14 results about "Phosphoryl choline" patented technology

The invention relates to the technical field of biology, in particular to a nicotinamide microcapsule and a preparation method and application thereof. The preparation method of the nicotinamide microcapsule comprises the following steps: mixing gelatin and water, and heating to obtain a gelatin solution; sequentially dissolving L-alpha-choline alfoscerate, sodium alginate, isomaltooligosacharide, nicotinamide and vitamin C in the gelatin solution under the condition of constant temperature of 38-45 DEG C to obtain a mixed solution; and adjusting the pH value of the mixed solution, and continuously stirring to obtain the nicotinamide microcapsule. The nicotinamide microcapsule is good in embedding effect, high in embedding rate and good in nicotinamide embedding capacity, the absorption efficiency of the nicotinamide can be effectively improved, and the nicotinamide can be converted into more NAD < + >, so that more ATP is generated, and the bioavailability of the nicotinamide is improved.

The present invention provides a contact lens monomer composition using a small molecular weight organosilicon compound, a polymer of the composition, and a contact lens using the polymer, which can produce a contact lens having excellent oxygen permeability, mechanical strength, transparency, durability, and wearing sensation. Specifically, a composition containing (A) a methacrylate monomer containing a phosphoryl choline group, (B) an itaconic acid diester monomer containing a siloxane group, (C) a specific hydrophilic monomer, (D) a (meth)acrylate containing a siloxane group, and (E) a specific crosslinking agent in specific proportions, a polymer thereof, and a contact lens using the polymer.

The application belongs to the field of oral composition and food application, and provides a composition containing choline alfoscerate and application thereof. The composition takes L-alpha-choline alfoscerate as a liquid phase component, takes a complex core formed by pyrroloquinoline quinone disodium salt and cyclodextrin as a core, forms a multi-layer core-shell particle through core particle construction and layer-by-layer assembly of gelatin and sodium alginate, and is cooperatively configured with a dual-phase or dual-cavity storage mode. Therefore, the storage stability of the active ingredient, the integrity of the particle structure and the active release performance when used are considered, the adverse effects of environmental exposure are reduced, and the use convenience is improved. The composition can solve the problem that the memory-improving function and storage stability are difficult to be considered, and the particle structure integrity and the active release performance are restricted by each other, and is suitable for memory-improving food development and application.

The present application relates to the medical immunological in-vitro diagnosis field, provide a kind of for AD marker detection composite immunopotentiator, including 2-methyl acryloyloxy ethyl phosphoryl choline copolymer, polyethylene glycol 20000, polyvinylpyrrolidone-10 and membrane lysing agent.The present application also provides the application of the above-mentioned composite immunopotentiator in the preparation of the kit for detecting Alzheimer's disease biomarker.The present application has the advantages that: the composite immunopotentiator is added to the reagent R1 and reagent R2 of the existing AD marker detection kit, can accelerate the reaction, shorten the immune response time, improve the detection sensitivity and accuracy, and keep stable.

The invention belongs to the field of biological medicine, and provides a preparation method of L-alpha-choline alfoscerate, which comprises the steps of esterification reaction, neutralization reaction, spray drying, condensation reaction, filtration, concentration, crystallization, redissolution and decoloration, resin impurity removal, secondary filtration and concentration, secondary crystallization, drying and packaging according to a process route. The esterification reaction adopts polyphosphoric acid and choline chloride for esterification reaction, the neutralization reaction takes a reaction product after esterification reaction, pure water is added for dilution, and then alkali is added for neutralization; drying the neutralization solution in a spray drying tower to obtain an intermediate product; an intermediate product obtained through spray drying is put into a condensation kettle, ethyl alcohol is added, and R-3-chloro-1, 2-propylene glycol is dropwise added till L-alpha-choline alfoscerate, metal chloride salt and metal phosphate salt are generated. The method is reasonable in design, the process difficulty between esterification reaction and condensation reaction is reduced, the process period can be shortened, the consumption of R-3-chloro-1, 2-propylene glycol can be reduced, the product purity can be guaranteed, and the method is suitable for large-scale popularization.

This invention discloses a water-resistant plant protein adhesive, its preparation method, and its application. The raw materials for preparing the water-resistant plant protein adhesive include: oilseed cake, oilseed cake protein isolate, choline glyphosate, and a modifier; the raw materials for preparing the modifier include: urea and aminosulfonic acid compounds. This invention proposes a water-resistant plant protein adhesive that avoids the separation of oilseed cake while simultaneously improving the flame retardancy, antibacterial properties, and mechanical properties of engineered wood products.

The present invention relates to a synergistically effective fungicidal composition comprising, as component (A), a fungicidally active amount of choline phosphonate and, as component (B), at least one additional fungicide selected from the group comprising quinone fungicides, succinate dehydrogenase inhibitors, benzamide fungicides, sulfur fungicides, carboxylic acid amide fungicides, demethylation inhibitor fungicides, phenylamide fungicides, copper fungicides, piperidinyl thiazol isoxazoline fungicides, and sugar alcohols, wherein the weight ratio of components (A) and (B) is in the range of 1:1000 to 1000:1. The invention further relates to a kit for using the fungicidal composition according to the invention in an amount effective for controlling one or more types of fungal infections by applying the fungicidal composition to the fungal infections.

