1211 results about "Dermatomal" patented technology

The invention discloses a working method of skin thermal therapy equipment which is convenient to use and can realize intelligent startup work and an itching relieving instrument. According to the technical scheme, the working method of the skin thermal therapy equipment comprises the following steps that a, whether a designated area makes contact with the skin of a user or not is detected, and if yes, the step b is executed; and b, detecting the skin contact time and the skin temperature of the contacted part, and if the detected temperature is within a preset range and the continuous contact time reaches the set time, starting the skin thermal therapy equipment to operate.

Wearable modular mask systems for combination face and skincare diagnostics and therapeutics. Systems include devices that can be attached to wearable masks for diagnosis and treatment of skin conditions, diseases, and disorders, as well as for cosmetic improvements to the skin of the face and scalp.

The invention discloses a recombinant XVII type collagen engineering bacterium as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering, and the recombinant XVII type collagen engineering bacterium is realized through three steps of designing and optimizing collagen, improving translation through codon optimization and selecting a vector for cloning. By optimizing the amino acid sequence and the codon, the expression efficiency and the stability of the recombinant XVII type collagen in engineering bacteria are improved. The optimization not only improves the production efficiency of the protein, but also reduces the production cost. The recombinant XVII type collagen has potential in the medical field, especially in the fields of skin repair, wound healing, aging resistance and the like. Meanwhile, in the fields of beauty and biological materials, collagen is widely applied to products such as masks and skin care products as a basic component, and can promote skin cell regeneration and enhance skin elasticity and repair capacity.

The utility model relates to a self-adaptive pressure tourniquet which comprises a fixing band body, the unfolding face of the fixing band body is in a sector shape with the upper portion wide and the lower portion narrow, rope drawing grooves are formed in the upper end and the lower end of the fixing band body along the edges, corresponding drawing ropes are arranged in the rope drawing grooves, and the other ends of the drawing ropes are movably connected with contraction blocks. The upper end of the side, attached to the skin, of the fixing band body is fixedly connected with a first air bag, the lower end of the side, attached to the skin, of the fixing band body is fixedly connected with a second air bag, and the fan-shaped tourniquet with the wide upper portion and the narrow lower portion can better adapt to differences of limb shapes and sizes of different patients; according to the tourniquet, the fixing band body is arranged, the attaching degree of the fixing band body and the limb is further adjusted through the drawing rope, the tourniquet can be tightly attached to the limb parts with different thicknesses, the multiple air bags can distribute pressure more evenly, and the risk of tissue ischemia and even necrosis caused by uneven pressure is reduced.

The invention relates to the technical field of medical instruments, in particular to a portable leading-in instrument which comprises a shell, a sleeve and a protruding block are arranged on the upper side of the shell in a matched mode, a butt-joint sleeve is coaxially, correspondingly and detachably fixed to the top of the sleeve, a reciprocating rod is slidably connected into the butt-joint sleeve, and a disc block is coaxially fixed to one end of the reciprocating rod. A plurality of micro needle tubes are arranged at the end, away from the reciprocating rod, of the disc block, a liquid storage structure used for supplying liquid to the micro needle tubes is arranged at the other end of the reciprocating rod, a driving structure used for driving the reciprocating rod to reciprocate is arranged in the sleeve, and an air blowing drying structure is further arranged on the shell. According to the device, the effect of guiding liquid medicine into the skin after skin breaking can be achieved, the accurate and uniform liquid medicine guiding effect is achieved, meanwhile, air blowing and skin drying operation can be conducted on the skin with many skin hairs, and the whole device is convenient to operate and convenient to carry.

The invention relates to artificial skin, in particular to self-generating full-layer artificial skin for wound treatment and application of the self-generating full-layer artificial skin. The artificial epidermis has an epidermis-dermis structure similar to skin, and the artificial epidermis structure is composed of an electrostatic spinning nano-film with piezoelectric capacity and has the functions of sterilization, protection and bioelectricity generation of an epidermis layer; the artificial dermal structure is composed of a photo-crosslinking polysaccharide and enzyme crosslinking protein interpenetrating hydrogel skeleton, by adding bioactive components and loading living cells, the effects of releasing active components and cytokines, remodeling wound extracellular matrix and promoting cell proliferation are achieved, and finally healing of acute and chronic wounds is remarkably accelerated. The invention provides a simple, feasible, economical and effective treatment method for sealing a large-area wound, sterilizing the wound and promoting healing of the wound.

