121 results about "Biocompatible polymers" patented technology

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The application discloses a soluble microneedle composition for transdermal delivery of polypeptides and application thereof. The soluble microneedle composition comprises a first composition and a second composition; wherein the first composition comprises the following components in mass percentage: 20-60% polypeptides, 0.5-20% capryol 98, 10-40% first biocompatible polymer material and 0.5-20% first surfactant; the second composition comprises the following components in mass percentage: 98-99.75% second biocompatible polymer material and 0.25-2% second surfactant. The microneedle composition is used in the microneedle, and the problems of low transdermal efficiency and poor stability of polypeptides are solved.

The invention relates to the technical field of biomedical material modification, in particular to a sulfhydrylation biocompatible polymer derivative, a preparation method thereof, extracellular matrix imitating injectable in-situ cross-linked hydrogel and application thereof. According to the invention, a pre-acylation strategy is firstly carried out on the biocompatible polymer containing both amino and carboxyl, so that a three-dimensional cross-linked byproduct formed by coupling of self amido bonds is avoided, meanwhile, the number of side chain carboxyl for sulfhydrylation modification is increased, and the accurate and adjustable pre-acylation rate can optimize the physical and chemical properties of the derivative; meanwhile, a disulfide bond is used as a protective precursor, active sulfydryl is introduced through amido bond coupling, self-oxidation of the active sulfydryl in the reaction process is avoided, sulfydryl activity is guaranteed, hydrazine-containing reagents are avoided, safety is further improved, virus residues and immunological rejection risks are avoided, universality is high, and the application prospect is wide; and in combination with a high-concentration preparation method, the method has the advantage of large-scale production, and further widens the industrial application potential.

The invention relates to the technical field of biological medicine nano-drug delivery, in particular to a nano-drug delivery system based on a metal polyphenol network, and solves the problems that an existing MPN nano-drug delivery system is low in drug loading capacity, obvious in burst release, poor in stability, single in response and lack of targeting capacity. The system comprises a nanoparticle core formed by self-assembly of metal ions and polyphenol compounds, the surface of the nanoparticle core is coated with a biocompatible polymer shell, a hydrophobic drug is loaded inside the nanoparticle core, the particle size of the nanoparticle core is 50-300 nanometers, the nanoparticle core has pH responsiveness and a dynamic reversible coordination structure, and an organic solvent is not needed in the preparation process. The drug loading efficiency is remarkably improved, burst release is inhibited, the in-vivo stability is enhanced, tumor microenvironment responsive drug release is achieved, the circulation time is prolonged through the polymer shell, tumor accumulation is improved, and a safe and controllable delivery platform is provided for precise and efficient treatment.

The invention provides anisotropic thermoelectric hydrogel, which is characterized in that hydrogel is used as a matrix, and a thermoelectric material is dispersed and fixed in the hydrogel matrix; the hydrogel matrix is formed by biocompatible macromolecules through a directional freezing method or a mechanical stretching method, and has an anisotropic internal microstructure oriented in a single direction. Through a directional freezing or mechanical stretching process, a microstructure oriented in a single direction is constructed in the thermoelectric hydrogel, so that the hydrogel has anisotropy of shrinkage characteristics. The two preparation methods disclosed by the invention are both based on physical crosslinking and orientation technologies, complex chemical modification or expensive equipment is not needed, and effective design of the shrinkage anisotropy of the material is realized by controlling freezing conditions (such as liquid level height and cooling direction) or stretching parameters (such as stretching ratio and cycle index); and mutual conversion between heat energy and electric energy can be realized through a thermoelectric material in the hydrogel network.

