18 results about "Galangin" patented technology

The invention relates to hyaluronic acid-based nanogel with intestinal targeting and inflammation responsiveness as well as a preparation method and application of the hyaluronic acid-based nanogel, and discloses multifunctional composite nanogel based on hyaluronic acid as well as a preparation method and application of the multifunctional composite nanogel. The preparation method comprises the following steps: loading galangin into bovine serum albumin to prepare BSA-GA nanoparticles with antioxidant and anti-inflammatory activity; 2, synthesizing a multifunctional molecule Se-MHA which is targeted to M2 macrophages and responds to ROS degradation on the basis of hyaluronic acid; 3, BSA-GA nano-particles with the same solution concentration are used as anti-inflammatory functional components to be mixed with Se-MHA to prepare Se-MHA / BG nano-gel, model probiotics are subjected to single-cell modification, probiotic-loaded nano-gel EcN-Se-MHA / BG is prepared, the nano-gel has specific binding and responding capacity on the colitis disease part, colonization of EcN on the colon part is promoted, and the anti-inflammatory effect is achieved. The IBD disease is effectively relieved.

According to the Hainan pig semen preservation diluent as well as the preparation method, the application and the detection method thereof disclosed by the invention, galangin and kaempferide are added into a basic diluent to develop a diluent formula capable of efficiently preserving semen at a low temperature (4 DEG C); the galangin and the kaempferol added into the diluent have a good sperm protection effect and a certain antibacterial ability and can replace antibiotics, and bovine serum albumin (BSA) is further combined as a low-temperature protective agent, so that sperm movement parameters are improved, and the low-temperature preservation time of the boar semen is effectively prolonged; the use amount of antibiotics in pig raising production is reduced, the problem of drug resistance of bacteria can be effectively relieved, and the use of the antibiotics and the generation of drug-resistant bacteria are greatly reduced. According to the method, the semen utilization rate of excellent breeding boars is increased, sow health is guaranteed, the conception rate of deep insemination is increased, and efficient and low-cost artificial insemination is achieved.

The invention discloses a nano preparation for natural product synergistic chemotherapy as well as a preparation method and application of the nano preparation, nanoparticles are formed by self-assembly of an SN38 prodrug sensitive to redox and galangin in a carrier-free manner, and can also be co-assembled nanoparticles modified by polyethylene glycol or entrapped with hydrophobic fluorescent molecules. According to the SN38 prodrug, a fluorene methanol side chain is coupled to an SN38 molecule through a redox-sensitive disulfide bond, so that a prodrug structure with a responsive release characteristic is constructed. The construction of the nano system not only significantly reduces the off-target toxicity of SN38 and improves the tolerance dose of SN38, but also enhances the SN38-mediated chemotherapy effect by the sensibilization effect of galangin, significantly improves the treatment efficiency, and realizes high-efficiency and low-toxicity cancer treatment. The invention provides a novel and synergistic prodrug nano drug delivery platform, and a new strategy is provided for precise treatment of refractory tumors.

The present invention relates to a composition for protecting cells from endoplasmic reticulum (ER) stress and oxidative stress induced by ultrafine dust, comprising galangin as an active ingredient. Galangin, which is an active ingredient of the composition for cell protection of the present invention, alleviated an increase in reactive oxygen species, intracellular calcium, and ER stress-related proteins induced by ultrafine dust PM2.5. In addition, galangin counteracted PM2.5-induced cell cycle arrest at the G0 / G1 phase and restored cell cycle regulators and matrix metalloproteinases. As a result, galangin can enhance cell protection against PM2.5-induced ER stress and cell cycle arrest via reactive oxygen species. Therefore, it is suggested that the composition comprising galangin as an active ingredient of the present invention has great potential as a candidate for a preventive agent or a therapeutic agent for diseases related to ER stress and oxidative stress induced by PM2.5.

The invention relates to the technical field of biological medicines, in particular to a galangal-sourced nano-vesicle as well as a preparation method and application thereof. The method specifically comprises the following steps: crushing rhizoma alpiniae officinarum rhizomes, mixing the crushed rhizoma alpiniae officinarum rhizomes with a buffer solution, soaking in a water bath, and filtering to remove solids so as to obtain a crude extract; and sequentially carrying out centrifugal treatment on the crude extract for four times, so as to obtain the galangal-derived nano-vesicles. The invention provides a method for extracting nano-vesicles from galangal, and finds for the first time that the obtained vesicles can promote osteogenic differentiation of human bone marrow mesenchymal stem cells with high efficiency and low toxicity, the effect of the vesicles is obviously superior to that of known active component galangin, and the cytotoxicity is obviously lower; the invention provides raw materials and methods with great potential for developing novel and safe anti-osteoporosis drugs or inducers.

