28 results about "Smart hydrogels" patented technology

The invention relates to the technical field of burn and scald treatment, in particular to an intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release. The dressing comprises a core-shell microsphere drug loading system used for realizing physical segmentation of a functional area; the dual-release system is used for realizing surface adsorption of quick-release drug nanoparticles and internal wrapping of sustained-release microspheres; a hydrogel matrix for forming a nanofiber network; and the magnetic control regulator is magnetic nanoparticles dispersed in the hydrogel matrix, and regulates the aperture of the hydrogel network through the action of an external magnetic field. According to the intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release, the Mongolian medicine compound intelligent hydrogel dressing is developed on the basis of a TRIZ innovative method; through a core-shell microsphere drug loading system and a dual release design, high drug loading capacity and accurate drug release control are synchronously realized.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

The invention provides super-stretched liquid metal-natural rubber composite hydrogel as well as a preparation method and driving-sensing synergistic bionic application thereof, liquid metal eutectic gallium indium is crushed into nano-particles, and then the nano-particles are combined with natural rubber latex to be compounded with poly (N-isopropylacrylamide), so that the super-stretched liquid metal-natural rubber composite hydrogel is prepared. The liquid metal-natural rubber composite intelligent hydrogel driving-sensing dual-function synergistic double-layer structure biomimetic material can be obtained. The material has the super-tensile property (the tensile rate is 1300%) and has the high deformation speed (the bending speed can reach 62 degrees / s) under photo-thermal driving. As the hydrogel contains liquid metal, the hydrogel has excellent conductivity (the conductivity can reach 5532 [mu] S / cm), and an electric signal can be monitored in real time in a photoresponse bending process, so that the hydrogel has an application prospect in the field of photothermal driving-self-sensing dual-function synergistic materials.

The invention relates to the technical field of intelligent hydrogel dressings, in particular to a preparation method and application of a chitosan-based hydrogel wound dressing, and the preparation method comprises the following steps: integrating sulfydryl chitosan (CS-SH), carbon nanotubes (CNTs) and protocatechualdehyde (PA), and forming the chitosan-based hydrogel wound dressing through a crosslinking effect. The chitosan-based hydrogel wound dressing disclosed by the invention has the characteristics of photo-thermal performance, excellent antibacterial activity, excellent electrical conductivity, sensing performance and the like. The hydrogel wound dressing has great potential in the aspects of infectious wound treatment and real-time body action monitoring, and a new design thought is provided for developing an intelligent wound management system with specific adaptability to patients.

The invention discloses a pH-responsive HG type pectin hydrogel based on Schiff base reaction and a preparation method and application thereof, the pH-responsive HG type pectin hydrogel has a structural formula as shown in the following formula I. According to the pH-responsive HG type pectin hydrogel, functional characteristics of HG type pectin, biological activity of oleanolic acid, 3, 4, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3-trimethyl-1, 3- The intelligent hydrogel system with ROS / pH dual response characteristics is successfully constructed through the redox responsiveness of oleanolic acid, 3, 3 '-dithiodipropionic acid and the pH responsiveness of Schiff base reaction, and the system can effectively protect the activity of oleanolic acid and can be used for preparing drugs for improving alcoholic liver injury.

This invention belongs to the field of DNA hydrogel technology, specifically relating to a VEGF-responsive, on-demand release smart DNA hydrogel of glycyrrhizin, its preparation method, and its applications. This invention constructs a VEGF-responsive smart DNA hydrogel, efficiently encapsulating glycyrrhizin within a three-dimensional gel network, utilizing the high expression of VEGF in the tumor microenvironment to trigger on-demand drug release. This invention achieves precise on-demand release of glycyrrhizin, significantly improving drug utilization efficiency and reducing systemic toxicity. Simultaneously, the VEGF aptamer introduced into the system can specifically bind to and neutralize free VEGF, blocking angiogenesis, cutting off tumor nutrient supply, and further inhibiting tumor proliferation and progression, achieving a synergistic effect of intelligent drug delivery and anti-angiogenesis.

