267 results about "Hydrogel film" patented technology

The invention discloses a method for preparing an Ag-carrying bacterial cellulose hydrogel antimicrobial dressing and a product thereof. The method comprises the following steps of: soaking a bacterial cellulose hydrogel film in solution of silver metal precursor; then heating the film to be between 121 and 135 DEG C in a high-pressure sterilizing pot, and pressurizing between 0.205 and 0.313MPa; standing bacterial cellulose for 5 to 30min; and then taking the treated bacterial cellulose out for washing, partial dehydration, packaging and sterilization to obtain an Ag-carrying bacterial cellulose hydrogel antimicrobial dressing which is formed by compounding silver metal nano-particles and bacterial cellulose and is attached with 0.01 to 10 weight percent of the silver metal nano-particles in a bacterial cellulose three-dimensional porous network structure. The preparation process of the invention has the advantages of simplicity, easiness, convenient operation, controllable preparation technology, no pollution and low cost; and the prepared nano-particles have the advantages of high purity, small particle size, uniform size and good dispersity. The obtained Ag-carrying bacterial cellulose hydrogel antimicrobial dressing has the characteristics of good antimicrobial property, high water content, good water-retaining property, strong toughness, good air permeability and the like, and can meet the requirements of treating various wounds by a wet method.

A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 mu m. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method using the fiber-reinforced composite are also provided.

The invention discloses a preparation method of bi-network hydrogel tubes having a complex structure. The method includes the steps of: 1) mechanically polishing iron wires in different sizes, arranging the iron wires in different ways, and soaking the iron wires in a monomer prepolymerization liquid or pouring a monomer prepolymer into the container, in which the iron wires are arranged in different shapes, so as to perform a polymerization reaction, wherein uniform primary-crosslinked single-network hydrogel film is generated on the surfaces of the iron wires; 2) soaking the hydrogel film into a secondary crosslinking solution to perform secondary crosslinking to form a second network hydrogel film; 3) performing soaking treatment and removing the iron wires away to form the hollow high-strength hydrogel tubes in different shapes. The diameter of the hydrogel tubes is 10 [mu]m to a few millimeters, wherein the structure and shape of internal diameters of the tubes are highly controllable. Tensile strength of the hydrogel tubes can reach up to 2 MPa and tensile rate reaches up to 2-5 times. The hydrogel tubes have potential application value in the fields of microfluids and biomedicines.

The invention discloses a hydrogel fire extinguishing agent. The hydrogel fire extinguishing agent is white powder and obtained in the manner that 5-10 parts of acrylic polymers, 10-15 parts of carboxy methyl cellulose, 10-15 parts of corn starch, 5-10 parts of dispersing agent, 10-20 parts of fire retardant, 1-3 parts of hydrocarbon surfactant and the like undergo modified treatment. The obtained fire extinguishing agent has the conventional water cooling fire extinguishment function, and the fire extinguishing agent and water can form a hydrogel film resistant to high temperature, good in fire resistance and high in coverage performance and adhesion performance, and the hydrogel film can isolate air, extinguish fire by smothering and effectively prevent the fire from burning again; if the fire extinguishing agent is sprayed to an unburned area close to the fire, an isolation strip can form, so that the spreading tendency of the fire can be effectively controlled, and the fire extinguishing efficiency can be significantly improved. Besides, fire extinguishment residues are free of pollution, easy to degrade, safe, environmentally friendly and free of doing harm to human beings, plants and the like. In this way, the hydrogel fire extinguishing agent is wide in application range, can be applied to civil facilities, public facilities, plant-station disaster relief, forest fire and the like, the dosage of the fire extinguishing agent is small, and therefore the hydrogel fire extinguishing agent has significant advantages.

There is provided new mono-(meth)acrylate functionalized silicone monomers containing carbosiloxane linkage for improved hydrolysis resistance, useful in making water absorbing silicone-hydrogel films for contact lens applications. This invention also provides homo-polymers and copolymers made from the mono-(meth)acrylate functionalized hydrophilic silicone monomers described herein. Also provided is a process for producing the monomers and polymers described herein and contact lenses produced from the same.

