602results about How to "High embedding rate" patented technology

The invention provides a functional oil microencapsulation and a manufacturing method thereof and relates to a microencapsulation, and the functional oil microencapsulation has the advantages of high stability and immobilized proteinaceous pellicle. The oil microencapsulation is prepared from the following raw materials: functional oil, plant oil, an antioxidant, aqueous-phase main-wall materials, aqueous-phase auxiliary-wall materials, bio-enzyme protein and water. The plant oil serving as a carrier is mixed with the functional oil, then the antioxidant is added, and then the materials are heated and dissolved in water bath, thus obtaining an oil-phase core material solution; the aqueous-phase main-wall materials and the aqueous-phase auxiliary-wall materials are added into deionized water, and then the materials are heated and dissolved in water bath, thus obtaining an aqueous-phase wall material solution; the oil-phase core material solution is added in the aqueous-phase wall material solution, the mixture is sheared and emulsified by a shearing machine, and then is homogenized by a homogenizer, thus obtaining a nanometer-level solution with uniform oil drop diameter; and bio-enzyme is added into the nanometer-level solution, the mixture is placed in hot-water bath for heating and stirring reaction, temperature is raised after the reaction so as to enable the bio-enzyme to be inactivated, and drying is carried out, thus obtaining the functional oil microencapsulation.

The invention relates to a microcapsule and a preparation method thereof, aiming at providing a vitamin D3 microcapsule and a preparation method thereof. The vitamin D3 microcapsule comprises core material vitamin D3, oil fat, an oil-soluble emulsifier and a wall material. The preparation method comprises the following steps of: (1) adopting the core material vitamin D3, the oil fat, the oil-soluble emulsifier as oil phase for dissolving and mixing evenly; (2) adding deionized water in the wall material, stirring and dissolving as water phase; (3) adding the oil phase into the water phase, mixing, stirring evenly, then carrying out homogenization and emulsifying the obtained mixture into microcapsule; (4) carrying out spray drying to the microcapsule to form the vitamin D3 microcapsule; and (5) screening, mixing, inspecting and packing to obtain the finished product. The microcapsule and the preparation method thereof have the advantages of high embedding rate, good flowability, hard photolysis, oxidation, high heat stability, even dispersion in water and the like. The microcapsule can be widely added into food or feedstuff, is easy to be absorbed by the human body or animals, also can be used as original drug of rat poison to strengthen the stability thereof greatly.

The invention discloses a polypeptide medicament sustained release microsphere or a microcapsule preparation with uniform grain size, a preparation method thereof and application. The average grain size of the microsphere or the microcapsule preparation is between 50 nanometers and 100 microns, and the grain size distribution coefficient CV value is less than 20 percent. The polypeptide medicament has a definite structure, has functions of therapy or adjuvant therapy of type-2 diabetes, and is preferably one or more of GLP-1, Exenatide, Exendin-4 and derivatives and analogs thereof. The microsphere or the microcapsule preparation uses a microsphere or a microcapsule with uniform grain size as a substrate to prepare the polypeptide medicament into a sustained release preparation through an embedding mode, and by changing the grain size of the microsphere or the microcapsule, the sustained release cycle is adjustable between one week and one month, and the microsphere or the microcapsule preparation can be applied to the therapy or the adjuvant therapy of the type-2 diabetes and body weight control. Besides, the microsphere or the microcapsule preparation has the advantages of simple preparation process and mild preparation course, and can protect the biological activity of the embedded polypeptide medicament.

The invention provides a method for preparing composite microspheres with the particle diameter of 0.01-100Mum and adjustable particle size distribution. The method is characterized in that one or more kinds of superfine particles is added to two or more kinds of polymer (or performed polymer) with fluxible processability to form composite microspheres by reaction mixing and oriented dispersion technique of superfine particles. The composite micropheres have the advantages of even dispersion of superfine particles and large embedding amount. The preparation method has the advantages of continuous preparation and low cost, and has wide application prospect in fields such as biological medical treatment, electronic message, daily life, etc.

The invention relates to the technical field of the food additive and the microcapsule equipment capable of controlling the release of bioactive substances, in particular to a preparation method of menthol microcapsules. The preparation method uses menthol, wall material, emulsifier, crosslinking agent, pH regulator and water as the raw materials, wherein menthol is used as the core material, chitosan is used as the wall material, monoglyceride and Tween-40 are used as the compound emulsifier, 10% acetic acid is used as the pH regulator. The preparation method comprises the following steps: emusifying the solution under high pressure, adding modified starch to crosslink, finally adopting the spray drying technology to prepare the powdery menthol microcapsule product. The invention aims to provide a menthol microcapsule preparation method with safe and easy technology and low cost, increase the stability and heat resistance of menthol, control the release process and expand the application range.

