238 results about "Biocompatible polymers" patented technology

A three-dimensional scaffold for use in engineered tissue includes a repeated 3D geometry; and at least one of a hydrogel, a biocompatible polymer, and a bioprintable polymer. The repeated 3D geometry may include an open geometry including a plurality of interconnected nodes configured to be seeded with living cells. The scaffold may be formed via bioprinting. The three-dimensional scaffold may also be used for (1) 3D tissue modelling (for liver, kidney, gut, pancreas, heart, lung, spleen, etc.), (2) disease modeling of different tumor types such as breast, colorectal, lung, liver, brain, ovarian and others, (3) drug testing / therapeutic screening of small molecule drugs, peptides, proteins, antibodies, ADCs, gene therapies, RNA-based therapeutics, cell therapies, and tissue therapies, and (4) therapeutic / drug delivery (i.e., via delivery device that can be used to control drug release based on different patterns).

According to some embodiments, a patch for organ and / or tissue application is provided which comprises a biocompatible polymeric material having an auxetic architecture and further matching a stiffness ratio and / or Poisson's ratio of an organ or tissue to which the patch is applied. According to some further embodiments, biocompatible patches and methods of making the same are provided comprising providing a layer of hydrogel and forming an auxetic architecture by selectively crosslinking areas of the hydrogel via exposure to light, wherein the auxetic architecture is selected to match a stiffness ratio and Poisson's ratio of an organ to which the biocompatible patch is applied.

There is described an artificial intelligence wearable ECG skin patch (400) to detect sudden cardiac arrest. The wearable ECG monitoring patch (400) with AI based predictive analytics and remote based cardiac monitoring (615) system that can detect cardiac arrhythmias automatically in real-time and make a diagnosis with AI models trained with acquired data. The wearable skin has a biocompatible polymer patch (400) which captures the electrical signal through a flexible printed electronic technology based conducting ink and a substrate. The microcontroller controls (201), store and transmit the data packets. The IoT connected signal transmission is capable of recording and transferring the data packets through wireless communication. The AI engine is capable of analysing, evaluating, testing and providing the data packets of sudden cardiac arrest through a peak detector algorithm. The ECG skin patch (400) to detect and measure the sudden cardiac arrest with the R-R interval time series to obtain heart rate variability.

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

A construct includes a biocompatible polymer-based shape morphing hydrogel or cell condensate that is configured to undergo multiple, reversible, and / or controllable different shape transformations over time via either pre-programmed design or user-controlled environmental condition alterations, wherein the hydrogel is cytocompatible and, upon degradation, produces substantially non-toxic products.

A waste collection system for collecting waste from a body of a patient. The waste collection system includes: an endoluminal stoma channel having a resilient deformable inner ring, an outer ring, a flexible polymer sleeve made from a biocompatible polymer and interconnecting the inner ring and the outer ring; an inner colostomy bag which can be detachably attached to the outer ring to collect and contain the waste; and a cover which can engage the outer ring in a sealed engagement, and where a portion of the flexible polymer sleeve and the inner ring are configured for insertion into a stoma formed in the body of the patient.

The application discloses a soluble microneedle composition for transdermal delivery of polypeptides and application thereof. The soluble microneedle composition comprises a first composition and a second composition; wherein the first composition comprises the following components in mass percentage: 20-60% polypeptides, 0.5-20% capryol 98, 10-40% first biocompatible polymer material and 0.5-20% first surfactant; the second composition comprises the following components in mass percentage: 98-99.75% second biocompatible polymer material and 0.25-2% second surfactant. The microneedle composition is used in the microneedle, and the problems of low transdermal efficiency and poor stability of polypeptides are solved.

