21 results about "Corneal implants" patented technology

The invention relates to a corneal inlay for a human eye, wherein the inlay comprises a biocompatible base material and a colorant that mimics the optical appearance of the iris of a human eye. The invention also relates to a method for changing the visible eye color of a human eye, comprising the steps of preparing a pocket in the cornea of ​​the eye and inserting an implant into the corneal pocket, wherein the implant is configured as a corneal inlay comprising a colorant to simulate an iris, and a method for preparing a corneal inlay for a human eye, comprising the steps of providing a biocompatible base layer and applying a colorant to the base layer, wherein the colorant mimics the optical appearance of the iris of a human eye.

A corneal inlay and pinhole lens structure for implantation into a cornea of an eye is disclosed herein. In one embodiment, a corneal inlay for implantation into a cornea of an eye includes an inlay body formed from natural tissue of a donor cornea; and a central pinhole disposed in the inlay body, the central pinhole being surrounded by a darkened bounding wall. In another embodiment, a pinhole lens structure includes an insertable pinhole body defining a through pinhole of approximately 0.9-2.0 mm in diameter with a surrounding darkened wall having an approximately 0.1-1 mm wall thickness, the insertable pinhole body configured to be inserted into a corneal pocket in a cornea of an eye.

The present disclosure provides corneal implants, comprising: a base membrane, a seal ring, and / or a soft edge, that can be used to replace a cornea or sclera of a patient in need thereof and methods of make the same.

The application discloses a kind of methacrylic acid succinic acid double ester starch and its preparation method and application in corneal defect in situ filling agent, belong to the technical field of biomedical materials.The methacrylic acid succinic acid double ester starch is grafted carboxylation treatment to starch, then graft double bond is prepared.The corneal defect in situ filling agent of the application is composed of methacrylic acid succinic acid double ester starch (StacMA), methacrylated gelatin (GelMA), photo initiator and solvent.The natural biological macromolecule based corneal filling agent of starch and gelatin in the application has good biocompatibility, excellent light response adhesion characteristics and excellent mechanical properties, and the in-situ photocrosslinking of hydrogel is realized by ultraviolet irradiation, while excellent mechanical properties and strong adhesion capacity are generated, to realize the stable adhesion of in-situ forming artificial cornea on corneal implant bed, promote the regeneration of damaged corneal natural structure and the reconstruction of visual function.

Devices and methods for the amelioration of ectatic corneal disorders using corneal augmentations derived from corneal tissue are disclosed. The shape of the augmentation is determined using data obtained from mapping of a patient's cornea based on computerized corneal topography and tomography. Factors considered include the maximum keratometry and specific iso-deviation contours. In one embodiment, an augmentation is a corneal inlay, intended for insertion into an intrastromal pocket. In a further embodiment, the augmentation is a corneal onlay, intended to be positioned over a region of the cornea from which the epithelial layer has been removed. The corneal onlay is held in place until the epithelial layer regrows over the augmentation. In a further embodiment, the inlay or onlay augmentation is followed by a post-augmentation, further reshaping of the corneal augmentation. In one embodiment, this further reshaping is photorefractive keratectomy (PRK) surgery.

There is also provided a lenticule-shaped corneal implant formed from a composite material comprising: an outer surface having a convex dome shape; and an inner surface having a concave dome shape, wherein the inner surface comprises at least two indented grooves that are circular and concentric. There is also provided a corneal implant comprising a central body formed from a first composite material and having a dome shape configured to conform to a curvature of a cornea of a subject; and a peripheral zone contacting, is at least partially coextensive with, or fully surrounds an outer rim of the central body. There is also provided molding apparatus for producing the lenticule-shaped corneal implant.

The present disclosure relates to a corneal implant, particularly the implant is useful for a corneal transplant. The implant avoids direct contact between the patient tissue and a donated cornea. The implant comprises: a disc in the centre of the implant, a ring in a superior plane parallel to the disc, and a radial connecting element between the disc and the ring wherein the implant is configured to perform the function of a mechanical barrier between the donor's cornea and the host descemet endothelium.

This invention is directed to compounds and compositions which are designed for use in light adjustable ophthalmic devices, such as intraocular implants, intraocular lenses, phakic intraocular lenses, contact lenses, orthokeratology lenses, rigid gas permeable lenses, corneal inlays, corneal outlays, or corneal inserts. The inventive compositions are produced from reactive monomer mixtures which when polymerized form polymers or polymeric networks having editable refractive indices. Such inventive compositions when exposed to light of certain wavelengths undergo intramolecular cycloaddition reactions thereby changing the refractive index in the irradiated regions. When used in ophthalmic devices, the inventive compositions enable post-manufacturing and / or post-operative adjustments to the optics of the devices by spatially modifying the refractive index. For example, the vision of a patient with an intraocular lens made of the inventive compositions can be fine-tuned after implantation and healing by a light treatment of the intraocular lens.