The invention mainly discloses vitamin powder and a preparation method of the vitamin powder. The vitamin comprises the following components in mass percentage: 5-60% of fat soluble vitamin, 30-70% of wall material, 5-30% of assistant wall material, 0.5-2% of emulsifier, 0.1-2% of antioxidant and 0.1-3% of cross linking agent. The invention further relates to a preparation method of the vitamin powder. By using a microencapsulation technique, the fat soluble vitamin oil (e.g. vitamin A, vitamin D3, vitamin E and vitamin K) is embedded to a micro-capsule, the wall material used in the embeeding process is starch sodium octenylsuccinate, the vitamin oil is embeeded in the wall and then the micro-capsule is subjected to cross linkage, mist spraying and drying are carried out to form the vitamin powder, and the embedding rate of the vitamin is more than 95.3%. According to the invention, the process is simple, the cost is low, the obtained vitamin powder is not soluble in water, high in oil loading amount and good in flowability, and can be used in the fields such as foods, daily-used industrial chemicals and medicines.

The invention provides a method for preparing cold water dispersing type carotenoid micro-capsule powder without using an organic solvent. The method concretely comprises the following steps: (a) enabling carotenoid crystal to suspend in a water solution containing antioxidant, protective colloid and at least one non-ionic emulsifier; (b) grinding and homogenizing the solution obtained in the step (a) under the nitrogen protection to enable crystal particles to be ground and stably suspend; (c) carrying out micronization on the suspended particles of the obtained solution by a heating device to form an emulsion; (d) dissolving the protective colloid into the emulsion obtained in the step (c), carrying out secondary embedding, dewatering and drying to obtain powder particles. The method can solubilize carotenoid without using the organic solvent or vegetable oil, thus solving the problems of residual solvent, low carrying capacity and the like caused by the existing solvent method and a high temperature melting method. In all the steps of the method, the organic solvent is not used, so that the method is environment-friendly in technology; the process of high-temperature treatment is not needed, so that trans isomer is not produced, and the method is high in carrying capacity and small in loss of active ingredients.

The invention discloses a macromolecular microcarrier and a preparation method thereof, belonging to the technical field of biomedicine. The preparation method comprises the following steps of: splitting a silk solution and a drug solution into micrometer grade liquid drops with core-shell structures under the action of a high-voltage electric field by adopting a coaxial high-voltage electrostatic technology and a freeze drying method; concreting through liquid nitrogen, and then preparing the microcarrier which is difficult to dissolve in water through freeze drying. The microcarrier is in the shape of a microsphere with the core-shell structure, and the diameter of the microsphere is 100-500 micrometers; the shell of the microcarrier comprises the components of silk fibroin; the random-coil conformation of silk fibroin molecules is 80-90 percent; the shell is in a porous structure, and an aperture is 5-20 micrometers; and a core of the microcarrier comprises the components of water-soluble drugs. The silk microcarrier has extensive application prospect in the fields of cell culture, drug release, and the like.

A protocyanidin sloow release microcapsule has microcapsule size smaller than 3 mm, protocyanidin content of 0.25-25 wt% and sustained release period of 12-48 hr in buffering phosphoric acid solutionof pH 7.4. The wall of the microcapsule is one three layer structure including agglomerate calcium alginate layer, chitosan and alginate complex layer and deposited chitosan layer. The microcapsule is prepared through compounding water solution of calcium alginate containing protocyanidin, preparing chitosan-CaCl2 solution, adding miniature liquid drop of water solution of calcium alginate containing protocyanidin into chitosan-CaCl2, solution and subsequent processing. The release rate of the coated protocyanidin is adjustable.

The invention belongs to the technical field of oil processing, and particularly relates to a preparation method of saccharose-free functional powdered peony seed oil. The method comprises the following steps: (1) dissolving wall materials with distilled water, and heating and stirring to obtain a solution A; (2) adding food functional factors and an emulsifier into peony seed oil, and mixing and stirring uniformly to obtain an emulsion; (3) shearing and emulsifying the emulsion obtained in the step (2) to obtain an emulsion solution; (4) adding the solution A obtained in the step (3) into the emulsion solution obtained in the step (3), and homogenizing at high pressure to obtain a solution B; and (5) spray-drying the solution B obtained in the step (4), thereby obtaining the powdered peony seed oil. The powdered peony seed oil prepared by the method can be compounded with different nutritive substances according to demands of different groups of special people; as the peony seed oil is high in content of alpha-linolenic acid, the powdered peony seed oil is high in nutritive value; and due to containing no saccharose, the powdered peony seed oil is suitable for patients with hyperglycemia and diabetes to take.

