48 results about "Smart hydrogels" patented technology

The invention discloses a preparation method of an intelligent driving material based on natural rubber-hydrogel, and a heterogeneous interpenetrating network intelligent driving material containing a gel network and a rubber network is obtained by compounding super-hydrophilic natural rubber latex and poly (N-isopropylacrylamide) and introducing single-sheet-layer MXene at the same time. The material disclosed by the invention not only has excellent mechanical properties (the tensile strength is 1.7 MPa, which is enhanced by 50 times or more than that of blank intelligent hydrogel) and super-tensile properties (the elongation at break can reach 1500% or more) which are far better than those of common intelligent driving hydrogel, but also keeps high photo-thermal conversion efficiency and good intelligent driving performance, can realize remote controllable near-infrared light driving, and has wide application prospects. Therefore, the method has a wide application prospect in the fields of miniature soft robots, artificial muscles, biomedicine and the like.

The invention relates to the technical field of burn and scald treatment, in particular to an intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release. The dressing comprises a core-shell microsphere drug loading system used for realizing physical segmentation of a functional area; the dual-release system is used for realizing surface adsorption of quick-release drug nanoparticles and internal wrapping of sustained-release microspheres; a hydrogel matrix for forming a nanofiber network; and the magnetic control regulator is magnetic nanoparticles dispersed in the hydrogel matrix, and regulates the aperture of the hydrogel network through the action of an external magnetic field. According to the intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release, the Mongolian medicine compound intelligent hydrogel dressing is developed on the basis of a TRIZ innovative method; through a core-shell microsphere drug loading system and a dual release design, high drug loading capacity and accurate drug release control are synchronously realized.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

The invention provides super-stretched liquid metal-natural rubber composite hydrogel as well as a preparation method and driving-sensing synergistic bionic application thereof, liquid metal eutectic gallium indium is crushed into nano-particles, and then the nano-particles are combined with natural rubber latex to be compounded with poly (N-isopropylacrylamide), so that the super-stretched liquid metal-natural rubber composite hydrogel is prepared. The liquid metal-natural rubber composite intelligent hydrogel driving-sensing dual-function synergistic double-layer structure biomimetic material can be obtained. The material has the super-tensile property (the tensile rate is 1300%) and has the high deformation speed (the bending speed can reach 62 degrees / s) under photo-thermal driving. As the hydrogel contains liquid metal, the hydrogel has excellent conductivity (the conductivity can reach 5532 [mu] S / cm), and an electric signal can be monitored in real time in a photoresponse bending process, so that the hydrogel has an application prospect in the field of photothermal driving-self-sensing dual-function synergistic materials.

The invention relates to the technical field of intelligent hydrogel dressings, in particular to a preparation method and application of a chitosan-based hydrogel wound dressing, and the preparation method comprises the following steps: integrating sulfydryl chitosan (CS-SH), carbon nanotubes (CNTs) and protocatechualdehyde (PA), and forming the chitosan-based hydrogel wound dressing through a crosslinking effect. The chitosan-based hydrogel wound dressing disclosed by the invention has the characteristics of photo-thermal performance, excellent antibacterial activity, excellent electrical conductivity, sensing performance and the like. The hydrogel wound dressing has great potential in the aspects of infectious wound treatment and real-time body action monitoring, and a new design thought is provided for developing an intelligent wound management system with specific adaptability to patients.

The invention discloses a pH-responsive HG type pectin hydrogel based on Schiff base reaction and a preparation method and application thereof, the pH-responsive HG type pectin hydrogel has a structural formula as shown in the following formula I. According to the pH-responsive HG type pectin hydrogel, functional characteristics of HG type pectin, biological activity of oleanolic acid, 3, 4, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3- The intelligent hydrogel system with ROS / pH dual response characteristics is successfully constructed through the redox responsiveness of oleanolic acid, 3, 3 '-dithiodipropionic acid and the pH responsiveness of Schiff base reaction, and the system can effectively protect the activity of oleanolic acid and can be used for preparing drugs for improving alcoholic liver injury.