The invention belongs to the technical field of hydrogel preparation, and relates to a cartilage-imitating multifunctional drug release hydrogel material and a preparation method thereof. According to the invention, biocompatible high polymer materials such as polyvinyl alcohol, chitosan, grape seed protein, acyl chloride, sulphobetaine methacrylate and lecithin are used as raw materials, a cartilage structure is simulated to prepare the multilayer hydrogel, gelatin and plant polyphenol are mixed as an adhesive to improve the binding capacity with subosseous bones, and a drug is loaded to improve the biological activity. The preparation method of the hydrogel material comprises the five steps of preparation of high-strength anti-swelling precursor hydrogel, introduction of double bonds through surface modification, introduction of a poly SBMA molecular brush through interfacial polymerization, drug loading and preparation of an adhesion layer. The hydrogel has excellent anti-swelling ability, lubricating property, anti-pollution ability, free radical scavenging ability, self-adhesion characteristic, drug controlled release ability and biocompatibility, and has important significance for widening the application of the hydrogel in the field of artificial cartilage.

The invention relates to the technical field of biomedical material modification, in particular to a sulfhydrylation biocompatible polymer derivative, a preparation method thereof, extracellular matrix imitating injectable in-situ cross-linked hydrogel and application thereof. According to the invention, a pre-acylation strategy is firstly carried out on the biocompatible polymer containing both amino and carboxyl, so that a three-dimensional cross-linked byproduct formed by coupling of self amido bonds is avoided, meanwhile, the number of side chain carboxyl for sulfhydrylation modification is increased, and the accurate and adjustable pre-acylation rate can optimize the physical and chemical properties of the derivative; meanwhile, a disulfide bond is used as a protective precursor, active sulfydryl is introduced through amido bond coupling, self-oxidation of the active sulfydryl in the reaction process is avoided, sulfydryl activity is guaranteed, hydrazine-containing reagents are avoided, safety is further improved, virus residues and immunological rejection risks are avoided, universality is high, and the application prospect is wide; and in combination with a high-concentration preparation method, the method has the advantage of large-scale production, and further widens the industrial application potential.

Provided is a dry eye therapeutic agent that can selectively inhibit IFN-y, have no risk of biological contamination, and can be stored at room temperature. Provided is a dry eye therapeutic agent, comprising as an active ingredient a DNA oligonucleotide having a nucleotide sequence set forth in any of SEQ ID NO:1 to 3 and selectively binding to IFN-y. A base, X, in the sequence of the DNA oligonucleotide having the nucleotide sequence set forth in SEQ ID NO: 3 is an artificially produced base, and the artificially produced base may be chemically modified with a low-molecular-weight compound, a medium-molecular-weight compound, a large-molecular-weight compound, a biopolymer, or a biocompatible polymer.

The invention relates to the technical field of biological medicine nano-drug delivery, in particular to a nano-drug delivery system based on a metal polyphenol network, and solves the problems that an existing MPN nano-drug delivery system is low in drug loading capacity, obvious in burst release, poor in stability, single in response and lack of targeting capacity. The system comprises a nanoparticle core formed by self-assembly of metal ions and polyphenol compounds, the surface of the nanoparticle core is coated with a biocompatible polymer shell, a hydrophobic drug is loaded inside the nanoparticle core, the particle size of the nanoparticle core is 50-300 nanometers, the nanoparticle core has pH responsiveness and a dynamic reversible coordination structure, and an organic solvent is not needed in the preparation process. The drug loading efficiency is remarkably improved, burst release is inhibited, the in-vivo stability is enhanced, tumor microenvironment responsive drug release is achieved, the circulation time is prolonged through the polymer shell, tumor accumulation is improved, and a safe and controllable delivery platform is provided for precise and efficient treatment.

Provided is a Hunner-type interstitial cystitis therapeutic agent that can selectively inhibit IFN-γ without risk of biological contamination and can be stored at room temperature. Provided is a Hunner-type interstitial cystitis therapeutic agent or a reagent for test and research, comprising as an active ingredient a DNA oligonucleotide having a nucleotide sequence set forth in any of SEQ ID NO:1 to 3 and selectively binding to IFN-γ. A base, X, in the sequence of the DNA oligonucleotide having the nucleotide sequence set forth in SEQ ID NO: 3 is an artificially produced base, and the artificially produced base may be chemically modified with a low-molecular-weight compound, a medium-molecular-weight compound, a high-molecular-weight compound, a biopolymer, or a biocompatible polymer.