The invention provides powder with reversible photochromic performance as well as a preparation method and application thereof, and the powder with reversible photochromic performance is a photochromic microcapsule and consists of a core material and a wall material, the core material accounts for 30%-50% of the total weight of the microcapsule, and the wall material accounts for 50%-70% of the total weight of the microcapsule; the core material is an indoline spiroheterocyclic compound, and the wall material is a biocompatible polymer. The core material is an indoline spiroheterocyclic compound, and the wall material is a biocompatible polymer; the powder is prepared by taking indoline spiropyran as a photochromic core material through a microcapsule coating process, has reversible response characteristics of developing under ultraviolet irradiation and decolorizing under strong light irradiation, and can be compounded with a tattooing pigment matrix to obtain a tattooing product with active developing and decolorizing regulation and control functions. The problem that the photochromic tattoo pigment is irreversible in color change is solved, and meanwhile the photochromic tattoo pigment has good stability and biocompatibility.

The invention provides responsive release polypeptide hydrogel. The hydrogel comprises a gel product of a raw material composition containing the following raw material components: (A) a biocompatible polymer containing at least two sulfydryl groups; (B) a matrix metalloproteinase substrate polypeptide; (C) a compound containing a phenolic hydroxyl group structure; (D) a cross-linking agent; and (E) water; the sequence of the matrix metalloproteinase substrate polypeptide is at least one of the following sequences (b1) to (b2): (b1) Cys-Pro-Leu-Gly-Val-Arg-Gly-Arg-Gly-Asp-Ser, (b2) Cys-Pro-Leu-Gly-Val-Arg-Gly-Asp-Ser, (b3) Cys-Pro-Leu-Gly-Val-Arg-Gly (b2), Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-C-ys, and (b3), Dnp-Pro-Leu-Gly- The responsive release polypeptide hydrogel can release polypeptide in a cell microenvironment to promote tissue regeneration and repair, and can be used for preparing muscle-bone healing promoting materials and treating ligament injury diseases such as rotator cuff injury.

Provision of drug-containing nanofibers. [Solution] A drug-containing nanofiber containing a biodegradable polymer or biocompatible polymer and a drug.

The present invention relates to a cosmetic composition for improving skin elasticity or reducing pore size, comprising an amphiphilic biocompatible polymer. The composition promotes collagen production, inhibits collagen degradation, and suppresses elastin degradation, and thus can be effectively used as a cosmetic composition for reducing the number of pores and decreasing pore areas.

In various embodiments tolerogenic nanoparticles are provided that induce immune tolerance to one or more desired antigen(s) and / or that reduce an immune response to those antigen(s). In certain embodiments the tolerogenic nanoparticle comprises a nanoparticle comprising a biocompatible polymer; an antigen disposed within or attached to said biocompatible polymer where said antigen comprises an antigen to which immune tolerance is to be induced by administration of said tolerogenic nanoparticle to a mammal; and a first targeting moiety that binds to a scavenger receptor in the liver, and / or a second targeting moiety that binds to a mannose receptor in the liver, and / or a third targeting moiety that binds to hepatocytes, wherein said first and / or second and / or third targeting moiety are attached to the surface of said nanoparticle.

The invention provides a medical beauty-grade sensitive skin repair dressing with a gamma-polyglutamic acid controlled release function, and belongs to the technical field of biomedical materials. The repair dressing is composed of controlled release microspheres dispersed in a matrix material, the controlled release microspheres take modified gamma-polyglutamic acid as an active core material and a biocompatible high polymer material as a wall material, and the matrix material comprises a medical grade gel matrix, a moisturizing component and an anti-inflammatory soothing component. The gamma-polyglutamic acid is subjected to acylation or graft modification to improve the stability and biocompatibility of the gamma-polyglutamic acid, and 12-72h gradient release of the gamma-polyglutamic acid is realized by virtue of the controlled release microspheres prepared by virtue of an emulsification-crosslinking method or a solvent evaporation method; meanwhile, through the synergistic matching of the matrix components, the dressing is endowed with the moisturizing, anti-inflammatory and soothing effects. The dressing can effectively reduce wound inflammatory response after medical art, promote epidermal cell proliferation and improve the water content and barrier function of a sensitive skin cuticle, and is suitable for scenes of wound repair after medical art, sensitive skin barrier reconstruction and the like.

