The application belongs to the technical field of biological
medicine, and specifically discloses a
trollius chinensis extract, a preparation method thereof, and application of the
trollius chinensis extract in preparation of
trollius chinensis granules. The trollius chinensis extract is prepared by using a two-phase low eutectic
solvent extraction process. The preparation method can simultaneously extract two types of active ingredients, i.e. hydrophilic and hydrophobic active ingredients, in trollius chinensis, effectively solving the problem of incomplete coverage of ingredients and low extraction yield caused by traditional single
solvent extraction. Meanwhile, the two-phase DES used for extraction has the advantages of high extraction efficiency, good
biocompatibility, strong adjustability, green
environmental protection, and the like, and the extraction process has low
energy consumption, high safety, and high industrial feasibility. Compared with the extract prepared by a conventional extraction method, the trollius chinensis extract provided by the application contains both hydrophilic and hydrophobic active ingredients, and the different active ingredients synergistically play a role, so that the antibacterial and anti-inflammatory effect is better. The application can be applied to the preparation of trollius chinensis extract and related oral preparations.