There is provided a mono-(meth)acrylate functionalized hydrophilic silicone monomers containing a polyether with branched linking group, useful in making water absorbing silicone-hydrogel films for contact lens applications. This invention also provides homo-polymers and copolymers made from the mono-(meth)acrylate functionalized hydrophilic silicone monomers described herein. Also provided is a process for producing the monomers and polymers described herein and contact lenses produced from the same.

The invention discloses a bacterial cellulose compound cuprous oxide antimicrobial dressing and a preparation method thereof. The bacterial cellulose compound cuprous oxide antimicrobial dressing lies in that cuprous oxide particles are adhered into a three-dimensional porous network structure of a bacterial cellulose hydrogel film, the cuprous oxide particles are of octahedral crystal forms, and the antimicrobial dressing is obtained by soaking a bacterial cellulose hydrogel film containing a glucose solution into a NaOH water solution and copper ion water solution mixed solution and heating and pressurizing for reaction. The bacterial cellulose compound cuprous oxide antimicrobial dressing is simple and convenient in preparation process and low in cost, has not only excellent bacteria resistance but also the advantages of high water content, good air permeability, excellent degradation property, no cytotoxicity and the like, and can well meet the demand of wet-process treatment for various wounds.

The invention discloses a preparing method of a biomimetic laminated high-strength composite hydrogel film. The method comprises the following steps of: mixing a polymer monomer with an inorganic nano-sheet to obtain mixed solution, filtering the mixed solution and carrying out photo-initiation in-situ polymerization to obtain the biomimetic laminated high-strength composite hydrogel film. The biomimetic laminated high-strength composite hydrogel film is formed by compounding the polymer and the organic nano-sheet, and the hydrogel film internally has a laminated micron and nano structure, and has the tensile strength being larger than 0.6 MPa, the tensile modulus being larger than 1.0 MPa and the tensile strain being larger than 700% after being soaked in water.

The present invention belongs to the natural macromolecule materials technical field, in particular to a natural polyampholyte electric field sensitive hydrogel and preparation method. The present invention adopts the blending of natural cationic polyelectrolyte and natural anionic polyelectrolyte, both of which are characterized by good biological compatibility and biological degradation, to prepare natural polyampholyte hydrogel film. Natural polyampholyte hydrogel film is immersed in electrolytic solution and bends under the role of direct current field. The bending direction and bending angle of hydrogel film can be adjusted. The hydrogel film has electric field response in electrolytic solution with varied pH value; and bends toward different directions under acid condition and alkali condition. The properties expand the scope of pH value for electric field sensitive hydrogel; thus leading to bright prospect of widespread application of electric field hydrogel in fields like artificial muscle, sensor, controlled drug release, automatic switch components and separation technology.

The invention discloses a preparation method of an irradiative crosslink network cellular porous hydrogel dressing of amniotic membrane, the specific methods are: put the hydrogel solutions comprising of PVA, chitosan and acrylic acid-acrylamide copolymer on the porous stainless steel plate used to put the netty cellular amniotic membrane, add a small amount of agar, agitate uniformly, evacuate, and the hydrogel prototype was obtained; then press the hydrogel to film; then expose the membrane to 60Coy- ray irradiation in room temperature to crosslink, then dehydrate, freeze-dried, radiative sterilized, packed under aseptic conditions. The invention possesses good protection treatments, such as alleviate pain, resist to phlogosis and bacterium, and promote healing. It also has good hygroscopic properties, water retention, permeability and flexibility, further more we can have a selection of drugs according to sensitive bacteria of wound, pain, the need of arristing or activzte bleeding to and to help achieve sustained-release drug treatment purposes.

The invention discloses a stretchable adhesive conductive structure color hydrogel film and a preparation method thereof. The method is based on a photonic crystal positive structure template, an inverse opal structure hydrogel film is prepared through a template sacrifice method, gaps of the inverse opal structure hydrogel film are filled with an adhesive conductive hydrogel precursor solution, the adhesive conductive structure color hydrogel film is obtained after curing, and the method is easy to operate, low in cost, capable of being repeatedly used, convenient to use and reliable. The conductive structure color hydrogel film prepared by the method has good conductivity, has firm adhesion and affinity to skin and has the characteristic of dual-signal response to mechanical movement andcan be used as a dual-signal sensor for human body activities and feeds back structural color sensing and electric signal sensing in real time according to the change of the human body activities.

