Controllable bidirectional three-dimensional deformed hydrogel film, preparation method thereof and flexible microelectrode array

A three-dimensional deformation and hydrogel technology, applied in the field of hydrogel, can solve the problems of complex structure and inability to control the deformation degree of hydrogel materials, and achieve the effect of controllable adjustment of deformation degree

Active Publication Date: 2019-02-01
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method fails to process more complex structures and cannot control the degree of deformation of hydrogel materials

Method used

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  • Controllable bidirectional three-dimensional deformed hydrogel film, preparation method thereof and flexible microelectrode array
  • Controllable bidirectional three-dimensional deformed hydrogel film, preparation method thereof and flexible microelectrode array
  • Controllable bidirectional three-dimensional deformed hydrogel film, preparation method thereof and flexible microelectrode array

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A controllable two-way three-dimensional deformable hydrogel film, the surface of the hydrogel film has oriented microchannels and a gradient of crosslinking degree on the thickness, and the hydrogel film is obtained by crosslinking sodium alginate with calcium ions ; Wherein, the depth of the microchannel is 100 μm, and the width is 800 μm.

[0055] The preparation method of the controllable bidirectional three-dimensional deformation hydrogel film comprises the following steps:

[0056] (1) Clean the silicon wafer with acetone, ethanol, and water in sequence, purge it with nitrogen gas, and place it in a plasma cleaning machine for 1 min. The photoresist SU-8 3050 was spin-coated onto the surface of the silicon wafer at a speed of 1200r / min for 30s, and then placed on a hot stage at 95°C for 30s. Finally, a silicon-based template (with a length and width of 4 cm×4 cm) with a specific structure was obtained after photolithography (using a photolithography machine mode...

Embodiment 2

[0062] A controllable two-way three-dimensional deformable hydrogel film, the surface of the hydrogel film has microchannels arranged in an orientation and a gradient of crosslinking degree on the thickness, and the material of the hydrogel film is sodium alginate crosslinked with zinc ions. The microchannels are obtained in a joint; the depth of the microchannel is 5 μm, and the width is 1 μm.

[0063] The preparation method of the controllable bidirectional three-dimensional deformation hydrogel film comprises the following steps:

[0064] (1) Clean the silicon wafer with acetone, ethanol, and water in sequence, purge it with nitrogen gas, and place it in a plasma cleaning machine for 1 min. The photoresist AZ 5214 was spin-coated onto the surface of the silicon wafer at a speed of 3000r / m for 30s, and then placed on a hot stage at 95°C for 30s. Finally, a silicon-based template (with a length and width of 4 cm×4 cm) with a specific structure was obtained after photolithogr...

Embodiment 3

[0070] A controllable two-way three-dimensional deformable hydrogel film, the surface of the hydrogel film has microchannels arranged in an orientation and a cross-linking degree gradient on the thickness, and the material of the hydrogel film is polyacrylic acid cross-linked by iron ions Obtained; wherein, the depth of the microchannel is 1mm, and the width is 5mm.

[0071] The preparation method of the controllable bidirectional three-dimensional deformation hydrogel film comprises the following steps:

[0072] (1) Clean the silicon wafer with acetone, ethanol, and water in sequence, purge it with nitrogen gas, and place it in a plasma cleaning machine for 1 min. The photoresist SU-8 3050 was drop-coated on the surface of the clean silicon wafer to form a photoresist layer with a thickness of 1mm, and then placed on a 95°C hot stage for heating for 30s. Finally, a silicon-based template (with a length and width of 4 cm×4 cm) with a specific structure was obtained after phot...

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Abstract

The invention provides a controllable bidirectional three-dimensional deformed hydrogel film, which is formed by cross-linking of a carboxyl group-containing polymer by divalent or trivalent cations.The hydrogel film forms a crosslinking degree gradient in a thickness direction, one side surface of the hydrogel film is provided with a plurality of microchannels with oriented arrangement, and oneside of the hydrogel film is curled toward to the microchannels and generates positive deformation. The hydrogel film can trigger reverse deformation under the stimulation of monovalent cations, pH values and chelating agents, and controllable adjustment of the deformation degree of the hydrogel film can be achieved by controlling the concentration of the monovalent cation, the pH values, and theconcentration of the chelating agent. The invention also provides a preparation method of the controllable bidirectional deformed three-dimensional hydrogel film and a flexible microelectrode array.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a controllable bidirectional three-dimensional deformation hydrogel film, a preparation method thereof and a flexible microelectrode array. Background technique [0002] The stimuli-responsive hydrogel is a three-dimensional network structure with water as the dispersion medium, which can produce significant volume swelling or shrinkage changes under the external environment such as temperature, pH, light, ions and other stimuli. In addition, the hydrogel has a soft and rich texture The advantage of elasticity that is very close to the texture of living soft tissue makes it widely used in soft robotics, drug sustained release, tissue engineering and other fields. Stimuli-responsive hydrogels combined with gradient crosslinking in the thickness direction or differences in Young's modulus in local areas can achieve regionalized differential swelling or shrinkage, resulting in div...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/04C08L33/02C08L5/08C08L89/00C08J5/18
CPCC08J5/18C08J2305/04C08J2305/08C08J2333/02C08J2389/00
Inventor 杜学敏崔欢庆
Owner SHENZHEN INST OF ADVANCED TECH
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