This invention belongs to the field of DNA hydrogel technology, specifically relating to a VEGF-responsive, on-demand release smart DNA hydrogel of glycyrrhizin, its preparation method, and its applications. This invention constructs a VEGF-responsive smart DNA hydrogel, efficiently encapsulating glycyrrhizin within a three-dimensional gel network, utilizing the high expression of VEGF in the tumor microenvironment to trigger on-demand drug release. This invention achieves precise on-demand release of glycyrrhizin, significantly improving drug utilization efficiency and reducing systemic toxicity. Simultaneously, the VEGF aptamer introduced into the system can specifically bind to and neutralize free VEGF, blocking angiogenesis, cutting off tumor nutrient supply, and further inhibiting tumor proliferation and progression, achieving a synergistic effect of intelligent drug delivery and anti-angiogenesis.

The present invention relates to the technical field of medical materials, and provides a smart hydrogel, a preparation method thereof, and an application thereof. The present invention introduces dopamine on the surface of TEMPO-oxidized nanocellulose, introduces 3-aminophenylboronic acid on the surface of oxidized dextran, and combines chitosan with polyvinyl alcohol to construct a hydrogel structure with a double cross-linked network based on Schiff base bonds and borate bonds. The present invention utilizes the characteristics of Schiff base bonds and borate bonds to enhance the mechanical properties of the hydrogel system; and due to the reversibility of Schiff base bonds and borate bonds, the smart hydrogel prepared by the present invention exhibits good self-repairing properties, further increasing the service life of the hydrogel; in addition, the smart hydrogel prepared by the present invention exhibits excellent antibacterial properties due to the presence of chitosan, which helps prevent bacterial infection at the wound site, thereby promoting wound repair, and has broad application prospects in the field of wound dressings.

The present invention provides a hydrogel for comprising a biodegradable polyphosphazene polymer, a radiation-sensitive diselenide cross-linker; and one or more payloads releasably loaded within the hydrogel. The present invention further provides methods for radiosensitizing target tissues such as tumors and providing sustained delivery of therapeutics triggered by irradiation. In another aspect, the present invention provides a method that includes: introducing the hydrogel, as describes herein, adjacent to malignant or marginal tissue; and administering radiation to the hydrogel, thereby disrupting the selenocystamine cross-linkers and releasing the one or more payloads.

The application provides a preparation method and application of tremella polysaccharide intelligent hydrogel for inhibiting ferroptosis, and relates to the technical field of biomaterial preparation, wherein the tremella polysaccharide intelligent hydrogel for inhibiting ferroptosis is prepared from methacrylated tremella polysaccharide TrepMA, oxidized tremella polysaccharide O-Trep and ketone thioalcohol diamine TK-NH2. The tremella polysaccharide intelligent hydrogel prepared by the method has a three-dimensional network structure, good mechanical properties and can load growth factors or active molecules to accelerate bone regeneration. In addition, the tremella polysaccharide intelligent hydrogel can inhibit ferroptosis and promote bone defect healing with osteoporosis. The tremella polysaccharide intelligent hydrogel prepared by the method has multiple biological activities, can not only provide certain support for bone regeneration, but also can inhibit ferroptosis, improve local osteoporosis, has antioxidant / anti-inflammatory and osteogenic differentiation induction effects through excellent biocompatibility, biological activity and drug controlled release effect, and can effectively promote bone tissue regeneration.

This invention belongs to the field of intelligent hydrogel preparation technology, and relates to a hydrogel coating constructed on the surface of titanium alloy and its preparation method. The method for constructing a hydrogel coating on the surface of titanium alloy includes the following steps: (1) preparing hydroxyapatite-coated MXene; (2) adding polyvinyl alcohol and polyacrylic acid to the hydroxyapatite-coated MXene to prepare a sol; (3) spin-coating the sol obtained in step (2) onto the surface of titanium alloy, and performing cyclic freeze-thaw operations, thereby constructing a hydrogel coating on the surface of titanium alloy. Compared with the prior art, this invention improves the tribological properties of the hydrogel coating on the surface of titanium alloy by adding MXene, and the overall process is simple and the effect is outstanding.

