12 results about "Analgesic agents" patented technology

Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting5 with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, 5 an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 20 24 28 71 87 23 D ec 2 02 4 2 0 2 4 2 8 7 1 8 7 2 3 D e c 2 0 2 4 A b s t r a c t 5 1 0

The present invention provides a composition comprising 5-aminolevulinic acid or a salt or ester thereof, comprising: (a) an active ingredient selected from 5-aminolevulinic acid or a salt or ester thereof; and (b) an aqueous carrier comprising an analgesic. The 5-aminolevulinic acid or the salt or ester thereof can be used for photodynamic therapy analgesia for more than 20 minutes, so that the clinical treatment cycle can be covered, the pain feeling after photodynamic therapy can be obviously relieved, the photodynamic therapy receiving time of a patient is prolonged, and the medication compliance of the patient is improved. Moreover, the composition provided by the invention can also improve the condition of tissue edema after photodynamic therapy, improve the skin smoothness after photodynamic therapy and shorten the pigmentation time, and meanwhile, compared with a marketed preparation, the composition has a better effect in the aspect of photodynamic therapy of inflammatory diseases (such as psoriasis or contact dermatitis) or acne and the like, and has a good application prospect. The acceptability of the patient to the photodynamic therapy is further improved; and the application scene of the photodynamic therapy is widened.

To provide a depot for treating post-operative pain via sustained controlled release of a therapeutic agent.SOLUTION: In some embodiments, the depot may comprise a therapeutic region comprising an analgesic agent and a control region comprising a bioabsorbable polymer and a release agent admixed with the polymer. The release agent may be configured to dissolve when the depot is placed invivo to form a diffusion aperture in the control region. The depot may be configured to be implanted at a treatment site invivo and release the therapeutic agent at the treatment site for 3 days or more while implanted.SELECTED DRAWING: None

The invention discloses an all-hydrocarbon cyclized endomorphin 2 as well as a preparation method and application thereof, natural endomorphin EM-2 (YPFF) is selected as a template, and a series of analogues (21 pieces) are designed and synthesized by adopting closed-loop olefin metathesis reaction through a chemical modification strategy. In-vivo and in-vitro analgesic activity and side effect fall experiments show that the total hydrocarbon cyclization binding endomorphin 2 analogue (EM2-5 / EM2-6) is a novel efficient and lasting analgesic with low side effect, and a new lead compound is provided for solving the problems of large side effect and the like of opioid analgesic clinically.

The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems / methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures / indicia of analgesia. The invention further relates to such control systems / methods that account for limitations of such indirect measures / indicia of analgesia.

The invention relates to a preparation method and application of a compound anacycline B. The compound is prepared by the following steps: crushing an anacycline root medicinal material, soaking in a mixed solvent of acetone and methanol, repeatedly extracting, combining extracting solutions, recovering the solvent to obtain a total extract, dissolving with a hydrochloric acid solution, extracting with ethyl acetate, adding a saturated sodium bicarbonate aqueous solution in an ice-water bath to adjust the pH value, filtering, and drying to obtain the anacycline B; the preparation method comprises the following steps: adding an alkali solution into an alkali solution, respectively extracting with ethyl acetate and n-butyl alcohol to obtain crude alkaloid, carrying out silica gel column chromatography, reversed-phase MCI gel normal-pressure column chromatography, Sephadex LH-20 column chromatography, normal-pressure normal-phase silica gel column chromatography or reversed-phase C-18 column chromatography, carrying out semi-preparative HPLC (High Performance Liquid Chromatography) separation, and carrying out normal-phase HPLC chiral resolution to obtain the compound anacycline B. An analgesic activity test shows that the compound has remarkable analgesic activity on mouse writhing induced by acetic acid under the dosage of 5mg / kg. The morphine derivative has a better analgesic effect than morphine under the dosage of 1mg / kg, can be used as a new drug component or a lead compound of an analgesic, and has a wide development prospect.

The invention discloses an anti-inflammatory and analgesic medicament and a preparation process thereof, and relates to the technical field of medicaments. The defects in the prior art are overcome. The medicine for diminishing inflammation and relieving pain is prepared from the following components in parts by weight: 80 to 200g of gypsum, 80 to 200g of mirabilite, 80 to 200ml of water and 1 to 2ml of vitamin B12 injection. The preparation process of the anti-inflammatory and analgesic medicine comprises the following steps: taking the components according to the weight for later use; adding water into a boiler, boiling until boiling, sequentially adding mirabilite and gypsum powder, and slowly and uniformly stirring to obtain liquid medicine; and airing the liquid medicine to normal temperature, adding the vitamin B12 injection, and uniformly mixing with the liquid medicine. The traditional Chinese medicine preparation is safe, effective, free of toxic and side effects, free of stimulation, good in antibacterial, anti-inflammatory and repairing effects and easy to obtain raw materials, does not generate dependence after being used for a long time, has high popularization value, is short in use course of treatment and can keep negative after curing HPV for a long time, and relapse is not prone to occurring.