The application provides a preparation method and application of tremella polysaccharide intelligent hydrogel for inhibiting ferroptosis, and relates to the technical field of biomaterial preparation, wherein the tremella polysaccharide intelligent hydrogel for inhibiting ferroptosis is prepared from methacrylated tremella polysaccharide TrepMA, oxidized tremella polysaccharide O-Trep and ketone thioalcohol diamine TK-NH2. The tremella polysaccharide intelligent hydrogel prepared by the method has a three-dimensional network structure, good mechanical properties and can load growth factors or active molecules to accelerate bone regeneration. In addition, the tremella polysaccharide intelligent hydrogel can inhibit ferroptosis and promote bone defect healing with osteoporosis. The tremella polysaccharide intelligent hydrogel prepared by the method has multiple biological activities, can not only provide certain support for bone regeneration, but also can inhibit ferroptosis, improve local osteoporosis, has antioxidant / anti-inflammatory and osteogenic differentiation induction effects through excellent biocompatibility, biological activity and drug controlled release effect, and can effectively promote bone tissue regeneration.

The invention belongs to the technical field of 3D printing materials, and particularly discloses intelligent hydrogel with an active shrinkage function and a preparation method and application thereof.The preparation method comprises the following steps that S1, 3-acrylamidophenylboronic acid is added into deionized water, and a 3-acrylamidophenylboronic acid solution is obtained; s2, tannic acid is added into the 3-acrylamido phenylboronic acid solution, and a tannic acid 3-acrylamido phenylboronic acid solution is obtained; s3, phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate and guar gum are sequentially added into the tannic acid 3-acrylamide phenylboronic acid solution, and the intelligent hydrogel with the active shrinkage function is obtained. According to the intelligent hydrogel with the active contraction function as well as the preparation method and the application, the problems of insufficient forming precision and structural resolution in an existing extrusion type 3D printing technology are solved, and a new technical path is provided for in-vitro bionic construction of fine tissues such as capillary networks and nerve microcatheters.

The invention discloses magnetic temperature-sensitive intelligent hydrogel and a preparation method thereof, and belongs to the field of intelligent hydrogel preparation. The preparation method comprises the following steps: firstly, adding an alginic acid aqueous solution into a CaCl2 aqueous solution to prepare spherical gel; sequentially adding the spherical gel into an acrylamide monomer solution and a nitrogen isopropylacrylamide monomer solution, and carrying out a polymerization reaction, so as to obtain temperature-sensitive gel; and then soaking and reacting the temperature-sensitive gel in a solution of Fe < 2 + >: Fe < 3 + > in a ratio of 1: 2, taking out the temperature-sensitive gel, and immediately soaking and reacting the temperature-sensitive gel in a NaOH solution to prepare the intelligent hydrogel with magnetism and temperature sensitivity. The magnetic temperature-sensitive intelligent hydrogel prepared by the method has better biocompatibility, the critical transition temperature and the zero charge point pH are very close to those of a human body, and magnetic particles are very uniformly distributed in a gel network, so that the prepared gel has better magnetic effect, and the application prospect of the gel in the field of biomedicine is increased.

The invention belongs to the technical field of biomedical materials, and provides an intelligent hydrogel dressing with a three-layer structure as well as a preparation method and application of the intelligent hydrogel dressing. The intelligent hydrogel dressing with the three-layer structure comprises an upper layer, a middle layer and a bottom layer which are sequentially stacked, the upper layer is methacrylated gelatin hydrogel containing silver nanoparticles, the middle layer is methacrylated gelatin hydrogel containing mangiferin-loaded PLGA microspheres, and the bottom layer is methacrylated gelatin hydrogel. The upper layer of the intelligent hydrogel dressing with the three-layer structure is used for broad-spectrum antibiosis in the initial stage and quickly coping with bacterial infection; the middle layer is used for continuously releasing mangiferin, exerting the effects of resisting oxidation, resisting inflammation and promoting angiogenesis and eliminating oxidative stress; the bottom layer provides mechanical support and biocompatibility; through the synergistic effect of the multi-layer structure of the upper layer, the middle layer and the bottom layer, remarkable advantages are shown in multiple aspects such as mechanical support, medicine controllable release, broad-spectrum antibiosis and inflammation-oxidative stress regulation, and layering and cooperative intervention are achieved.