The invention belongs to the technical field of 3D printing materials, and particularly discloses intelligent hydrogel with an active shrinkage function and a preparation method and application thereof.The preparation method comprises the following steps that S1, 3-acrylamidophenylboronic acid is added into deionized water, and a 3-acrylamidophenylboronic acid solution is obtained; s2, tannic acid is added into the 3-acrylamido phenylboronic acid solution, and a tannic acid 3-acrylamido phenylboronic acid solution is obtained; s3, phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate and guar gum are sequentially added into the tannic acid 3-acrylamide phenylboronic acid solution, and the intelligent hydrogel with the active shrinkage function is obtained. According to the intelligent hydrogel with the active contraction function as well as the preparation method and the application, the problems of insufficient forming precision and structural resolution in an existing extrusion type 3D printing technology are solved, and a new technical path is provided for in-vitro bionic construction of fine tissues such as capillary networks and nerve microcatheters.

The invention discloses a dual response type intelligent hydrogel drug carrier, and relates to the technical field of biological medicine, the preparation method comprises the following steps: raw material pretreatment, preparation of a shell pH response prepolymerization solution, preparation of a transition layer solution and preparation of a core enzyme response dispersion solution, coaxial electrospray molding, multi-stage cross-linking solidification and post-treatment purification, and construction of a core-shell structure by using specific raw materials. The preparation method has the advantages that a core-shell structure is constructed, the cyclodextrin modified hyaluronic acid forms a shell layer, the adamantane modified polylactic acid-glycolic acid copolymer forms an inner core, pH and an enzyme response unit are physically isolated, mechanism conflicts are avoided, and the stability of the enzyme is improved; then through multistage crosslinking, sequential control of a shell layer is achieved, pre-enrichment is completed through pH response adaptive lesion edge microenvironment gradient, and after a transition layer is degraded, an inner core is adaptive to a lesion core gradient through enzyme response to release drugs; the defect of early drug release or delayed drug release caused by the fact that an existing dual-response carrier cannot adapt to the focus microenvironment gradient due to response mechanism conflicts is overcome.

The invention discloses magnetic temperature-sensitive intelligent hydrogel and a preparation method thereof, and belongs to the field of intelligent hydrogel preparation. The preparation method comprises the following steps: firstly, adding an alginic acid aqueous solution into a CaCl2 aqueous solution to prepare spherical gel; sequentially adding the spherical gel into an acrylamide monomer solution and a nitrogen isopropylacrylamide monomer solution, and carrying out a polymerization reaction, so as to obtain temperature-sensitive gel; and then soaking and reacting the temperature-sensitive gel in a solution of Fe < 2 + >: Fe < 3 + > in a ratio of 1: 2, taking out the temperature-sensitive gel, and immediately soaking and reacting the temperature-sensitive gel in a NaOH solution to prepare the intelligent hydrogel with magnetism and temperature sensitivity. The magnetic temperature-sensitive intelligent hydrogel prepared by the method has better biocompatibility, the critical transition temperature and the zero charge point pH are very close to those of a human body, and magnetic particles are very uniformly distributed in a gel network, so that the prepared gel has better magnetic effect, and the application prospect of the gel in the field of biomedicine is increased.

The invention belongs to the technical field of biomedical materials, and provides an intelligent hydrogel dressing with a three-layer structure as well as a preparation method and application of the intelligent hydrogel dressing. The intelligent hydrogel dressing with the three-layer structure comprises an upper layer, a middle layer and a bottom layer which are sequentially stacked, the upper layer is methacrylated gelatin hydrogel containing silver nanoparticles, the middle layer is methacrylated gelatin hydrogel containing mangiferin-loaded PLGA microspheres, and the bottom layer is methacrylated gelatin hydrogel. The upper layer of the intelligent hydrogel dressing with the three-layer structure is used for broad-spectrum antibiosis in the initial stage and quickly coping with bacterial infection; the middle layer is used for continuously releasing mangiferin, exerting the effects of resisting oxidation, resisting inflammation and promoting angiogenesis and eliminating oxidative stress; the bottom layer provides mechanical support and biocompatibility; through the synergistic effect of the multi-layer structure of the upper layer, the middle layer and the bottom layer, remarkable advantages are shown in multiple aspects such as mechanical support, medicine controllable release, broad-spectrum antibiosis and inflammation-oxidative stress regulation, and layering and cooperative intervention are achieved.

Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.

The invention provides a multifunctional bioprosthetic valve material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the material, an acellular biological tissue matrix is used as a substrate, and formyl-free hydroxymethylated melamine is adopted for crosslinking to solve the calcification problem; an active oxygen response type intelligent hydrogel coating is constructed on the surface of the hydrogel, is composed of gelatin and diselenide bond-containing nanogel loaded with an anti-inflammatory drug, and can respond to an inflammatory microenvironment and intelligently release; through double-module cooperation of non-glutaraldehyde crosslinking and the intelligent response coating, the material has excellent anti-calcification and anti-thrombus performance, inflammation can be actively regulated and controlled, endothelialization is promoted, and the long-term durability and biocompatibility of the bioprosthetic valve are remarkably improved.

This invention discloses a smart, responsive comb-shaped gelatin-based hydrogel and its applications, belonging to the field of biomedical materials technology. The preparation method of the hydrogel is as follows: S1, Prussian blue is modified with tannic acid to obtain TA-coated Prussian blue core-shell nanoparticles, referred to as the PB-TA complex; S2, gelatin is dissolved in PBS solution, then methacrylic anhydride is added dropwise, and the reaction is carried out at 50-60℃ for 90-120 min, followed by dialyzing and freeze-drying to obtain acylated gelatin; S3, an initiator and NIPAM solution are added to the acylated gelatin solution, and the reaction is stirred for 10-14 h to obtain a comb-shaped gelatin solution; S4, zein solution and PB-TA complex solution are added to the comb-shaped gelatin solution to prepare a smart hydrogel exhibiting both temperature and near-infrared photothermal response. This hydrogel can be used for drug delivery, enabling controlled drug release.

The invention discloses a targeted exosome-hydrogel preparation as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation is composed of an umbilical cord mesenchymal stem cell exosome which is subjected to targeting modification by cartilage affinity peptide, therapeutic nucleic acid loaded in the umbilical cord mesenchymal stem cell exosome, and PLGA-PEG-PLGA temperature-sensitive hydrogel encapsulating the carrier. The preparation method comprises the following steps: efficiently preparing an active exosome by combining three-dimensional dynamic hypoxia culture with TSG-6 agonist stimulation; rapid and mild separation is carried out by using a micro-fluidic chip; carrying out CAP peptide targeted modification through chemical coupling; and finally, mixing the drug-loaded exosome with the pH response type hydrogel precursor solution to further prepare freeze-dried powder. Through combination of targeted modification and the intelligent hydrogel carrier, the enrichment retention capacity of the exosome in the articular cartilage and the response release efficiency of the exosome in a lesion environment are remarkably improved, collaborative treatment of anti-inflammation and cartilage regeneration promotion is achieved, and the preparation is good in stability and lasting in effect.

The application belongs to the field of biomedical polymer materials and regenerative medicine, and particularly relates to an intelligent hydrogel for treating skin tissue damage, a preparation method and a medicine thereof, and application thereof. The intelligent hydrogel comprises a hydrogel support and a functional module. The hydrogel support takes methacrylated gelatin as a matrix and forms a stable three-dimensional network structure through photo-crosslinking. The functional module comprises two core DNA chains, one of which is a ZnR-Cage chain with a sulfhydryl group directly or indirectly connected to one end of the chain, and the other is a CD44-link chain. The two chains form a non-active assembly through base complementary pairing. The intelligent hydrogel has many advantages such as strong spatiotemporal controllability, overcoming drug burst defects, efficient cascade repair, realizing targeted synergistic treatment, efficient integration, excellent stability and clinical transformation potential. It is particularly suitable for clinical treatment of complex wounds such as diabetic ulcers and infected wounds.

