The invention relates to the technical field of
drug-loaded microparticles, in particular to a preparation method and application of medical stone /
PLGA composite
drug-loaded microparticles, medical stone and
PLGA are prepared into a structure with activated nano medical stone as a core and a
PLGA polymer as a shell through the processes of ball milling,
acid activation, emulsification,
solvent volatilization and the like, and the medical stone and the PLGA are synergistically matched, so that the
drug-loaded microparticles have the advantages that the drug-loaded microparticles are uniform in
particle size distribution, and the drug-loaded microparticles have good drug-loaded performance. Firstly, the hydrogel has intelligent responsiveness, can accelerate degradation in alkaline and
enzyme environments of wound surfaces, and realizes accurate release of drugs as required; secondly, the long-acting
controlled release property is shown, and a dual sustained release barrier is constructed through medical stone adsorption and PLGA wrapping, so that the
medicine is released for more than 72 hours at a
constant speed following zero-order dynamics, and burst release is effectively avoided. And thirdly, when the drug-loaded particles are used for hydrogel, the drug-loaded particles in nanoscale are combined with the hydration effect of a
hydrogel matrix, so that the efficient permeability of the drug in the
cuticle is greatly improved.