93 results about "Vitexin" patented technology

A process for preparing globeflower flavone, luxtexin, vitexin and quercetin-neohesperidoside from Chinese globeflower flower includes such steps as reflux extract in alcohol solution, adsorbing by macroreticular resin, cluting, concentrating, drying to obtain globeflower flavone, and separating and purifying, luxtexin, vitexin and quercetin-neohesperioside by HSCCC.

The invention discloses a preparation method of a Flos Trollii Flavonoid for injection. The extract of the Flos Trollii Flavonoid substantially comprises orientoside, vitexin, etc., flavone ingredients, the flavonoid content of which is more than 70 percent. The invention discloses the preparation method of the extract, which is mainly characterized in that the extract is acquired through refined treatment with twice column chromatography; the adsorption materials adopted are two among macroporous resin, polyamide or silica gel, reverse phase silica gel and gelatin and so on; the extract is prepared with modern technology of extraction, concentration and refining; the method is simple and easy to operate, improves the effective component purity of the raw medicinal materials and reduces the dosage and adverse reactions.

The present invention discloses the extraction process of vitexin and the extraction process includes the following steps: obtaining coarse haw leaf extract, hydrolyzing the coarse haw leaf extract in water solution of strong acid, separating crystal, and re-crystallization to obtain the product vitexin. The vitexin product has purity over 98%, and may be used in preparing instilment liquid, freeze dried powder, tablet, capsule or dripping pill applied in the treatment of cardiac vascular diseases, including coronary heart disease, myocardial infarction and angina pectoris.

This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3′,4′,5′-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

This invention discloses a method for separating vitexin derivatives, vitexin-4'-O-glucoside and vitexin-2''-O-glucoside. The method comprises: (1) pulverizing hawthorn leaves into coarse powder, extracting by refluxing in alcohol aqueous solution, filtering, incorporating the filtrates, vacuum-concentrating to no alcohol odor, removing impurities with macroporous adsorption resin AB-8 or D101, eluting with 30-80% ethanol, vacuum-concentrating to no alcohol odor, decolorizing with petroleum ether, extracting with n-butanol, vacuum-recovering n-butanol, separating the extract by silica gel column chromatography, eluting with chloroform-methanol at a ratio of (4-3):1, vacuum-concentrating the eluate, separating by silica gel column chromatography,, eluting with ethyl acetate-butanone-methanoic acid-water or ethyl acetate-acetone-methanoic acid-water, and standing at 0-15 deg.C to obtain vitexin-4'-O-glucoside and vitexin-2''-O-glucoside. The method has such advantages as high yield, high purity, simple process and low toxicity, and is environmentally friendly.

The invention discloses a soil improvement agent. The soil improvement agent is characterized by being prepared from the following raw materials in parts by weight: 50-70 parts of pond sludge and cow dung firing soil, 5-8 parts of oyster shells, 10-15 parts of pomacea canaliculata, 5-10 parts of vitexin leaf ash, 2-5 parts of stellera chameajasme, 3-5 parts of winter cherry, 2-6 parts of castor beans, 3-6 parts of peach leaves and 1-4 parts of cocklebur fruit. The invention also discloses a preparation method of the soil improvement agent. By the soil improvement agent, fertilizer efficiency can be improved, and furthermore, underground injurious insects can be prevented and controlled. The soil improvement agent provided by the invention is a bio-organic fertilizer, and is safe and environmentally friendly; waste materials are changed into things of value; a soil structure can be adjusted, and the soil can be loosened; the effect of moisturizing is achieved; soil physical and chemical properties are improved; the soil improvement agent is particularly suitable for growth of garden plants. Biological insecticidal plants are mixed in the soil improvement agent, injurious insects in the soil can be killed directly, and healthful growth of trees is guaranteed.

A method for treating and/or preventing the cardiovascular and hepatic diseases induced by hyperlipidemia which comprises administered thereto an effective amount of bioflavonoids extract derived from fructus crataegus such as; rutin, quercetin, kaempferol and vitexin or a mixture thereof.

The invention discloses a moringa oleifera leaf extract with lipid lowering activity. The total content of total phenolic acid and total flavonoids reaches 50% or above, the content of isoquercitrin is not lower than 6%, the content of kaempferol-3-glucoside is not lower than 1.5%, the content of vicenin-2 is not lower than 1.5%, the content of chlorogenic acid is not lower than 2%, the content ofisovitex is not lower than 0.15% and the content of vitexin is not lower than 0.15%. The invention further discloses an extraction method of the moringa oleifera leaf extract. The moringa oleifera leaf extract prepared through the method is relatively high in extraction rate and stable in component content.