A precursor (100) for corneal implant (1) comprising a structural body (2), the structural body (2) comprising an outer peripheral ring (10), an inner peripheral ring (11), and a connection structure (20) pre-arranged to connect the outer peripheral ring (10) and the inner peripheral ring (11), wherein said outer peripheral ring (10), said inner peripheral ring (11) and said connection structure (20) lie in one and the same plane, and wherein said outer peripheral ring (10) and said inner peripheral ring (11) lie at a first distance apart. The connection structure is designed to undergo a deformation to obtain a predefined dome-like conformation of said structural body (2),, wherein said outer peripheral ring (10) lies in a first plane and said inner peripheral ring (11) lies in a second plane distinct from and parallel to said first plane and at a second distance apart from said outer peripheral ring (10) greater than said first distance. The connection structure (20) comprises at least one connection element (23) for connecting the outer peripheral ring to the inner peripheral ring that extends along a profile (22) that deviates from a connection path of minimum length, equal to said first distance, so as to have a length in excess of said first distance that is such as to cover said second distance between said outer peripheral ring and said inner peripheral ring in said dome-like conformation of said structural body.

This invention is directed to compounds and compositions which are designed for use in light adjustable ophthalmic devices, such as intraocular implants, intraocular lenses, phakic intraocular lenses, contact lenses, orthokeratology lenses, rigid gas permeable lenses, corneal inlays, corneal outlays, or corneal inserts. The inventive compositions are produced from reactive monomer mixtures which when polymerized form polymers or polymeric networks having editable refractive indices. Such inventive compositions when exposed to light of certain wavelengths undergo intramolecular cycloaddition reactions thereby changing the refractive index in the irradiated regions. When used in ophthalmic devices, the inventive compositions enable post-manufacturing and / or post-operative adjustments to the optics of the devices by spatially modifying the refractive index. For example, the vision of a patient with an intraocular lens made of the inventive compositions can be fine-tuned after implantation and healing by a light treatment of the intraocular lens.

A precursor (100) for a corneal implant (1), the precursor (100) comprising a structural body (2) comprising an outer peripheral ring (10), an inner peripheral ring (11) and a connecting structure (20) prearranged to connect the outer peripheral ring (10) and the inner peripheral ring (11), where the outer peripheral ring (10), the inner peripheral ring (11) and the connecting structure (20) lie in the same plane, and where the outer peripheral ring (10), the inner peripheral ring (11) and the connecting structure (20) lie in the same plane. The outer peripheral ring (10) and the inner peripheral ring (11) are positioned spaced apart by a first distance. The connection structure is designed to undergo deformation to obtain a predetermined dome-like configuration of the structural body (2) in which the outer peripheral ring (10) lies in a first plane and the inner peripheral ring (11) lies in a second plane different but parallel to the first plane and at a second distance from the outer peripheral ring (10), the second distance is greater than the first distance. The connection structure (20) comprises at least one connection element (23) for connecting the outer peripheral ring to the inner peripheral ring, the connection element (23) extending along a profile (22) offset from a connection path having a minimum length equal to the first distance so as to have a length exceeding the first distance, the second distance between the outer peripheral ring and the inner peripheral ring is covered in the domed configuration of the structural body.

A precursor (100) of a corneal implant (1) including a structure (2), the structure (2) including an outer ring (10), an inner ring (11), and a connecting structure (20) pre-positioned to connect the outer ring (10) and the inner ring (11), wherein the outer ring (10), the inner ring (11), and the connecting structure (20) are located in one and the same plane, and the outer ring (10) and the inner ring (11) are located a first distance apart. The connecting structure is designed to undergo deformation to obtain a predetermined dome-shaped shape of the structure (2), wherein the outer ring (10) is located in the first plane, and the inner ring (11) is located in a second plane different from and parallel to the first plane, a second distance apart from the outer ring (10), the second distance being greater than the first distance. The connecting structure (20) includes at least one connecting element (23) for connecting the outer ring to the inner ring, the connecting element (23) extending along a profile (22) that deviates from a connecting path of a minimum length equal to the first distance, thereby having a length that exceeds the first distance so as to cover the second distance between the outer ring and the inner ring in the dome-shaped configuration of the structure.

The invention relates to methods and devices for holding, positioning and controlling the temperature of a corneal implant or corneal transplant made of human donor tissue or artificial tissue. The invention relates to a corneal implant holder (1), methods for controlling the temperature of an implant or transplant, and methods for processing tissue at the dew point or frozen tissue.

This invention is directed to compounds and compositions which are designed for use in light adjustable ophthalmic devices, such as intraocular implants, intraocular lenses, phakic intraocular lenses, contact lenses, orthokeratology lenses, rigid gas permeable lenses, corneal inlays, corneal outlays, or corneal inserts. The inventive compositions are produced from reactive monomer mixtures which when polymerized form polymers or polymeric networks having editable refractive indices. Such inventive compositions when exposed to light of certain wavelengths undergo intramolecular cycloaddition reactions thereby changing the refractive index in the irradiated regions. When used in ophthalmic devices, the inventive compositions enable post-manufacturing and / or post-operative adjustments to the optics of the devices by spatially modifying the refractive index. For example, the vision of a patient with an intraocular lens made of the inventive compositions can be fine-tuned after implantation and healing by a light treatment of the intraocular lens.

