Kernel-shell structural nanofiber membrane, preparation method thereof and application

A technology of nanofiber membrane and shell structure, applied in application, fiber treatment, pharmaceutical formulation, etc., can solve the problems of poor stability and low bioavailability, and achieve the effects of high porosity, improved release rate, and excellent release performance.

Active Publication Date: 2017-05-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the problems of poor stability and low bioavailability in the application of active substances, the object of the present invention is to provide a colon-targeted controlled release system loaded with active substances prepared based on electrospinning method and its preparation method and its functional Application in sexual food

Method used

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  • Kernel-shell structural nanofiber membrane, preparation method thereof and application
  • Kernel-shell structural nanofiber membrane, preparation method thereof and application
  • Kernel-shell structural nanofiber membrane, preparation method thereof and application

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Embodiment 1

[0047]A method for preparing a colon-targeted controlled-release system loaded with bovine serum albumin prepared based on an electrospinning method, the specific steps are as follows:

[0048] (1) Prepare chitosan nanoparticles loaded with active substances by ionic cross-linking: take bovine serum albumin as the model of functional protein, first dissolve the chitosan of medium viscosity in (1%, v / v) acetic acid solution, stirred to obtain a 4mg / ml chitosan solution, then adjusted the pH to 5.3 and filtered with a 0.45μm membrane; then added 1.5mg / ml bovine serum albumin solution to it, stirred for 2h and adjusted the pH to 5.3; finally 1mg The sodium tripolyphosphate solution per ml was added dropwise to the solution at a rate of 400 μl / min to obtain a chitosan nanoparticle solution. Transmission electron microscopy results show that the diameter of a single nanoparticle is 15-30nm, and the average diameter of the nanoparticles obtained by the particle size analyzer is 145n...

Embodiment 2

[0054] The difference between this embodiment and embodiment 1 is that the spinning voltage is 10kv.

[0055] The SEM image of the colon-targeted controlled-release system prepared under the above process conditions is shown in image 3 .

Embodiment 3

[0057] The difference between this embodiment and embodiment 1 is that the spinning voltage is 25kv.

[0058] The SEM image of the colon-targeted controlled-release system prepared under the above process conditions is shown in Figure 4 .

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Abstract

The invention discloses a kernel-shell structural nanofiber membrane, a preparation method thereof and an application; the preparation method includes steps of (1), preparation of spinning; dissolving sodium alginate, polyoxyethylene and poloxamer F127 in distilled water, stirring evenly and acquiring shell layer spinning solution; mixing the chitosan nanoparticle solution loaded with active matters with polyving akohol solution evenly, and acquiring the kernel layer spinning solution; (2), coaxial electrostatic spinning: respectively injecting the shell layer spinning fluid and kernel layer spinning fluid in a static spinning device containing a coaxial needle, performing the coaxial electrostatic spinning under room temperature, performing solvent evaporation in the spinning process, and acquiring the kernel-shell structural nanofiber membrane loaded with the nanoparticle. The preparation method is simple in operation and gentle in reaction condition and can well control the slow release of the active matter; moreover, the prepared colon targeting controlled release system has obvious colon targeting property, thereby improving the utilization degree of the active matter. The colon targeting controlled release system can be applied to functional food domain.

Description

technical field [0001] The invention belongs to the field of controlled release of nanomaterials and functional substances, and in particular relates to a preparation method and application of a colon targeting controlled release system loaded with active substances prepared by coaxial electrospinning technology. Background technique [0002] In recent years, as people pay more and more attention to the function of food to improve human nutrition and health, the research and development of functional food has become a new trend in the development of modern food industry. The substances that play a role in functional foods are called biologically active substances, such as active proteins and peptides, microecological regulators, flavonoids and polyphenols, functional oils, alkaloids, vitamins, and other physiologically active substances. However, the active substance has poor stability during production, processing and storage; after oral administration, it is also easily in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D01D5/00D01D5/34A61K47/36A61K47/32A61K38/38A23L33/10A23L33/125A23L33/135A23L33/16A23L33/15A23L33/17A23L33/18A23P10/30
CPCA23V2002/00A61K9/0002A61K38/385A61K47/32A61K47/36D01D5/0015D01D5/34D04H1/728A23V2200/30A23V2200/32A23V2200/308
Inventor 吴虹温棚宗敏华朱定和
Owner SOUTH CHINA UNIV OF TECH
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