The invention relates to the technical field of cosmetics, in particular to a product containing flexible glucan, which can be prepared by treating materials containing glucan by adopting high-pressure microjet. According to the product containing the flexible dextran, the flexible dextran has a special intramolecular and intermolecular arrangement mode, has excellent effects of promoting wound healing and resisting inflammation, has an outstanding effect of promoting skin repair after being added into cosmetics, can effectively improve the after-healing effect of dot matrix laser, acid brushing, microneedle and other medical beauty projects, and has a good application prospect. Meanwhile, the repair of sensitive skin can be promoted. According to the preparation method of the product containing the flexible glucan, the intramolecular and intermolecular arrangement form of the glucan can be adjusted, the flexibility of the product is improved, meanwhile, the room-temperature stability of the product is improved, and the product can be massively added into cosmetics.

The present invention relates to the field of biomaterials, specifically a collagen material comprising recombinant humanized collagen type 21 (ColpepA1 21) and its application in facial augmentation. This invention utilizes collagen to not only provide an effective solution to skin aging but also promotes the natural synthesis of collagen within the skin, optimizing skin hydration and barrier function, and enhancing the skin's self-repair capacity. The resulting collagen material is a facial augmentation material. Through local injection or external application, it rapidly smoothes and firms the facial skin, while also improving overall skin health with long-term use.

It relates to Centella asiatica-derived exosomes, which is useful in the treatment and / or care of skin. In particular, Centella asiatica-derived exosomes is effective in enhancing skin whitening, reducing skin wrinkles, enhancing skin hydration, and improving skin antioxidant capacity.

Methods, devices, and systems for treating a region of interest (ROI) of skin of a subject or patient in need thereof are disclosed. Such a method of treating a ROI, in some embodiments, comprises irradiating a test region (TR) of the skin with a sub-therapeutic dose of electromagnetic radiation or with a series of sub -therapeutic doses, determining a tissue response of the TR, and generating one or more therapeutic dose parameters based at least in part on the tissue response of the TR. In some embodiments, the method further comprises irradiating the ROI with one or more therapeutic doses of electromagnetic radiation in accordance with the one or more therapeutic dose parameters.

The invention relates to the technical field of medical instruments, in particular to a microneedle array device for skin. Comprising a shell, and the array assembly comprises a microneedle assembly and a driving assembly used for driving the microneedle assembly; the guide assembly is used for guiding the movement of the microneedle array; the detection assembly is provided with a high-frequency ultrasonic sensor and used for detecting the skin thickness. The data acquisition module acquires thickness information, and the data analysis module determines the target penetration depth of the microneedle and generates a control instruction according to the thickness information. And the microneedle driving module drives the microneedle to act after receiving the instruction. The penetration feedback module detects the actual penetration depth in real time and judges whether the actual penetration depth reaches the standard or not. And when the penetration is unqualified, the strategy regulation and control unit adjusts the driving strategy according to the deviation direction between the actual depth and the target depth, so that accurate and controllable micro-needle penetration is realized. The problems that medicine liquid cannot be effectively injected according to different skin thicknesses, and whether potential safety hazards exist in the actual penetration depth of the skin or not cannot be found in time are solved.

The invention discloses a skin anti-wrinkle whitening composition containing ginkgetin and a preparation method of the skin anti-wrinkle whitening composition. The composition takes ginkgo biflavone as a main active component, has the characteristics of safety and effectiveness, can remarkably improve skin elasticity and reduce wrinkles, and has the effect of whitening skin.