A hydrogel material is provided that includes a polymer matrix and a plurality of cellular units dispersed within the polymer matrix to form a cellular structure, wherein each cellular unit of the plurality of cellular units includes a stiff region and at least one soft region enclosed by the stiff region, and the hydrogel material develops a plurality of strain-induced heterogeneous subdomains upon application of a tensile load. Also provided is a method of preparing such hydrogel material, use of such hydrogel material, and an article of manufacture including such hydrogel material.

The intelligent hydrogel mask comprises a matrix and functional components, the matrix at least comprises 5%-10% by weight of sodium carboxymethyl cellulose, 10%-20% by weight of polyethylene glycol, 10%-20% by weight of glycerin, 10%-20% by weight of benzalkonium bromide and 10%-20% by weight of water. By adopting the technical scheme provided by the invention, the hydrogel matrix in which the weight percentage of sodium carboxymethyl cellulose is 5%-10% is utilized, so that the moisturizing performance, the antibacterial performance and the nourishing performance of the intelligent hydrogel mask can be optimal.

The application provides a Semi-IPN type, Full-IPN type temperature / pH dual-response intelligent hydrogel and a preparation method and application thereof, and belongs to the field of response materials. The preparation method is as follows: N-isopropyl acrylamide, N-hydroxymethyl acrylamide and N,N'-methylene bisacrylamide are dissolved in distilled water under a nitrogen atmosphere, and a mixed solution A is obtained by stirring in a cold water bath; carboxymethyl chitosan is added into the mixed solution A and uniformly mixed, then an initiator ammonium persulfate is added and uniformly stirred, then tetramethyl ethylenediamine solution is added and uniformly stirred, and the Semi-IPN temperature / pH dual-response intelligent hydrogel is obtained by transferring into a container and reacting; then the hydrogel is dialyzed, soaked in a ninhydrin aqueous solution and dialyzed again to obtain the Full-IPN temperature / pH dual-response intelligent hydrogel; the obtained IPN type temperature / pH dual-response intelligent hydrogel has good biocompatibility, simultaneously has temperature and pH dual-response, and has a potential application prospect in the fields of wound dressings, drug delivery and tissue engineering.

The present invention relates to a method for constructing a smart hydrogel in double-layer insulating glass, and the smart hydrogel. First, a methacrylated hyaluronic acid solution and a monomer solution containing N-isopropylacrylamide and N,N'-methylenebisacrylamide are prepared, and N,N,N',N'-tetramethylethylenediamine is added. The mixture is then ultrasonically dispersed to obtain a uniform dispersion. The monomer solution containing N-isopropylacrylamide and N,N'-methylenebisacrylamide is thoroughly mixed with the methacrylated hyaluronic acid solution. Ammonium persulfate is added to the mixture, and the mixture is quickly transferred to a double-layer insulating glass mold. The smart hydrogel is then prepared in a super-constant temperature water bath. Compared with the prior art, the preparation method of the present invention is significantly simpler and reduces manufacturing costs. The thermochromic temperature of the smart hydrogel can be accurately controlled by adjusting the concentration of the methacrylated hyaluronic acid and the synthesis temperature. The hydrogel has excellent moisture retention properties, exhibits no significant shrinkage after multiple cycles, and exhibits excellent structural robustness.

The invention discloses an intelligent polygonatum cyrtonema tissue culture method in the field of plant tissue culture, and the method comprises the following steps: collecting terminal buds of polygonatum cyrtonema as explants, carrying out disinfection and anti-oxidation pretreatment, inoculating the terminal buds into a culture medium containing intelligent response hydrogel, and the hydrogel can release a plant growth regulator to induce formation of calluses; after the calluses are transferred to a differential culture medium, hydrogel is triggered to release cytokinin by adjusting the temperature, and adventitious bud differentiation is promoted; after rootless seedlings are inoculated to a rooting culture medium, hydrogel is activated by adjusting the pH value to release growth promoting substances, and adventitious roots are induced to be generated. According to the method, accurate controlled release of the growth regulator is realized by utilizing the response characteristic of the intelligent hydrogel, and the efficiency and the stability of tissue culture are improved.