The invention relates to a microcapsule preparation method and a product thereof. The microcapsule preparation method is characterized by comprising the following steps that: the powder embedding material is put into a drying device in advance, and is kept in a suspension or boiling fluidized state under hot blast, and is lactose or lactose composite powder; and meanwhile, the emulsified liquid which is prepared from core materials, emulsifier and water is atomized into liquid drop to be sprayed into the drying device, the atomized liquid drop is contacted with the powder embedding material which is in the suspension or boiling fluidized state and is wrapped by the powder embedding material, meanwhile, particles are formed by the drying of the hot blast, and the microcapsule product is obtained after separation. The method adopts the lactose or lactose composite powder as the powder embedding material, the prepared microcapsule takes the single particle as the main part, and the particles are more regular in shapes, are not adhered with one another, have better stability, better liquidity and higher safety at the same time.

The invention discloses a kernel-shell structural nanofiber membrane, a preparation method thereof and an application; the preparation method includes steps of (1), preparation of spinning; dissolving sodium alginate, polyoxyethylene and poloxamer F127 in distilled water, stirring evenly and acquiring shell layer spinning solution; mixing the chitosan nanoparticle solution loaded with active matters with polyving akohol solution evenly, and acquiring the kernel layer spinning solution; (2), coaxial electrostatic spinning: respectively injecting the shell layer spinning fluid and kernel layer spinning fluid in a static spinning device containing a coaxial needle, performing the coaxial electrostatic spinning under room temperature, performing solvent evaporation in the spinning process, and acquiring the kernel-shell structural nanofiber membrane loaded with the nanoparticle. The preparation method is simple in operation and gentle in reaction condition and can well control the slow release of the active matter; moreover, the prepared colon targeting controlled release system has obvious colon targeting property, thereby improving the utilization degree of the active matter. The colon targeting controlled release system can be applied to functional food domain.

The present invention relates to a preparation method of a lactic acid bacterium microcapsule. The preparation method comprises the following steps: firstly, lactic acid bacteria and prebiotics are used to obtain a synbiotic solution; secondly, sodium alginate and pectin are dissolved in distilled water and stirred at room temperature to obtain a thick mixed solution, then CaCO<3> powder is uniformly dispersed in the mixed solution to obtain a microcapsule wall material, and the microcapsule wall material and the synbiotic solution are evenly mixed to obtain a mixed bacteria and pectin solution; and thirdly, the microcapsule is prepared. The prepared lactic acid bacterium microcapsule can tolerate effects of stomach acid and bile salt and thus better colonize intestines, also exerts probiotic effects of many lactic acid bacteria in regulating immunity, improving digestion, preventing tumors and mutation, adjusting acid-base balance, at the same time is even in particles, and has a particle size of about 100 [mu]m.

The invention relates to peony seed oil microcapsule powder. The yeast peony seed oil microcapsules are prepared from peony seed oil serving as a raw material and a yeast wall material by using a yeast microcapsule method or are prepared by emulsification, encapsulation, solidifying and drying of a complex coacervation capsule method. The produced peony seed oil microcapsules can be applied to solid beverages such as milky tea and coffee, are capable of improving the instant solubility of products and intensifying nutrition of the products and can also be directly applied to health products, cosmetics and food. Chemical solvents are not added in a peony seed oil microcapsule preparation process, so that the peony seed oil microcapsules are green, environment-friendly and beneficial to the physical health of eaters; the relatively low temperature is always maintained in the whole process, so that the activity of functional components in the peony seed oil can be kept to the maximum degree.

