Highly oxygen-permeable fluorosiloxanes aquogel contact lens material and preparation thereof

A technology of high oxygen permeability fluorosiloxane and fluorosiloxane, applied in glasses/goggles, instruments, optics, etc., can solve problems affecting the oxygen permeability of contact lenses and achieve good oxygen permeability

Active Publication Date: 2009-08-12
HAICHANG CONTACT LENSES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Johnson&Johnson invented a polymerizable silicone monomer containing hydroxyl groups through epoxy ring opening to improve the interaction between silicone monomer components and hydrophilic monomer components in contact lenses, but it may affect contact lenses Oxygen permeability

Method used

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  • Highly oxygen-permeable fluorosiloxanes aquogel contact lens material and preparation thereof
  • Highly oxygen-permeable fluorosiloxanes aquogel contact lens material and preparation thereof
  • Highly oxygen-permeable fluorosiloxanes aquogel contact lens material and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Synthesis of Epoxy Terminated Compound R

[0044] Weigh 10g allyl glycidyl ether in a flask, N 2 Protect, heat to 90 degrees, add chloroplatinic acid catalyst to make 1ml chloroplatinic acid isopropanol solution, slowly add 3g tetramethyldihydrosiloxane into the flask in a constant pressure dropping funnel with magnetic stirring, and reflux for 15h. Toluene was removed by rotary evaporation. Finally, distill under reduced pressure, collect the fraction with a boiling point of 150-155°C / 2mmHg, and obtain a light yellow transparent liquid product, which is the epoxy-terminated product R, whose structural formula is

[0045]

Embodiment 2

[0047] Synthesis of capping agent X

[0048] Weigh 10g of epoxy-terminated product R, add excess n-hexanol 50ml and 100ul trifluoromethanesulfonic acid, stir magnetically, reflux at 65°C for 24h, remove methanol by rotary evaporation to obtain light yellow product X, whose structural formula is

[0049]

Embodiment 3

[0051] Synthesis of Polymers Containing Silicon-Hydrogen Bonds (A)

[0052] 200g octamethylcyclotetrasiloxane (D4), 5g tetramethyltetrahydrocyclotetrasiloxane (D4H), 5g 1,3,5-trimethyltrifluoropropylcyclotrisiloxane (D3F), 4g of capping agent X was dissolved in a round bottom flask by adding 500ml of chloroform, stirred magnetically, added 1g of trifluoromethanesulfonic acid as a catalyst, and reacted for 10h at room temperature, washed and layered repeatedly with distilled water until the system was neutral, and the organic compound of the lower layer was obtained. phase, rotary evaporation removes chloroform to obtain a product with a certain viscosity, and removes volatile matter under reduced pressure to obtain a colorless and transparent liquid with a certain viscosity, which is product (A), and its structural formula is

[0053]

[0054] , where Y's are:

[0055]

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Abstract

The invention discloses a high oxygen-permeability fluorosilicone hydrogel contact lens material and a preparation method thereof. The high oxygen-permeability fluorosilicone hydrogel contact lens material is obtained by crosslinking copolymerization of a fluorine-containing polysilicone monomer with hydrophilic groups and ends capped by methacrylate and one or more hydrophilic monomers and siloxane monomers initiated by ultraviolet light or heat. The content of a fluorosilicone amphiphilic monomer in the mixed monomers is 20%-60%. The preparation method comprises the following steps: evenly mixing the fluorosilicone amphiphilic monomer, the hydrophilic monomers, the siloxane monomers, a crosslinking agent, an initiator and a diluent, injecting the mixture into a mold, initiating polymerization by ultraviolet irradiation or heat, then demolding, removing unreacted monomers or oligomers, and immersing in water to obtain hydrogel. The hydrogel material has high oxygen permeability, wettability, proteinosis resistance and the like, and is a corneal contact lens with excellent properties.

Description

technical field [0001] The invention relates to a highly oxygen-permeable fluorosiloxane hydrogel contact lens, which belongs to the technical field of biomedical materials. Background technique [0002] Corneal contact lenses can be divided into two types: hard contact lenses and soft contact lenses. Hard contact lenses are less comfortable to wear, while soft contact lenses are more comfortable to wear. Traditional soft contact lenses are polymerized from hydrophilic monomers, such as HEMA, NVP, etc. This type of contact lens can be prepared by centrifugal casting or molding methods, and the water content of the material is usually between 30% and 80%. between. Because the oxygen permeability of ordinary soft contact lenses cannot meet the oxygen demand of corneal metabolism, the wearer usually needs to remove them from the eyes every night. [0003] Polysiloxane hydrogel materials combine the water molecule, ion permeability of hydrogel and the high oxygen permeability ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/36C08F220/56C08F220/28C08F220/06C08F226/10C08F226/02G02B1/04G02C7/04
Inventor 李新松孙复钱
Owner HAICHANG CONTACT LENSES
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