achieved, and the operation safety and stability are improved.

The invention discloses magnetic temperature-sensitive intelligent hydrogel and a preparation method thereof, and belongs to the field of intelligent hydrogel preparation. The preparation method comprises the following steps: firstly, adding an alginic acid aqueous solution into a CaCl2 aqueous solution to prepare spherical gel; sequentially adding the spherical gel into an acrylamide monomer solution and a nitrogen isopropylacrylamide monomer solution, and carrying out a polymerization reaction, so as to obtain temperature-sensitive gel; and then soaking and reacting the temperature-sensitive gel in a solution of Fe < 2 + >: Fe < 3 + > in a ratio of 1: 2, taking out the temperature-sensitive gel, and immediately soaking and reacting the temperature-sensitive gel in a NaOH solution to prepare the intelligent hydrogel with magnetism and temperature sensitivity. The magnetic temperature-sensitive intelligent hydrogel prepared by the method has better biocompatibility, the critical transition temperature and the zero charge point pH are very close to those of a human body, and magnetic particles are very uniformly distributed in a gel network, so that the prepared gel has better magnetic effect, and the application prospect of the gel in the field of biomedicine is increased.

The invention belongs to the technical field of biomedical materials, and provides an intelligent hydrogel dressing with a three-layer structure as well as a preparation method and application of the intelligent hydrogel dressing. The intelligent hydrogel dressing with the three-layer structure comprises an upper layer, a middle layer and a bottom layer which are sequentially stacked, the upper layer is methacrylated gelatin hydrogel containing silver nanoparticles, the middle layer is methacrylated gelatin hydrogel containing mangiferin-loaded PLGA microspheres, and the bottom layer is methacrylated gelatin hydrogel. The upper layer of the intelligent hydrogel dressing with the three-layer structure is used for broad-spectrum antibiosis in the initial stage and quickly coping with bacterial infection; the middle layer is used for continuously releasing mangiferin, exerting the effects of resisting oxidation, resisting inflammation and promoting angiogenesis and eliminating oxidative stress; the bottom layer provides mechanical support and biocompatibility; through the synergistic effect of the multi-layer structure of the upper layer, the middle layer and the bottom layer, remarkable advantages are shown in multiple aspects such as mechanical support, medicine controllable release, broad-spectrum antibiosis and inflammation-oxidative stress regulation, and layering and cooperative intervention are achieved.

Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.

The invention discloses a preparation method of sensing intelligent hydrogel with a photo-thermal antibacterial effect. The preparation method comprises the following steps: firstly, preparing reactive poly (N-isopropylacrylamide) microgel and polydopamine nanoparticles; the preparation method comprises the following steps: uniformly mixing poly (N-isopropylacrylamide) microgel, polydopamine nanoparticles and silver nanowires with N-isopropylacrylamide, acrylamide and N, N '-methylene bisacrylamide, adding an initiator and N, N, N', N '-tetramethylethylenediamine, uniformly stirring and mixing with the mixture, and standing for reaction to form the hydrogel. The steps are simple and easy to operate, the prepared hydrogel can be compressed, stretched, bent and twisted, has excellent adhesion performance, self-healing ability, temperature responsiveness, near-infrared responsiveness, oxidation resistance, antibacterial performance and good biocompatibility, can realize sensitive strain sensing, and has wide application prospects. The method has potential application in the fields of bionic skin, novel wound dressings and the like.

The invention provides a multifunctional bioprosthetic valve material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the material, an acellular biological tissue matrix is used as a substrate, and formyl-free hydroxymethylated melamine is adopted for crosslinking to solve the calcification problem; an active oxygen response type intelligent hydrogel coating is constructed on the surface of the hydrogel, is composed of gelatin and diselenide bond-containing nanogel loaded with an anti-inflammatory drug, and can respond to an inflammatory microenvironment and intelligently release; through double-module cooperation of non-glutaraldehyde crosslinking and the intelligent response coating, the material has excellent anti-calcification and anti-thrombus performance, inflammation can be actively regulated and controlled, endothelialization is promoted, and the long-term durability and biocompatibility of the bioprosthetic valve are remarkably improved.