The invention relates to medicine technology field, which precisely relates to the method of separating and purifying a monomer 4'' '-O-rhamnosylrutin, a vitexin-2'' -O-rhamnoside and a 4''-O-glucopyranosylvitexin from hawthorn leaves. At home or abroad, the methods of column chromatography, recrystallization and so on are generally adopted to separate and purify the effective monomers from the hawthorn leaves. The invention method comprises preparing hawthorn leaf crude extracts by immersing or refluxing the hawthorn leaves into water or ethanol water solution, using macroporous adsorption resin to wash and eliminate the water-soluble impurity respectively by water or low concentration ethanol, washing by means of the lower concentration ethanol, obtaining the hawthorn leaf macroporous adsorption resin extracts by decompressing and concentrating the eluent and separating and purifying the extracts using the method of combining the high speed countercurrent chromatography with the preparative liquid chromatography, by which the 99 percent above purity 4'' '-O-rhamnosylrutin, vitexin-2''-O-rhamnoside and 4''-O-glucopyranosylvitexin are prepared. The preparation method is simple to operate, of high separating efficiency and excellent product purity, which is suitable for industrial production.

The invention relates to the technical field of medicine, and in particular, relates to a use of vitexin. The invention discloses the use of vitexin, prodrugs and pharmaceutically acceptable salts or vitexin-containing plant extracts in preparation of drugs or health-care products for prevention or treatment of ulcerative colitis. The vitexin disclosed for the first time can significantly improve the experimental ulcerative colitis mice bloody stool, shortening of colon, tissue pathological damage and other symptoms, provides a new choice for clinical treatment of ulcerative colitis, and has a good application prospect.

The invention relates to a natural food preservative containing lysozyme. Preservative active ingredients in the composition consist of lysozyme and vitexin, wherein the lysozyme accounts for 20-80% of the weight percentages of the preservative active ingredients and the vitexin accounts for 80-20% of the weight percentages of the preservative active ingredients. Compared with the traditional chemical preservatives, the preservative is simple in preparation method and reasonable in compatibility. The two active ingredients play their own functions, and at the same time can synergistically inhibit specific bacteria, yeast, etc. in food and prolong the shelf life of the products. The lysozyme and vitexin are natural in source and free of toxic or side effects.

The invention discloses an Apio americana medikus leaf flavone extract, a preparation method and applications thereof, wherein the Apio americana medikus leaf flavone extract contains 78-87% by mass of total flavonoids, the total flavonoids contain vitexin and schaftoside, and by using the Apio americana medikus leaf flavone extract as the reference, the mass fraction of the vitexin is 45-50%, and the mass fraction of the schaftoside is 19-24%. According to the present invention, by using the Apio americana medikus leaf as the object to extract the flavone substances, the obtained Apio americana medikus leaf flavone extract is rich in flavones, especially vitexin and schaftoside, can effectively inhibit the activity of alpha-glucosidase, can promote the carbohydrate metabolism of cells, and has blood glucose lowering activity.

The invention discloses semen hoveniae extracts with a liver protection function and an extraction and separation method and application thereof. The extracts comprise, by mass, 10-99% of total flavone C-glycoside, wherein the main flavone C-glycoside comprises six kinds of flavone C-glycoside including vitexin 2''-O-beta-D-glucopyranoside, spinosin, poloretin-3', 5'-di-C-beta-D-glucopyranoside, 6'' '-acetyl spinosin, 6'' '-p- hydroxyl-cinnamoyl-spinosin and 6'' '- sinapoyl-spinosin. The total flavone C-glycoside is extracted from semen hoveniae and used for preventing and treating acute and chronic hepatitis and alcoholic liver disease; compositions at effective parts are accurate; toxicity is small; the pharmacological action is high, and a good medicine prospect is achieved. The extracts and acceptable agents on pharmacy are adopted to be prepared into various dosage forms through a conventional method, like tablets, pills, capsules and granules. The dosage is 200-800 mg/each person/day.

