54 results about "Phosphoryl choline" patented technology

A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such as an angioplasty balloon comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

An artificial joint member made of a polymeric material including a portion made of a polymeric substance has a sliding surface composed of a polymer having phosphoryl choline groups. With such an arrangement, the artificial joint member is provided with a sliding part capable of keeping a satisfactory lubricating state for a long time.

A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments which may be the same or different,wherein said one or more pendant group segments are the same or different and are selected from:(i) siloxane segments;(ii) segments containing phosphoryl choline or a derivative or analogue thereof;(iii) segments containing a di- or trifluoromethyl group;(iv) heparin-like segments containing a group of formula (XII)D-N═N—Ar—SO3−  (XII)wherein D is an aliphatic or aromatic group and Ar—SO3− comprises one or more linked aryl and / or heteroaryl groups, at least one of the aryl and / or heteroaryl groups having an SO3− substituent; and(v) segments containing a group of formula (I)[P]n′-[Lys]n-Lys-[Spacer]-Lys-[Al]x  (I)wherein:[Al] is an inert amino acid;x is 0, 1, 2 or 3;[Spacer] is a fatty acid, amino acid, peptide or PEG;[P]n′-[Lys]n is a dendritic structure formed from n lysine groups and terminating in n′ groups P;n is an integer of from 1 to 15;n′ is zero or an integer of up to 16; andeach P is the same or different and is an amino acid or a peptide having up to 25 amino acids,and wherein at least a part of each of said pendant group segment(s) is on a side chain of the copolymer.The copolymer is useful in the production of implantable devices such as vascular grafts.

A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

The present invention relates to implantable medical devices coated with phosphoryl choline acrylate polymer topcoat layer and their use in the treatment of vascular diseases.

The invention discloses a low-temperature plasma induced membrane-type artificial lung graft modification method. The modification method includes the following steps that poly 4-methyl-1-amylene membrane materials for a membrane-type artificial lung are placed into a cavity of a plasma processing instrument, working gas is any one or two of pure ammonia gas, pure oxygen, pure argon and pure carbon dioxide, the pressure of the working gas is kept to be 20 Pa, the materials are processed for 1-5 min at the discharge power of 30-300 W, the gas flow is 30 ml / min-120 ml / min, phosphoryl choline compound steam is led into the cavity to induce vapor phase grafting, the steam pressure is stabilized to be 20 Pa, and the materials are processed for 1-5 min at the discharge power of 30-300 W. According to the method, the artificial lung membrane materials are modified through the low-temperature plasma technology, the process is simple, consumed time is short, the efficiency is high, the energy consumption is low, the biocompatibility of a poly 4-methyl-1-amylene (PMP) membrane is obviously improved, and the transmission performance of O2 and CO2 is slightly reduced compared with that before modification, however, the method still has wide medical application prospects.

A method for manufacturing a hydrophilic silicone macromer is provided. A hydrosilylation between a Si—H bond of a polysiloxane and a C═C bond of a hydrophilic monomer is performed by using a rhodium-containing catalyst to form the polysiloxane having a hydrophilic side chain having an amide group or a phosphoryl choline group. After performing an end-capping reaction, the hydrophilic silicone macromer is formed.