20 results about "Porous hydrogel" patented technology

The application belongs to the technical field of biomedical materials, and discloses a collagen-based double-network porous hydrogel scaffold capable of recruiting endogenous stem cells and a construction method and application thereof. The scaffold takes collagen II (Col-II) and oxidized methyl acrylated hyaluronic acid (AHAMA) as an organic phase, and is constructed into a physical / chemical double-network structure through Schiff base dynamic crosslinking and ultraviolet light-induced methacryl radical polymerization. An air-in-water emulsion template method is used to form a through-porous structure, and 5' aldehyde-modified nucleic acid aptamer Apt19S is anchored in the scaffold network to achieve specific recruitment of endogenous pluripotent stem cells. The scaffold has excellent mechanical properties, a biomimetic extracellular matrix microenvironment and a targeted stem cell recruitment function, can effectively promote the directional differentiation of stem cells into chondrocytes, avoids the immune rejection and ethical issues caused by exogenous stem cell transplantation, and is suitable for the field of articular cartilage defect repair.

The invention provides a process for preparing a plasticised superporous hydrogel material comprising subjecting initial hydrogel material to treatment with an acidic solution, an optional treatment with a monovalent metal salt solution, freeze drying and plasticisation. Optionally, the process of the invention produces moulded plasticised superporous hydrogel material bodies that have one or more through-holes formed therein. The plasticised superporous hydrogel material of the present invention may be formulated as a suitable oral dosage form for use an appetite suppressant and for use to deliver a pharmaceutical and / or nutraceutical into a human or animal body.

The present application relates to the technical field of biological tissue engineering, and particularly relates to an artificial blood vessel and a preparation method thereof. The present application creatively develops an artificial blood vessel with a double-network interpenetrating structure based on a design of space-time coupling, wherein a double-layered openwork scaffold serves as a space maintenance network, and a porous hydrogel tube wall serves as a temporary filling network, so that accurate space-time adaptation of degradation and regeneration is realized. Specifically, the double-layered openwork scaffold serves as a main load-bearing framework, and the slow degradation characteristic of the double-layered openwork scaffold provides independent, stable and long-term mechanical support, thereby fundamentally avoiding premature degradation of mechanical properties. Meanwhile, the fast-degrading hydrogel tube wall ensures the airtightness of the blood vessel in the early stage after implantation, and then degrades rapidly to leave a preset and through three-dimensional space for tissue regeneration, thereby ensuring the speed and integrity of the regeneration.

Disclosed in the present invention are a frameless electric motor based on a porous hydrogel, and a heat dissipation method therefor. A front sealing shell and a rear sealing shell are respectively mounted at a front end and a rear end of a motor stator, and the front sealing shell, the motor stator and the rear sealing shell are all annular; a motor rotor is arranged on the inner side of the motor stator, the front sealing shell mates with one end of the motor stator in an embedded manner to form a plurality of axially distributed slots, and a hot-end hydrogel is provided inside the slots; the rear sealing shell and the other end of the motor stator are embedded, an annular cold-end hydrogel is provided inside the rear sealing shell close to the rear end of the motor stator, the cold-end hydrogel is in contact with the hot-end hydrogel, and an inner graphene heat-conducting strip and an outer graphene heat-conducting strip are respectively provided on the inner side and the outer side of the annular cold-end hydrogel; and the hot-end hydrogel and the cold-end hydrogel are both provided with cavities which are in communication with each other, and are internally filled with a cooling liquid. The heat dissipation solution provided by the present invention has a simple structure and is easy to integrate. The manufacturing of a capillary structure closely fitting against a heat source of an electric motor is realized by means of the hydrogel. The porous hydrogel has high thermal conductivity and a simple preparation method.

This invention discloses a flame-retardant, tough, conductive, porous hydrogel, its preparation method, and its applications, belonging to the field of hydrogel materials technology. The method involves solid-state mixing of polyvinyl alcohol and tannic acid, liquid-phase preparation of MXene and glutaraldehyde dispersions, followed by solid-liquid crosslinking, washing, and then composite with silver paste, carbon fiber cloth, and a PDMS membrane to obtain a composite material. Key parameters such as the amount of MXene added and the crosslinking time were optimized. The resulting hydrogel has a porous structure and exhibits excellent flame retardancy, toughness, and hygroscopicity. It can generate a water voltaic voltage during moisture absorption and dripping. The composite structure further enhances its power generation performance, and its electrical output is modulated by temperature and humidity, dripping volume, solution ion concentration, and polarity. This invention solves the problems of short battery life, mechanical mismatch, and poor air permeability in traditional smart textile materials, and has promising application prospects in smart textile fields such as fabric weaving and the manufacture of new sensors.