The invention relates to a preparation method of modified silicon dioxide hydrogel, the modified silicon dioxide hydrogel and application of the modified silicon dioxide hydrogel. The preparation method comprises the following steps: under a magnetic stirring condition, dissolving sodium alginate, then adding carboxyl-modified SiO2 nanoparticles, uniformly dispersing the SiO2 nanoparticles into sodium alginate, then adding proper amounts of an initiator and a crosslinking agent, stirring for 10 min, then pouring into a square mould to form a gel, fixing and moulding to obtain carboxyl-modifiedSiO2 hydrogel, and cutting the carboxyl-modified SiO2 hydrogel into small square blocks of 1*1 cm as required. A SiO2 hydrogel material effectively improves the stability of an adsorbent material, can be repeatedly used for multiple times, effectively reduces the cost and solves the adsorbent recycling problem. The modified SiO2 hydrogel provided by the invention is simple in preparation technology, low in cost, high in selectivity and high in adsorption capacity, and has a good application prospect in heavy metal treatment.

The invention belongs to the technical field of natural product microcapsules and discloses natural carotene microencapsulated powder and a preparation method thereof. The natural carotene microencapsulated powder is prepared from the following components in parts by weight: 5 to 15 parts of a core material, 20 to 80 parts of a wall material, 0.1 to 2 parts of an oil-phase antioxidant, 0.1 to 5 parts of a water-phase antioxidant, 0.1 to 7 parts of an emulsifier, 0.1 to 2 parts of a thickener, 0.1 to 2 parts of an acidity regulator and 30 to 140 parts of a dispersant, wherein the core material is natural carotene oil suspension liquid; the wall material is selected from one or more of starch sodium octenyl succinate, Arabic gum and porous starch; the dispersant is selected from one or more of maltodextrin, sucrose and starch syrup. By regulating a formula and a spraying process, the natural carotene microencapsulated powder which has a high encapsulation rate, can be dissolved in cold water and has good stability is prepared.

The invention relates to a probiotics microcapsule product. The probiotics microcapsule product is a spherical or irregular microcapsule with grain size of 10 to 1,000 microns and has a structure being divided into two parts, namely, a wall layer and an inner core, wherein the wall layer is composed of alginate, chitosan and a methacrylic acid-methacrylate high polymer material; and the inner core is high-density probiotics.

The invention relates to a spray freeze-drying preparation technology for a polyunsaturated fatty acid oil microcapsule, which comprises the following technological steps: mixing oil containing polyunsaturated fatty acid with emulsifier and water to obtain mixture; homogenizing the mixture to obtain emulsion; atomizing the emulsion into liquid drops which are sprayed into a spray drying device with temperature of negative 60 DEG C to negative 10 DEG C, wherein powder embedding materials are contained at the bottom part of the spray drying device, and blasting low-temperature gas to fully mix the materials in the spray drying device and to keep the temperature in the spray drying device to be the set temperature; and further drying and screening to obtain polyunsaturated fatty acid oil microcapsule products. The invention has the advantages that the drying temperature of the preparation technology is low, the speed is fast and the nutritional ingredients are not apt to be damaged; the technology is simple and convenient and the automatic mass production can be realized; and the oil embedding rate of the obtained independent polyunsaturated fatty acid oil microcapsule particles is high, the embedding performance is good, the product shelf life is long and the stability is good.

A preparation method of hydrophobically modified sodium alginate gel belongs to the technical field of biomedical materials. The invention prepares a star polymer which contains inorganic matter and hydrophobic polymers; the prepared polymer is ultrasonically dispersed into a sodium alginate solution by ultrasonic dispersion technology; and a calcium alginate hybrid gel with both hydrophobicity and hydrophilicity is prepared by a dropping liquid method. A hydrophobic drug of ibuprofen has a high embedding rate of up to above 90% in the gel, and has a good sustained release effect with a drug release amount of the first 2 hours being reduced by nearly 45%; the problem is overcome that since sodium alginate has strong hydrophilicity and the loading amount for hydrophobic drugs is less, burst release is easy to occur in an early stage of drug release. The drug-loaded microsphere of the invention is convenient for preparation, controllable in particle size (about 1 mm), good in biocompatibility, has no toxicity to human body, and has potential application value for being used as a drug carrier.

The invention discloses an anti-adhesion fiber membrane with hemostasis and antibiosis functions and a preparation method thereof. The preparation method comprises the following steps of: dissolving medicinal molecules into an organic or inorganic solvent to prepare a medicinal molecular solution; dissolving different high molecular materials into medicinal solutions of a hemostasis agent and an antibiosis agent respectively to prepare a high molecular solution; and performing electrostatic spinning on a mixed solution of organic high molecules and the hemostasis agent and a mixed solution of high molecules and the antibiosis agent to obtain a compound fiber material. In the invention, nanofiber is produced by using an electrostatic spinning technology; an organic high molecular solution and the medicinal molecules are mixed for electrostatic spinning to obtain the compound fiber material; by adjusting the high molecular material, the embedding amount and embedding rate of medicaments are increased, a fiber material which can keep the medicinal bioactivity and is used for controlling the release of different medicaments at different stages is prepared, and dual effects of preventing postoperative adhesion and postoperative infection can be achieved; and moreover, the entire preparation process is simple, has low cost, and has wide application prospect in the field of surgical operation.