Microparticulate compositions and methods for delivery and pulsatile release of one or more sting agonists and / or receptors have been developed. The compositions include polymeric microdevices formed from biodegradable and biocompatible polymers or co-polymers thereof including a shell and compartment(s) or discrete regions in the compartment(s) formed by an additive process such as micromolding, three dimensional printing and lithography. The compositions include microdevices that release individual doses of incorporated STING agonist and / or receptors at defined times, for example, in pulses up to several months after administration with essentially no leakage between releases.

A composition includes a drying method-applied fibrous acellular dermal matrix. Such a composition includes 48 to 95.5% by weight of a fibrous acellular dermal matrix; and 0.5 to 52% by weight of water. The composition has no biocompatible polymer added thereto. A method for preparing the composition includes steps of: (a) pulverizing an acellular dermal matrix to prepare a fibrous acellular dermal matrix; (b) adding water to the fibrous acellular dermal matrix to rehydrate it; and (c) heat-drying the rehydrated fibrous acellular dermal matrix.

The invention provides anisotropic thermoelectric hydrogel, which is characterized in that hydrogel is used as a matrix, and a thermoelectric material is dispersed and fixed in the hydrogel matrix; the hydrogel matrix is formed by biocompatible macromolecules through a directional freezing method or a mechanical stretching method, and has an anisotropic internal microstructure oriented in a single direction. Through a directional freezing or mechanical stretching process, a microstructure oriented in a single direction is constructed in the thermoelectric hydrogel, so that the hydrogel has anisotropy of shrinkage characteristics. The two preparation methods disclosed by the invention are both based on physical crosslinking and orientation technologies, complex chemical modification or expensive equipment is not needed, and effective design of the shrinkage anisotropy of the material is realized by controlling freezing conditions (such as liquid level height and cooling direction) or stretching parameters (such as stretching ratio and cycle index); and mutual conversion between heat energy and electric energy can be realized through a thermoelectric material in the hydrogel network.

The present invention relates to a scaffold for cartilage regeneration and a construction method therefor and, more specifically, to a scaffold for cartilage regeneration and a construction method therefor, wherein the scaffold is constructed by a scaffold construction device including a predetermined mold and structure, whereby the scaffold, even if produced in a large area, allows for excellent uniformity in the thickness of a biocompatible polymer sheet and in the pattern formed on the sheet, thus exhibiting excellent cartilage regeneration effects and adhesion to the affected area.

The present invention relates to a composition comprising a fibrotic acellular dermal matrix, which does not apply a biocompatible polymer, thereby having improved physical properties and tensile strength, and which is easier to use than in the prior art, and a method for preparing the same.

The invention provides powder with reversible photochromic performance as well as a preparation method and application thereof, and the powder with reversible photochromic performance is a photochromic microcapsule and consists of a core material and a wall material, the core material accounts for 30%-50% of the total weight of the microcapsule, and the wall material accounts for 50%-70% of the total weight of the microcapsule; the core material is an indoline spiroheterocyclic compound, and the wall material is a biocompatible polymer. The core material is an indoline spiroheterocyclic compound, and the wall material is a biocompatible polymer; the powder is prepared by taking indoline spiropyran as a photochromic core material through a microcapsule coating process, has reversible response characteristics of developing under ultraviolet irradiation and decolorizing under strong light irradiation, and can be compounded with a tattooing pigment matrix to obtain a tattooing product with active developing and decolorizing regulation and control functions. The problem that the photochromic tattoo pigment is irreversible in color change is solved, and meanwhile the photochromic tattoo pigment has good stability and biocompatibility.