The present invention relates to a synthesis method and application of a PNIPAm-HPC thermosensitive smart hydrogel, comprising the following steps: 1. Adding N-isopropylacrylamide, hydroxypropylcellulose (HPC) and N,N'-methylenebisacrylamide to deionized water respectively and mixing them evenly to obtain a mixed solution; 2. Adding ammonium persulfate to the mixed solution of step 1 and stirring; 3. Adding N,N,N',N'-tetramethylethylenediamine to the mixed solution of step 2 and stirring to obtain a gel solution; 4. Placing it at 20-30°C for 2-3 hours can obtain a PNIPAm-HPC thermosensitive hydrogel. The present invention provides a simple preparation process of a PNIPAm-HPC dual-network thermosensitive hydrogel and a method for easily manufacturing a PNIPAm-HPC smart window, which opens up a new way for building energy conservation.

This invention discloses a smart, responsive comb-shaped gelatin-based hydrogel and its applications, belonging to the field of biomedical materials technology. The preparation method of the hydrogel is as follows: S1, Prussian blue is modified with tannic acid to obtain TA-coated Prussian blue core-shell nanoparticles, referred to as the PB-TA complex; S2, gelatin is dissolved in PBS solution, then methacrylic anhydride is added dropwise, and the reaction is carried out at 50-60℃ for 90-120 min, followed by dialyzing and freeze-drying to obtain acylated gelatin; S3, an initiator and NIPAM solution are added to the acylated gelatin solution, and the reaction is stirred for 10-14 h to obtain a comb-shaped gelatin solution; S4, zein solution and PB-TA complex solution are added to the comb-shaped gelatin solution to prepare a smart hydrogel exhibiting both temperature and near-infrared photothermal response. This hydrogel can be used for drug delivery, enabling controlled drug release.

The invention discloses a targeted exosome-hydrogel preparation as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation is composed of an umbilical cord mesenchymal stem cell exosome which is subjected to targeting modification by cartilage affinity peptide, therapeutic nucleic acid loaded in the umbilical cord mesenchymal stem cell exosome, and PLGA-PEG-PLGA temperature-sensitive hydrogel encapsulating the carrier. The preparation method comprises the following steps: efficiently preparing an active exosome by combining three-dimensional dynamic hypoxia culture with TSG-6 agonist stimulation; rapid and mild separation is carried out by using a micro-fluidic chip; carrying out CAP peptide targeted modification through chemical coupling; and finally, mixing the drug-loaded exosome with the pH response type hydrogel precursor solution to further prepare freeze-dried powder. Through combination of targeted modification and the intelligent hydrogel carrier, the enrichment retention capacity of the exosome in the articular cartilage and the response release efficiency of the exosome in a lesion environment are remarkably improved, collaborative treatment of anti-inflammation and cartilage regeneration promotion is achieved, and the preparation is good in stability and lasting in effect.

The application belongs to the field of biomedical polymer materials and regenerative medicine, and particularly relates to an intelligent hydrogel for treating skin tissue damage, a preparation method and a medicine thereof, and application thereof. The intelligent hydrogel comprises a hydrogel support and a functional module. The hydrogel support takes methacrylated gelatin as a matrix and forms a stable three-dimensional network structure through photo-crosslinking. The functional module comprises two core DNA chains, one of which is a ZnR-Cage chain with a sulfhydryl group directly or indirectly connected to one end of the chain, and the other is a CD44-link chain. The two chains form a non-active assembly through base complementary pairing. The intelligent hydrogel has many advantages such as strong spatiotemporal controllability, overcoming drug burst defects, efficient cascade repair, realizing targeted synergistic treatment, efficient integration, excellent stability and clinical transformation potential. It is particularly suitable for clinical treatment of complex wounds such as diabetic ulcers and infected wounds.

A hydrogel material is provided that includes a polymer matrix and a plurality of cellular units dispersed within the polymer matrix to form a cellular structure, wherein each cellular unit of the plurality of cellular units includes a stiff region and at least one soft region enclosed by the stiff region, and the hydrogel material develops a plurality of strain-induced heterogeneous subdomains upon application of a tensile load. Also provided is a method of preparing such hydrogel material, use of such hydrogel material, and an article of manufacture including such hydrogel material.