108 results about "Formyl group" patented technology

The invention discloses a preparation method of a grafted and substituted thiophene polymer material, which comprises the following steps: mixing poly (3-hexylthiophene), a grafting monomer, a catalyst and an auxiliary agent, and heating for reaction to obtain the grafted and substituted thiophene polymer material, the structural formula of the grafting monomer is as shown in formula (I); wherein B is fluorine, chlorine, bromine or iodine, A is a carbon atom or a nitrogen atom, and R is cyano, formyl, methoxycarbonyl or; according to the method, pre-synthesis of complex functional monomers is avoided, the main chain of the poly (3-hexylthiophene) can be directly modified without using an expensive catalyst or ligand, the polymerization reaction of the poly (3-hexylthiophene) is not interfered, and meanwhile, the method has the advantages of simplified steps and low cost.

The present invention relates to the preparation of cyantraniliprole, comprising the preparation of 8-methyl-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-carbonitrile key intermediate via 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid. Wherein hydroxylamine attacks a benzylic formyl group, to obtain the 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid, that undergoes simultaneously or by consecutive steps dehydrogenation and cyclization to obtain the benzo[d][1,3]oxazine group and the cyano group of the desired product. In addition, an improved method for the synthesis of the benzylic formyl group is also displayed.

The invention discloses a 2-amino-4-(5-cyano-1-isopropyl-1H-indole-3-yl) pyrimidine compound and application thereof, the compound has the following structural general formula: in the formula, substituent R is substituted phenyl, the number of substituent groups on the benzene ring of the substituted phenyl is 1-2, and the substituent groups on the benzene ring of the substituted phenyl are 1-2. Substituent groups are respectively and independently selected from nitro, cyano, halogen, carbamoyl, furyl or pyridyl. The 2-amino-4-(5-cyano-1-isopropyl-1H-indole-3-yl) pyrimidine compound designed and synthesized by the invention is a novel efficient NF-kappa B induced kinase (NIK) inhibitor, and is suitable for drug development taking NF-kappa B induced kinase (NIK) as a target spot, and the obtained drug can be used for treating malignant tumors such as leukemia, multiple myeloma and the like.

The present invention provides a compound with which a molecular probe capable of distinguishing NSCs from CSCs can be produced, and a method for detecting cancer stem cells using the compound. The present invention relates to a compound having a formyl group, a substrate moiety, a quenching moiety, and a luminescent moiety that is non-luminous due to the quenching moiety, wherein the luminescent moiety may be rendered luminous by detaching the substrate moiety by a substrate-degrading enzyme and also converting the formyl group to a carboxy group by an aldehyde dehydrogenase to allow the quenching moiety to dissociate.

This invention relates to a potassium ion-responsive hydrogel based on iminoboronic ester bonds, its preparation method, and its applications. The hydrogel is prepared using guanosine, 2-formylphenylboronic acid, and polyoxyethylenediamine. The diol of guanosine forms a borate ester bond with 2-formylphenylboronic acid, and the primary amine in the polyoxyethylenediamine forms an imino group with the aldehyde group of 2-formylphenylboronic acid. The bases of guanosine form a G-quadruplex under the influence of potassium ions. The hydrogel has a porous network structure. The preparation method is as follows: A mixed aqueous solution of guanosine, 2-formylphenylboronic acid, and polyoxyethylenediamine is heated to boiling to obtain a clear solution. After cooling, the solution is mixed with a potassium ion solution to prepare the potassium ion-responsive hydrogel based on iminoboronic ester bonds. Compared with the prior art, the hydrogel prepared by this invention exhibits both temperature and potassium ion responsive characteristics.