The invention belongs to the technical field of nano biomedicine, and particularly discloses a preparation method of a galangin-loaded bionic nano dendritic cell (DCs) vaccine and application of the galangin-loaded bionic nano dendritic cell (DCs) vaccine in ovarian cancer treatment. The inner core of the vaccine is galangin (GA)-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles, and the shell of the vaccine is formed by coating a DCs film carrying tumor antigens. The nano DC vaccine retains the antigen presentation function of natural DCs, and the GA loaded on the nano DC vaccine can induce tumor cells to generate immunogenic cell death. By means of the design, the vaccine can efficiently load specific tumor-associated antigens, and the homing capacity of the vaccine to lymph nodes and tumor microenvironments is remarkably enhanced. Experiments show that GA-NPs (at) DCV is used for treating subcutaneous tumor and in-situ ovarian cancer mouse models.

The present invention discloses a new use of a plant-derived glycoside compound, relating to the fields of pesticides and plant protection. The plant-derived glycoside compound is galangin or isomandibolic acid. At the same time, the present invention discloses an agent for resisting tobacco mosaic virus or preventing and controlling crop diseases, comprising the plant-derived glycoside compound as described above. During treatment, an effective amount of the plant-derived glycoside compound can be applied, sprayed, or injected onto tobacco leaves or crops. The present invention first discovered that galangin and isomandibolic acid have good anti-TMV activity, wherein the anti-TMV activity of galangin reaches 82.22%, and the anti-TMV activity of isomandibolic acid reaches 75.00%, providing a material basis for anti-TMV research; molecular docking technology is used to simulate the binding mode of galangin and isomandibolic acid with target proteins, and three potential targets of galangin and isomandibolic acid are screened out based on the minimum binding energy and the number of hydrogen bonds, providing a theoretical basis for anti-TMV research.

The invention relates to the technical field of ultrasonic extraction, and discloses galangin ultrasonic extraction equipment which comprises an extraction tank and an ultrasonic vibration rod, the extraction tank comprises an outer tank body and an inner filtering tank, the inner filtering tank is located in the outer tank body, a rotating cover is arranged on the inner filtering tank, the ultrasonic vibration rod is arranged below the rotating cover, and the ultrasonic vibration rod is arranged below the outer tank body. The ultrasonic vibration rod can move relative to the rotating cover, in the ultrasonic extraction process, the rotating cover drives the ultrasonic vibration rod to rotate in the inner filtering tank, and the ultrasonic vibration rod can move along the diameter of the rotating cover relative to the rotating cover; according to the technical scheme, the ultrasonic vibration rod is arranged in the inner filtering tank, the movement track of the ultrasonic vibration rod can spread all over the whole cavity of the inner filtering tank, meanwhile, the ultrasonic vibration rod can be attached to the inner wall of a tank body of the inner filtering tank, and the inner filtering tank is driven to vibrate through the ultrasonic vibration rod. Meanwhile, the filtering efficiency after extraction can be accelerated.

The invention relates to the technical field of traditional Chinese medicine, and discloses acupoint massage essential oil for assisting in controlling smoke and refreshing and a preparation method of the acupoint massage essential oil. Comprising a monarch drug of galangal essential oil, a ministerial drug of lemon essential oil, an adjuvant drug of mint essential oil, an adjuvant drug of coenzyme Q10, an adjuvant drug of limonene, an adjuvant drug of linalool, an adjuvant drug of methyl cinnamate, a conductant drug of jojoba oil and a conductant drug of vanillin. Through synergistic improvement of a formula and a process, effective components of the massage essential oil enter a human body through mutual cooperation of smelling and acupoint massage, the activity of monoamine oxidase is rapidly inhibited, the fragrance is mild, the smell is pleasant, the massage essential oil is convenient to carry and use at any time, and the user experience and the psychological feeling during use are remarkably improved; when the cigarette holder is used, a user can feel pleasant during smoking, untoward effects and pains caused by smoking addiction are relieved, the number of smoking times can be gradually reduced, and the purposes of controlling smoking and quitting smoking are achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to application and a method of flavonoid compounds in enhancing nucleic acid molecule delivery efficiency of lipid nanoparticles. The invention aims to solve the problems of limited LNP in-vivo and in-vitro delivery efficiency, toxic risk and the like. According to the invention, seven low-toxicity and biocompatible natural compounds such as genistein, glabridin, rhoifolin, luteolin, hesperetin, galangin or pinocembrin are used as an LNP high-efficiency expression enhancer, the compounds and target cells are co-incubated, and then LNP containing nucleic acid molecules is added. According to the scheme, the LNP-mediated gene expression efficiency can be remarkably improved, the cytotoxicity can be reduced, and in-vivo experiments prove that LNP biological distribution can be optimized, target tissue expression can be enhanced, and collaborative optimization of LNP safety and high efficiency is achieved.

The invention provides an application of galangin-3-methyl ether (G3-ME) in preparation of a medicine for treating or preventing pathological cardiac hypertrophy, a pharmaceutical composition of the galangin-3-methyl ether (G3-ME) and a treatment or prevention method of the galangin-3-methyl ether (G3-ME). The pathological cardiac hypertrophy comprises types caused by pressure load, hereditary or inflammatory factors. The active ingredient of the pharmaceutical composition is galangin 3-methyl ether, and the administration dosage is preferably 20-50 mg / kg. Through in-vitro and in-vivo researches, the application value of G3-ME in the medicine for preventing or treating pathological cardiac hypertrophy is disclosed for the first time, and a new way and means are provided for treatment of related diseases.

