666 results about "Formyl group" patented technology

A method for producing furan-2,5-dicarboxylic acid (FDCA) is provided which can efficiently and quantitatively producing FDCA under mild conditions, without employing an expensive catalyst and with a reduced energy consumption. A furan ring compound having two functional groups selected from a hydroxymethyl group, a formyl group and a carboxyl group in the 2- and 5-positions of the furan ring, is oxidized with a metal permanganate in an alkaline environment to produce furan-2,5-dicarboxylic acid. Advantageously, the alkaline environment contains at least one of alkali metal hydroxides and alkali earth metal hydroxides, and the oxidation is performed at a temperature of from 1 to 50° C. by adding the permanganate metal salt to the alkaline aqueous solution containing the furan ring compound.

A compound represented by the formula (1):

wherein A is a nitrogen atom or CR⁴, B is an oxygen atom, a sulfur atom or NR⁹ (provided that when A is a nitrogen atom, B is not NH), R¹ is a C_2-14 aryl group, L¹ is a bond, CR¹⁰R¹¹, an oxygen atom, a sulfur atom or NR¹², X is OR¹³ SR¹³ or NR¹⁴NR¹⁵, R² is a hydrogen atom, a formyl group, a C_1-10 alkyl group or the like, L² is a bond or the like, L³ is a bond, CR¹⁷R¹⁸, an oxygen atom, a sulfur atom or NR¹⁹, L⁴ is a bond, CR²⁰R²¹, an oxygen atom, a sulfur atom or NR²², Y is an oxygen atom, a sulfur atom or NR²³, and R³ is a C_2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

The invention provides a phenanthrene and imidazole-coumarin double-fluorescent group ratio fluorescent molecular probe for iron ion detection and synthesis and use methods thereof, relates to fluorescent molecular probes and synthesis and application thereof and aims to solve the problem that an existing Fe<3+> fluorescent probe is prone to being interfered by pH, concentration and other metal ions. The fluorescent molecular probe is 4-methyl-7-hydroxide radical-8-[2-(1- phenyl group-1H-phenanthrene and [9, 10-d] imidazole-2-)benzene ammonia methylene]-2H-pyran-2-ketone. The phenanthrene and imidazole-coumarin double-fluorescent group ratio fluorescent molecular probe is formed by conducting condensation on 1-N-phenyl group-2-(2-aminophenyl)-1H-phenanthrene and [9, 10-d] imidazole and 4-methyl-7-hydroxide radical-8- formyl group coumarin, and the yield is 75-85%. The fluorescent molecular probe is dissolved in mixed liquid of N, N- dimethylformamide and an HEPES buffering solution, existence of iron ions is judged through the absorbance value or fluorescence intensity change before and after adding of test samples, and the fluorescent molecular probe can be used for detection of Fe<3+> pollution in water.

A method of converting (Z)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (II) to (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I) wherein R1, R2 and R3 are same or different and independently represent (C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkoxy(C1-C4)alkyl, allyl, vinyl, silyl, formyl, acyl, aryl(C1-C4)alkyl or substituted aryl(C1-C4)alkyl group. The present invention also provides a process for the conversion of (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I) prepared by a process described above to E-resveratrol of the formula (III).

Amide derivatives represented by the formula (I):

wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m—, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, ZR18 and the like, Z is —O—, —S(O)p—, —S(O)pO—, —NH—, —NR19—, and the like; or R1 and R2 may in combination form a ring, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.

The invention belongs to the technical field of biomass nanometer materials and discloses a nano-crystalline cellulose fiber high in carboxyl group content and preparation and application thereof. A preparation method comprises the steps of preheating fiber slurry for 0.5-1.5h with sodium periodate at the temperature of 50-60 DEG C; adding a sodium chlorite solution and acetum into the slurry to be reacted for 1-3h at the temperature of 30-50 DEG C, adding TEMPO, NaClO2 and NaClO, and performing microwave heating to the temperature of 55-65 DEG C to enable the mixture to be reacted for 1-3h; performing ultrasonic dispersion and freeze drying to obtain the nano-crystalline cellulose fiber high in carboxyl group content. According to the nano-crystalline cellulose fiber, hydroxyl at the positions of C2 and C3 of cellulose is oxidized into a formyl group which is oxidized into carboxyl by sodium chlorite, hydroxyl at the position of C6 is selectively oxidized into carboxyl through a TEMPO neutral oxidation system, and accordingly the total carboxyl group content of the fiber is greatly increased, and obtained products can be used for advanced treatment of waste water at the middle section of paper making.