The invention relates to an inhibitor for efficiently separating copper and sulfur under a low-alkalinity condition, a flotation reagent and a flotation method. The inhibitor is a compound as shown in a formula I (formula I), wherein R1, R2, R3 and R4 are respectively and independently selected from one of-R5X,-X,-H and-N + R6, R5 is alkyl of C1-C10, naphthenic base of C3-C10 or heterocyclic group of C3-C10, and the ring of the heterocyclic group is provided with or not provided with a substituent group; x is one of F, Cl, Br, I, tertiary amine positive ions, nitro, cyano, sulfo, formyl, acyl and carboxyl; r6 is a C1-C5 alkyl group or a C3-C5 cycloalkyl group; the inhibitor is low in viscosity and good in fluidity, pyrite and chalcopyrite in complex copper sulfide ore copper-sulfur ore can be effectively separated under the low-alkalinity condition, and the separation effect is remarkable.

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

Provided herein are methods for preparing crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate.

The invention discloses a quasi-three-dimensional covalent organic framework material based on a two-dimensional substrate piled functional group, a preparation method and application of the quasi-three-dimensional covalent organic framework material in iodine adsorption, and the preparation method comprises the following steps: carrying out hydrothermal reaction on a mixture containing a phenyl compound, hexane (4-formylphenoxy) cyclotriphosphazene, 4-dimethylaminopyridine and water to obtain the quasi-three-dimensional covalent organic framework material based on the two-dimensional substrate piled functional group. The quasi-three-dimensional covalent organic framework material based on the two-dimensional substrate piled functional groups is obtained. According to the invention, a similar three-dimensional pore network is formed by orderly stacking two-dimensional substrates, and the three-dimensional covalent organic framework material has the characteristics of high specific surface area and strong structural stability of a three-dimensional covalent organic framework material; meanwhile, the problems that two-dimensional covalent organic framework materials are easy to peel off between layers and adsorption and mass transfer are limited are effectively solved, the defects that three-dimensional covalent organic framework materials are high in synthesis difficulty and poor in photoelectric property are avoided, and collaborative optimization of stability, adsorption efficiency and functional suitability is achieved.

The application discloses a synthesis method of 3,3-difluorocyclopentylamine hydrochloride, and particularly relates to the technical field of chemical synthesis. The synthesis method comprises the following steps: taking 2-cyclopentenone and phthalimide as raw materials, and sequentially performing a Michael addition reaction, deoxygenation fluorination, removal of a phthaloyl protecting group, Boc protection and deprotection and salt formation reaction to obtain 3,3-difluorocyclopentylamine hydrochloride. The synthesis route and process design of the application are reasonable, the starting raw material is 2-cyclopentenone, the required reaction condition is mild, the post-treatment method is simple, the operability is strong, the raw material and reagent are cheap and easy to obtain, and the total yield can reach 43.6%, so the synthesis method has large-scale preparation value.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

This invention discloses a hydrazone-linked fluorine-substituted covalent organic framework material, its preparation method, and its applications, belonging to the field of semiconductor photocatalysis technology. The material is synthesized by hydrazone condensation of 1,3,5-trifluoro-2,4,6-tris(4-formylphenyl)benzene and terephthalohydrazide, denoted as F-TPDH-COF. A one-step solvothermal synthesis is employed, resulting in a mild, environmentally friendly, low-cost, and easily scalable process. The material obtained by this invention utilizes hydrazone bonds to achieve proton enrichment in acidic media, and fluorine atoms regulate the electronic structure to improve charge separation efficiency. Under pH=2 conditions, the photocatalytic hydrogen peroxide production rate reaches as high as 5825.2 μmolg. ‑1 h ‑1 Its activity and stability are significantly better than most existing COF photocatalytic materials, and it can be used for efficient photocatalytic preparation of hydrogen peroxide in acidic systems, showing good prospects for industrialization.

The invention belongs to the field of organic synthesis, and particularly discloses an acoustic resonance synthesis method of 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine, which comprises the following steps: under acoustic resonance and room temperature conditions, formamide, glyoxal and alkali liquor are subjected to a reaction for 5-10 min to synthesize 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine, and the 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine is subjected to a reaction for 5-10 min to obtain the 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine. The acceleration of acoustic resonance is 196-980 m / s < 2 >, and the alkali liquor is selected from a sodium hydroxide aqueous solution, a potassium hydroxide aqueous solution or triethylamine. According to the present invention, the alkali-catalyzed aldehyde amine condensation reaction is achieved by using acoustic resonance reinforcement, the 1, 4-diformyl-2, 3, 5, 6-tetrahydroxypiperazine is rapidly and efficiently synthesized, the reaction time is substantially shortened, the product yield is improved, and the method has broad industrial application prospects.