A fracture plating system may be configured to stabilize a fracture of a bone. The bone may include an interior surface facing toward an interior body cavity of the patient, and an exterior surface facing away from the interior body cavity. The fracture plating system may include a plate formed of a biocompatible polymer and configured to span the fracture. The plate may include an exterior plate surface configured to abut the interior surface, an interior plate surface opposite the exterior plate surface, and a slot passing between the exterior plate surface and the interior plate surface. The fracture plating system may further include a tether configured to apply a force to the plate to draw the exterior plate surface against the interior surface of the bone, and a bracing member securable to the plate to restrict flexure of the plate parallel to a width of the slot.

The present disclosure provides microneedles and microneedle patches for transdermal drug delivery and methods of making and using the same. The microneedles are comprised of a solid composite material comprising a polymerized / cured biocompatible polymer matrix, drug particles, and a surfactant, wherein drug particles and surfactant are dispersed throughout the polymer matrix forming an interconnected drug network extending to surfaces of the microneedle.

A nanodiamond-reinforced nanofiber scaffold system for skin regeneration, consisting of a multilayered, electrospun nanofiber matrix formed from one or more biocompatible polymers selected from polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), chitosan, gelatin or collagen, wherein nanodiamonds are present in an amount of 0.1 to 5 wt.-% are incorporated and surface-functionalized with oxygen, hydroxyl, or carboxyl groups to ensure homogeneous dispersion within the polymer matrix, the scaffold being characterized by a controlled fiber diameter in the range of 100 to 800 nm, an interconnected porosity between 60 and 90%, a tensile strength of 2 to 10 MPa, a degradation time of 2 to 8 weeks, and the ability to improve cell adhesion, proliferation, and migration of fibroblasts and keratinocytes, while simultaneously exhibiting antioxidant activity, reduced formation of reactive oxygen species, and the optional incorporation of bioactive agents selected from growth factors, antioxidants, or antimicrobial compounds to accelerate wound healing and skin tissue regeneration.

The invention discloses an internal jugular vein semi-permanent catheter with a self-adaptive epidermal growth factor release mechanism, and belongs to the technical field of medical instruments. The catheter comprises a catheter body and a multifunctional medicine release covering film arranged at the telecentric end in a covering mode, the covering film is made of biocompatible polymers, epidermal growth factors (EGF) and antibacterial agents are loaded on the covering film in a gradient mode, and a micro sensor is arranged in the covering film. The sensor is linked with an intelligent feedback system, the drug release rate can be dynamically adjusted according to local physiological conditions, and meanwhile wireless data transmission and remote monitoring are supported. The defects of an existing semi-permanent catheter in the aspects of infection prevention, healing promotion and dynamic adjustment are overcome, targeted drug release, continuous antibiosis, self-adaptive feedback and remote management are achieved, and the long-term implantation requirement is met.

The invention belongs to the technical field of medicines, and particularly relates to a cariprazine sustained-release microsphere preparation and a preparation method thereof. The preparation comprises an active component cariprazine base or a pharmaceutically acceptable salt thereof, a biocompatible polymer carrier material and an antioxidant. The obtained sustained-release microsphere preparation has the excellent characteristics of round shape, uniform and controllable particle size, high stability, low organic solvent residual quantity, high drug loading capacity and the like; and the sustained and slow release can be realized as long as 3 months in vivo, so that the requirement of long-term treatment is effectively met. In addition, the preparation method provided by the invention is simple in process and easy to operate, and has a good industrial large-scale production prospect.

The invention relates to a suture thread material comprising at least one polymer and at least one eutectic mixture. The polymer can be a biocompatible polymer such as polycaprolactone or PLGA. The eutectic mixture comprises triclosan. Other eutectic mixtures can be used in suture thread materials to reduce SSis and / or to decrease pain and / or to increase lubricity of sutures. The invention also provides a method for the production of sutures with drug loadings, the method comprising the use of therapeutic deep eutectic solvent (THEDES) technology to significantly increase drug content in suture matrices.