The invention provides a multifunctional bioprosthetic valve material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the material, an acellular biological tissue matrix is used as a substrate, and formyl-free hydroxymethylated melamine is adopted for crosslinking to solve the calcification problem; an active oxygen response type intelligent hydrogel coating is constructed on the surface of the hydrogel, is composed of gelatin and diselenide bond-containing nanogel loaded with an anti-inflammatory drug, and can respond to an inflammatory microenvironment and intelligently release; through double-module cooperation of non-glutaraldehyde crosslinking and the intelligent response coating, the material has excellent anti-calcification and anti-thrombus performance, inflammation can be actively regulated and controlled, endothelialization is promoted, and the long-term durability and biocompatibility of the bioprosthetic valve are remarkably improved.

This invention discloses a smart, responsive comb-shaped gelatin-based hydrogel and its applications, belonging to the field of biomedical materials technology. The preparation method of the hydrogel is as follows: S1, Prussian blue is modified with tannic acid to obtain TA-coated Prussian blue core-shell nanoparticles, referred to as the PB-TA complex; S2, gelatin is dissolved in PBS solution, then methacrylic anhydride is added dropwise, and the reaction is carried out at 50-60℃ for 90-120 min, followed by dialyzing and freeze-drying to obtain acylated gelatin; S3, an initiator and NIPAM solution are added to the acylated gelatin solution, and the reaction is stirred for 10-14 h to obtain a comb-shaped gelatin solution; S4, zein solution and PB-TA complex solution are added to the comb-shaped gelatin solution to prepare a smart hydrogel exhibiting both temperature and near-infrared photothermal response. This hydrogel can be used for drug delivery, enabling controlled drug release.

The application belongs to the field of biomedical polymer materials and regenerative medicine, and particularly relates to an intelligent hydrogel for treating skin tissue damage, a preparation method and a medicine thereof, and application thereof. The intelligent hydrogel comprises a hydrogel support and a functional module. The hydrogel support takes methacrylated gelatin as a matrix and forms a stable three-dimensional network structure through photo-crosslinking. The functional module comprises two core DNA chains, one of which is a ZnR-Cage chain with a sulfhydryl group directly or indirectly connected to one end of the chain, and the other is a CD44-link chain. The two chains form a non-active assembly through base complementary pairing. The intelligent hydrogel has many advantages such as strong spatiotemporal controllability, overcoming drug burst defects, efficient cascade repair, realizing targeted synergistic treatment, efficient integration, excellent stability and clinical transformation potential. It is particularly suitable for clinical treatment of complex wounds such as diabetic ulcers and infected wounds.

A hydrogel material is provided that includes a polymer matrix and a plurality of cellular units dispersed within the polymer matrix to form a cellular structure, wherein each cellular unit of the plurality of cellular units includes a stiff region and at least one soft region enclosed by the stiff region, and the hydrogel material develops a plurality of strain-induced heterogeneous subdomains upon application of a tensile load. Also provided is a method of preparing such hydrogel material, use of such hydrogel material, and an article of manufacture including such hydrogel material.

The application discloses a kind of intelligent hydrogel wound dressings with built-in logic gates and preparation method thereof.The dressing contains sensing layer, logic operation layer and drug depot layer, sensing layer captures wound microenvironment parameters through various responsive elements and generates chemical signals, logic operation layer outputs instructions after receiving signals through logical judgment, triggers drug depot layer to release therapeutic drugs.No external circuit is needed, self-closed loop precise drug delivery is realized, misrelease is avoided, biocompatibility is high, response is rapid, and it is suitable for precise treatment needs of scenarios such as chronic wounds.