The present application relates to 2-formylquinoline carboxamide compounds and medical uses thereof, the structure is shown as formula (I). The present application also relates to the preparation method of the compounds, pharmaceutical compositions and the use thereof as FGFR4 inhibitors in the treatment of cancer.

The invention discloses a pentagonal porphyrinyl covalent organic framework material as well as a preparation method and application thereof. According to the material, 5, 10, 15, 20-tetra (4-aminophenyl) nickel porphyrin and N, N '-bis (4-formylphenyl)-N, N'-diphenyl benzidine are used as construction units, and a two-dimensional covalent organic framework structure with pentagonal pore topological characteristics is formed through a Schiff base condensation reaction. Ni-N4 coordination structures which are uniformly distributed in the material construct catalytic sites similar to a natural enzyme active center in a non-uniform pore microenvironment, and the material shows excellent and stable peroxidase-like catalytic activity. The preparation method of the material has the advantages of clear process steps and mild reaction conditions, and is suitable for stable and repeated preparation. A catechol inhibition type colorimetric sensing system constructed on the basis of the material has good analysis performance in the aspects of detection linear range, detection limit and the like and does not need to depend on large-scale instruments and equipment, and a detection result can be observed through naked eyes.

The invention discloses a photocatalyst porphyrinyl COFs for thioether oxidation as well as a preparation method and application thereof, and belongs to the technical field of material science. The preparation method comprises the following steps: synthesizing 2, 5-di-p-methylphenylpyridine from 2, 5-dibromopyridine and 4-formylphenylboronic acid under the catalysis of tetrakis (triphenylphosphine) palladium, dispersing the 2, 5-di-p-methylphenylpyridine and two monomers of 5, 10, 15, 20-tetra (tetranitrophenyl) porphyrin in an organic solvent, and carrying out solvothermal polymerization under the action of a catalyst anhydrous acetic acid to obtain the COF material. The COF material is simple in synthetic route and relatively high in yield, the utilization efficiency of visible light can be effectively improved, photon-generated carrier recombination can be remarkably reduced, and efficient selective oxidation of thioether can be realized. An environment-friendly solution is provided for production of fine chemicals, and industrial transformation of green chemicals is promoted; meanwhile, active oxygen species generated in the photocatalysis process can synchronously degrade organic pollutants, the synergistic effect of thioether oxidation and wastewater treatment is achieved, and the problem of environmental pollution abatement is expected to be solved.

A high-molecular compound has a repeating unit (U) including a diazabenzene ring, a substituent directly bonded to the diazabenzene ring, and a carbonyl group. The substituent includes at least one selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxy group, a formyl group, a carboxy group, an alkyl group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, and a hydroxy alkyl group having 1 to 6 carbon atoms.

The invention provides a method for preparing 5-formyl furoic acid, and relates to the technical field of biological platform compounds. According to the method for preparing the 5-formyl furoic acid, a solution composed of substrates HMF, TEMPO, acid, salt and a solvent is subjected to an oxidation reaction under oxidizing gas, and the 5-formyl furoic acid is obtained. The salt is selected from nitrite and / or nitrate. According to the method, the HMF conversion rate is high, and the FFCA selectivity is high.

