13 results about "Contact lens material" patented technology

The invention provides a preparation process of a hyaluronic acid-chitosan coating and a contact lens with the hyaluronic acid-chitosan coating, and belongs to the technical field of surface coatings of contact lenses. The preparation method comprises the following steps: carrying out surface grafting treatment on a bare contact lens with high oxygen permeation rate, and alternately coating a chitosan solution and a hyaluronic acid solution with certain concentrations, so as to form a composite coating consisting of discontinuous single layers on the surface of the contact lens; the obtained contact lens with the hyaluronic acid-chitosan coating has high oxygen permeation rate, good antibacterial effect and moisturizing capacity, and has important significance.

The present invention provides a hard contact lens that has high oxygen permeability and a large bending deformation capacity, making it resistant to breakage from bending deformation, and a hard contact lens material that can be used to manufacture such a hard contact lens. [Solution] According to one aspect of the present invention, a hard contact lens material is provided, comprising a substituted methacrylate (A) having a molecular structure in which the ratio of the number of fluorine atoms to the number of carbon atoms is 0.6 or more and 0.9 or less, a substituted styrene (B), a methacryloyl group-containing silicone monomer (C), a (meth)acryloyl group-containing monomer (D), an unsaturated double bond-containing hydrophilic monomer (E), and a methacryloyl group-containing monomer (F), wherein the molar ratio of (meth)acryloyl group-containing monomer (D) to methacryloyl group-containing monomer (F) is 0.12 or more and 0.2 or less.

The invention belongs to the technical field of contact lens materials, and discloses a high-moisture-retention contact lens material and a preparation method thereof. The raw materials of the invention comprise 50-70 parts of a silicon-based monomer, 40-60 parts of a hydrophilic monomer, 5-15 parts of hyaluronic acid, 3-10 parts of water-soluble collagen, 2-8 parts of modified chitosan, 1-5 parts of a moisturizing aid, 0.5-3 parts of a cross-linking agent, 0.1-1 part of a photoinitiator and 10-20 parts of water. The contact lens material prepared by the invention is low in water loss rate, long in moisturizing time, excellent in biocompatibility, excellent in oxygen permeability, simple in preparation process and easy to industrialize.

The invention discloses a high-light-transmittance contact lens silicone hydrogel material and a preparation method thereof, and relates to the technical field of contact lens materials, the high-light-transmittance contact lens silicone hydrogel material comprises the following raw materials by weight: 25-35 parts of a silane monomer, 20-25 parts of a functional monomer, 0.6-1.0 part of a cross-linking agent, 0.3-0.5 part of an initiator, and 40-50 parts of a solvent. The silane monomer, the functional monomer and the cross-linking agent are combined for use, so that the high light transmittance of the prepared silicon hydrogel material meets the use requirement. The functional monomer is prepared from 4-nitrophenyl-beta-D-glucuronic acid sodium salt, 2-cyano-5-(dimethylamino)-3-ethoxy penta-2, 4-dienoic acid ethyl ester, 5-chloro-2-pentanone and the like through a reaction, and the contact lens silicon hydrogel material is endowed with relatively high water content and relatively strong antibacterial property.

The invention belongs to the technical field of contact lenses, and provides a bionic protein contact lens material capable of being degraded by tear enzyme. The biomimetic protein contact lens material capable of being degraded by the tear enzyme comprises the following raw materials in specific parts by mass: a siloxane monomer, a hydrophobic acrylic monomer, a hydrophilic monomer, a biomimetic material, a biocompatibility agent, a cross-linking agent, an initiator and a solvent. On the basis of a siloxane monomer and a hydrophilic monomer, a hydrophobic acrylic monomer is added and compounded with the siloxane monomer to form a hydrophobic and high-oxygen-permeability system; by controlling the dosage of the biomimetic material, the biomimetic material forms a self-crosslinking body, so that the light transmittance of the contact lens material is prevented from being influenced; due to the addition of the biomimetic material, the contact lens material is endowed with high biocompatibility and biodegradability; the biological compatibilizer has good hydrophilicity and biocompatibility, and is matched with the hydrophilic monomers, so that the hydrophilic effect is remarkably improved, and the compatibility among the raw material monomers is improved; the film has the characteristics of high oxygen and light permeability, strong hydrophilicity and biodegradability.

The application discloses a kind of hydrophilic rigid gas-permeable contact lens materials and its surface grafting modified preparation method, comprising the following steps: using the monomer containing isocyanate group or epoxy group and the copolymerization of silane monomer and methyl methacrylate to prepare rigid contact lens;The above-mentioned rigid contact lens is immersed into the solution containing hydrophilic macromolecule of hydroxyl or amino, and the covalent reaction of epoxy group and amino or isocyanate group and hydroxyl or amino is carried out at high temperature, and the hydrophilic macromolecule is grafted on the surface of lens;The present application is simple and easy to operate, and the product after grafting is stable, which can significantly improve the hydrophilicity of the lens without affecting the transparency of the lens.

The invention relates to the technical field of preparation of contact lens materials, and particularly discloses a high-moisture-retention and antibacterial silicone hydrogel contact lens material and a preparation method thereof.The high-moisture-retention and antibacterial silicone hydrogel contact lens material is prepared through the following steps that S1, a silicon-containing component is prepared; s2, preparing a hydrogel contact lens material; the antibacterial dispersion liquid is added, the antibacterial dispersion liquid contains a sodium alginate structure, a chlorogenic acid structure, zinc glycinate and an aloe extract, on one hand, active hydroxyl contained in the molecular structure of the sodium alginate can be combined with water molecules through hydrogen bonds, and on the other hand, the active hydroxyl serves as an anchoring point to be subjected to esterification reaction with carboxyl of chlorogenic acid, so that the antibacterial effect is achieved. The zinc glycinate is used as a source of organic zinc, and the aloe extract is rich in aloe polysaccharide and anthraquinone compounds, so that the moisture retention, oxygen permeability and antibacterial property of the hydrogel contact lens material can be improved by introducing the aloe extract into the hydrogel contact lens material.