The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and / or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

The invention discloses a rapid response optical glucose sensor based on glucose sensitive hydrogel film. The hydrogel film used for sensing has two properties that on one hand, a swellbility of the hydrogel film in aqueous solution is changed with a glucose concentration in the solution; on the other hand, an absorption spectrum or a reflection spectrum has Fabry-Perot interference fringes. The change of glucose concentration leads to change of hydrogel film swellbility, so as to cause moving of the Fabry-Perot interference fringes; therefore the moving of the Fabry-Perot interference fringes indicates the change of glucose concentration in the solution. The invention utilizes a layer by layer assembly method to prepare the glucose sensitive hydrogel film with a thickness from hundreds nanometers to micrometers, so as to conduct rapid response.

The invention discloses a preparation method of a semi-interpenetrating network hydrogel film material for extracting uranium from seawater. The preparation method comprises the steps: dissolving polypropylene amidoxime, a monomer, a photoinitiator and a crosslinking agent at a certain mass ratio in an alkaline aqueous solution so as to obtain a precursor solution firstly, then injecting the precursor solution into a mold, and performing a polymerization reaction under ultraviolet light or sunlight so as to obtain the semi-interpenetrating network hydrogel film material. The preparation methodis simple and rapid, has low cost, and can be applied to large-scale production of the PAO semi-interpenetrating network hydrogel film material through low energy consumption and environment-friendlysunlight polymerization under the alkaline condition; and the material has a thickness of 0.2 mm, uniform micro-pore size, high adsorption efficiency, high selectivity and excellent mechanical properties, and can be reused multiple times.

The invention discloses a colloidal crystal gel label-free visual detection method with an aptamer as an identification unit. According to the method, a colloidal crystal hydrogel film is used as a carrier, the aptamer is combined with the colloidal crystal hydrogel film, and target molecules are detected by the high-specificity and high-sensitivity combination of the aptamer and a target detected object. After the aptamer is combined with the target molecules, the change of the conformation of the aptamer causes the change of the volume of a colloidal crystal gel, and the change of the volume of the gel is directly embodied by the change of a reflective peak of colloidal crystals (namely the color of the colloidal crystals), namely the existence or amount of a substance to be measured is embodied by the displacement of the reflective peak or the color of the colloidal crystal hydrogel film. The aptamer-based colloidal crystal hydrogel film label-free visual detection method has the advantages of high sensitivity and specificity, easiness for operation, low detection cost and the like.

The invention discloses a method for preparing a photo-crosslinking chitosan hydrogel film. Biocompatible macromolecular chitosan as an initiator is subjected to chemical modification and introduced with hydroxypropyl and nitrine radicals at the 6-O site and N site respectively to form water-soluble photo-crosslinking chitosan; and the water solution of the photo-crosslinking chitosan is irradiated by ultraviolet light to form chitosan hydrogel so as to obtain the photo-crosslinking chitosan hydrogel film. The photo-crosslinking chitosan hydrogel film formed by a chitosan hydrogel film through ultraviolet light crosslinking by a physical method avoids chemical crosslinking with biological toxicity, improves the biocompatibility of the chitosan hydrogel film, realizes the clinical application of the chitosan hydrogel film, and provides a new path for the clinical application of the chitosan hydrogel film.

The invention discloses a high-strength natural high-molecular hydrogel film which is prepared from carrageenan and chitosan through ionic bond bonding and hydrogen bond bonding; maximal breaking stress of the hydrogel film is not smaller than 6.7 MPa, and maximal elongation is not smaller than 120%. The invention further discloses a preparation method for the high-strength natural high-molecularhydrogel film, and the preparation method comprises the following steps: uniformly mixing a dilute acetic acid solution of carrageenan and chitosan at room temperature to obtain a white mixed solutionsystem; transferring the mixed solution into a flat-bottom container, and performing vacuum drying at a temperature of 70-90 DEG C, thereby obtaining a dry-state film; soaking the dry-state film intodeionized water to reach swelling balance, thereby obtaining a carrageenan / chitosan hydrogel film. The high-strength natural high-molecular hydrogel film prepared is transparent, is uniform, is goodin toughness, is strong in cell adhesion resistance, and can be applied to the medical field as a biological diaphragm material.