The application belongs to the technical field of organic photoelectric materials, and particularly relates to a 1,3-di-aromatic formyl benzene compound, a preparation method and application. The structural formula of the 1,3-di-aromatic formyl benzene compound is shown as formula (I). The novel compound can effectively separate photo-generated charges, promote efficient transmission of excited state electrons or hydrogen, improve photo quantum efficiency and catalytic efficiency, and can be applied to the fields of photosensitive materials, photoelectric materials, fluorescent probes, photocatalysis, photocuring and the like, and has a wide market application prospect. Meanwhile, the preparation method provided by the application is simple in operation, mild in conditions, green and environment-friendly, reagents and substrates are simple, economical, inexpensive and easy to obtain, the reaction is efficient, the substrate has wide applicability, and the application has a wide industrial application prospect.

The invention relates to the technical field of photocatalytic materials, in particular to a Si-COF photocatalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: taking 2, 5-diamino-1, 4-benzene dithiol dihydrochloride and tetra (4-formylphenyl) silane as raw materials, carrying out aldimine condensation reaction, and carrying out condensation on amino and sulfydryl of the 2, 5-diamino-1, 4-benzene dithiol dihydrochloride and aromatic aldehyde of the tetra (4-formylphenyl) silane to form benzobithiazole structural sites, so as to obtain the Si-COF photocatalyst. The photocatalyst has very strong self-assembly ability and can produce H2O2 without a sacrificial agent, when the dosage of the photocatalyst is 5 mg, the yield of H2O2 reaches up to 6059.86 [mu] mol.g <-1 >. H <-1 > / 100 mmol.L <-1 >, the operation is simple and convenient, the condition is mild, and the photocatalyst is suitable for green and efficient production of H2O2.

The invention discloses a naphthalene diimine ligand compound, and particularly relates to 1, 4, 5, 8-naphthalene tetraformyl diimide. The ligand compound is high in rigidity and coordination capacity, and N and O atoms on the ligand can participate in coordination, so that the catalyst composition is formed by the ligand compound, a transition metal compound and an aluminum alkyl cocatalyst, and when the catalyst composition is used for selective oligomerization of ethylene, the catalyst composition and transition metal can form a relatively stable complex, and the selectivity of ethylene is improved. The reaction has the characteristics of strong high temperature resistance, strong selectivity and less side reaction.

The application provides a purification method of 2,5-furan dicarboxylic acid containing 5-formyl-furan-2-carboxylic acid impurities. The method of the application converts 5-formyl-furan-2-carboxylic acid with lower water solubility into 5-hydroxymethyl-furan-2-carboxylic acid with higher water solubility through high-selective hydrogenation, and then removes 5-hydroxymethyl-furan-2-carboxylic acid through water washing to achieve the purpose of purifying 2,5-furan dicarboxylic acid product. In the high-selective hydrogenation reaction of 5-formyl-furan-2-carboxylic acid, the method of the application uses a supported metal catalyst with low loading, has high catalytic activity and selectivity, and can realize selective hydrogenation of a small amount of 5-formyl-furan-2-carboxylic acid impurities in 2,5-furan dicarboxylic acid crude product.

The invention discloses a method for preparing a drug conjugate through carboxylic acid participated multi-component reaction. The method comprises the following steps: taking an alpha-alkynyl MBH addition product, a carboxylic acid compound and a 2-formyl-3-acrylonitrile compound as raw materials, reacting in a solvent under the action of a catalyst, and separating to obtain a multi-component reaction product. The method has the advantages of simple process, convenience in operation, relatively high yield, relatively few byproducts and the like; meanwhile, the preparation method disclosed by the invention is wide in substrate applicability, can be compatible with various functional groups, and is suitable for various carboxylic acids and 2-formyl-3-acrylonitrile compounds, so that derivatives of various bioactive carboxylic acids are obtained, and a new thought is provided for modification and molecular design of carboxylic acid-containing drug molecules.

This invention relates to a metal-organic adsorbent, its preparation method, and its application, belonging to the field of composite material technology. The invention utilizes the condensation reaction of terephthalaldehyde and aminothiourea, followed by the incorporation of 3-formyl-4-hydroxybenzoic acid to form an organic ligand. This organic ligand is then combined with ZrCl4 to prepare a metal-organic adsorbent. The metal-organic adsorbent can be used for targeted removal of copper ions from solution. The adsorption rate of copper ions by the metal-organic adsorbent can reach 98.5%, and after five repetitions, the adsorption rate can still reach 89.71%.