The invention provides responsive release polypeptide hydrogel. The hydrogel comprises a gel product of a raw material composition containing the following raw material components: (A) a biocompatible polymer containing at least two sulfydryl groups; (B) a matrix metalloproteinase substrate polypeptide; (C) a compound containing a phenolic hydroxyl group structure; (D) a cross-linking agent; and (E) water; the sequence of the matrix metalloproteinase substrate polypeptide is at least one of the following sequences (b1) to (b2): (b1) Cys-Pro-Leu-Gly-Val-Arg-Gly-Arg-Gly-Asp-Ser, (b2) Cys-Pro-Leu-Gly-Val-Arg-Gly-Asp-Ser, (b3) Cys-Pro-Leu-Gly-Val-Arg-Gly (b2), Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-C-ys, and (b3), Dnp-Pro-Leu-Gly- The responsive release polypeptide hydrogel can release polypeptide in a cell microenvironment to promote tissue regeneration and repair, and can be used for preparing muscle-bone healing promoting materials and treating ligament injury diseases such as rotator cuff injury.

Provision of drug-containing nanofibers. [Solution] A drug-containing nanofiber containing a biodegradable polymer or biocompatible polymer and a drug.

The present invention relates to a cosmetic composition for improving skin elasticity or reducing pore size, comprising an amphiphilic biocompatible polymer. The composition promotes collagen production, inhibits collagen degradation, and suppresses elastin degradation, and thus can be effectively used as a cosmetic composition for reducing the number of pores and decreasing pore areas.

To allow superior control of electrodeposition on indented portions of an electrodeposition target.SOLUTION: A method of making a valve structure includes a step of rotating a mandrel and an electrodeposition target attached to the mandrel about a rotational axis of the mandrel. The target includes an exterior surface having at least one conductive surface portion and at least one non-conductive surface portion. The method also includes a step of electrodepositing a polymer matrix of a biodegradable, biocompatible polymer composition onto the at least one conductive surface portion and the at least one non-conductive surface portion of the exterior surface of the rotating electrodeposition target to form the valve structure.SELECTED DRAWING: Figure 1A

In various embodiments tolerogenic nanoparticles are provided that induce immune tolerance to one or more desired antigen(s) and / or that reduce an immune response to those antigen(s). In certain embodiments the tolerogenic nanoparticle comprises a nanoparticle comprising a biocompatible polymer; an antigen disposed within or attached to said biocompatible polymer where said antigen comprises an antigen to which immune tolerance is to be induced by administration of said tolerogenic nanoparticle to a mammal; and a first targeting moiety that binds to a scavenger receptor in the liver, and / or a second targeting moiety that binds to a mannose receptor in the liver, and / or a third targeting moiety that binds to hepatocytes, wherein said first and / or second and / or third targeting moiety are attached to the surface of said nanoparticle.

The invention provides a medical beauty-grade sensitive skin repair dressing with a gamma-polyglutamic acid controlled release function, and belongs to the technical field of biomedical materials. The repair dressing is composed of controlled release microspheres dispersed in a matrix material, the controlled release microspheres take modified gamma-polyglutamic acid as an active core material and a biocompatible high polymer material as a wall material, and the matrix material comprises a medical grade gel matrix, a moisturizing component and an anti-inflammatory soothing component. The gamma-polyglutamic acid is subjected to acylation or graft modification to improve the stability and biocompatibility of the gamma-polyglutamic acid, and 12-72h gradient release of the gamma-polyglutamic acid is realized by virtue of the controlled release microspheres prepared by virtue of an emulsification-crosslinking method or a solvent evaporation method; meanwhile, through the synergistic matching of the matrix components, the dressing is endowed with the moisturizing, anti-inflammatory and soothing effects. The dressing can effectively reduce wound inflammatory response after medical art, promote epidermal cell proliferation and improve the water content and barrier function of a sensitive skin cuticle, and is suitable for scenes of wound repair after medical art, sensitive skin barrier reconstruction and the like.

