76 results about "Corneal implants" patented technology

This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of terminal functionalized surfactants to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.

A corneal implant injector assembly includes a barrel, a plunger, and an injector tip with a channel having a size and orientation adapted to store and deliver a corneal implant. The corneal implant is preferably stored in the channel in a contracted state. The plunger has an implant engagement tip for engaging and moving the implant within the channel and to deploy the implant. In some embodiments, the injector tip is selectively detachable from the remaining portion of the injector assembly.

A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.

A corneal implant adapted for implantation between layers of a cornea to focus an image on a retina of an eye includes an inlay, an outer perimeter, and a clear central region capable of refracting light to compensate for a refractive error of an eye. The inlay also has an annular opaque region comprising a plurality of holes or otherwise being adapted to transport nutrients. The annular opaque region extends from the outer circumference of the inlay to the clear central portion. The opaque region extends over a minority of the surface area of the implant. The anterior and posterior surfaces of the inlay are configured to abut adjacent layers of the cornea.

A system comprising a hollow member is used to deliver a constrained corneal implant into a corneal pocket. The hollow member may be tapered and the system may further include an implant deformation chamber and an axial pusher to advance the implant through the hollow member.

The corneal implant of the current invention takes the general form of a thin, transparent, flexible, porous, biocompatible film of suitable polymer material. The implant is sufficiently porous, the porosity being imparted by the film being irradiated to produce tracks and the material in those tracks being subsequently removed through an etching process, to allow the adequate flow of gaseous and tissue fluid components through the film. Specific embodiments of the invention are achieved by the addition of features to the general form. The embodiment applicable to corneal reshaping features a surface relief pattern in the implant. The artificial iris embodiment features an imprinted partly to fully opaque or partially reflective annular iris pattern of selected inner and outer diameters.

The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.

A method of implanting a transcorneal shunt into a cornea, the shunt having a head and a foot, each having a hole therein, the method including the operations of engaging an insertion tool with a foot hole of the shunt; making an entry incision in the cornea; inserting the shunt, while still engaged with the insertion tool, through the entry incision; making an implant incision in the cornea; inserting the head of the shunt through the implant incision to position and seat the shunt; and releasing the shunt from the insertion tool.

Devices and methods for handling and depositing corneal implants onto corneal tissue. Devices and methods for packaging and storing corneal implants.

Corneal implant retaining devices and their methods of use. The retaining devices can be a cap adapted to be disposed over a portion of a corneal implant insertion device.

This disclosure relates to a novel Collagen Mimetic Peptide; a multi-arm conjugate comprising said peptide that mimics the higher order triple helical self-assembly of a collagen; a hydrogel comprising said Collagen Mimetic Peptide, optionally comprising collagen and optionally comprising a chemically modified surface; a corneal implant based on said hydrogel/modified hydrogel comprising a transparent central portion formed by an interpenetrating network comprising one or more additional biocompatible polymers wherein the central portion is adapted to remain cell free to ensure unhindered transmission of light.

The present invention features a hybrid superporous hydrogel scaffold for cornea regeneration and a method for producing the same. The hybrid hydrogel is composed of a superporous poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The hybrid scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.

A corneal cover or corneal implant to be placed within or onto the surface of the cornea is made of bony fish scales and a contact lens is made of bony fish scales.

The present invention features a superporous hydrogel scaffold for corneal regeneration or replacement and a method for producing the same. The superporous hydrogel is composed of a poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.

The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention.

Corneal implant for introduction into the visual centre (Z) of the cornea of the human eye for the purpose of rectifying impaired vision, in particular presbyopia, or presbyopia in combination with hypermetropia or myopia. To make available a corneal implant which is suitable for use in the visual centre (Z) of the human eye and can be used to correct presbyopia on its own or in combination with hypermetropia or myopia, it is provided that the effective thickness (d) of the corneal implant (2), measured in the direction of the optic axis (5) of the eye, is more than 50[mu]m and the maximum width (b), measured in a plane perpendicular to the direction of thickness, is less than l mm, the corneal implant (2) having no imaging function in relation to the human eye.