The invention discloses a high-decontamination low-irritation saponin compound enzyme laundry detergent and a preparation method thereof. The preparation method of the laundry detergent comprises the following steps: firstly, by taking acrylamide, sodium alginate and N-isopropylacrylamide as raw materials, constructing an intelligent hydrogel carrier with a temperature-pH response characteristic, and co-immobilizing a Chinese honeylocust fruit extract, low-temperature-resistant protease, lipase and pectinase in the carrier to form compound enzyme particles; secondly, compounding surfactants such as saponin and the like with a cosurfactant isopropyl myristate to construct a base solution of the plant-based bicontinuous microemulsion; finally, the compound enzyme particles and the base solution are integrated through staged temperature control stirring, and a finished product is obtained after high-pressure microjet homogenization, low-temperature curing and pH adjustment are conducted. According to the laundry detergent, through controlled release protection of the immobilized carrier and stable bearing of a microemulsion system, the excellent decontamination performance is guaranteed, meanwhile, the potential irritation of a product is remarkably reduced, and the laundry detergent has good storage stability and low-temperature washing adaptability.

This invention belongs to the field of intelligent hydrogel materials technology, specifically relating to a hydrogel with multiple responses to compression, strain, and temperature, and possessing both antifreeze and anti-swelling properties. The purpose of this invention is to overcome the technical problems of existing intelligent hydrogels, such as poor antifreeze properties, insufficient anti-swelling properties, and single response signals, and to provide a hydrogel with multiple responses to compression, strain, and temperature, and excellent antifreeze and anti-swelling properties, as well as its preparation method. This hydrogel uses lignocellulose nanofiber (LCNF), zwitterionic SBMA, methacrylic acid MAA, and inorganic salts as core components. LCNF, as a natural nanosupport material, can compensate for the shortcomings of single SBMA-based hydrogels. Its core function lies in forming strong interactions with components such as SBMA through its own active groups, thereby precisely regulating the intermolecular forces within the system. The composite of LCNF and SBMA can achieve "functional complementarity + synergistic effect," ultimately realizing the directional regulation of the hydrogel's mechanical properties and adapting it to wearable and interactive needs.

The invention discloses a saline-alkaline tolerant plant screening and cultivating method based on tissue culture, and belongs to the technical field of plant screening. The invention discloses a temperature response type intelligent hydrogel microsphere loaded with a saline-alkali stress factor, which is used as a stress slow-release carrier. The method comprises the following steps: co-culturing a callus formed by inducing a plant explant and a hydrogel carrier, and carrying out programmed control on culture temperature to circulate up and down at a gel phase change point to drive gel to generate reversible swelling-shrinkage, so that internal stress factors are slowly and controllably released into a culture medium according to a preset mode. Therefore, progressive and gradient enhanced saline-alkaline stress is applied to the callus, a cell line with high tolerance is directionally screened out, and finally, a complete saline-alkaline tolerant plant is regenerated. According to the scheme, stress simulation naturalization, release control precision and screening process high efficiency are realized. According to the method, the hydrogel is driven to slowly release salt and alkali through programmed temperature control, and progressive stress in a natural environment is simulated, so that excellent germplasm with physiological regulation capability instead of pure structure tolerance can be screened out.

The application relates to the field of biomedical technology, and discloses a smart hydrogel based on copper sulfide nanomaterial, a preparation method and application. By constructing a hydrogel system for treating diabetic wounds with the effects of blood sugar control, antibiosis and wound healing promotion, on one hand, glucose oxidase is used to catalytically decompose glucose on a wound surface to reduce the blood sugar concentration; on the other hand, the oxidative dynamics and the photothermal conversion performance of copper sulfide nanomaterial are used to inhibit infection in a dual antibacterial activity mode to avoid the risk of antibiotic resistance; the hydrogel is used as a carrier to realize controllable release of the two, and meanwhile, the hydrogel can maintain the moisture of the wound surface and synergistically promote cell proliferation and blood vessel regeneration. The smart hydrogel based on copper sulfide nanomaterial prepared by the application breaks through the limitation of the existing single-function product, and as a drug for treating diabetic wounds, the healing efficiency of the wound is improved, and the two core problems of the high blood sugar microenvironment and the susceptibility to multiple drug-resistant bacterial infection in the healing of diabetic wounds are solved.