An N-heteroaryl-4-(haloalkyl)nicotinamide derivative represented by formula (I):

[wherein R represents a C₁-C₆ haloalkyl group; R¹ represents a hydrogen atom, a C₁-C₆alkyl group which may be substituted a C₂-C₆ alkenyl group or an acyl group; X represents a group represented by formula C—R², or a nitrogen atom; R² and R³ each independently represent a hydrogen atom, a halogen atom, a C₁-C₆ alkyl group which may be substituted, a C₃-C₇ cycloalkyl group, a C₂-C₆ alkenyl group, a C₃-C₇ cycloalkenyl group, a formyl group, a group represented by formula CH═NOR⁴, a cyano group, a phenyl group which may be substituted, a heterocyclic group which may be substituted, a C₁-C₆ alkoxy group which may be substituted, a C₁-C₆ alkylthio group or a phenoxy group]; or a salt thereof, a pesticide containing it as an active component, a method for producing it and intermediates thereof.

The present invention relates to cellulose fibers wherein a part of the hydroxyl groups of the cellulose have been substituted with at least one of a carboxy group and formyl group of 0.1 mmol/g or larger based on the weight of the cellulose fibers, and have been further substituted with a chemical modification group other than the carboxy and formyl groups.

The invention discloses am amphipathy carbon quantum dot and a preparation method thereof. The amphipathy carbon quantum dot is prepared by virtue of the following steps: carrying out pyrolysis on chili powder which is adopted as a carbon source in an air atmosphere, and then carrying out the extraction and purification by virtue of ethanol. The particle size of the carbon quantum dot prepared in the method is 0.5nm to 4.5nm, and the surface of the carbon quantum dot is not only provided with hydrophilic groups such as hydroxyl, carboxyl, formyl groups and amino groups but also provided with hydrophobic groups such as methyl, methylene and phenyl, so the carbon quantum dot is amphipathic. The fluorescent quantum yield of the carbon quantum dot is 70 to 75 percent. The preparation method is simple to operate, and raw materials are low in price and easy to obtain and can be used for preparing the amphipathy carbon quantum dots in a large scale. Compared with other single hydrophilic and single hydrophobic carbon quantum dots, the prepared amphipathy carbon quantum dot is better in biological compatibility, the cell developing effect is better, and the amphipathy carbon quantum dot can be well applied to the fields such as biological developing, biological medical imaging and fluorescent detection.

PCT No. PCT/JP97/02649 Sec. 371 Date Mar. 31, 1998 Sec. 102(e) Date Mar. 31, 1998 PCT Filed Jul. 30, 1997 PCT Pub. No. WO98/04558 PCT Pub. Date May 2, 1998An active oxygen scavenger comprising as an active ingredient a pterin derivative of the formula (I): wherein R1 and R2 are independently a hydrogen atom, an alkyl group of 1 to 4 carbon atoms, or an acyl group of the formula R3-CO-, R3 is an alkyl group of 1 to 4 carbon atoms, X is a formyl group or hydroxymethyl group, A is a group of the formula (Ia): and n is 0 or an integer of 1 or more, with the proviso that when X is a hydroxymethyl group, n is 0, or when n is an integer of 1 or more, each of R1 and R2 is a hydrogen atoms, and X is a formyl group, or a cyclic compound thereof, or a salt thereof is disclosed.

The invention provides a method for preparing adsorbable oxycellulose through a ramie oxidation degumming process. The method includes the steps that ramie original hemp serves as a raw material, the original hemp is smashed into short fibers through a smashing machine, and the short fibers are added with deionized water and soaked for pretreatment; a degumming solution is prepared from an oxidizing agent, a stabilizing agent, a fiber expanding agent, a penetrating agent, a chelating agent and water, the ramie original hemp and the degumming solution are mixed, gum in the ramie original hemp is fully removed by means of oxidizability of hyperoxide, and cellulose with active hydroxyl groups is oxidized into oxycellulose containing a great number of formyl groups; the oxycellulose is separated from water and dried to obtain the oxycellulose in the powder state. The method is simple in flow path, environmentally friendly, low in requirement for equipment and beneficial for large-scale production and has good economic and social benefits, the total reaction time is shortened, chemicals and cost are saved, efficiency is greatly improved, reaction conditions are moderate, and additional value of the cellulose is substantially increased.

The invention discloses a preparation method of a compound 2-[4-((3S)-3-piperidin) phenyl]-2H-indazole-7-carboxamide; through the reaction of 4-nitryl phenylpyridine and benzyl halides, the benzyl quaternary ammonium salt is generated; the pyridine quaternary ammonium salt is restored selectively through sodium borohydride; under the effect of palladium reagent, the 3-(4- aminophenyl)- piperidine is obtained the (S)-3-(4- halogenated phenyl) piperidine is obtained through manually splitting the reagent, and then condensed with 3- formyl group-2- nitrobenzene methyl benzoate and forms pyrazol ring under the effect of sodium azide; through aminolysis, the Niraparib (molecule entity is: 2-[4-((3S)-3-piperidin) phenyl]-2H-indazole-7-carboxamide) is prepared.

The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; R^A represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; ring B represents aryl or heteroaryl; R^B represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; E¹ and E² represent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, —SO₂—Y, —O— (alkylene)-Y, —O-Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like.