The invention discloses a C-glycosylflavones composition. The composition is extracted from plants of genus Trollius, and mainly contains orientin, vitexin, or vitexin esters and orientin esters. The invention also discloses a preparation method of the C-glycosylflavones composition. The preparation method is characterized by comprising extracting Trollius Chinensis Bge., performing macroporous resin column chromatography, and performing selective gradient elution with ethanol-water mixed solvent. The macroporous resin is preferably weak polarity macroporous resin. The C-glycosylflavones composition has pharmacological effects in resisting oxidation and inflammation, and inhibiting bacterial infection; and can be applied as ingredient of drugs and functional foods.

The invention relates to a drug combination for preventing and treating cardiovascular diseases, in particular to drug using EPA and vitexin as main active ingredients. The drug combination is formed by combining polyunsaturated fatty acid with c-glycosyl flavone. Experimental studies show that the combination has obvious improving and treating effect on cardiovascular system diseases. Raw materials used for the drug combination are extensive in source, natural, nontoxic, little in side effect and low in cost, and the drug combination has high actual application value.

The invention provides a special traditional Chinese medicine polysaccharide feed additive for pets. The formula is selected from astragalus polysaccharide, polysaccharides from radix codonopsis, glycyrrhiza polysaccharide and vitamins; plant polysaccharide is one of the main active components of traditional Chinese medicine; vitamins are necessary substances for maintaining the normal growth and metabolism of animals; the combination of plant polysaccharide and vitamins has the effect of enhancing the anti-stress of pets in the high-temperature and low-temperature severe environments; by virtue of the combined utilization of rosmarinic acid, sodium tripolyphosphate, titanium dioxide, sorbitol, microcrystalline cellulose and vitexin, the anti-stress effect of astragalus polysaccharide, polysaccharides from radix codonopsis, glycyrrhiza polysaccharide and vitamins on pets can be improved, the survival rate of pets in severe environments can be enhanced, meanwhile the immune response capability of pets can be reduced, and the immune antibody level of pseudo rabies vaccines can be reduced. By virtue of a great amount of explorations, the problem of reduction of immune response capability of pets can be solved by combining the special preparation technology, and the immune antibody level of pseudo rabies vaccines can be improved.

The invention provides a quality test method for hawthorn leaf medicine, hawthorn leaf extractives or products. Mobile phase composition is tetrahydrofuran-acetic acid-water-carbinol-acetonitrile. The specific composition comprises 10 volume parts to 30 volume parts of tetrahydrofuran, 0.5 volume parts to 4 volume parts of acetic acid, 60 volume parts to 89.5 volume parts of water, 0 volume part to 3 volume parts of carbinol and 0 volume part to 3 volume parts of acetonitrile. A mobile phase is matched according to the appropriation, and a potential of hydrogen (pH) value is adjusted to 3.5 to 4.4 with truethylamine. The mobile phase is used for measuring characteristic atlas of the content of hyperin, the content of rhamnosylvitexin or hawthorn leaf extractives in the hawthorn leaf medicine, the hawthorn leaf extractives and the products. Separation situations of hyperin, rhamnosylvitexin and vitexin with adjacent peaks are remarkably improved, service life of chromatographic columns is prolonged, and great significance is provided for controlling quality of the hawthorn leaf medicine, the hawthorn leaf extractives and the products.

The invention relates to a Vitexin injection or oral administration preparation for treating cardiovascular diseases and process for preparation, wherein each 1000ml of the Vitexin injection comprises Vitexin 0.1-100g, each 1000 dosage units of the oral administration preparation comprises Vitexin 0.1-100g, and medicinal supplementary materials comprises diluent, flow aid, auxiliary solvent, excipient and osmoregulation agent.

The invention relates to a method for extracting vitexin from sandalwood leaves, which comprises the following steps: (1) taking sandalwood leaves, washing with water, drying, pulverizing, adding a methanol solution, immersing, extracting under reflux 1-3 times, merging the extracting solutions, and filtering to obtain a filtrate; (2) drying the filtrate by distillation to obtain a dry extractum, adding 50-95 DEG C hot water into the dry extractum to obtain a suspension, and regulating the pH value to an acidic state; (3) extracting with an organic solvent 1-3 times, discarding the supernate, and taking the middle emulsion layer for later use; enhancing the alcohol concentration of the understratum suspension with methanol, carrying out ultrasonic treatment, standing, and mixing the understratum precipitate-containing solution with the middle emulsion layer; carrying out vacuum filtration; and (4) washing the precipitate obtained after vacuum filtration, dissolving in an ethanol solution under reflux, filtering, recrystallizing, and carrying out vacuum filtration to obtain the vitexin. The method has the advantages of simple technique and low production cost; and the vitexin yield can achieve more than 75% of the theoretical content of vitexin.