The invention discloses a pH and glucose dual-response intelligent hydrogel loaded with rhinacanthus nasutus element-C. The preparation method comprises the following steps: stirring and mixing rhinacanthus nasutus element-C and a polyvinyl alcohol aqueous solution to obtain a mixed solution 1, mixing the mixed solution 1 with a carboxymethyl chitosan aqueous solution and an oxidized sodium alginate-phenylboronic acid graft aqueous solution, and carrying out a reaction to obtain the pH and glucose dual-response intelligent hydrogel loaded with rhinacanthus nasutus element-C; the pH and glucose double-response intelligent hydrogel loaded with the rhinacanthus nasutus element-C. The hydrogel disclosed by the invention is sensitive to the change of the concentration of environmental glucose, and is more likely to release the drug rhinacanthus nasutus element-C in a high-glucose environment; the pH responsiveness is realized. The dual response mechanism can intelligently adjust the drug release rate according to the actual microenvironment (glucose concentration and pH change) of the diabetic wound, so as to promote the healing of the diabetic wound.

The invention discloses a nerve bionic type antibacterial hydrogel dressing for diabetes infected wounds and a preparation method of the nerve bionic type antibacterial hydrogel dressing. The preparation method of hydrogel comprises the following steps: synthesizing phenylboronic acid modified gold-silver alloy nanoparticles (A / M-AuAgNPs); and synthesizing an intelligent hydrogel system composed of aminated gelatin (AGel) and oxidized hyaluronic acid (OHA). And through Schiff bond crosslinking, space-time synergistic release of the calcitonin gene related peptide (CGRP) and A / M-AuAgNPs is realized. According to the hydrogel, wound infection is efficiently removed, and meanwhile, by simulating the dynamic release process of endogenous CGRP, nerve-immune signal interaction of diabetic wound damage is recovered, the wound immune homeostasis is remodeled, and wound repair is accelerated.

The invention discloses a pH response type intelligent hydrogel interface layer and application. The pH response type intelligent hydrogel interface layer is hydrogel. The pH response type intelligent hydrogel interface layer has a micropore or nanopore network structure, the micropore network structure is naturally formed by crosslinking and stacking polymer chains in the polymerization process, and the pore diameter of micropores or nanopores ranges from several nanometers to hundreds of nanometers. The preparation method comprises the following steps: a) dissolving a hydrophilic main monomer, a functional monomer containing a nitrogen-containing heterocyclic group sensitive to pH, a cross-linking agent and an initiator in a solvent to form a gel precursor solution; b) coating the gel precursor solution on the surface of a metal negative electrode substrate; and c) initiating a polymerization reaction through heating or illumination, and forming a gel interface layer on the surface of the negative electrode to obtain the intelligent protective metal negative electrode.

The invention relates to the technical field of hydrogel, in particular to temperature-sensitive composite intelligent hydrogel and a preparation method and application thereof.Hydroxybutyl chitosan and silk fibroin form an interpenetrating network, and the requirements for rapid gelling and mechanical strength can be met at the same time; the mussel mucoprotein enhances the antibacterial property of the system while providing interface adhesion; the hydroxybutyl chitosan, the silk fibroin, the shellfish mucin, the transglutaminase and the exosome cooperate to jointly construct an intelligent drug release system, gradient release matched with the wound healing process is achieved, and the hydrogel can be suitable for healing of acute wounds or chronic wounds at the same time. The temperature-sensitive composite intelligent hydrogel which is capable of sensing the environment temperature, actively adhering, resisting bacteria and intelligently dosing is jointly constructed.