The application discloses a preparation method of a two-dimensional covalent organic framework solid solution and application thereof, and the preparation method comprises the following steps: mixing 2,6-dimethylbenzo[1,2-b:5,4-b']dioxazole, trimesic aldehyde, 1,3,5-tri(4-formylphenyl)benzene and benzoic anhydride, and heating and reacting under vacuum condition to obtain a series of ethenyl-linked covalent organic framework solid solutions. The covalent organic framework solid solution material prepared by the method has a full conjugated structure and high crystallinity, and has good photocatalytic water splitting hydrogen production activity after ball milling treatment.

The invention discloses a method for synthesizing a phthalide compound with high selectivity under a biological compatibility condition. According to the method, a thiol compound and a 2-formyl benzoate compound are taken as raw materials, coupling is efficiently and rapidly realized in a PBS buffer solution under the action of potassium carbonate, and a phthalide product is generated. The reaction has the advantages of high yield and high reaction speed, shows excellent chemical selectivity on cysteine sulfydryl, and can effectively distinguish other nucleophilic amino acids. The method disclosed by the invention is wide in substrate applicability, simple and convenient in steps, low in cost, mild and green in conditions and good in functional group compatibility, and provides an efficient, safe and practical new way for construction of a linker of an antibody-coupled drug (ADC) and modification of phthalide active molecules.

Disclosed are an acylphosphine oxide compound and a preparation method therefor, which belong to the field of initiators. The method comprises: reacting compound B and compound C under the conditions of an organic base and an organic solvent so as to obtain the acylphosphine oxide compound. The chemical structural formula of compound B is as follows:the chemical structural formula of compound C is as follows:andthe chemical structural formula of the acyl phosphine oxide compound is as follows:wherein R1 is hydrogen, a C1-C6 alkyl group, methoxy, methylthio, dimethylamino, chloroformyl, phenyl, benzoyl, (4-dimethylamino) phenyl, α-naphthyl, β-naphthyl or (9-ethyl-9H-carbazole)-3-yl, R2 and R1 are the same, n is the substitution number of R1 on the corresponding phenyl ring, and is 1, 2 or 3, and m is the substitution number of R2 on the corresponding phenyl ring, and is 1, 2 or 3. The preparation method is safe and environmentally friendly, and has a high yield.

The present invention relates to 3(4),8(9)-bisformyltricyclo[5.2.1.0 2,6 According to the present invention, a separate catalyst recovery step is not required, and 3(4),8(9)-bisformyltricyclo[5.2.1.0]decane can be produced with high conversion and purity. 2,6 ] decane (TCDDA) can be produced.

The invention relates to a dynamic borate dimer micromolecule, a high self-repairing material containing the dynamic borate dimer micromolecule and a preparation method and application of the dynamic borate dimer micromolecule. The dynamic borate dimer micromolecule (BOB-X) is obtained by reacting 2-formyl phenylboronic acid and a derivative thereof with an acid hydrazine compound, and a stable boron-oxygen coordination structure is formed; due to boron-oxygen coordination, the dimer can stably exist while having high dynamic property, and the boron-oxygen coordinated dimer micromolecule has dynamic exchange capacity at room temperature; bOB-X and hydrazide with two degrees of functionality are synergistically used as a chain extender and introduced into a polyurethane prepolymer, and a polyurethane cross-linked structure with a dynamic boron-oxygen coordination bond and quadruple hydrogen bond network is constructed; according to the polyurethane material, the synergistic effect between a B-O coordinate bond and quadruple hydrogen bonds of a hydrazide structure is achieved through molecular design, the material is endowed with the excellent graded relaxation characteristic, the multi-level energy dissipation and strain recovery capacity is shown under different stress levels and time scales, and the mechanical response and self-repairing capacity of the material is remarkably enhanced.