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Galangin molecular imprinting polymer, and preparation method and application thereof

A technology of galangin and molecular imprinting, applied in chemical instruments and methods, other chemical processes, organic chemistry, etc., can solve the problems of high cost, low recovery rate, poor separation efficiency, etc., achieve high selectivity, improve purity and Recovery, effect of reducing separation steps

Inactive Publication Date: 2014-01-22
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention mainly aims at the shortcomings of poor separation efficiency, low recovery rate and high cost in the separation method of galangin, and provides a molecularly imprinted polymer of galangin

Method used

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  • Galangin molecular imprinting polymer, and preparation method and application thereof
  • Galangin molecular imprinting polymer, and preparation method and application thereof
  • Galangin molecular imprinting polymer, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Weigh 0.27g (1mmol) of galangin and 0.28g (4mmol) of functional monomer acrylamide and dissolve them in 4mL of acetone, and ultrasonicate for 120min in a 10mL colorimetric tube to fully generate template molecules and functional monomers function, then add 3.8mL (20mmol) crosslinking agent ethylene glycol dimethacrylate and 0.033g (0.2mmol) initiator azobisisobutyronitrile, ultrasonic 15min, after fully miscible, pass N 2 Deoxidize for 10 minutes, seal immediately, and polymerize in a water bath at 60°C for 24 hours to obtain a rod-shaped polymer;

[0028] (2) Grind and sieve the rod-shaped polymer obtained in step (1), take a polymer of 200-400 meshes, and repeatedly extract it with a methanol solution with a volume ratio of 10% acetic acid in a Soxhlet extractor, each time for 24 hours, To remove template molecules and unreacted compounds, and then wash with methanol repeatedly, each time for 5h, to remove residual acetic acid to neutral until the eluate is detect...

Embodiment 2

[0031] (1) Weigh 0.27g (1mmol) of galangin and 0.43g (6mmol) of functional monomer acrylamide and dissolve them in 5mL of acetone, and ultrasonicate for 120min in a 10mL colorimetric tube to fully generate template molecules and functional monomers effect, then add 3.8mL (20mmol) crosslinking agent ethylene glycol dimethacrylate and 0.041g (0.25mmol) initiator azobisisobutyronitrile, ultrasonic 15min, after fully miscible, pass N 2 Deoxidize for 15 minutes, seal immediately, and polymerize in a water bath at 65°C for 20 hours to obtain a rod-shaped polymer;

[0032] (2) Grind and sieve the obtained rod-shaped polymer, take 200-400 mesh polymer, and use a methanol solution with a volume ratio of 10% acetic acid to extract repeatedly in a Soxhlet extractor for 24 hours each time to remove template molecules and unreacted compounds, and then washed repeatedly with methanol for 5 hours each time to remove residual acetic acid to neutral until the eluate was detected by ultraviolet...

Embodiment 3

[0034] (1) Weigh 0.27g (1mmol) of galangin and 0.22g (3mmol) of functional monomer acrylamide and fully dissolve them in 4mL of acetone, and ultrasonicate for 120min in a 10mL colorimetric tube to fully generate template molecules and functional monomers function, then add 3.8mL (20mmol) crosslinking agent ethylene glycol dimethacrylate and 0.033g (0.2mmol) initiator azobisisobutyronitrile, ultrasonic 15min, after fully miscible, pass N 2Deoxidize for 10 minutes, seal immediately, and polymerize in a water bath at 55°C for 28 hours to obtain a rod-shaped polymer;

[0035] (2) Grind and sieve the obtained rod-shaped polymer, take 200-400 mesh polymer, and use a methanol solution with a volume ratio of 10% acetic acid to extract repeatedly in a Soxhlet extractor for 24 hours each time to remove template molecules and unreacted compounds, and then washed repeatedly with methanol for 5 hours each time to remove residual acetic acid to neutral until the eluate was detected by ultra...

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Abstract

The invention relates to a galangin molecular imprinting polymer, belongs to the technical field of new materials, and mainly solves the defects that a galangin separation method is poor in separation efficiency, low in recovery rate and high in cost. The technical scheme of the invention is that the galangin molecular imprinting polymer is prepared by the following steps: (1), dissolving a template molecule galangin and a functional monomer acrylamide in a pore forming agent, and fully mixing uniformly; then adding a cross-linking agent and an initiator, mixing uniformly, introducing N2 for deoxidation, sealing, and carrying out water bath polymerization at the temperature of 55-65 DEG C for 20-28 h to obtain a polymer; (2), grinding the polymer obtained in the step (1) into a powder and sieving, successively eluting with a methanol solution having acetic acid with the volume ratio of 10% and methanol, removing the template molecule galangin and residual acetic acid, carrying out vacuum drying to reach a constant weight, and thus obtaining the galangin molecular imprinting polymer. The galangin molecular imprinting polymer has the advantages of high selectivity, high affinity and high efficiency.

Description

technical field [0001] The invention relates to a galangin molecularly imprinted polymer, which belongs to the technical field of new materials. Background technique [0002] Galangin (Galangin, 3,5,7-trihydroxyflavone) is a natural active substance. Clinical pharmacology studies have shown that galangin has antioxidant, antitumor, antiviral, antibacterial, antiteratogenic, and antimutagenic properties. and many other biological activities. In addition, galangin also has certain antispasmodic and antiemetic effects, which has good clinical application value and research prospect. [0003] Galangal is the dry rhizome of Alpinia officinarum Hance, a plant of Zingiberaceae. It is a traditional Chinese herbal medicine in my country and one of the main sources of galangin. At present, there are many methods to extract and purify galangin from galangal. In addition to galangin, galangal also contains kaempferol, quercetin, volatile oil, starch, fat and various trace elements, a...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F220/56C08J9/26B01J20/26C07D311/30C07D311/40
Inventor 孙体健吕慧卿刘文乔华姚杰杨岚
Owner SHANXI MEDICAL UNIV
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