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Medicine containing galangin and preparation method thereof

A kind of technology of galangin and galangal, applied in the field of medicine, can solve the problems of extracting and making medicine products, low content and the like

Inactive Publication Date: 2006-12-20
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the content of galangin in galangin is relatively low, it is easily interfered by other components, which brings great difficulties to the purification of total flavonoids of galangin
Therefore, at present, there is no technical report that is more effective and convenient for large-scale purification of galangin total flavonoids, and there is no product that contains galangin total flavonoids active ingredients extracted from the plant galangin to make medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1: Preparation of total flavonoids of galangin

[0069] Take 20kg of galangal rhizomes, crush them into small pieces, add 95% ethanol to heat and reflux, each time 20000ml, extract 3 times in total, filter, combine the filtrate, and recover the ethanol from the filtrate under reduced pressure to get the concentrate, add water to the concentrate to about 10000ml, add ethyl acetate to extract 3 times, 10000ml each time, combine the ethyl acetate solution, recover the ethyl acetate solution to about 10000ml, and use 5% Na 2 CO 3 The aqueous solution was extracted 4 times, 6000ml each time, combined with Na 2 CO 3 Extract. The extract was adjusted to a pH value of 3 to 4 with 10% hydrochloric acid, allowed to stand for precipitation, and the precipitate was filtered to obtain 298.8 g of crude extract of galangin total flavonoids. The crude extract contained 48.7% of galangin by weight of dry product, containing The total flavonoids are 68.8%;

[0070] The cr...

Embodiment 2

[0071] Embodiment 2: The second preparation of galangin total flavonoids

[0072] Take 20kg of galangal rhizomes, crush them into small pieces, add 75% ethanol and heat to reflux 3 times, 20000ml each time, 2 hours each time, filter, combine the filtrates, and recover the ethanol from the filtrate under reduced pressure to get the concentrate, add water to the concentrate to about 10000ml, add ethyl acetate to extract 3 times, 10000ml each time, combine the ethyl acetate solution, recover the ethyl acetate solution to about 10000ml, and use 4% K 2 CO 3 The aqueous solution was extracted 4 times, 6000ml each time, combined with K 2 CO 3Extract. The extract was adjusted to a pH value of 2 to 3 with hydrochloric acid, allowed to stand for precipitation, and the precipitate was filtered to obtain 308.8 g of a crude extract of galangin total flavonoids. The crude extract contained 41.5% of galangin and total flavonoids in terms of dry weight. 69.5%;

[0073] The crude extract ...

Embodiment 3

[0074] Embodiment 3: Preparation of total flavonoids of galangin

[0075] Take 2kg of galanga rhizome, crush it into small pieces, add 85% ethanol to heat and reflux, 2000ml each time, extract 3 times in total, filter, combine the filtrate, and recover the ethanol from the filtrate under reduced pressure to obtain a concentrate, add water to the concentrate to about 1000ml, add ethyl acetate to extract 3 times, 1000ml each time, combine the ethyl acetate solution, recover the ethyl acetate solution to about 1000ml, extract 4 times with 0.5% NaOH aqueous solution, 500ml each time, combine the NaOH extract. The extract was adjusted to a pH value of 3 to 4 with hydrochloric acid, allowed to stand for precipitation, and the precipitate was filtered to obtain 38.4 g of a crude extract of galangin total flavonoids. The crude extract contained 31.7% of galangin and total flavonoids in terms of dry weight. 52.3%;

[0076] The crude extract of total flavonoids of galanga is dissolved ...

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Abstract

The invention relates to a medicine that contains galangal rhizome and relative preparation, wherein the galangal rhizome chromocor separated from the root of galangal rhizome contains chromocor at 50-99.8% and galangal rhizome at 30-80%. The preparation comprises: (1) extracting, abstracting, inverted abstracting, depositing chromocor, and purifying the galangal rhizome to obtain the galangal rhizome chromocor, to be used to prepare oral or ejection agent. The invention has simple process and easy operation, while the product has high purity. And the inventive medicine can be used to resist oxidization, etc.

Description

technical field [0001] The invention relates to the field of medicine, in particular to extracting galangin-containing total flavonoids from plant galanga and preparing them into injections or oral preparations, and to a preparation method thereof. Background technique [0002] Galangal is the dry rhizome of Alpinia officinarum Hance. As a commonly used traditional Chinese medicine, it has the functions of warming the stomach and dispelling cold, eliminating food and relieving pain. There are many patents applied for in China with galangal as a compatible ingredient, but they are all compound preparations, in which galangal is used as an agent for warming the stomach and dispelling cold, eliminating food and relieving pain, or correcting flavor. [0003] The common name of galangin is galangin, and its chemical name is 3,5,7-trihydroxyflavone. It is one of the main active ingredients in the traditional Chinese medicine galangal, and it belongs to flavonoids. In addition to...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K36/9062A61K9/20A61K9/48A61P31/12A61P35/00
Inventor 李吉来刘菊妍钟鸣陈路林吴德玄宁德山
Owner GUANGZHOU HANFANG PHARMA
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