2583 results about "Dermatomal" patented technology

Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.

In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin. Thus, therapeutic or immunizing agents can be delivered into cells of skin for local and systemic treatments or for immunization with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

A method of delivery of a substance to a human subject's skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of s pre-selected volume of the substance, e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.

The present invention provides a method and device for exposing injured mammalian tissues, in a non-abrasive manner, to an effective amount of exogenous gaseous nitric oxide (gNO) in order to promote healing by reducing the size, duration and severity of wounds as well as controlling the infection by reducing number of pathogens at the site and the surrounding area. The present invention also provides methods of cosmetically treating the skin wherein a cosmetic agent in combination with gNO is applied to the skin.

This invention relates to in-situ preparation of the derivatives of various hydroxy acids (HA), such as alpha-(Alpha) Hydroxy Acids (AHA), beta-(Beta) Hydroxy Acids (BHA), and Poly-Hydroxy Acids (PHA) with certain skin beneficial organic hetero-atom bases and their application in skin resurfacing (exfoliation), and in the synergistic treatment and regulation of topical disorders of skin such as skin aging, wrinkles, acne, rosacea, age-spots, canker sores, striae distensae (stretch marks), pimples, skin redness, and dry skin conditions of cracking, flaking, and scaling. Most HA derivatives produced by the in-situ method do not cause skin irritation and skin redness effects that are commonly experienced with AHA and BHA, yet there is no loss of their skin beneficial effects. These compositions can be traditional water and oil emulsions, liposomes, suspensions, colloids, solutions, masks, muds, serums, sprays, gels, lotions, creams, cleansers, and anhydrous systems, thus offering a wide choice of formulations to meet their consumer appeal and acceptance requirements.

The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

A method and system for performing abrasion on a surface, such as on the skin of a patient, is disclosed. The dermabrasion apparatus includes apparatus for delivering and retrieving material to and from a selected site to be abraded, a delivery and retrieval hand piece, an abrasive handling device, and a waste retrieval holding device. The hand piece is coupled to the abrasive handling device as well as the waste retrieval holding device, which is further coupled to the delivery and retrieval apparatus. The abrasive handling device further includes an abrasive supply device, a receiving channel, a feeding chamber, and a delivery channel. The abrasive supply device typically is a canister fitted with a funnel-shaped spout that is inverted into the receiving channel. The receiving channel feeds abrasive to the feeding chamber. The delivery and retrieval apparatus, typically a vacuum source that generates a pneumatic air supply within the abrasion apparatus, causes the abrasive within the feeding chamber to loft in an arc such that it reaches the delivery channel. The delivery channel then leads to the hand piece, which is utilized to apply the abrasive to the surface and then retrieve the waste debris during the procedure.

The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device that contains at east one stratum corneum-piercing microprotrusion and a compressible cover such that the compressible cover substantially encases the at least one stratum corneum-piercing microprotrusion, and wherein upon contacting the skin with the compressible cover, the at least one stratum corneum-piercing microprotrusion protrudes from the compressible cover and pierces the stratum corneum of the skin.

A system and method for using a light source to treat tissue with NIR light. The operation provides for generating higher temperatures in deeper layers of tissue relative to higher layers of tissue. The increased temperature in dermal layers can operate to induce collagen shrinkage, or remodeling. One of the light sources for providing a broad spectrum of NIR light is a filament light. The light from the filament lamp can be selectively filtered, and after filtering this light is applied to the skin, where the selective filtering can enhance the ability to elevate the temperature of deeper layers of tissue, relative to layers of tissue which are closer to the surface of the skin.

The invention relates to device making it possible to apply a chromophoric composition to the skin, said device including a chromophoric composition containing at least one chromophoric agent. The chromophoric composition is in the form of a layer of constant thickness bonded to one face of backing, at least prior to being applied to the skin, the chromophoric agent or agents being distributed uniformly in said composition, and the type of the composition being chosen such that light energy from laser radiation is transformed locally into heat and / or the chemical structure(s) of the chromophoric agent(s) is / are modified locally.

A method of non-invasive determination of a glucose concentration in blood based on the measurements of the total impedance of the skin of a patient is disclosed. The method is based on a linear model of a first order correlation between the glucose concentration and the total impedance, the model taking into account the rate of change of the glucose concentration. The coefficients used in an approximating function are determined at the preliminary stage measurements by an invasive method.