The present application discloses a corneal transplant eyeball stabilization system, comprising an elastic implant membrane, the elastic implant membrane comprising a membrane body and an annular elastic support, the membrane body being supported on the inner side of the annular elastic support, and the annular elastic support being arranged around the membrane body. The elastic implant membrane comprises an annular elastic support and a membrane body, and the elastic implant membrane is in an unfolded, flat and taut state in its initial state, and can be folded when subjected to external force. Therefore, before preparing a corneal implant hole, the folded elastic implant membrane can be implanted into the eye, and after the elastic implant membrane loses the external force, it can unfold again, thereby sealing the position where the implant hole is required, and then the implant hole is prepared. After the implant hole is prepared, the implant is placed and sutured, and the elastic implant membrane is removed after the implant is sutured and fixed. Therefore, during the entire surgical process, the intraocular tissue is not directly exposed, the intraocular pressure can be maintained stable, and the occurrence of surgical complications is greatly reduced.

This invention is directed to compounds and compositions which are designed for use in light adjustable ophthalmic devices, such as intraocular implants, intraocular lenses, phakic intraocular lenses, contact lenses, orthokeratology lenses, rigid gas permeable lenses, corneal inlays, corneal outlays, or corneal inserts. The inventive compositions are produced from reactive monomer mixtures which when polymerized form polymers or polymeric networks having editable refractive indices. Such inventive compositions when exposed to light of certain wavelengths undergo intramolecular cycloaddition reactions thereby changing the refractive index in the irradiated regions. When used in ophthalmic devices, the inventive compositions enable post-manufacturing and / or post-operative adjustments to the optics of the devices by spatially modifying the refractive index. For example, the vision of a patient with an intraocular lens made of the inventive compositions can be fine-tuned after implantation and healing by a light treatment of the intraocular lens.

The invention relates to methods and devices for holding, positioning, and temperature-controlling a corneal implant (also: corneal graft) or corneal transplant made from human donor tissue or artificial tissue. The invention relates to a corneal implant holder (1), methods for temperature-controlling an implant or transplant, and methods for processing tissue at the dew point or frozen tissue.

The present disclosure relates to a method for implanting a corneal inlay based on high-precision visual axis positioning and intraocular pressure adjustment, the method including: performing visual axis positioning on a target object to determine a visual axis center of the target object; producing a corneal implant cavity for the target object; adjusting an intraocular pressure of the target object; and implanting a lens into the corneal implant cavity of the target object to align the lens with the visual axis center of the target object.

An example method for cutting a plurality of lenticules from a donor cornea includes receiving a donor cornea, cutting a first layer of a first set of lenticules from the donor cornea, and cutting a second layer of a second set of lenticules from the donor cornea. The lenticules are cut according to a pattern that to maximizes the number of lenticules, thereby maximizing the number of implants from the single donor cornea.An example implant handling device includes a body. The body includes a flattened end configured to receive a corneal implant and keep the corneal implant from rolling or folding. The flattened end has a width and a height, the width being greater than the height. The body includes a slit opening to the flattened end, the slit opening configured to allow the corneal implant to pass into the flattened end.

In certain embodiments, the corneal implant includes a transparent dome and a ring. The transparent dome has a circular base with a periphery having a diameter of less than 2 centimeters. The transparent dome includes a transparent biocompatible material. The ring has an annular shape and is disposed around the periphery of the circular base of the transparent dome. The ring includes a biocompatible material having a surface. A peripheral portion of the surface forms openings that promote attachment of ocular tissue to the ring. Each opening has a diameter of less than 2 millimeters.

This invention discloses a sutureless composite artificial cornea, comprising a polymer posterior membrane and a biological anterior membrane fixed to the anterior surface of the polymer posterior membrane. The biological anterior membrane is divided into a central zone and a peripheral zone. The peripheral zone contains several radially arranged tunnels, with the head end of each tunnel located on the upper surface of the peripheral zone and the tail end located at the outer edge of the peripheral zone. Each tunnel contains a pre-embedded tissue fixation guidewire, and the length of the tissue fixation guidewire is greater than the length of the tunnel. The advantages of this invention are: by setting radial tunnels within the peripheral zone of the biological anterior membrane and pre-embedding tissue fixation guidewires within the tunnels, during surgery, the tissue fixation guidewires are pushed in along the tail end of the tunnels, allowing them to be inserted into the corneal implant bed, achieving fixation between the cornea and the corneal implant bed. This avoids corneal astigmatism caused by suturing and simplifies the surgical procedure.