The invention discloses a vitexin glucoside injection and a preparation method thereof. The injection employs vitexin glucoside as an active ingredient and water for injection as a solvent, wherein the effective dose of the active ingredient is 1-10 mg vitexin glucoside per 1 ml injection. The preparation method comprises the following steps of: weighing the vitexin glucoside and antioxidant according to the prescription quantities thereof, and adding the water for injection, which accounts for 80% of the prescription quantity, to the mixture of the vitexin glucoside and the antioxidant so that the mixture is dissolved; regulating the pH to a range of 5.5 to 7.5 by using 10% of sodium hydroxide solution; next, adding 0.1% of active carbon to the solution obtained in the previous step, stirring the solution evenly, decarbonizing and filtering the solution, leading the filtrate to flow through a filter membrane of 0.22 microns; adding the water for injection to the full quantity, and then performing filling and sealing; and finally, sterilizing the product in a water bath at 100 DEG C for 30 minutes. The vitexin glucoside injection solves the problems of taking effect slowly, low bioavailability and great difficulty in control of product quality in the existing hawthorn leaf preparation, and provides a new medicine for treating ischemic heart diseases for clinical therapy.

Non-therapeutic cosmetic or dermatological use of at least one of a compound selected from the group consisting of: gibberellic acids, naringenins, N-acetylaspartic acids, β-aescin, arachadonic acid, quercetin, vitexin and docosahexaenoic acid (ethyl ester). Suitably, the use is in the treatment of, and/or prevention of, at least one sign of skin ageing or at least one sign of a skin damage condition associated with ageing, wherein the sign of skin ageing or skin damage is present on skin of the face, body or the scalp of a subject.

The invention provides a method for synchronous extraction of vasicine and vitexin from adhatoda vasica. The method includes: subjecting dried adhatoda vasica stems and leaves to microbial fermentation, then using ethanol and chloroform solutions for extraction, and carrying out fractionation, filtering, pressure reduced concentration, adsorption column chromatography, ion exchange chromatography,decolorization and crystallization, thus obtaining vitexin and vasicine pure products with purity of more than 95%. The method employs aspergillus for fermentation treatment, effectively reduces theinfluence of starch and fiber in adhatoda vasica on extraction of active substances, and improves the dissolution rate and yield of vasicine and vitexin. Ethanol and chloroform are employed for synchronous extraction of vitexin and vasicine, and a variety of active ingredients can be acquired rapidly.

The invention relates to a new use of vitexin xyloside, and concretely relates to an application of the vitexin xyloside in the preparation of medicines for treating metabolic diseases. The metabolic diseases are hyperlipidemia or hyperglycemia, and complications thereof. A test result shows that the vitexin xyloside has obvious diabetic mouse blood sugar and blood fat reducing effects, and is better than substances in the prior art, and the action of the vitexin xyloside has a certain dose-effect relationship.

The invention relates to the technical field of medicines, in particular to an application of vitexin in preparation of a drug for treating postoperative pain. A medicinal preparation is generally used in an intraperitoneal injection mode, and also can adopt other drug delivery modes: after molding, acute (single time) drug delivery dosage is 1-10 mg/kg, and chronic (repeated times) drug delivery dosage is 3-10 mg/kg. According to the medicinal preparation, the postoperative pain can be effectively relieved with the adoption of both acute drug delivery and chronic drug delivery, sedative side effects are avoided, and tolerance and addiction are not observed.

The invention relates to a method which is easy for industrial separation and purification of vitexin xyloside. The method has high extraction efficiency. The technology comprises steps as follows: extraction of ethanol, macroporous resin column chromatography and preparation of high performance liquid chromatography for separation and purification. Purity of vitexin xyloside prepared by the method reaches more than 90%. The preparation method is safe, simple and low-cost, and is suitable for industrial production.

The invention provides a preparation method of vitexin-2''-O-rhamnoside pills, which comprises the following steps: heating hawthorn leaf activated monomer component vitexin-2''-O-rhamnoside and matrix, fusing and stirring evenly; and pouring into a condenser at a certain speed and shrinking the solid solution to prepare into the vitexin-2''-O-rhamnoside pills. The vitexin-2''-O-rhamnoside pills prepared by the invention can be solely or jointly applied to treatment of chest obstruction and heart ache with high efficacy.