The invention provides a composition for improving learning memory and / or cognitive function and application thereof. The composition provided by the invention comprises alpha-choline glycerophosphate and galactose, and the mass ratio of the alpha-choline glycerophosphate to the galactose is 1: (8-100). The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product helpful for improving learning memory and / or cognitive functions.

The invention belongs to the technical field of agricultural intelligent detection, and particularly relates to a tremella aurantialba bacterial contamination diagnosis method and system based on characteristic metabolite detection.The method comprises the steps that firstly, quantitative values of three characteristic metabolites including azelaic acid, choline glycerophosphate and L-arabitol are accurately obtained through optimized ternary solvent extraction and targeted mass spectrometry; and in combination with sample growth stage information, calculating a standardized diagnosis index relative to a stage health benchmark so as to eliminate growth difference interference. Secondly, performing two-stage intelligent analysis: performing abnormal preliminary screening based on a first-class support vector machine model, and generating first contamination assessment information containing a specific contamination type tendency through similarity matching between metabolic characteristics and a historical contamination clustering mode; meanwhile, by calculating the mahalanobis distance between the to-be-detected sample and the same batch of samples, second contamination evaluation information representing the metabolism consistency of the group is generated. And finally, fusing the two types of evaluation information, querying the multi-dimensional decision rule table, and outputting a hierarchical diagnosis result.

The application provides a composition for improving learning memory and / or cognitive function and application thereof. The composition of the application comprises alpha-glycerophosphocholine and galactose, wherein the mass ratio of the alpha-glycerophosphocholine to the galactose is 1:(8-100).

The invention provides modified milk powder capable of improving learning memory and / or cognitive functions as well as a preparation method and application of the modified milk powder. The total protein content of the modified milk powder is 16.5-30 g / 100 g, the fat content of the modified milk powder is 10-35 g / 100 g, the carbohydrate content of the modified milk powder is 35-70 g / 100 g, the modified milk powder comprises alpha-choline alfoscerate and galactose, and the mass ratio of the alpha-choline alfoscerate to the galactose is 1: (8-100). The modified milk powder disclosed by the invention is beneficial to improving learning memory and / or cognitive functions.

The invention discloses a bio-based flame-retardant antistatic thermoplastic elastomer and a preparation method thereof, and belongs to the technical field of thermoplastic elastomers, the bio-based flame-retardant antistatic thermoplastic elastomer is prepared by carrying out ring-opening reaction on epoxidized soybean oil by using phosphorylcholine to synthesize bio-based polyether polyol, taking the bio-based polyether polyol as a soft segment, and carrying out prepolymerization and chain extension reaction on the bio-based polyether polyol, bio-based diisocyanate and asymmetric diisocyanate to prepare the bio-based flame-retardant antistatic thermoplastic elastomer. The preparation method comprises the following steps: preparing bio-based thermoplastic polyurethane, performing in-situ construction of a tannic acid-zinc complex shell layer on the surface of ammonium polyphosphate through zinc ion coordination to obtain bio-based modified ammonium polyphosphate, and finally performing melt blending on the bio-based thermoplastic polyurethane, the bio-based modified ammonium polyphosphate, aluminum hydroxide, mixed conductive filler and other components to obtain the conductive coating. The bio-based flame-retardant antistatic thermoplastic elastomer is obtained; on the premise of environmental protection, high balance of flame retardance, antistatic property, mechanical strength and processability is realized.

To provide an antiadhesion gel-forming agent set excellent in spray deposition property and spray diffusibility.SOLUTION: The antiadhesion gel-forming agent set of the present invention is used to form an anti-adhesion gel by a two-component mixing spray application and includes a first agent and a second agent, each having a viscosity of 100.0 mPa s or less, which satisfy any of the following conditions (i) to (iii):(i) The first agent contains (X) and (Y), and the second agent contains (Y) but not (X).(ii) The first agent contains (X) and (Y), and the second agent contains (X) and (Y).(iii) The first agent contains (X) but not (Y), and the second agent contains (X) and (Y).(X): A compound having a weight-average molecular weight of 1,000 to 50,000 and two or more hydroxyl groups.(Y): A polymer having a weight-average molecular weight of 10,000 to 35,000 and containing phosphorylcholine groups and phenylboronic acid groups.SELECTED DRAWING: None

The invention provides a composition for improving memory as well as a preparation method and application thereof, and belongs to the technical field of biology. The invention provides a composition with effects of assisting in improving memory and relieving visual fatigue. The composition is prepared from the following raw materials in parts by weight: 300 to 330 parts of DHA algal oil, 35 to 50 parts of arachidonic acid grease, 4 to 10 parts of phosphatidylserine and 4 to 9 parts of L-alpha-choline alfoscerate. According to the composition disclosed by the invention, functional grease (DHA algal oil and arachidonic acid grease), phospholipid substances (phosphatidylserine and L-alpha-choline alfoscerate) and medicinal and edible raw materials (gastrodia elata, American ginseng and ginseng) are scientifically matched, and all the components have a synergistic effect and complementary advantages, so that the dual effects of assisting in improving memory and relieving visual fatigue are realized; the safety is high, the bioavailability is good, the multi-target synergistic interaction is realized, and the memory improvement effect is obvious.