The invention discloses a hollow-core anti-resonance optical fiber design method and system for a femtosecond laser stone crusher, and relates to the technical field of medical laser instruments. The method comprises the steps that an anti-resonance transmission unit is constructed, the anti-resonance transmission unit is composed of an air core and anti-resonance quartz cladding tubes periodically arranged on the periphery, the cladding tubes form an anti-resonance transmission band gap with a specific wavelength through precisely designed wall thickness and spacing, and the air core serves as a main transmission channel; a water-cooling temperature control unit is integrated, the water-cooling temperature control unit comprises a spiral or snakelike micro-channel structure integrated in an outer cladding of the anti-resonance transmission unit, the outer cladding is made of a biocompatible high polymer material, a micro-channel and an optical fiber are axially arranged at a preset angle, and a forced convection heat dissipation path is formed by injecting a cooling medium. By optimizing the anti-resonance transmission unit and the water-cooling temperature control unit, stable laser transmission, efficient thermal management and reliability under long-time high-power laser operation are realized.

A fracture plating system may be configured to stabilize a fracture of a bone. The bone may include an interior surface facing toward an interior body cavity of the patient, and an exterior surface facing away from the interior body cavity. The fracture plating system may include a plate formed of a biocompatible polymer and configured to span the fracture. The plate may include an exterior plate surface configured to abut the interior surface, an interior plate surface opposite the exterior plate surface, and a slot passing between the exterior plate surface and the interior plate surface. The fracture plating system may further include a tether configured to apply a force to the plate to draw the exterior plate surface against the interior surface of the bone, and a bracing member securable to the plate to restrict flexure of the plate parallel to a width of the slot.

The present disclosure provides microneedles and microneedle patches for transdermal drug delivery and methods of making and using the same. The microneedles are comprised of a solid composite material comprising a polymerized / cured biocompatible polymer matrix, drug particles, and a surfactant, wherein drug particles and surfactant are dispersed throughout the polymer matrix forming an interconnected drug network extending to surfaces of the microneedle.

A nanodiamond-reinforced nanofiber scaffold system for skin regeneration, consisting of a multilayered, electrospun nanofiber matrix formed from one or more biocompatible polymers selected from polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), chitosan, gelatin or collagen, wherein nanodiamonds are present in an amount of 0.1 to 5 wt.-% are incorporated and surface-functionalized with oxygen, hydroxyl, or carboxyl groups to ensure homogeneous dispersion within the polymer matrix, the scaffold being characterized by a controlled fiber diameter in the range of 100 to 800 nm, an interconnected porosity between 60 and 90%, a tensile strength of 2 to 10 MPa, a degradation time of 2 to 8 weeks, and the ability to improve cell adhesion, proliferation, and migration of fibroblasts and keratinocytes, while simultaneously exhibiting antioxidant activity, reduced formation of reactive oxygen species, and the optional incorporation of bioactive agents selected from growth factors, antioxidants, or antimicrobial compounds to accelerate wound healing and skin tissue regeneration.

The invention discloses an internal jugular vein semi-permanent catheter with a self-adaptive epidermal growth factor release mechanism, and belongs to the technical field of medical instruments. The catheter comprises a catheter body and a multifunctional medicine release covering film arranged at the telecentric end in a covering mode, the covering film is made of biocompatible polymers, epidermal growth factors (EGF) and antibacterial agents are loaded on the covering film in a gradient mode, and a micro sensor is arranged in the covering film. The sensor is linked with an intelligent feedback system, the drug release rate can be dynamically adjusted according to local physiological conditions, and meanwhile wireless data transmission and remote monitoring are supported. The defects of an existing semi-permanent catheter in the aspects of infection prevention, healing promotion and dynamic adjustment are overcome, targeted drug release, continuous antibiosis, self-adaptive feedback and remote management are achieved, and the long-term implantation requirement is met.

The invention belongs to the technical field of medicines, and particularly relates to a cariprazine sustained-release microsphere preparation and a preparation method thereof. The preparation comprises an active component cariprazine base or a pharmaceutically acceptable salt thereof, a biocompatible polymer carrier material and an antioxidant. The obtained sustained-release microsphere preparation has the excellent characteristics of round shape, uniform and controllable particle size, high stability, low organic solvent residual quantity, high drug loading capacity and the like; and the sustained and slow release can be realized as long as 3 months in vivo, so that the requirement of long-term treatment is effectively met. In addition, the preparation method provided by the invention is simple in process and easy to operate, and has a good industrial large-scale production prospect.