The application discloses a kind of high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage, belong to medical porous hydrogel technical field, specifically related to monomer, crosslinking agent and initiator are added to water and mixed to obtain the reaction solution of temperature-sensitive hydrogel, freeze polymerization obtains ice gel;Ice gel is placed in salt solution and is handled to obtain porous hydrogel;Monomer includes at least one of N-isopropyl acrylamide, N-vinyl caprolactam, N,N-diethyl acrylamide, N-vinyl carbazole, acrylic acid, methyl methacrylate, ethylene glycol methyl ether acrylate, butyl methacrylate, maleic anhydride and styrene.The application provides a kind of temperature-sensitive effect, can be dynamically controlled by electric heating, good mechanical property, good drainage effect high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage.

The application discloses a cell-loaded porous hydrogel biomaterial and a preparation method and application thereof. The preparation method of the cell-loaded porous hydrogel biomaterial comprises the following steps: preparing a filamentous or multi-arm sacrificial hydrogel; preparing a matrix hydrogel precursor solution; wherein, the sacrificial hydrogel and / or the matrix hydrogel precursor solution are loaded with living cells; and mixing the sacrificial hydrogel and the matrix hydrogel precursor solution to obtain the cell-loaded porous hydrogel biomaterial. The special-shaped hydrogel such as the filamentous or multi-arm hydrogel is used as a sacrificial template, and after the sacrificial hydrogel is removed, a biomimetic blood vessel lumen form with better connectivity of the pore structure can be obtained, and cells can be loaded in the filamentous sacrificial hydrogel, so that the cells can be released in situ in the three-dimensional pore network, and secondary planting is not needed, and the efficiency and uniformity of cell planting are improved.

The application relates to the technical field of orthopedic clinical repair, and particularly discloses a piezoelectric driving layered bionic support for repairing diabetic bone defects as well as a preparation method and application thereof. The support is a double-layer bionic structure, and the support comprises an upper-layer piezoelectric bionic periosteum simulating a periosteum and a lower-layer conductive filling hydrogel simulating a defect filling matrix. The upper-layer piezoelectric bionic periosteum is a nanofiber membrane, and the lower-layer conductive filling hydrogel is a composite three-dimensional porous hydrogel. The scheme designs a kind of physical hierarchical structure capable of simulating bone tissue, and the composite bionic support can conduct surface electrical signals to the deep part of the defect, and can synergistically regulate local immune metabolism and angiogenesis. The physical hierarchical structure material of the support exhibits excellent mechanical compressive strength, low impedance conductivity, and ultrasound-responsive on-demand degradation and drug release behavior adapted to the bone tissue healing period, and has extremely high clinical conversion potential.

This invention discloses an ultralight porous hydrogel based on the salting-out effect and its preparation method. The ultralight porous hydrogel based on the salting-out effect has the following structural formula: [Structure formula would be inserted here]. This invention utilizes hydrogen generated by the in-situ redox reaction between gallium-based liquid metal (LM) and an aqueous medium to drive the rapid foaming of the system to form a porous structure. Combined with hydrophobic association induced by the salting-out effect, and under the multiple physicochemical crosslinking effects of dynamic borate ester bonds, metal ion coordination bonds, and hydrogen bonds, an LMCNF porous hydrogel with high strength, high toughness, and high conductivity is prepared. It exhibits excellent mechanical strength; high electrical conductivity; sensitive, stable, and reversible resistance response; a high strain coefficient (GF up to 1.68); and a wide operating range; and excellent cyclic compression stability and fatigue resistance.

This invention proposes a porous hydrogel, its preparation method, and its application. The preparation method of the porous hydrogel includes: (1) electrospinning a first mixture to obtain an electrospun material, wherein the first mixture comprises a carbon-based material, polyvinyl alcohol, yeast, glucose, and water, and the mass ratio of polyvinyl alcohol to water is 1:(10-15); (2) contacting and combining a second mixture with the electrospun material to obtain a composite structure, wherein the second mixture comprises a carbon-based material, polyvinyl alcohol, yeast, glucose, and water, and the mass ratio of polyvinyl alcohol to water is 1:(2-10); (3) fermenting the composite structure and then performing a freeze-thaw treatment to obtain a porous hydrogel. The hydrogel provided by this invention has good internal pore connectivity, and its mechanical properties and photothermal conversion capabilities are synergistically improved, which can significantly improve the evaporation efficiency of interfacial water and has broad application prospects in the fields of seawater desalination and sewage treatment.

