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Sugar-sensitive intelligent hydrogel based on gold surface and synthesis method thereof

A synthesis method and hydrogel technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of complex steps, intrusion into the human body, and high cost, and achieve the effects of high selectivity, improved specificity, and low exchange resistance.

Active Publication Date: 2014-08-13
中科康磁医疗科技(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to provide a real-time and rapid glucose detection material and method to solve the problems of traditional methods such as high cost, complicated steps, and the need to invade the human body

Method used

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  • Sugar-sensitive intelligent hydrogel based on gold surface and synthesis method thereof

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Embodiment 1

[0023] Example 1: (1) Surface pretreatment of gold flakes: put the gold metal flakes in the prepared Piranha reagent (Piranha), ultrasonically clean them for 15 minutes, then ultrasonically clean them with acetone, ethanol, and double-distilled water for 10 minutes, and blow them with N2. dry; among them, the configuration of Peel's reagent is concentrated H2SO4: H2O2=5 : 3 (V:V); (2) Amination: dissolve 3-aminopropyltrimethoxysilane in toluene, and the treated gold Place in the above solution under N2 atmosphere, react at 110 °C for 12 h, rinse the gold sheet with absolute ethanol and double distilled water in sequence, and blow dry with N2; the concentration of the silane coupling agent is 3 mmol / L; (3) Double bonding: Dissolve a certain amount of maleic anhydride in dimethyl sulfoxide, place the gold flakes described in step (2) in the above solution, and react at 25 °C for 10 h, Rinse the gold flakes with absolute ethanol and double distilled water in turn, and blow dry wi...

Embodiment 2

[0026] Example 2: (1) Surface pretreatment of gold wafers: place gold-plated silicon wafers in prepared Piranha reagent (Piranha), ultrasonically clean them for 30 min, then ultrasonically clean them with acetone, ethanol, and twice distilled water for 10 min, and blow them with N2. dry; wherein, the configuration of Peel's reagent is concentrated H2SO4: H2O2=7: 3 (V:V); (2) amination: a certain amount of 3-aminopropyl triethoxysilane is dissolved in ethanol, and the treated The processed gold flakes were placed in the above solution under N2 atmosphere. After reacting at 78 °C for 5 h, the gold flakes were rinsed with absolute ethanol and double distilled water in sequence, and dried with N2; the concentration of the silane coupling agent was 5 mmol / L; (3) Double bond: Dissolve a certain amount of succinic anhydride in N, N'-dimethylformamide, place the gold flakes described in step (2) in the above solution, and After reacting at 25°C for 12 h, the gold flakes were rinsed wi...

Embodiment 3

[0027] Example 3: (1) Surface pretreatment of gold wafers: place the gold-plated silicon wafers in prepared Piranha reagent (Piranha), ultrasonically clean them for 60 min, then ultrasonically clean them with acetone, ethanol, and double-distilled water for 10 min, and blow them with N2. Dry; wherein, the configuration of Peel's reagent is concentrated H2SO4: H2O2=4: 3 (V:V); (2) Amination: Dissolve a certain amount of γ-aminopropylmethyldiethoxysilane in a volume ratio of 1:1 ethanol and distilled water, put the treated gold flakes in the above solution, N2 atmosphere, react at 50 ℃ for 12 h, rinse the gold flakes with absolute ethanol and double distilled water in turn, and blow dry with N2 ; Among them, the concentration of γ-aminopropylmethyldiethoxysilane = 4 mmol / L; (3) double bond: dissolve a certain amount of phthalic anhydride in dichloromethane, and the step (2 ) was placed in the above solution, and after reacting at 35 °C for 12 h, the gold flakes were rinsed with ...

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Abstract

The invention relates to sugar-sensitive intelligent hydrogel based on a gold surface and a synthesis method thereof. The synthesis method of the gold surface-based sugar-sensitive intelligent hydrogel comprises the following three steps of pre-treating a gold sheet so that the surface of the gold sheet is provided with -OH, efficiently introducing double bonds on the surface of the gold sheet orderly by a silane coupling agent and an acid anhydride, synthesizing the hydrogel on the surface of the gold sheet from acryamidophenylboronic acid as a monomer, a glucose molecule as a template and N, N'-methylene bisacrylamide as a cross-linking agent by an ultraviolet light-initiated polymerization reaction, and after the reaction, removing the glucose molecule by washing so that a large amount of glucose molecular imprinting cavities are formed on a hydrogel membrane on the surface of the gold sheet. The sugar-sensitive intelligent hydrogel based on a gold surface will be used in the field of biological signal detection and realizes dynamic identification and detection of glucose and other physiological indexes under the human physiological conditions.

Description

technical field [0001] The present invention relates to a sugar-sensitive intelligent hydrogel based on a gold surface and a synthesis method thereof, more precisely, relates to the preparation of a sensitive hydrogel film capable of dynamically identifying and detecting glucose under human physiological conditions, Belongs to the field of biotechnology. Background technique [0002] As one of the by-products of the progress of the times, the prevalence of diabetes has been increasing year by year, and it has become an epidemic disease that seriously threatens human health. However, there is currently no cure for diabetes in medicine, and the only way to delay the emergence of complications is by controlling the patient's blood sugar level. Therefore, for the control and treatment of diabetes, it is very meaningful to develop smart materials that can sense changes in blood glucose concentration in the body. Such materials can evaluate and detect the patient's blood sugar c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/291B01J20/30
Inventor 戴庆
Owner 中科康磁医疗科技(苏州)有限公司
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