408results about How to "High oxygen permeability" patented technology

A soft contact lens containing a silicone-hydrogel made by curing a reaction mixture containing a silicone-containing monomer.

The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.

The present invention provides methods for lathing at room temperature a silicone hydrogel material, in particular silicone hydrogel material having a high oxygen permeability and made of a polymerizable composition containing a relative large amount of oxyperm component, into contact lenses.

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.

A method for reducing the modulus of polymer silicone hydrogel compositions by employing monomeric polysiloxanes endcapped with trimethylsilyl to reduce the crosslinking density of the hydrogel. The synthesis consists of a single vessel acid catalyzed ring opening polymerization and may be employed to produce copolymers useful as hydrogel contact lens materials.

A hydrophilic polysiloxane macromonomer containing polyoxyethylene as a hydrophilic side chains pendant to a polysiloxane main chain for imparting transparency, oxygen permeability, and hydrophilic properties to a contact lens is disclosed. The properties of the material are controlled by regulating the length of the polysiloxane main chain, the length of the hydrophilic polyoxyethylene side chains, and the number of the side chains.

A silicone hydrogel formulation may contains random and / or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).

A method of using nanostructured chemicals as alloying agents for the reinforcement of flouropolymer microstructures, including polymer coils, domains, chains, and segments, at the molecular level. Because of their tailorable compatibility with fluorinated polymers, nanostructured chemicals can be readily and selectively incorporated into polymers by direct blending processes. Properties most favorably improved are time dependent mechanical and thermal properties such as heat distortion, creep, compression set, shrinkage, modulus, hardness and abrasion resistance. In addition to mechanical properties, other physical properties are favorably improved, including lower thermal conductivity, fire resistance, and improved oxygen permeability. These improved properties may be useful in a number of applications, including space-survivable materials and creep resistant seals and gaskets. Improved surface properties may be useful for applications such as anti-icing or non-wetting surfaces or as low friction surfaces.

A polysiloxane prepolymer that is useful for forming biomedical devices has the formula: M(*Dii*PS)x*Dii*M  (I) wherein: each M is independently a polymerizable ethylenically unsaturated radical; each Dii is independently a diradical residue of a diisocyanate; each PS is independently a diradical residue of a polysiloxane-diol or a polysiloxane-diamine; each * is independently —NH—CO—NH—, —NH—COO— or —OCO—NH—; and x is at least 2.

An ocular lens material comprising a copolymer prepared by polymerization with heating of a monomer mixture and / or with irradiating a monomer mixture with ultraviolet ray by means of a molding method, the monomer mixture containing a polysiloxane macromonomer A, a Si-containing alkyl methacrylate B, a hydrophilic monomer C comprising NVP as C-1 and another hydrophilic monomer C-2, another monomer D and a crosslinkable monomer E comprising a crosslinkable monomer E-1 containing at least one group selected from acryloyl group, vinyl group and allyl group, and methacryloyl group, and a crosslinkable monomer E-2 containing at least two methacryloyl groups as main components, wherein (A+B) / C (weight ratio) is 30 / 70 to 70 / 30, A / B is 25 / 75 to 75 / 25, C-1 / C-2 is 50 / 50 to 100 / 0, the amount of D is 0 to 20% by weight in the monomer mixture, which has high oxygen permeability, high mechanical strength, excellent surface wettability and low surface frictional property.

A hybrid contact lens includes a substantially rigid center portion having a flexural deformation of about 10% at an applied load of at least about 50 grams and a Dk of at least about 30×10−11 (cm2 / sec) (mL O2) / (mL mm Hg). The hybrid contact lens also includes a substantially flexible skirt portion connected to the center portion. A method of designing a hybrid contact lens includes determining the applied load that results in a selected flexural deformation.

The invention discloses a high oxygen-permeability fluorosilicone hydrogel contact lens material and a preparation method thereof. The high oxygen-permeability fluorosilicone hydrogel contact lens material is obtained by crosslinking copolymerization of a fluorine-containing polysilicone monomer with hydrophilic groups and ends capped by methacrylate and one or more hydrophilic monomers and siloxane monomers initiated by ultraviolet light or heat. The content of a fluorosilicone amphiphilic monomer in the mixed monomers is 20%-60%. The preparation method comprises the following steps: evenly mixing the fluorosilicone amphiphilic monomer, the hydrophilic monomers, the siloxane monomers, a crosslinking agent, an initiator and a diluent, injecting the mixture into a mold, initiating polymerization by ultraviolet irradiation or heat, then demolding, removing unreacted monomers or oligomers, and immersing in water to obtain hydrogel. The hydrogel material has high oxygen permeability, wettability, proteinosis resistance and the like, and is a corneal contact lens with excellent properties.

This invention relates to films having selective permeability and / or permeation rates for different gases, liquids, particulate matter, and combinations thereof. The films may be employed as packaging films or separation membranes. The films may be comprised of at least one layer including one or more high permeability polymers blended with one or more low permeability polymers. Blending of different amounts and combinations of low and high permeability polymers may provide a method by which individual permeation and permeation rates can be increased or decreased, and made selective for one or more gasses, liquids, particulate matter or combinations thereof. Methods for making such films are also disclosed.