The invention relates to the technical field of food processing, in particular to a preparation method and application of zein-citrus pectin nanoparticles loaded with galangin. The preparation method comprises the following steps: providing a zein solution, and carrying out first mixing treatment on galangin powder and the zein solution to obtain a galangin-zein solution; dropwise adding the galangin-zein solution into a continuously stirred water phase, and concentrating to remove ethanol, so as to obtain a galangin-loaded zein nanoparticle dispersion liquid; providing a citrus pectin solution, carrying out second mixing treatment on the citrus pectin solution and the zein nanoparticle dispersion liquid loaded with galangin, and then carrying out post-treatment to obtain the zein-citrus pectin nanoparticles loaded with galangin, the nanoparticles are applied to the sauced products for the first time, the heterocyclic amine content in the sauced meat products is effectively reduced, and the safety of the sauced meat products is improved.

The invention relates to the technical field of chewable tablets, and discloses a hawthorn chewable tablet with a health-care function and a preparation method thereof, the hawthorn chewable tablet comprises the following raw materials: hawthorn powder, isomaltooligosacharide, erythritol, sweet orange powder, a galangin inclusion compound and a lubricant; wherein the galangin inclusion compound takes a hyperbranched intermediate as a shell and galangin as an inner core, when the chewable tablet enters the stomach through the oral cavity, the pharynx and the esophagus, chitosan in the hyperbranched intermediate can dissolve and release galangin due to the acid environment of gastric juice, so that the slow-release effect is realized, the chitosan has an excellent antibacterial effect, and the galangin inclusion compound can be used for preparing the chewable tablet. The galangin can reduce gastric acid secretion to protect gastric mucosa, so that gastric ulcer is reduced, inflammatory response can be reduced, wound healing at the gastric ulcer is promoted, and a good treatment effect is achieved.

The invention relates to a composition comprising galangin, oleic acid and adenosine. Said composition can be used as an oral care composition or as a medicament for use in the prevention from or treatment of a disease or symptoms of a disease in a subject, e.g. dentin hypersensitivity, periodontitis and / or gingivitis.

The invention provides application of gallic acid combined galangin in improving body color and muscle flavor of plectropomus latifolius, and belongs to the technical field of development of aquatic feed additives. After gallic acid and galangin are combined according to the mass ratio of (1-3): (1-3), the body color of the red pink bass can be effectively improved, the content of flavor amino acid in muscular tissue of the red pink bass is increased, and on the basis, the invention provides a feed additive, a red pink bass feed and a method for breeding the red pink bass by adopting the red pink bass feed. The feed cost and the breeding cost can be effectively reduced, and the body color and the muscle flavor of the red plectropomus japonicus can be improved.

The present application relates to the technical field of honey detection, and particularly relates to a vitexin, a preparation method thereof and a method for identifying vitex honey. The vitexin has a structure shown in formula 1: The present application finds a new compound, vitexin, in vitex honey through research on the vitex honey. The present application also finds that when the to-be-tested honey contains vitexin (p-hydroxybenzoic acid 1-O-gentio-bioside-5-hydroxy-3,7-diene-[2,6] cyclopentanopyranyl-3-methyl ester), or contains vitexin and new chlorogenic acid, 4-hydroxybenzoic acid, chlorogenic acid, caffeic acid, p-coumaric acid, red flower phaseolus acid, trans, trans-epiabscisic acid, cis, trans-epiabscisic acid, 5-methoxy pinocembrin, pinocembrin, kaempferol, pinocembrin, benzyl caffeate, kojic acid, galangin at the same time, the to-be-tested honey can be determined as vitex honey. The present application also provides a new method for constructing a vitex honey authenticity and quality evaluation system.

The application discloses a self-assembled nano drug of berberine and galangin, which comprises berberine and galangin, and the molar ratio of the berberine and the galangin is 1:1-2. The berberine and the galangin can be self-assembled through a pi-pi bond, electrostatic force and a hydrogen bond to form the self-assembled nano drug, so that the problem of poor water solubility of single berberine and single galangin is improved. Meanwhile, when the self-assembled nano drug is applied to a mouse model of ulcerative colitis, compared with single berberine or single galangin, the self-assembled nano drug significantly relieves the colon shortening, the increase of disease activity index and the intestinal pathological damage phenomenon of the mouse with ulcerative colitis caused by sodium sulfate.

The application discloses a propolis extract and a production process thereof. According to mass percentage, the propolis extract comprises 25-40% of total flavones, 15-30% of total phenolic acids, 10-20% of propolis anthracene acid compounds, ≤3% of moisture, ≤2% of ash, and the balance of other natural propolis components; and the sum of acacetin, galangin and pinocembrin in the total flavones accounts for 30-50% of the mass of the total flavones. The production process comprises freezing and crushing, complex enzymolysis, ultrasonic-assisted ethanol extraction, dewaxing, macroporous adsorption resin purification and drying. The application combines enzymolysis and ultrasonic to significantly improve the extraction rate and purity of active ingredients, and the obtained propolis extract has clear components, high active ingredient content, few impurities, and the process is green and efficient, and is suitable for industrial production.