Disclosed is an apparatus and method which employs an energy source, one or more switches, electronic control circuitry, and a surface that can be placed in contact with a region of a person's skin containing a benign pigmented lesion. Within the apparatus, electrical current is passed through a heating element that is thermally coupled to the surface so that this surface is heated rapidly and then is subsequently cooled rapidly. By judicious choice of the rate of heating, maximum temperatures achieved, and rate of cooling, thermal injury to the skin can be confined primarily to the epidermal region of the skin in contact with the surface.

The present invention relates to the use of optical skin measurements to determine skin properties such as surface topography, hydration, elasticity, pigmentation intensity or uniformity, dermal thickness, dermal perfusion, presence or concentration or composition of oil on or near the surface, and apparent age of the skin. An apparatus according to the present invention can comprise a skin positioning system for positioning the skin relative to other parts of the apparatus. An illumination system, adapted to produce illumination radiation, can mount with the skin positioning system such that illumination radiation impinges on a first portion of the skin at a first determined angle thereto. A detection system can mount with the skin positioning system such that radiation from a second portion of the skin at a second determined angle therefrom impinges on the detector. An analysis system can receive information from the detection system, and determine one or more skin properties from the detected radiation and the illumination radiation.

A device and a method for thermal treatments of target material with various thermal interactions are disclosed. A device for treating hair on the skin comprises a treatment head coupled to a housing; a hair remover for removing the hair from a target area of the skin; a light source for transmitting a predetermined amount of energy to the skin. A device and method for treatment of tissue. The device comprises of an energy source for treatment of surface and subsurface tissue, And of a mechanical source of energy for mechanically deforming the treated tissue. Both the Mechanical Energy (ME) and the Treatment Energy (TE) may be either continuously operating (CO) or modulated in time and space.

A robotic system for delivering energy for medical or cosmetic treatment of a region of skin of a subject includes a multi-axis robotic arm mounted on a base and terminating at a holder. An applicator for delivering energy to the skin is mounted in the holder. The holder has at least three range sensors generating outputs of a distance to at least three spaced apart locations on the surface of the skin. A controller associated with the robotic arm and the range sensors processes the outputs from the at least three range sensors to determine an orientation of the holder relative to the skin, and actuates the robotic arm to adjust an orientation of the holder such that an orientation of the applicator relative to the skin is maintained within a predefined range of desired angles.

The applicator includes a housing and a motor contained therewithin which includes an output member, such as a shaft, which in operation moves in a reciprocating manner. A contact member is mounted for operation and moves in response to the action of the output shaft, such that the contact element in operation repeatedly contacts a selected skin area, moving toward and away from the skin area, substantially perpendicularly thereto. The contact member moves at a frequency within the range of 50 Hz to 200 Hz and with an amplitude of 0.010 to 0.075 inches. The repeated tapping action of the contact member against the skin increases the absorption of a skin formulation into the skin area being contacted.

A topical skin care composition comprising kakadu plum extract or acai berry extract, or a combination of both, is disclosed. The composition can include a high oxygen radical absorbance capacity (ORAC) value. The composition can improve the skin's visual appearance, physiological functions, clinical properties, and / or biophysical properties.

A nasal dilator adapted to stretch facial skin, including a resilient layer and attachment means. The resilient layer has an equilibrium configuration and a plurality of nonequilibrium configurations. Portions of the resilient layer are disposed upon a plurality of points upon the facial skin. The facial skin may be stretched by attaching the nasal dilator in a nonequilibrium configuration to the facial skin by the attachment means and allowing the nasal dilator to stretch the facial skin as the resilient layer moves towards the equilibrium.

The present invention is of an apparatus and method for enhancing skin, muscle and nerve stimulation and controlled delivery of an active substance to a subject's skin. Moreover, the present invention is of an apparatus, featuring a combination of a stimulating device and an exothermic heating source. Preferably, the stimulating device is an iontophoretic device, or an electrical stimulation device, such as, but not limited to TENS, IFC and GC devices or a combination thereof. The present invention also provides a method of using such an apparatus for enhancing skin, muscle and nerve stimulation. Furthermore, the present invention provides a method of use of such an apparatus for enhancing controlled delivery of an active substance.