The invention discloses a preparation method of a covalent organic framework/carbon nitride composite material and application thereof. Firstly, a covalent organic framework material is synthesized byusing p-phenylenediamine and triformyl phloroglucinol as synthetic monomers through a room-temperature solid-phase method, then the covalent organic framework material and carbon nitride are mixed, stirred and dried in methyl alcohol, and pyrolysis is carried out under the protection of inert gas to obtain a target product. The covalent organic framework/carbon nitride composite material disclosed by the invention is large in specific surface area, high in nitrogen doping amount and rich in pore structure and can effectively remove toxic organic pollutants in water by constructing a novel Fenton-like system, and new application of the covalent organic framework material in the field of catalysis is expanded; unavoidable metal ion leaching in the activating process of a metal nano catalystis overcome; and the preparation method has the advantages of simple process, easiness for repeated operation, controllable structure, suitability for large-scale production and the like.

The invention discloses a preparation method of a conjugated three-dimensional porphyrin-based covalent organic framework material. The preparation method comprises the following steps: taking 3,3', 5,5'-tetra (4-formylphenyl) hexamethylbiphenyl (TFBM) and a series of porphyrin derivatives as raw materials, o-dichlorobenzene and n-butanol as solvents and acetic acid as a catalyst, and carrying outsolvothermal reaction for several days; after the reaction is finished, sequentially using DMF and THF for suction filtration and washing, carrying out soxhlet extraction for 24 hours, and carrying out vacuum drying to obtain purple black powder, namely the target product. For the first time, tetrahedral tetraaldehyde based on steric hindrance effect is used as a building block, so that the material has a fully conjugated three-dimensional skeleton structure, good thermal stability and chemical stability, and porphyrin units facing three-dimensional pore channels are used as single active catalytic sites, so that the material shows good application prospects in the field of bionic catalysis.

The invention provides a porous pyrenyl organic framework material rich in hydroxyl and a preparation method thereof. The method comprises the following steps of under inert atmosphere, performing condensation polymerization on a phenol compound and tetra-formyl group aromatic aldehyde in an organic solvent to obtain the porous pyrenyl organic framework material rich in the hydroxyl, wherein the phenol compound is polybasic phenol or polybasic naphthol; the tetra-formyl group aromatic aldehyde contains 4 to 8 benzene rings, and four formyl groups are respectively connected with four different benzene rings; and the organic solvent is an alcohol organic solvent or an ether organic solvent. The porous pyrenyl organic framework material rich in the hydroxyl, provided by the invention, is a formless macromolecule net working polymer obtained by leading the phenolic group ortho-position or para-position of the phenol compound and the formyl groups in the tetra-formyl group aromatic aldehyde to generate condensation polymerization, and has fluorescence.

The invention discloses a preparation method for a polyimide thin film. The preparation method comprises the steps of adding an inorganic filler dispersing liquid, the surface of which is modified by coupling agents, and dianhydride and diamine into a polarity organic solvent to be mixed, and performing condensation polymerization on the dianhydride and diamine to obtain polyamide acid resin; and performing de-foaming, curtain coating and imidization on the polyamide acid resin in sequence to obtain the polyimide thin film, wherein the coupling agents comprise a coupling agent A and a coupling agent B; the coupling agent A is selected from a silane coupling agent or a titanate coupling agent with any one reactive group of amino group, formyl group, epoxy group, isocyanato, anhydride group, sulfydryl group and the like; the coupling agent B is selected from the silane coupling agent or the titanate coupling agent comprising long-chain alkyl; and the molar ratio of the coupling agent A to the coupling agent B is 2:8-8:2. The polyimide thin film prepared by the preparation method is 165-180MPa in tensile strength, 48-60% in breaking elongation, 210-230MV/m in power frequency electric strength, and 60-80h in corona resistance service life.

The invention discloses a method for carrying out real silk fabric anti-crease and antibacterial finishing by virtue of a laccase-TEMPO process. Quinones active groups are generated through catalyzing tyrosine residual groups in real silks by laccase so that chitosan molecules are grafted on the real silks; then 2,2,6,6-tetramethylpiperidine-nitrogen oxide (TEMPO) is added and is used for catalyzing chitosan and tyrosine in the real silks to generate formyl groups, so that the grafting amount and bonding firmness of the chitosan on the real silks are increased, and the real silk fabric anti-crease and antibacterial finishing is realized. The method comprises the following specific steps of: (1) catalytically oxidizing the tyrosine residual groups in the real silks by the laccase; (2) taking the chitosan and the quinones active groups in the real silks to react; (3) catalyzing the real silks by laccase-TEMPO to graft the chitosan; and (4) washing the real silks with water and then treating. Compared with traditional chemical cross-linking-process vacuum fabric anti-crease and antibacterial finishing, the method has the advantages that the grafting efficiency of the chitosan is high, enzyme treatment conditions are moderate, the real silk fabric anti-crease and antibacterial effect is relatively good and the strength of the fabric is improved.