The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.

The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

The present invention provides a multilayer film having an active oxygen barrier and at least one layer containing an iron-based oxygen scavenging composition. In one embodiment, the active barrier layer comprises a composition that is a blend of a thermoplastic resin (A) having carbon-carbon double bonds substantially in its main chain, a transition metal salt (B), and an oxygen barrier polymer (C). In some embodiments the active barrier layer may also include a compatibilizer (D). The layer containing the iron-based oxygen scavenging composition helps to maintain the oxygen barrier properties of the active barrier layer, and under both retort and non-retort conditions. As a result, the useful shelf life of the multilayer film can be extended.

An ocular lens material comprising a siloxane-containing polymer obtained by polymerizing a monomer mixture containing (A) a siloxane macromonomer having at least two active unsaturated groups and a number average molecular weight of 2,000 to 100,000; and (B) a vinyl ester of lower fatty acid as essential components. An ocular lens material comprising a polymer obtained by saponification of the siloxane-containing polymer. Processes for producing the ocular lens materials. The ocular lens materials are excellent not only in lipid-stain resistance, wettability and oxygen permeability, but also in flexibility, particularly, shape recovery at the same time.

The present invention relates to a surface-treated plastic article including a thin layer composed of a polymer complex on the surface. The surface-treated plastic article can be produced by a treatment with at least one kind of aqueous solutions of polymers having a weight average molecular weight of 200 or more. According to the present invention, the plastic articles, such as contact lenses, having superior transparency, wettability, oxygen permeability, and mechanical properties can be provided.

The invention discloses montmorillonite / isotactic polypropylene / polylactic acid composite sound absorbing cotton, which consists of a top surface layer, a back surface layer and a fiber cotton layer, wherein the fiber cotton layer is clamped and arranged between the top surface layer and the back surface layer, and the top surface layer and the back surface layer are made of non-woven fabric materials. The montmorillonite / isotactic polypropylene / polylactic acid composite sound absorbing cotton is characterized in that the non-woven fabric is prepared form the following ingredients in parts by weight by a melt blowing method: 100 parts of isotactic polypropylene, 10 to 12 parts of polylactic acid, 10 to 12 parts of montmorillonite powder, 5 to 7 parts of dilauryl thiodipropionate, 2 to 3 parts of zinc oxide, 12 to 15 parts of diethylene glycol dibenzoate, 4 to 6 parts of triethyl citrate, 2 to 3 parts of zinc chloride, 5 to 7 parts of chitosan, 2 to 3 parts of molecular sieves, 12 to 15 parts of yellow cinnamon leaf, 2 to 3 parts of rhizoma gastrodiae, 2 to 3 parts of mint, 2 to 3 parts of radix angelicae pubescentis and 4 to 5 parts of auxiliary agents. The montmorillonite / isotactic polypropylene / polylactic acid composite sound absorbing cotton has the advantages that the montmorillonite, the isotactic polypropylene and the polylactic acid are compounded for preparing the sound absorbing cotton by the melt blowing method, the production process is simple, the raw materials are easy to obtain, the cost is low, and the prepared product has the advantages that the air permeability and the oxygen permeability are good, the tensile strength and the extension degree are high, the sound absorbing effect is obvious, and the like.

An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

The invention discloses a brightly colorful contact lens which is characterized by being prepared by using a method comprising the following steps of: (1) preparing structural color hydrogel with an inverse opal photon crystal structure by using a sequenced colloid nano particle photon crystal structure as a template through a colloid crystal template method; (2) paving the structural color hydrogel with the inverse opal photon crystal structure in a PV (polyvinyl) mould of the contact lens; adding the contact lens standard hot-solid liquid to completely permeate into the network structure ofthe hydrogel; processing the thermal solidification sequence to form the initial film of the contact lens; immersing the initial film of the contact lens in a standard saline water solution to process hydration treatment until swelling is in equilibrium. Compared with other colored contact lenses, the brightly colorful contact lens is beautiful in appearance, good in biological compatibility and good in practicability.

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

Vinyl carbonate endcapped polysiloxanes containing a fluorinated side chain are useful as biomaterials, especially hydrogel biomaterials, including contact lens materials.

An ocular lens material comprising a siloxane-containing polymer obtained by polymerizing a monomer mixture containing (A) a siloxane macromonomer having at least two active unsaturated groups and a number average molecular weight of 2,000 to 100,000; and (B) a vinyl ester of lower fatty acid as essential components. An ocular lens material comprising a polymer obtained by saponification of the siloxane-containing polymer. Processes for producing the ocular lens materials. The ocular lens materials are excellent not only in lipid-stain resistance, wettability and oxygen permeability, but also in flexibility, particularly, shape recovery at the same time.

A low water content soft lens for eye is provided, which includes a layer made of an acidic polymer and a basic polymer on at least a part of a surface of a base material containing a polysiloxane compound. Adhesion of the lens to the cornea during wear, which has hitherto been regarded as a problem in a conventional low water content soft lens for eye, can be reduced or avoided when using the low water content soft lens.