The preparation method comprises the following steps: mixing and stirring polyvinyl alcohol and deionized water, cooling, adding glycerol and hyaluronic acid, stirring, adjusting the pH value to be acidic, cooling, adding a modified additive, stirring, injecting into a mold, repeatedly freezing and thawing, and carrying out vacuum drying to obtain the anti-wrinkle and anti-aging polymer hydrogel mask. In the using process of the hydrogel mask, when the internal modified additive makes contact with the skin surface, due to the weak acidity of the skin, an iron organic frame structure on the surface of the modified additive is attacked by hydrogen ions, coordinate bonds of the modified additive are damaged, and a skeleton is partially or completely dissociated; the active substances can be slowly released under the action of the modified additive, advanced oxidation caused by too fast release of the active substances is prevented, and the modified additive also contains a nano silicon dioxide structure, so that the mask has certain air permeability, the strength, elasticity and toughness of the mask are improved, and the mask cloth is prevented from being easily torn.

A system for treating infantile hemangioma includes a first active substance delivery portion and a second active substance delivery portion. The first active substance delivery part delivers a first active substance to the superficial surface of the skin; the second active material delivery unit delivers a second active material to the deep part of the skin. The first active substance contains a beta receptor blocker, and the second active substance contains an antibiotic. Through verification, the beta receptor blocker and the antibiotic are delivered subcutaneously, and the effect of synergistically enhancing anti-angiogenesis and hardening promotion on infantile hemangioma is achieved.

A multi-technology dermal therapy monolithic handpiece includes a spray spray delivery handpiece having an elongate housing terminating in one or more nozzles for directing a therapeutic spray along an axis toward a subject's skin at a desired spray application distance from the subject's skin; and one or more symbiotic therapeutic handpiece elements terminating in an operative end member having a dermal touch surface for delivering a therapeutic substance to the skin, the therapeutic substance symbiotic with the therapy provided by the therapeutic spray, wherein the operating end member and the touch surface are laterally spaced apart from the axis, and wherein the operating end member and the touch surface are axially offset from the one or more nozzles determined to limit proximity of the one or more nozzles to the skin of the subject to a distance not less than the desired spray application distance.

The invention discloses intelligent tongue muscle pressure detection equipment, and relates to the technical field of tongue muscle pressure detection. Comprising an array type sensing assembly, and the array type sensing assembly comprises an array type Hall sensor, a middle elastic body and a magnetic film which are sequentially connected from bottom to top; the array type Hall sensor comprises a substrate layer, a plurality of graphene active parts are uniformly arranged on the substrate layer in an array mode, and metal electrodes are arranged on the peripheral sides of the graphene active parts. The device further comprises a handheld assembly, and the handheld assembly is connected with the array type sensing assembly. The array type sensing assembly is integrally soft and can fully combine with the deformation characteristic of human skin, and the multiple graphene active parts are arranged in an array and matched with the vertical periodic magnetization magnetic film, so that the force resolution, the sensitivity, the linearity, the hysteresis and the like are greatly improved; and a basis is provided for subsequent clinical experiments such as tongue muscle pressure test and marketization application.

The invention relates to a consumable device for sweat-based monitoring, the consumable device comprising a proximal part configured to contact with a user, and further comprising: a) a sweat induction means on the proximal part, comprising: i. a sweat promoter configured to contact the skin of a user, and ii. a microfluidic structure; and b) a sweat interrogation means, located distally to the sweat induction means and comprising: i. a sample area; and ii. a passive fluid pump configured to induce the flow of the liquid through the sample area. The microfluidic structure is configured to convey fluid from the sweat promoter to the sample area. The invention also relates to a sweat-monitoring system comprising: a consumable device as above and a sweat-based monitoring device, the sweat-based monitoring device comprising sensing means and processing means.

Disclosed are effective, non-irritating, skincare formulations containing an alpha hydroxy acid and urea or a urea derivative for topical application to the skin. The disclosed topical formulations provide enhanced penetration of the active ingredients to the skin for the treatment of amenable skin conditions, such as very dry skin and keratosis pilaris, as well as for improvement of aesthetic skin properties. Also provided are methods for therapeutic treatment of dermatological conditions by topically applying a formulation comprising (% w / w) at least 10% alpha hydroxy acid and at least 10% urea. The formulations may be cream emulsions, spray-ons, among other delivery systems.