The present application provides a biocompatible polymer material having cancer cell adhesion. The present application is a cancer cell adhesion composition comprising a biocompatible copolymer containing at least one repeating unit (A) represented by the following formula (1) and at least one repeating unit (B) represented by the following formula (2). In formula (1), R 1 represents a methyl group or an ethyl group. In formula (2), R 2 represents an aliphatic hydrocarbon group.

The application discloses a polymer microneedle patch co-loaded with self-antigen peptides and immunomodulators and a preparation method thereof, and studies the ability of the polymer microneedle patch to reverse immune dysfunction of rheumatoid arthritis (RA). The preparation method is as follows: a biocompatible polymer matrix material and a self-antigen are dissolved in pure water, and then an immunomodulator is added to obtain a suspension by stirring. The suspension is added to a mold to form needle tips, a backing layer solution is poured after drying, and finally the microneedle patch is demolded. Animal experiments show that the microneedle has sufficient mechanical strength to deliver drugs transdermally, effectively induces tolerogenic dendritic cells at the drug delivery site, further activates the differentiation of regulatory T cells (Treg), significantly up-regulates anti-inflammatory cytokines, down-regulates pro-inflammatory cells, antibodies and cytokines, effectively restores the immune balance of rheumatoid arthritis, and finally almost completely eliminates the symptoms and inflammatory infiltrates of rheumatoid arthritis. The microneedle preparation method is simple and rapid, and has a good clinical transformation prospect.

The present invention relates to a composition comprising a biocompatible polymer having tropoelastin cross-linking activity, and a method for producing same, and more specifically, to: a composition having the effects of providing improved elasticity and volume, reducing foreign body sensation, and having improved stability; and a method for producing same.

The present disclosure relates to the delivery of multiple copies of a payload molecule such as an active agent or a chelating agent capable of capturing an active agent, using as a carrier for their delivery a biocompatible copolymer comprising side chain-linked amino acids functionalized at their alpha-amino group by a reactive azide moiety by means of which the payload molecules are coupled to the copolymer. The copolymer is typically further functionalized to contain a single copy of a cell type- or tissue type-specific targeting moiety.

The present disclosure relates to a bio-implantable microfiber graft and a method of manufacturing the same. A method of manufacturing a bio-implantable microfiber graft according to an exemplary embodiment of the present disclosure includes: manufacturing a porous nanofiber membrane based on a biocompatible polymer; and manufacturing one-dimensional porous microfibers by forming the porous nanofiber membrane in a twisted structure.

A method for preparing drug sustained-release microspheres using small-particle-size drug active ingredient particles, and prepared microspheres. The formulation enables the drug to be released in a sustained manner for one to two months, and the preparation process of the formulation is relatively simple, such that the formulation is relatively easy and feasible for industrial production, offering better universality. The formulation is a sustained-release microsphere injection, and the prepared microspheres exhibit a narrow particle size distribution, high encapsulation efficiency, and low burst release. According to the preparation method, by means of controlling the particle size of the drug active ingredient, and adjusting the ratio of the drug active ingredient to a biocompatible polymer material in an oil phase, the ratio of the mass of an organic solvent to the volume of an external aqueous phase, and the amount of a surfactant, the formulation can be matched with the properties of the drug active ingredient to achieve the effect of sustained release.

The present application relates to fibers having a diameter of 1 nm to 10,000 nm, of one or more biocompatible polymers, wherein the polymers have a backbone which includes a positively charged component from a zwitterionic moiety. Additionally, this application discloses an implantable therapeutic delivery system and its method of formation, comprising a housing defining a chamber, wherein said housing is porous and formed from the fibers. Inside of the housing includes a preparation of cells which release a therapeutic agent from the chamber. The implantable therapeutic delivery system can be used in the treatment of diabetes.

Disclosed herein are example implantable piezoelectric ultrasound stimulator devices and related systems, structures, and methods. An implantable piezoelectric ultrasound stimulator device may comprise a piezoelectric film, a cavity, and electrodes that cause the piezoelectric film to generate ultrasound waves. The piezoelectric film, cavity, and electrodes may be encapsulated in a biocompatible polymer. Implantation of such a device in the brain and generation of ultrasound waves may stimulate neurons in the brain. Also disclosed herein are example structures for such a device. Further disclosed herein are example methods of making example implantable piezoelectric ultrasound stimulator devices disclosed herein. Still further disclosed herein are example systems for operating example implantable piezoelectric ultrasound stimulator devices disclosed herein.