The invention discloses a preparation method of a light-triggered violet phosphorus alkene nanosheet loaded antibacterial peptide cascade sterilization intelligent hydrogel wound dressing. The preparation method comprises the following steps: preparing a polyether F127 diacrylate / methacrylated polylysine (F127DA / PLMA) intelligent hydrogel solution under an ice bath condition; defensin is added into the violaphorene nanosheet solution, full suspension is carried out through ultrasound, centrifugation is carried out, supernate is discarded, and violaphorene nanosheet sediment loaded with the antibacterial peptide is obtained; and taking an F127DA / PLMA intelligent hydrogel solution as a carrier, adding the F127DA / PLMA intelligent hydrogel solution into the precipitate, carrying out sufficient ultrasonic suspension to obtain an antibacterial peptide violet phosphorus alkene nanosheet-F127DA / PLMA hydrogel suspension, and carrying out crosslinking and sterilization to obtain the light-triggered violet phosphorus alkene nanosheet loaded antibacterial peptide cascade sterilization intelligent hydrogel wound dressing. The prepared antibacterial peptide loaded purpurene nano drug-loading system can continuously release antibacterial peptide on a wound surface to play a cascade sterilization role and promote healing of the wound surface with drug-resistant bacteria.

This invention discloses an environmentally responsive hydrogel, its preparation method, and its applications, belonging to the field of intelligent hydrogels and microchannel control technology. The invention uses stimulus-responsive hydrogel monomers and an aqueous dispersant as raw materials. Linear molecular chains are formed under the action of a free radical thermal initiator. After generating free radicals, the aqueous dispersant polymerizes on the stimulus-responsive hydrogel monomer molecules due to the action of a cross-linking agent. During polymerization, the carbon-carbon double bonds of the cross-linking agent break, reacting with the aqueous dispersant and the stimulus-responsive hydrogel monomer to form a cross-linked structure, thus obtaining the environmentally responsive hydrogel. The environmentally responsive hydrogel prepared by this invention has a triple cross-linked network structure and exhibits dual-response functionality for pH and temperature, with fast response speed and high precision, while also demonstrating hysteresis during the response process.

The application discloses a kind of photothermal antibacterial controllable debonding intelligent hydrogel dressings for chronic wound care and its preparation method and application, the hydrogel dressings include gold modified conductive enhanced fiber network support body, and the functional hydrogel matrix completely wrapped the support body;The functional hydrogel matrix is with gelatin-sodium alginate blend system as skeleton, with the chelate compound pre-constructed with pyrocatechol and trivalent iron ion as core functional unit to form interpenetrating double crosslinking network structure, can be realized by spraying diethylene triamine pentaacetic acid without secondary damage controllable debonding.The hydrogel dressings of the application have high strong wet state adhesion, efficient photothermal antibacterial, anti-inflammatory repair and wound sensing function, effectively solve the industry pain point that existing dressing adhesion and debonding are difficult to consider, single function, mechanical property mismatch, adapt to chronic wound whole cycle nursing needs, and clinical application value is high.

The invention discloses an antibacterial and antioxidant intelligent hydrogel dressing as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the hydrogel dressing, polyvinyl alcohol serves as a matrix, tannic acid serves as a natural functional cross-linking agent, a three-dimensional network is constructed through a physical cross-linking method, and cannabidiol and mupirocin are cooperatively loaded. According to the invention, a safe freezing and thawing cycle process is adopted for molding, so that the biotoxicity risk of a chemical cross-linking agent is thoroughly avoided. The hydrogel not only has excellent biocompatibility, but also has the remarkable characteristics that the hydrogel has pH-responsive drug release capacity, and drug release can be intelligently accelerated in a wound alkaline microenvironment; meanwhile, the antioxidant activity and the broad-spectrum antibacterial property are high, and particularly, the bacteriostasis rate on staphylococcus aureus is close to 100%. In-vitro and animal experiments prove that the dressing can remarkably promote wound healing, the healing rate reaches up to 97% or above within 14 days, and the dressing has wide clinical application prospects in the field of intelligent wound dressings.