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The present application relates to the field of artificial intelligence, and discloses a VEM-multimodal emotional skin system, which adopts a micro electromagnet to realize expression simulation of skin through a magnetic peristalsis method in a soft magnetic colloid, and adopts various touch sensing methods to realize touch sensing of the skin, wherein the multimodal emotional skin system supports a VEM-Token rhythm model, a VEM-sync emotion synchronization model and a VEM-fe expression function model through expression instructions and touch functions which can be closed-loop and standardized, forms an innovative scheme of emotional skin, provides a multimodal emotional skin product of expression output and touch sensing input of a humanoid robot, realizes an emotional simulation function of 'blushing at a touch', and can be used for facial skin and body skin.

The invention relates to composite cosmetic nanoparticles with an acne removing effect and a preparation method of the composite cosmetic nanoparticles, and belongs to the technical field of functional skin care products and nano entrapment. According to the nano-particles, low-molecular chitosan is used as a main carrier, and natural multifunctional acne-removing components including a white willow bark extract, a tea catechin substance, a pomegranate peel extract and a hovenia dulcis thunb fruit extract are jointly embedded, so that a stable nano-particle structure with the particle size of 50-200 nm is formed; and sodium hyaluronate is used for surface modification so as to enhance skin adhesiveness and permeability. The multi-target synergistic active component can effectively inhibit the growth of propionibacterium acnes, relieve inflammatory response, regulate sebum secretion and enhance the antioxidant repair capacity of skin. The nano-particles prepared by the invention are concentrated in particle size distribution, high in entrapment rate and good in biocompatibility, are suitable for essence, spray, mask type and gel type acne-removing skin care products, and show excellent product transformation potential.

The invention discloses a novel bifidobacterium infantis strain and application of extracellular products of the novel bifidobacterium infantis strain in delaying skin aging and regulating skin micro-ecology, and bifidobacterium infantis is bifidobacterium infantis BSJM24L007 which is preserved in the China General Microbiological Culture Collection Center (CGMCC for short) and has the preservation number of CGMCC No.33258. The invention further discloses a preparation method of the novel bifidobacterium infantis strain and the application of the extracellular products of the novel bifidobacterium infantis strain. The bifidobacterium infantis extracellular product prepared by the invention has an ideal effect of delaying skin aging, enables the skin to be more compact and elastic, reduces the generation of wrinkles and maintains normal metabolism of the skin, has relatively high safety, can effectively reduce the skin infection problem caused by staphylococcus aureus and propionibacterium acnes, and has a good application prospect. Skin infection and inflammation are reduced, skin health is promoted, and skin micro-ecological balance is maintained. The requirements of a modern skin external preparation on functionality and safety are met.

The invention discloses a composite gel for skin correction and a preparation method thereof. The composite gel is formed by dissolving sodium hyaluronate, epidermal growth factors and a protein stabilizer in a buffer system; the content of the sodium hyaluronate is 1.0-50.0 g / L, the content of the epidermal growth factor is 1000-30000 IU / mL, and the content of the stabilizer is 5.0-100.0 mg / L; the pH value of the buffer system is 6.5-7.5. The preparation method comprises the following steps: S1, dissolving sodium hyaluronate and a stabilizer in a buffer system under a sterile condition, and stirring to obtain gel A; s2, adding epidermal growth factors into the gel A, and stirring to obtain the composite gel. The composite gel disclosed by the invention can activate epithelial fibroblasts, update and reconstruct ECM and maintain the stability of an ECM microenvironment. The composite gel disclosed by the invention integrates the functions of supplementing lost extracellular matrix, increasing the number of cells and promoting synthesis of collagen by a traditional filling material, can solve the skin problems caused by various factors, and achieves the effect of correcting the skin.

The invention provides a preparation method of a composite artificial flap with a bionic structure and function induction activity. The preparation method comprises the following steps: S1, preparing an epidermis induction layer; s2, preparing a dermis functional remodeling layer; s3, preparation of a vascularization integration substrate layer; and S4, three-layer compounding and sterilization. Through an epidermis-basilar membrane-dermis three-layer integrated structure, a micron-nano multistage gradient pore and basilar membrane belt adhesion structure of natural skin is accurately simulated, and the problems of epidermis-dermis layering and non-uniform cell infiltration of an existing skin flap are solved.