A system comprises one or more sensor devices for subcutaneous electroencephalography where each sensor device includes a flexible biocompatible polymer sensor strip adapted to be inserted into a cranial subdermal space and including a plurality of electrodes. The strip includes a microchip responsive to each of the electrodes and comprising a multi-channel integrated circuit system-on-chip with a wireless transceiver, a low-noise neural amplifier, a unique network address, and RF energy harvesting microcircuits. In one embodiment, the sensor strip is no more than about 1 mm wide, at least about 5 cm long, and no more than about 300 μm thick. An external transceiver is disposed on the exterior of the subject's skin near one or more sensor devices in secure wireless communication with the respective wireless transceivers comprised in the sensor devices microchips. The system is configured to communicate using a network communication protocol, such as time division multiple access or code division multiple access.

Provided is a hemostatic dressing. The hemostatic dressing includes: a porous matrix layer including a biocompatible polymer; a hemostatic layer loaded on the porous matrix layer and including a polymer in which polyhydric phenol-containing moieties are introduced; and a binding layer interposed between the porous matrix layer and the hemostatic layer to prevent the porous matrix layer from being separated from the hemostatic layer.

Disclosed herein is a versatile injectable nano-bioactive scaffold designed to achieve both immediate soft tissue volumization and long-term tissue regeneration. By utilizing biocompatible polymers such as hyaluronic acid, chitosan, and alginate, along with self-assembling peptides and nano-structured carriers including mesoporous silica nanoparticles and liposomes, the system facilitates controlled release of essential growth factors. This innovative approach delivers sustained bioactivity, significantly reducing the need for repeated injections and minimizing inflammatory complications. The system promises superior clinical outcomes, advancing the field of tissue engineering and regenerative medicine by providing an effective and lasting solution for tissue repair and regeneration.

The application relates to the field of medical devices, and discloses a CGM working electrode and a preparation method thereof. The working electrode comprises a flexible base layer, a metal conductive layer, a catalytic reaction layer, a surface modification layer, a biological enzyme sensing layer and a hydrophilic-hydrophobic semi-permeable membrane layer which are sequentially stacked; the surface modification layer forms a three-dimensional network structure on the surface of the catalytic reaction layer through silanization treatment, and is used for enhancing biological enzyme fixation; the semi-permeable membrane layer is composed of a biocompatible polymer, and is used for selectively controlling the permeation of glucose molecules. The technical scheme of the application not only improves the biocompatibility and measurement accuracy of the electrode, but also prolongs the service life of the electrode through special structural design, and the preparation process is simple, the cost is controllable, and the application is suitable for industrialization and popularization.

The invention discloses a pH response microcapsule dental floss and a preparation and use method thereof, and belongs to the technical field of oral care. The dental floss comprises a matrix and a color developing coating, the coating contains pH response microcapsules, the average particle size is 5-20 microns, the single-layer wall thickness is 0.5-2.0 microns, and the ratio of the wall thickness to the particle size is 0.03-0.3; the core material is a pH color-changing dye conforming to the GB / T 16886.10 standard, develops color in a plaque acid environment with the pH being less than or equal to 5.5, and automatically fades color in a neutral environment with the pH being greater than or equal to 6.8; and the wall material is a biocompatible polymer. The microcapsule is stable in saliva, is only broken and released under the friction shearing force of the dental floss, realizes the specific color development of the plaque, and disappears and is not stained after being washed with clear water. The preparation method comprises the following steps: preparing microcapsules by a complex coacervation method, preparing a coating solution, dipping and coating, and drying and sub-packaging. The dental floss is stable in storage and controllable in use, has cleaning, bacterial plaque visual detection and antibacterial functions, and remarkably improves user compliance.