The invention provides a controllable bidirectional three-dimensional deformed hydrogel film, which is formed by cross-linking of a carboxyl group-containing polymer by divalent or trivalent cations.The hydrogel film forms a crosslinking degree gradient in a thickness direction, one side surface of the hydrogel film is provided with a plurality of microchannels with oriented arrangement, and oneside of the hydrogel film is curled toward to the microchannels and generates positive deformation. The hydrogel film can trigger reverse deformation under the stimulation of monovalent cations, pH values and chelating agents, and controllable adjustment of the deformation degree of the hydrogel film can be achieved by controlling the concentration of the monovalent cation, the pH values, and theconcentration of the chelating agent. The invention also provides a preparation method of the controllable bidirectional deformed three-dimensional hydrogel film and a flexible microelectrode array.

The invention provides a high-temperature proton exchange membrane in a porous hydrogel base as well as a preparation method and an application of the membrane. The preparation method of the high-temperature proton exchange membrane comprises the following steps of: automatically-polymerizing a hydrophilic monomer or enabling the hydrophilic monomer and a hydrophilic macromolecule to form a (semi) interpenetrating network structure hydrogel film; swelling the (semi) interpenetrating network structure hydrogel film by adsorbing deionized water; and adsorbing a proton conductor aqueous solution through vacuum-freezing and drying to obtain the high-temperature proton exchange membrane in the porous hydrogel base, wherein the proton conductivity of the prepared proton exchange membrane in the porous hydrogel base can reach 0.1S.cm<-1> to 0.15S.cm<-1>. The preparation method disclosed by the invention is better than the conventional preparation method for the proton exchange membrane doped with a proton conductor, and capable of adsorbing the proton conductor to the three-dimensional network structure of the hydrogel film and firmly sealing the proton conductor by utilizing the porous structure, the swelling property, the unique adsorption and the retainability of the hydrogel film. The high-temperature proton exchange membrane in the porous hydrogel base is large in proton conductor adsorbing capacity, high in proton conductivity, wide in operation temperature range, simple and easy in preparation method, low in cost and large in improvement space.

The invention relates to an alginate-drug loaded nanoparticle-polycation microcapsule and preparation and application thereof. The microcapsule product is a spherical microcapsule with a particle sizeof 100 to 1000 microns. The structure of the microcapsule product is divided into two parts of a microcapsule membrane and an inner core. The microcapsule membrane is self-assembled layer by layer byalginate, drug-loaded nanoparticles and polycations to form a polyelectrolyte composite hydrogel film, and the inner core is a hydrogel or hydrosol environment containing animal cells. The microcapsule product is used as an immunosuppressive tool in embedding carriers for cell transplantation. Under the premise of ensuring the microcapsule strength and immuno-isolation performances, the surface roughness and surface charge of the microcapsule membrane can be reduced, the in-situ release of an anti-inflammatory drug on the surface of the microcapsule is realized, and the problem of fibrillation wrapping is solved from two aspects of stabilization of the microcapsule membrane by the drug-loaded nanoparticles and in-situ release of the anti-inflammatory drug for anti-inflammation.

The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and / or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

The invention relates to a self-healing hydrogel electrolyte film, and a preparation method and an application thereof. The electrolyte film is prepared by copolymerization of [2-(methylacryloyloxy)ethyl]dimethyl-(3-sulfonic acid propyl)ammonium hydroxide and a methacrylic acid monomer. Compared with the prior art, the hydrogel electrolyte film disclosed by the invention not only has very high tensile strength, but also shows excellent repeatable self-healing performance. The hydrogel film is used as an electrolyte, and a wrinkled electrode is prepared on the surface of the hydrogel electrolyte film by a pre-stretching method; a flexible supercapacitor prepared from the hydrogel film has good tensile property (1,000%) and self-healing performance, and the healed supercapacitor shows the energy storage performance consistent with that of an original device. The high-tensile and self-healing supercapacitor is relatively simple in structure and preparation process, and has a wide application prospect in the field of flexible stretchable electronic devices.

The invention discloses a production method of a hydrogel skin caring film, and the production method comprises the following steps in sequence: (A) compounding: preparing feed liquid from carrageenan, potassium citrate, citric acid and preservative raw materials with deionized water; (B) pouring: pouring the feed liquid into a film mold which is a bottom support constituting an external package;(C) freezing: freezing the feed solution in the mold; (D) secondary pouring: pouring essence liquid into the mold, wherein the essence liquid contains thermally-instable active substances and high polymers that are not easily released by hydrogel; and (E) packaging: carrying out heat sealing and packaging. The production method disclosed by the invention has the advantages of high production efficiency, low contamination risk during production, and low energy consumption. Since the product contains skin caring components that are not suitable to be added during hydrogel film formation process, the quality and efficacy of the product are improved.