The embodiment of the invention discloses a bionic skin, which comprises a uniform humidity layer, a third detection layer and a heating layer which are stacked, the third detection layer is arranged between the uniform humidity layer and the heating layer, the third detection layer is used for detecting the surface pressure of the bionic skin, the uniform humidity layer is used for uniformizing the surface humidity of the bionic skin, and the heating layer is used for heating the heating layer. The heating layer is used for adjusting the actual temperature value of the surface of the bionic skin, and the heating layer can deform. Therefore, through cooperation of the third detection layer, the humidity equalizing layer and the heating layer, multiple functions of pressure sensing, humidity adjusting and temperature adjusting can be achieved, and therefore the complex and diversified functions of human skin can be simulated. Compared with a single simulation function, the bionic skin provided by the invention can realize simulation of multiple functions, so that the real state of the human skin after the wearable product is worn can be better simulated, the wearable product can be improved, and the use comfort of a user of the wearable product can be improved.

A system for applying a transdermal monitor to a person may include a retractable assembly, a sensor, and a base having an adhesive for coupling the sensor to the skin. The sensor is positioned within the retractable assembly as the base extends from a distal end of the system. The system may be configured to couple the sensor to the base by compressing the retractable assembly.

The invention provides a whitening and anti-aging extracellular vesicle compound as well as a preparation method and application thereof. The extracellular vesicle compound comprises extracellular vesicles derived from mesenchymal stem cells and active ingredients loaded in the extracellular vesicles, the active component comprises any one or a combination of at least two of retinoic acid, arbutin, panthenol, nicotinamide, ectoine, vitamine, hyaluronic acid, vitamin C, resveratrol or retinol; the ratio of the extracellular vesicles to the active ingredients is (1-10) * 10 < 8 >: (0.01-1) mg. The skin-care active ingredients are entrapped in the extracellular vesicles derived from the mesenchymal stem cells, so that the delivery efficiency of the skin-care active ingredients can be remarkably improved, the direct irritation of free components to the skin can be reduced, the generation of matrix metalloproteinase-1 (MMP-1) and melanin can be effectively inhibited, the light aging process of the skin can be delayed, and the skin-care composition has excellent whitening and anti-aging effects.

The present invention relates to an antimicrobial and healing formulation for skin, designed to effectively target and treat skin conditions such as acne caused by Cutibacterium acnes, cold sore lesions due to the herpes simplex virus, and superficial wounds. This unique formulation combines antimicrobial agents, plant extracts and essential oils in specific proportions in order to exert a synergistic action, enhancing their individual efficacy in the treatment of skin conditions and promoting skin healing. The innovative formulation composed of niaouli (Melaleuca viridiflora) essential oil and tea tree (Melaleuca alternifolia) essential oil, chlorhexidine digluconate, Hamamelis virginiana extract, panthenol, glycerol, and propylene glycol. Each ingredient has been selected for its proven pharmacological properties and its synergistic potential. The formulation works in concert to reduce microbial load, alleviate inflammation, and accelerate skin healing, while providing a gentle and effective application.

The utility model relates to the field of skin care equipment, and provides skin care equipment and a control circuit thereof. The control circuit of the skin care equipment comprises a light-emitting unit, a contact recognition unit, a skin color detection unit and a control unit. The control unit is connected with the light emitting unit, the contact recognition unit and the skin color detection unit, the contact recognition unit is used for generating the contact electric signal used for determining that the light emitting part makes contact with the skin when the light emitting part makes contact with the skin partially or completely, and skin color information of the skin can be detected through the skin color detection unit. The light emitting unit can be controlled to output light energy by determining that the preset condition is met according to the skin information under the condition that the light emitting part is in contact with the skin part. While the skin care requirements of the user on different parts of the human body are met, the user can be prevented from misjudging the failure or damage of the skin care equipment, the application range of the skin care equipment can be widened, the use experience of the user is improved, and the viscosity of the user is increased.

A container including a multi-part cap assembly including upper and lower caps and an applicator for applying creams, gels, ointments, powders, and / or cosmetics, and / or adapted for massaging, cleaning, and / or exfoliating the skin of a human, is shown and described.