Preparation method of bi-network hydrogel tubes having complex structure

A complex structure, dual network technology, applied in catheters, household appliances, applications, etc., can solve the problems of poor printing accuracy, large cell damage, and low strength of hydrogel tubes, and achieve the effect of low cost and simple process

Inactive Publication Date: 2017-05-31
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

2. Surface modification can only improve the performance of the catheter surface. The inner wall of the once-molded catheter still does not have ion permeability. After implanting in the human environment, it is difficult to exchange material and energy with the extracellular matrix environment.
However, after investigation, it was found that there are no patents related to the preparation technology of hollow hydrogel tubes.
Recently, the emergence of 3D bioprinting technology has provided the possibility for the preparation of artificial hydrogel tubes. However, the printing technology has high requirements on the rheological properties of raw materials, and the types of printing pastes to choose from are relatively limited [Literature (Biomaterials, 2015, 61,203-215) pointed out that hollow hydrogel tubes can be prepared by bio-3D printing technology, but this system is only suitable for sodium alginate and calcium ions, which is not universal], the printing accuracy is often poor, and the prepared hydrogel The strength of the tube is low; UV or heating is often used in the curing process, which is more damaging to the cells; it is impossible to print complex hydrogel tube arrays

Method used

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  • Preparation method of bi-network hydrogel tubes having complex structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation of uniform size hydrogel tube: acrylic acid / acrylamide-iron two-component chemical-physical cross-linked network hydrogel tube

[0026] 1. Prepare the hydrogel prepolymer of acrylic acid and acrylamide. Weigh 4.0 g of acrylamide, 0.6 g of acrylic acid, 0.008 g of N,N-bisacrylamide, and 0.02 g of potassium persulfate in 40 mL of water, and blow nitrogen gas for 1 h to remove oxygen.

[0027] 2. Formation of the hydrogel film on the wire. Dip a 1.6 mm diameter iron wire into the pre-polymerized monomer solution in the air, take it out after reacting for 10 min (20°C), and age it in air isolation for 2 h, then immerse it in ultrapure water for cleaning.

[0028] 3. Fe 3+ Physical coordination crosslinking in solution. Immerse the iron wire with the gel layer in 0.06 mol / L Fe 3+ Soak in the solution for 2 h, then soak in pure water for 1 h to clean, remove the iron wire template, and you can get a hollow hydrogel tube with a diameter of 1.8-2.0 mm...

Embodiment 2

[0029] Example 2: Preparation of Uniform Size Hydrogel Tube: Acrylamide / Hydroxyethyl Methacrylate / Polyvinyl Alcohol Composite Network Hydrogel Tube

[0030] 1. Prepare an acrylamide / hydroxyethyl methacrylate / polyvinyl alcohol aqueous solution. Weigh 1 g of acrylamide, 6.0 g of hydroxyethyl methacrylate, 0.01 g of N,N-bisacrylamide, and 0.02 g of potassium persulfate in 30 mL of water, and blow nitrogen gas for 1 h to remove oxygen. Then add 20 mL of 5% polyvinyl alcohol (polyethylene glycol) aqueous solution, stir well and place in an ice-water bath for later use.

[0031] 2. Formation of the hydrogel film on the wire. Dip a 1.6 mm diameter iron wire into the mixed aqueous solution of acrylamide / hydroxyethyl methacrylate / polyvinyl alcohol, take it out after reacting for 30 min (20°C), and place it in a freeze dryer (-20°C), 3 After thawing for 3 hours, the freezing-thawing process was continued for 3 times, and the iron wire template was removed to obtain a hollow hydrogel t...

Embodiment 3

[0032] Example 3: Preparation of Uniform Size Hydrogel Tube: Hydroxyethyl Methacrylate / Sodium Alginate-Calcium Composite Network Hydrogel Tube

[0033] 1. Hydroxyethyl methacrylate / sodium alginate aqueous solution. Weigh 6.0 g, 0.006 g N,N-bisacrylamide, 0.01 g potassium persulfate and dissolve in 50 mL water, add 5.0 g sodium alginate, stir until the solution becomes clear, and blow nitrogen for 1 h to remove oxygen.

[0034] 2. Formation of the hydrogel film on the wire. Suspend and immerse a 4.0 mm diameter iron wire in hydroxyethyl methacrylate / sodium alginate aqueous solution, take it out after reacting for 30 min (20°C), and age it in air isolation for 2 h, then immerse it in ultrapure water cleaning.

[0035] 3. Ca 2+ Physical coordination crosslinking in solution. Immerse the iron wire with the gel layer grown in 0.06 mol / L Ca 2+ solution, soaked for 10 h, then soaked in pure water for 1 h to clean, and removed the wire template to obtain a hollow hydrogel tube wi...

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Abstract

The invention discloses a preparation method of bi-network hydrogel tubes having a complex structure. The method includes the steps of: 1) mechanically polishing iron wires in different sizes, arranging the iron wires in different ways, and soaking the iron wires in a monomer prepolymerization liquid or pouring a monomer prepolymer into the container, in which the iron wires are arranged in different shapes, so as to perform a polymerization reaction, wherein uniform primary-crosslinked single-network hydrogel film is generated on the surfaces of the iron wires; 2) soaking the hydrogel film into a secondary crosslinking solution to perform secondary crosslinking to form a second network hydrogel film; 3) performing soaking treatment and removing the iron wires away to form the hollow high-strength hydrogel tubes in different shapes. The diameter of the hydrogel tubes is 10 [mu]m to a few millimeters, wherein the structure and shape of internal diameters of the tubes are highly controllable. Tensile strength of the hydrogel tubes can reach up to 2 MPa and tensile rate reaches up to 2-5 times. The hydrogel tubes have potential application value in the fields of microfluids and biomedicines.

Description

technical field [0001] The invention relates to a preparation method of a double-network hydrogel tube with complex structure. Background technique [0002] Hydrogel tube can be used as a new type of implantable biological catheter, which plays a very important role in bioclinical medicine. First, the hydrogel tube can be used as a delivery catheter implanted outside the body. For example, the delivery of fluid-like food and drugs; the delivery of excreta in vitro; artificial insemination, etc. Among them, the excellent low-friction properties of hydrogels provide a guarantee for the transportation of fluid-like food and excreta; the excellent stimulus responsiveness of hydrogels provides the possibility for the controllable delivery of drugs. Therefore, it is of great scientific and technological significance to develop various universal biological three-dimensional hydrogel fluid transport tubes. [0003] In addition, the hydrogel tube can be used as an artificial blood...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F220/06C08F222/38C08F220/28C08F265/10C08F220/54C08J3/24C08J3/075C08L33/14C08L71/02C08L89/00
CPCC08F220/56C08F265/10C08J3/24C08J3/246C08J2333/14C08J2333/26C08J2351/00C08L33/14C08F220/281C08F220/06C08F222/385C08F220/54C08L71/02C08L89/00C08L5/04C08L29/04A61L29/049A61L29/145C08J3/075C08J2405/04C08J2429/04C08J2471/02C08J2489/00C08L33/08C08L33/26B29C41/003B29C41/14B29K2077/00B29K2105/0002B29K2105/24B29L2031/7542
Inventor 周峰麻拴红刘维民
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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