This invention provides a porous hydrogel material for medical dressings and its preparation method, relating to the technical field of porous hydrogel materials. The invention uses pharmaceutical-grade sodium hyaluronate, carboxymethyl chitosan, and polyvinyl alcohol as raw materials to prepare a porous hydrogel material through material cross-linking. This preparation method is simple to operate, does not use any toxic or harmful reagents, and the resulting porous hydrogel material has good biocompatibility, strong adsorption capacity, and excellent mechanical properties. It can adsorb water to provide moisturizing capabilities and adsorb drugs to achieve a sustained-release effect, making it suitable as a matrix for medical dressings.

The application discloses a sodium alginate / polyethyleneimine composite aerogel dehumidification material and a preparation method and application thereof. The preparation method of the composite aerogel dehumidification material comprises the following steps: taking sodium alginate and polyethyleneimine as a matrix, constructing a three-dimensional porous hydrogel network under the crosslinking action of epichlorohydrin, and obtaining the sodium alginate / polyethyleneimine aerogel through freeze drying; then, the aerogel is immersed in a composite alcohol solution containing lithium chloride and ethanolamine, and the sodium alginate / polyethyleneimine composite aerogel dehumidification material is obtained through freeze drying. The sodium alginate and the polyethyleneimine are taken as the matrix, a three-dimensional porous aerogel skeleton is constructed through chemical crosslinking, and hygroscopic inorganic salts are further loaded, so that the composite aerogel dehumidification material with high hygroscopic capacity and recyclability is obtained.

The utility model discloses a kind of special-shaped variable cross-section ultrahigh-strength steel hot stamping B column reinforcing plate structure, comprising: a kind of special-shaped variable cross-section ultrahigh-strength steel hot stamping B column reinforcing plate structure, comprising: B column upper reinforcing plate piece, B column lower reinforcing plate piece connected in the bottom end of the B column upper reinforcing plate piece, the top of the B column lower reinforcing plate piece and the bottom end of the B column upper reinforcing plate piece are welded to form welding division line, carbon fiber reinforcing sheet is provided on the B column upper reinforcing plate piece, honeycomb core is embedded in the B column lower reinforcing plate piece, the B column lower reinforcing plate piece is fixed with the composite mode of local welding and global gluing by honeycomb core.Through honeycomb core local welding and global gluing composite fixation, in combination with the porous hydrogel material filled in honeycomb core, the structure energy absorption efficiency is greatly enhanced.

The present application relates to the technical field of biomaterials, and particularly relates to a porous hydrogel microsphere, a preparation method and application thereof. The method comprises the following steps: dissolving sodium alginate and polyvinyl alcohol in water to obtain a multi-component polymer aqueous solution; adding the multi-component polymer aqueous solution into an oil phase to disperse the multi-component polymer aqueous solution into droplets to form a water-in-oil emulsion; and mixing the water-in-oil emulsion and calcium chloride to cause ion cross-linking reaction of sodium alginate in the droplets, wherein the multi-component polymer in the droplets undergoes phase separation structure evolution and is in-situ fixed under the cross-linking effect to obtain the porous hydrogel microsphere. The present application provides a preparation method of the porous hydrogel microsphere with controllable structure and simple process, and realizes in-situ construction of the internal connected porous structure of the microsphere in the emulsification and cross-linking process, thereby overcoming the problems of dense internal structure, difficult connection of the pores, complex preparation process and insufficient structural stability in the prior art.

This invention provides a polyglutamic acid composite porous hydrogel, its preparation method, and its applications. Polyglutamic acid and polyvinyl alcohol aqueous solutions are mixed and crosslinked with glycidyl ether under alkaline and acidic conditions to form an interpenetrating network hydrogel. Calcium ions are then introduced to prepare a multifunctional composite hydrogel. The carboxyl groups on the polyglutamic acid molecular chain and the hydroxyl groups in the polyvinyl alcohol molecular structure can generate strong hydrogen bonds, further improving the mechanical strength of the hydrogel. Furthermore, the introduction of calcium ions (Ca) into the hydrogel network... 2+ This gives the hydrogel superior hemostatic properties.