The invention relates to the technical field of intelligent hydrogel drivers, in particular to a double-layer hydrogel driver based on ionic strength driving and a preparation method and application of the double-layer hydrogel driver. The double-layer hydrogel driver comprises hydrogel A and hydrogel B which are sequentially arranged in a stacked mode. The hydrogel A only contains negative electricity monomers, so that the hydrogel A has the property of polyanion electrolyte hydrogel; the hydrogel B simultaneously contains a negative electricity monomer and a positive electricity monomer, and accords with the properties of the polyampholyte hydrogel; the salt with spontaneous decomposition property is selected as the ionic strength fuel, the decomposition product of the salt is gas, accumulation of waste materials in a system is not caused, and spontaneous circulation response of the double-layer hydrogel driver driven by the ionic strength fuel can be achieved by combining different swelling behaviors of the hydrogel A and the hydrogel B in a salt solution and deionized water.

The application discloses a kind of intelligent hydrogel wound dressings with built-in logic gates and preparation method thereof.The dressing contains sensing layer, logic operation layer and drug depot layer, sensing layer captures wound microenvironment parameters through various responsive elements and generates chemical signals, logic operation layer outputs instructions after receiving signals through logical judgment, triggers drug depot layer to release therapeutic drugs.No external circuit is needed, self-closed loop precise drug delivery is realized, misrelease is avoided, biocompatibility is high, response is rapid, and it is suitable for precise treatment needs of scenarios such as chronic wounds.

The invention discloses intelligent hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogel materials. The preparation method of the intelligent hydrogel comprises the following steps: blending polyvinyl alcohol, sodium carboxymethyl cellulose, phytic acid and lithium chloride in water, stirring at 90-100 DEG C, and freezing and thawing to obtain the intelligent hydrogel. The polyvinyl alcohol, the sodium carboxymethylcellulose and the phytic acid aqueous solution are taken as matrixes, the intelligent hydrogel is successfully prepared after lithium chloride is loaded, and the prepared intelligent hydrogel has the piezoresistive characteristic and can continuously, stably and accurately respond to an electric signal; and meanwhile, the cable also has the advantages of excellent mechanical property, high conductivity, excellent frost resistance and the like.

The invention discloses double-network hydrogel based on host-guest interaction and amino-imide reaction and a preparation method and application thereof, and relates to the field of intelligent hydrogel materials, the preparation method comprises the following steps: S1, grafting a beta-cyclodextrin amino derivative to polysuccinimide to obtain a polysuccinimide derivative with a host unit for later use; s2, amantadine is grafted to polysuccinimide, and a polysuccinimide derivative with a guest unit is obtained; and S3, mixing the polysuccinimide derivative with the host unit, the polysuccinimide derivative with the guest unit and an amino donor compound with deionized water, adjusting the pH value of the mixed system to be greater than 7, and reacting to obtain the dual-network hydrogel. The hydrogel is endowed with intelligence through the participation of the subject-object interaction of cyclodextrin and adamantane, the mechanical property of the hydrogel is guaranteed through the clamping of the covalent bond interaction, and the problem that the mechanical property and the intelligence of a conventional hydrogel material are not considered at the same time is solved.

The present invention discloses a temperature-visualized intelligent hydrogel patch and its preparation method and application. The intelligent hydrogel patch is mainly assembled by light-triggered antibacterial hydrogel and temperature-responsive thermochromic liquid crystal; the light-triggered antibacterial hydrogel is gradually grafted with endogenous antibacterial agents and photosensitizers by a chemical grafting method on carboxylated cellulose nanofibers, and then adsorbs photothermal agents, and finally is photocured with methacrylated gelatin; the temperature-responsive thermochromic liquid crystal is self-assembled by hydroxypropyl cellulose, thermoresponsive molecules, and nano-carbon black. The hydrogel has a highly efficient antibacterial effect on drug-resistant bacteria under visible light + near-infrared triggering, and the liquid crystal has a temperature recognition function through color change. When the near-infrared photothermal temperature of the hydrogel rises from 20°C to 56°C, the color of the liquid crystal changes from purple to red, and the yellow area (43°C-48°C) is used as the photothermal treatment area and the orange (>50°C) is used as the overheating mark.