This invention belongs to the field of contact lens materials technology, specifically relating to 3D-printed hydrogel materials, their preparation methods, and their application in the fabrication of smart contact lenses. The 3D-printed hydrogel material comprises the following raw material components: hydroxyethyl methacrylate, polyethylene glycol diacrylate, 3-(trimethoxysilyl)propyl methacrylate, Pluronic F-127, poly(3,4-ethylenedioxythiophene):poly(p-phenylene sulfonate), and a photoinitiator. The 3D-printed hydrogel material provided by this invention can be directly molded into a contact lens substrate through high-precision 3D printing, thus providing a core material basis for developing next-generation comfortable, precise, and mass-producible personalized smart intraocular pressure monitoring contact lenses. This invention also provides its preparation method. Applying the hydrogel material of this invention to 3D-printed contact lenses meets the requirements for mechanical performance and comfort in contact lenses.

The invention belongs to the technical field of contact lens materials, and particularly relates to a 3D printing hydrogel material, a preparation method thereof and application of the 3D printing hydrogel material in preparation of intelligent contact lenses. The 3D printing hydrogel material is prepared from the following raw material components: hydroxyethyl methylacrylate, polyethylene glycol diacrylate, methacrylic acid-3-(trimethoxysilyl) propyl ester, PluronicF-127, poly (3, 4-ethylenedioxythiophene), poly (p-styrene sulfonate) and a photoinitiator. According to the 3D printing hydrogel material provided by the invention, the material can be directly formed into a contact lens matrix through high-precision 3D printing, so that a core material basis is provided for developing a next-generation comfortable and precise intelligent intraocular pressure monitoring contact lens which can be manufactured in a large-scale personalized manner, and the invention further provides a preparation method of the 3D printing hydrogel material. The hydrogel material disclosed by the invention is applied to 3D printed contact lenses, and the requirements of comfortable mechanical properties and the like of the contact lenses are met.

Disclosed in the present invention are an ophthalmic material and a method for preparing contact lenses from same, relating to the field of materials of contact lenses. Specifically disclosed is an ophthalmic material, comprising the following components in percentage by mass: 0.01-0.5% of methyldopa, 99.1-99.5% of an acrylate compound and 0.2-0.8% of a cross-linking agent. The present invention has the advantages of improving properties and the comfort of wearing of contact lenses and improving eye health.

The invention discloses a mixed solution and a method for extracting hard corneal contact lens protein from the mixed solution. The method comprises the following specific steps: preparing a lysozyme solution with the pH value range of 10-11.4; a certain amount of lysozyme solution is measured and placed in a container, a hard cornea contact lens is placed in the lysozyme solution in the container and cultured in a constant-temperature incubator for a period of time, and precipitable protein is deposited on the hard cornea contact lens; the lysozyme solution cultured in the container is moved out, the mixed solution is added into the container where the hard corneal contact lens is placed, oscillation is conducted for a certain time, and the protein content in the mixed solution is detected; wherein the mixed solution is composed of calcium chloride, ethanol and water. The mixed solution does not contain chemical substances which react with a hard cornea contact lens material, and does not contain chemical substances which interfere with detection, and the method for extracting the protein by using the mixed solution is convenient and effective, does not damage the hard cornea contact lens, and is high in repeatability.

[Problem] To provide: a hard contact lens that has high oxygen permeability and, as a result of having a large bending deformation amount, is not easily damaged by bending deformation; and a hard contact lens material with which it is possible to manufacture the hard contact lens. [Solution] One aspect of the present invention provides a hard contact lens material which comprises a substituted methacrylate (A) having a molecular structure where the ratio of the number of fluorine atoms to the number of carbon atoms is 0.6-0.9, a substituted styrene (B), a methacryloyl group-containing silicone monomer (C), a (meth)acryloyl group-containing monomer (D), an unsaturated double bond-containing hydrophilic monomer (E), and a methacryloyl group-containing monomer (F), and in which the mole ratio of the (meth)acryloyl group-containing monomer (D) to the methacryloyl group-containing monomer (F) is 0.12-0.2.

This invention discloses a method for preparing a photothermal controlled-release hydrogel contact lens material. The method involves chemically bonding ganciclovir with hydroxypropyltrimethylammonium chloride chitosan, then adding methacrylic anhydride to introduce double bonds. The resulting product is used as a crosslinking agent to crosslink and copolymerize with hydroxyethyl methacrylate (MXene) nanosheets to prepare the hydrogel material. The prepared photothermal controlled-release hydrogel contact lens material can bond drugs to the polymer chains of the hydrogel contact lens for drug loading, avoiding drug loss due to tear rinsing, thereby improving drug storage stability. Furthermore, it can be modulated with near-infrared light to generate a photothermal effect, raising the hydrogel temperature and triggering the breakage of thermosensitive azo bonds, releasing the drug into the contact lens matrix. When the lens is worn, the drug can be slowly released from the contact lens into the eye, potentially making it a multifunctional contact lens material for treating eye diseases.