The invention discloses an anisotropic structural color hydrogel film based on reduced graphene oxide doping, and a preparation method thereof, and applications in detection of myocardial cells. According to the invention, the grow areas of cells are controlled by using the difference of the cell adhesion rates of different hydrogel materials, and a specific pattern is copied on the surface of thematerial to achieve the functional partition of photonic crystal sensing and cell directional growth, so that the reduced graphene oxide doped hydrogel film with the anisotropic structure color is prepared; compared with the method in the prior art, the preparation method provided by the invention is simple to operate and low in cost, and does not need a large detection instrument; and the prepared anisotropic structure color hydrogel film has advantages of good biocompatibility, stable optical characteristics, flexible adjustability and efficient sensing properties, does not depend on a large detection instrument, and can realize naked eye observation of beating frequency and contractility of myocardial cells.

The invention provides a negative pole piece of a zinc secondary battery as well as a preparation method and application of the negative pole piece. The negative pole piece comprises a zinc-containing metal substrate and a protective layer arranged on the surface of the zinc-containing metal substrate, wherein the protective layer comprises a hydrogel film and a zinc salt dispersed in the hydrogel film. The preparation method comprises the following steps of: (1) mixing a gel polymer, zinc salt and a solvent to obtain hydrogel dispersed with the zinc salt; and (2) coating a zinc-containing metal substrate with the hydrogel obtained in the step (1), and drying to obtain the negative pole piece. The negative pole piece provided by the invention has the advantages of uniform zinc deposition, corrosion resistance, good cyclicity, high safety and the like, and is an excellent choice of a negative electrode material in a zinc secondary battery.

The invention provides a preparation method of a fibroin aquagel film. Natural silk is added into a sodium carbonate solution; stirring reaction is performed for 30 to 50 min at the temperature of 100to 110 DEG C; the operation is repeated for 3 to 5 times to obtain pure fibroin fiber; lithium bromide, butyl oxide and water are mixed and are subjected to ultrasonic treatment for 5 to 10 min to obtain a uniform mixed solution A; the pure fibroin fiber is added into the mixed solution A; dissolution reaction is performed for 30 to 50 min at the temperature of 80 to 120 DEG C; then, dialysis andfiltering are performed to obtain a fibroin water solution; a polyvinyl alcohol solution is prepared; nanometer titanium dioxide, elastin, the fibroin water solution and the polyvinyl alcohol solution are mixed; the reaction treatment is performed for 3 to 8h at the temperature being 60 to 80 DEG C and the pH being 7.3 to 8.1; obtained products are subjected to spreading flowing to realize the flat spreading in a shaping mode; freeze drying is performed at the temperature of -30 to -10 DEG C to obtain the fibroin aquagel film.

The invention relates to a method for rapidly preparing photonic crystal hydrogel bilayer film capable of changing the color by stretching in a large area, and belongs to the field of nano-composites. The method comprises steps as follows: acrylamide, a photoinitiator and N, N-methylenebisacrylamide are added to composite microspheres with high concentration of 50 wt%, the composite microspheres are prepared from styrene, methyl methacrylate and acrylic emulsion by polymerization, the materials are evenly mixed, injected into a glass plate and subjected to ultraviolet initiation, and a photonic crystal hydrogel monolayer film is formed; with water taken as a solvent, inorganic nanoparticles as a crosslinking agent, acrylamide and / or acrylic ester as a monomer, a catalyst and / or an initiator are / is added, the materials are evenly mixed and poured into a photonic crystal hydrogel film, and the photonic crystal hydrogel bilayer film capable of changing the color by stretching is formed under the condition of ultraviolet initiation or standing at the room temperature. The bilayer film can change the color by fast stretching, the method is simple, large-area preparation can be realized, and the bilayer film is outstanding in mechanical property, can be used repeatedly and has quite good application prospect in terms of anti-counterfeiting, optical mechanical sensor parts, bionic skin and the like.