The invention relates to the technical field of critical care, and discloses a mouth bite device for critical care, which comprises a central catheter channel, an external tooth guard plate and an internal tooth guard plate are arranged outside the central catheter channel, and an upper bite plate and a lower bite plate are arranged between the external tooth guard plate and the internal tooth guard plate. The upper biteplate and the lower biteplate are arranged on the left side and the right side of the upper biteplate, the inner side of the upper biteplate and the inner side of the lower biteplate are each provided with a preset dismounting opening, and an air cylinder is arranged below the preset dismounting openings. The dismounting openings, the air cylinders, the stabbing cones, the upper biteplate and the lower biteplate are matched, so that air can be blown to an affected tooth body of a patient and the vicinity of the affected tooth body through the stabbing cones and the air cylinders; the temperature of input gas is controlled through an external air pump and temperature control equipment, so that cold air or hot air is blown to the diseased teeth to cool or preserve heat of the diseased teeth, a temporary analgesic effect is achieved on the diseased teeth suffering from acute pulpitis, no analgesic agent or other dental instruments are needed to be matched with doctors, and the operation is simple and convenient. Only a nurse is needed to quickly and temporarily relieve pain of the diseased teeth of a patient.

This disclosure relates to compositions for treating skin conditions and improving skin health. In particular, the disclosure relates to compositions formulated as an absorbent article to be topically applied to skin, the absorbent article comprising an analgesic agent, antihistamine agent and / or a corticosteroid.

The invention provides a super-smooth absorbable polyester material capable of continuously easing pain, a medical instrument and a preparation method of the absorbable polyester material. The absorbable polyester material provided by the invention comprises a polyester material and at least one alternating coating formed on the surface of the polyester material, the alternating coating comprises a polymer network interpenetrating analgesic layer and a polymer network interpenetrating super-smooth layer formed on the surface of the polymer network interpenetrating analgesic layer, and the polymer network interpenetrating analgesic layer is in contact with the polyester material layer. The absorbable polyester material provided by the invention has the advantages that the surface coating is firmly combined and does not peel or crack, the analgesic in the analgesic layer is uniformly distributed and can be slowly released, the surface friction coefficient of the super-smooth layer is obviously reduced, the resistance of the polyester material in the implanting process is greatly reduced, the antibacterial property and the tissue adhesion resistance are increased, and meanwhile, the absorbable polyester material has a long-acting analgesic function; and the process is simple, continuous processing is easy, and large-scale production is facilitated.

This invention discloses a Yao bath composition for promoting blood circulation and dispelling wind, its preparation method, and its application, belonging to the field of Yao medicine technology. The Yao bath composition of this invention uses *Polygonum cuspidatum*, *Uncaria rhynchophylla*, and *Symplocos buergeriana* as the principal herbs, serving as the main anti-inflammatory and analgesic agents; *Clematis chinensis*, *Cinnamomum cassia*, *Angelica pubescens*, *Commiphora myrrha*, and *Artemisia argyi* as the assistant herbs, promoting blood circulation, dispelling cold, and relieving pain; *Polygonum multiflorum*, *Eucommia ulmoides*, and *Achyranthes bidentata* as adjuvant herbs, strengthening the body's resistance and guiding the medicine downwards; and *Glycyrrhiza uralensis* as the guiding herb, harmonizing the effects of all the herbs. It can be seen that the composition follows the traditional Chinese medicine theory of "promoting blood circulation, removing blood stasis, dispelling wind, clearing heat, and promoting diuresis." The combined effects of these herbs are anti-inflammatory, analgesic, and improve pelvic microcirculation, exerting therapeutic effects through multiple components, targets, and pathways. The pharmacological targets are clearly defined, effectively improving symptoms such as pain and inflammation caused by pelvic inflammatory disease, and showing significant therapeutic effects on pelvic inflammatory disease and other gynecological inflammations. Furthermore, through process optimization, the extraction of active ingredients can be promoted, thereby significantly improving the efficacy of the Yao bath composition.

Implantable depots for delivering therapeutic agents and associated systems and methods are provided. In some embodiments, an implantable depot for treating pain includes a therapeutic region including a polymer, an analgesic agent, and a plasticizer. When implanted in vivo, the therapeutic region can be configured to release the analgesic agent for a treatment period of at least 3 days. The implantable depot can have a flexural modulus within a range from 1 MPa to 400 MPa.