The invention discloses a method for preparing a melissa officinalis L. essential oil and beta-cyclodextrin molecule microcapsule and aims to improve the physical and chemical properties and the stability of the melissa officinalis L. essential oil and expand the application range of the melissa officinalis L. essential oil. The method comprises the following steps of: adding ethanol solution of the melissa officinalis L. essential oil into saturated aqueous solution of beta-cyclodextrin slowly, wherein the molar ratio of citral in the melissa officinalis L. essential oil to beta-cyclodextrin is 1:2, and the volume ratio of the melissa officinalis L. essential oil to ethanol is 3:100; oscillating the solutions for 3 hours at a rotating speed of 160r / min at the temperature of 30 DEGC for complete reaction, preserving a product of reaction at the temperature of 4 DEG C for 4 hours, standing, and precipitating; and filtering the obtained solution, and drying a precipitate at the temperature of 50-70 DEG C for 4 hours to obtain the melissa officinalis L. essential oil and beta-cyclodextrin molecule microcapsule. By encapsulating beta-cyclodextrin and the melissa officinalis L. essential oil, the powder of the molecule microcapsule has extremely good optical and thermal stability; the range of application of the melissa officinalis L. essential oil is expanded; and the method is simple and highly practical.

The invention relates to an acid-proof type microalgae DHA oil microcapsule powder and a preparation method thereof. The acid-proof type microalgae DHA oil microcapsule powder is prepared from 12.6%-30.3% of core materials and 69.7%-87.4% of wall materials, concretely comprising the following active ingredients in percentage by weight: 12.5%-30.0% of microalgae DHA oil, 0.1%-0.3% of antioxidant, 25.0%-50.0% of whey protein, 3.0%-8.0% of food emulsifier, 20.0%-54.4% of sweetener, 4.40%-8.0% of hydrophilic colloid, and 0.60%-1.20% of acidity regulator. The prepared acid-proof type microalgae DHA oil microcapsule powder has good acid-proof property, and can be applied in a food system of an acid water system with pH of more than or equal to 3.5, the oxidization speed of microalgae DHA can be effectively reduced and delayed, the activity of the microalgae DHA can be maintained, the stability of microalgae DHA in acid water system food can be enhanced, and the shelf life of the acid water system food with microalgae DHA can be prolonged.

The invention relates to a method for preparing a small molecule hydrophilic drug-embedded sustained-release capsule. The method comprises the following steps: filtering a prepared'internal aqueous phase / oil phase / external aqueous phase' pre-multi-emulsion solution through a microporous membrane; and then removing a solvent, washing and drying to obtain the small molecule hydrophilic drug-embedded sustained-release capsule, wherein the internal aqueous phase comprises a small molecule hydrophilic drug and a thickening agent. The small molecule hydrophilic drug-embedded sustained-release capsule provided by the invention has the advantages of uniform grain diameter, high embedding rate, low burst-release rate, stable drug release and long action.

The invention provides an embedding system based on a eutectic solvent and using the eutectic solvent as a solvent. The embedding system comprises an embedding material, a carrier and the eutectic solvent, and the eutectic solvent is formed by a hydrogen bond donor and a hydrogen bond acceptor through hydrogen bond association; the hydrogen bond acceptor includes quaternary ammonium salt, and thehydrogen bond donor includes one or more of urea, polyol, monosaccharide and carboxylic acid. The embedding system uses the eutectic solvent to serve as the solvent, and the eutectic solvent can increase the embedding rate of medicine, is low in toxicity and degradable, can reduce the side effects of the medicine in a controlled release and medicine delivery process and can improve the permeability and controllable release performance of cell membranes.

The invention discloses a microcapsule production technology including five steps of preparation of a wall material solution, emulsification mixing of a core material and a wall material, ultrasonic embedding, homogeneous dispersion and micro capsule spray drying. The preparation technology has the advantages of simple operation, selection of the reasonable wall materials such as octenyl succinic starch ester, seaweed gum, carrageenan and the like, easily obtained raw materials, wide scope of application, safe and reliable use, capability of well preventing the volatilization, oxidation or inactivation of instable raw materials, and effectively preventing the release of the core material, by selection of a suitable emulsifier and stirring speed, the micro capsule embedding rate is improved; microcapsule is prepared by spray drying method, and the microcapsule production technology is high in production capacity, simple in technology, and suitable for continuous industrial and automatic production.