This invention discloses a self-gelling porous hemostatic microsheet, its preparation method, and its application; belonging to the field of hydrogel technology. The method first prepares two raw materials in a sponge-like state: quaternized chitosan grafted with gallic acid and oxidized hyaluronic acid. Then, the two raw materials are separately pulverized into microsheets using a pulverizer. After controlling the size of the microsheets through a sieve, the two types of microsheets are mixed to prepare a porous hemostatic microsheet. This hemostatic microsheet combines the advantages of sponge, hydrogel, and powder, achieving rapid hemostasis and efficient wound healing. The hemostatic microsheet has a large specific surface area and excellent hydrophilicity, enabling rapid blood absorption. It achieves self-gelling through electrostatic interaction and Schiff base crosslinking, forming a dense, porous hydrogel adhesive. The porous hemostatic microsheet possesses excellent mechanical properties, adhesive strength, and ultra-high burst pressure, while also exhibiting biocompatibility, biodegradability, and procoagulant and antibacterial properties.

This invention belongs to the field of biomedical sensing and flexible electronics technology, and proposes a hydrogel electrode for long-term bioelectrical signal monitoring, its preparation method, and its application. The hydrogel electrode of this invention comprises a porous hydrogel and a network conductive layer embedded within the hydrogel, forming a three-dimensional mechanically interlocked structure. The average pore size of the hydrogel is 100 μm-500 μm, and its porosity is 60%-90%. The raw materials for preparing the hydrogel include the following components in parts by weight: 5-30 parts of a thermosensitive polymer, 0.5-15 parts of a conductive component, 5-40 parts of a water-retaining agent, 0.1-10 parts of an adhesive, and 0.01-2 parts of a crosslinking agent. Through multi-scale structural design and the synergistic effect of multiple components, the hydrogel electrode of this invention constructs a structure integrating a through-pore framework and a three-dimensional interlocked conductive network, achieving excellent comprehensive performance in terms of breathability, moisture retention, interfacial mechanics, and bioelectrical signal acquisition.

The present invention provides a product which is capable of the release of one or more active ingredients, in which the product comprises a superporous hydrogel structure formed by freeze-drying. The invention also relates to a method of making said product and to various uses of said product.

This invention discloses a microcarrier for delivering active mitochondria, its preparation method, and its applications. The microcarrier comprises porous hydrogel microspheres, engineered mitochondria encapsulated within the microspheres, and a polydopamine coating on its surface. The engineered mitochondria are obtained by surface modification of active mitochondria with a polyamide-amine dendritic polymer modified with phenylboronic acid. The preparation method involves mixing the engineered mitochondria with a hydrogel prepolymer as the inner phase, preparing water-in-oil monodisperse droplets using microfluidic technology, curing them under ultraviolet light to obtain hydrogel microspheres, and then mixing them with a dopamine solution to form a polydopamine coating. This microcarrier effectively maintains mitochondrial activity and promotes cellular uptake, repairs damaged mitochondrial function, resists oxidative stress, and promotes cell proliferation, migration, and angiogenesis. Animal experiments show that this microcarrier significantly accelerates the healing of photodamaged skin wounds. This invention can be used to prepare drugs for treating skin wounds and has promising clinical applications.

This invention discloses a wearable hydrogel sensor and method for rapid detection of glucose concentration in sweat. The sensor is obtained by cold crosslinking and photocrosslinking of a pregel solution. The pregel solution contains: a glucose-responsive material, 3-acrylamidophenylboronic acid; an ion-conducting material, sodium alginate; a thermosensitive material, methacrylamide gelatin; a photocrosslinking monomer material, acrylic acid; a photocrosslinking agent; and a photoinitiator. Cold crosslinking involves spraying the pregel solution to induce instantaneous cooling, forming a porous hydrogel with a porous framework. Subsequently, photocrosslinking is performed by irradiation with ultraviolet light to create a loose polymer network within the porous hydrogel. Finally, the gelatin molecular framework and silica particles are removed by etching, resulting in a porous network hydrogel with a submicron to micron-scale composite pore structure and a loose polymer network. The wearable hydrogel sensor is obtained by immersing the porous network hydrogel in an ethylene glycol aqueous solution.