Gradient laminated porous scaffold based on microsphere selective laser sintering and preparation method thereof

Abstract

The invention relates to a gradient laminated porous scaffold based on microsphere selective laser sintering and a preparation method thereof. The scaffold is prepared by taking polymer microspheres and compound microspheres of high polymers and calcium-phosphate materials as sintering raw materials and carrying out selective laser sintering on the sintering raw materials, the contents of the calcium-phosphate materials in the scaffold are ascended in a layer by layer manner from the surface layer to the bottom layer of the scaffold, and bore diameters and porosities of the scaffold are gradually ascended. The preparation method comprises the following steps of: preparing calcium-phosphate materials / high polymer composite microspheres by a solvent evaporation method; designing a three-dimensional model of the gradient-laminated porous scaffold by computer modeling software; and realizing precise manufacturing of the gradient laminated porous scaffold by virtue of a selective laser sintering device through feeding controlling and single-layer manufacturing. The mutual communication and the gradient distribution of the scaffold are beneficial for nutrient transport and tissue penetration; and the contents of calcium-phosphate materials are in continuous gradient distribution in space, the disadvantage of interface bonding strength is effectively solved, and the biological functions of the scaffold in comprehensive defect repairing of cartilages and subchondral bones are beneficially exerted.

Description

technical field

[0001] The invention belongs to the field of biomedical materials, and relates to a preparation method of selective laser sintering of a porous scaffold, more specifically, to a porous tissue engineering scaffold used for osteocartilage tissue repair, with gradient distribution of components and contents method of preparation. Background technique

[0002] Trauma, tumors, and arthritis often lead to damage to articular cartilage. Since there are no blood vessels in articular cartilage, it is difficult for chondrocytes to migrate to the damaged area, making it difficult for joints to heal after injury. Tissue engineering provides a new means to solve this clinical problem. In the process of articular cartilage repair, osseointegration is an important criterion for evaluating the repair effect.

[0003] Articular cartilage (osteocartilage) has a complex structure and a natural laminated structure, which can be divided into cartilage layer, calcified cartilage...

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