The invention provides a method for acknowledging an IP core copyright by a digital watermarking technology. The method has the advantages of low cost, high universality, high compatibility, high feasibility and fully integrated automation. The technical scheme is that the method is characterized by comprising a watermark embedding step and a watermark extracting step. The watermark embedding steps comprises the following procedures: first, selecting a coordinate of an initial watermark point in a layout, and processing copyright information by a one-way Hash function to obtain an offset of the watermark point coordinate, and obtaining the scattered watermark point coordinate pseudo-randomly distributed in the layout; and then normalizing the attribute of the selected watermark point to embed the special watermark representing the copyright information; and finally, successfully embedding the watermark information for the watermark point which is not normalized by the two methods by repeated diffusion, judgment and additional means, thus obtaining a layout data file with the watermark information. The watermark extracting step comprises the following procedures: obtaining the pseudo-randomly scattered watermark point coordinate by the method similar to the watermark embedding step based on record files of the watermark embedding information, thus recovering the watermark point coordinate successfully embedded finally and then judging whether the watermark point successfully embedded finally coincides with a polysilicon layer in the layout and outputting a watermark extraction report.

The invention discloses a natural volatile solid fresh-keeping agent for fruit and vegetables and a preparation method thereof. The fresh-keeping agent is prepared by mixing main raw material and adjuvants at a certain ratio in parts by weight, and taking rice flour and maltodextrin as a wall materials and essential oil mixed with natural spices as a core material; ingredients of the main raw material are rice flour, maltodextrin and essential oil mixed with natural spices, and the adjuvants comprise an antiseptic, an adhesive, a crisp-keeping agent, an emulsifier and an ethylene receptor inhibitor. The natural volatile solid fresh-keeping agent for fruit and vegetables has the main advantages of realizing freshness keeping of fruit and vegetables by volatilizing the essential oil mixed with natural spices and 1-MCP which respectively contact surfaces of fruit and vegetables; employing microcapsule technology to embed the essential oil mixed with natural spices and the 1-MCP to effectively control volatilization rate of the essential oil mixed with natural spices and the 1-MCP, improve utilization rate of effective ingredients and solve freshness-keeping technical problems of fruit and vegetables in the course of transport; and the product made from natural materials is safe and nontoxic. See the accompanying drawings of the abstract for processing technology of the fresh-keeping agent.

In order to solve the problems that the granules are non-uniform, the surface is provided with cracks and recesses and the compactness of the microcapsule wall is low in the conventional microcapsule product and the product is low in thermal solubility, low in emulsifying property and high in sugar content and has the soybean smell, the invention provides a walnut oil microcapsule and a preparation method thereof belonging to the technical field of oil microencapsulation. The walnut oil microcapsule is prepared by taking 15-25 parts of walnut oil, 0.6-3.4 part of sucrose ester and 1.5-3.2 parts of monoglyceride as the core material and taking 3-10 parts of cane sugar, 18.3-27.6 parts of maltodextrin, 17.6-28.3 parts of peanut protein isolate and 1.3-3.5 parts of dipotassium phosphate as the wall material. Therefore, the prepared walnut oil microcapsule has the advantages of smooth surface, uniform particle size and high compactness of microcapsule wall.

The invention provides a seaweed ferment probiotic microcapsule and a preparation method thereof. The microcapsule comprises a microcapsule wall, a microcapsule core material and a core material carrier, wherein the microcapsule wall is prepared from sodium alginate, chitosan and calcium chloride, the microcapsule core material is prepared from seaweed ferment and probiotic, and the core materialcarrier is corn starch. The seaweed ferment probiotic microcapsule of the invention can effectively block the influence of gastric acid and the like on the viable bacteria number and activity of the probiotic, so that the seaweed ferment and probiotic act on the intestinal micro-ecological environment together, and the unique biological effect is achieved. The preparation method is simple in process, is relatively low in cost, and is easy to store and transport. Compared with other probiotic products, the microcapsule has the advantages of good film-forming property, strong stability, high probiotic survival rate, good slow release efficiency and the like, is suitable for embedding and controllable release of various probiotics, and has good application prospects.