A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

A cervical collar assembly to immobilize the neck and head of a user. The assembly includes an adjustable and conformable shell member having a pad member secured on its interior to engage the skin of the user. The shell member is comprised of a front member, a back member and means to adjustably join the front and back members. A chin support member is adjustably secured to the front member and an occipital support member is secured to the back member. The front and back members are provided with a plurality of elongated slits which permit the shell member to conform to the neck and head areas of the user. Further, the front member is provided with opposing upwardly extending tab members to engage the mandibula of a user's jaw to aid in the immobilization of the neck and head of the user. Cervical collar device size identifiers are further provided.

An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E. Also preferably dissolved in the adhesive are glycerine and a polydiorganosiloxane adhesion-adjusting agent. Optionally dissolved in the adhesive is also one or more members selected from the group consisting of moisturizing agents, skin collagen synthesis promoting agents and exfoliating agents. When applied to a wrinkled skin area the composition acts to diminish fine wrinkles and improves the overall thickness, elasticity, firmness and smoothness of the skin. The modified adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended treatment period while allowing the patch to be readily removed without causing skin irritation or leaving adhesive residue on the skin.

The present invention provides a skin surface imaging system for capturing at least one image of the skin of a patient's body, comprising: a. a base; b. a plurality of image sensors, connectable to said base, arranged in a predetermined arrangement; each of said image sensors adapted to capture an image of a predetermined area of said body, so that as a set of images is provided; and, c. a processing unit communicatable with said image sensors, comprising a program of machine-readable instructions embodied on a computer readable memory and executable by a digital data processor adapted to: (i) collect said set of images from said image sensors; (ii) analyze said set of images; (iii) construct a record of personal data associated with the skin of said body of said patient; and (iv) output a dermatological data associated with said skin of said body.

Skin dermabrasion device by gently contacting the skin with an abrasive, comprising a handleable housing (10) and driving means for the abrasive. This device is intended in particular for cosmetic treatments of the epidermis called microepidermabrasion. The device comprises a curved abrasive surface (30) held by a support (32) mounted in or on the housing (10, 18) for an oscillatory motion allowing the oscillation of the curved abrasive surface (30) about its axis. A support surface (40) surrounds the abrasive surface (30) on at least two opposing sides leaving a gap to allow the oscillating motion. The device is arranged in such a way as to allow, by the application of the support surface (44) against the skin (50) and around the region of the skin to be treated, the gentle contact of this region of skin with the oscillating abrasive surface. Thus a microabrasion of the epidermis through the oscillation of the curved abrasive surface (30) lightly applied against the skin is achieved, thanks to the support surface (40) that prevents any injury or penetration beyond the epidermis.

In certain variations, methods, systems and / or devices for enhancing conductivity of an electrical signal through a subject's skin using one or more microneedle electrodes are provided. A microneedle electrode may be applied to the subject's skin by placing the microneedle electrode in direct contact with the subject's skin. The microneedles of the microneedle electrode may be inserted into the skin such that the microneedles pierce stratum corneum of the skin up to or through dermis of the skin. An electrical signal passes or is conducted through or across the microneedle electrode and the subject's skin, where impedance of the microneedle electrode is minimal and greatly reduced compared to existing technologies.

Absorption of a therapeutic agent across a mucosal membrane or the skin can be enhanced using an absorption enhancer comprising a hydroxy fatty acid ester of polyethylene glycol.

A surgical thread for plastic surgery which is extremely simple in structure, is safe for human use, effectively removes sagging and wrinkling of skin, and further enables the tensing action to the skin to be maintained for a long period of time, that is, a surgical thread for plastic surgery comprised of a thread shaped member comprised of a thread body, to be implanted in the inside layers of the skin, partially formed in its longitudinal direction with projections for anchoring in the inside skin layers, wherein at least the thread body is comprised of an absorbable thread, and the thread body or the projections are formed with residual film parts which will not be absorbed by the inside skin layers, and a method of imparting tension to the skin using the same.

The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device including a microprotrusion member having a skin-contacting surface and plurality of stratum corneum-piercing microprotrusions thereon.

Compositions for application to human skin have a continuous phase which contains water-immiscible oil structured by incorporation of a compound of formulain which Y and Y1 are each independently -CH2 or >CO Q and Q1 are each independently a hydrocarbyl group of at least 6 carbon atoms and m is from 2 to 4.The composition may be an antiperspirant containing suspended particulate antiperspirant active or containing a dispersed phase in which antiperspirant active is dissolved in water or water-immiscible solvent.