22 results about "Contact lens material" patented technology

The invention belongs to the technical field of contact lenses, and provides a moisturizing contact lens containing a hyaluronic acid coating and a preparation method of the moisturizing contact lens. The preparation method comprises the following steps: carrying out ultrasonic mixing on a hydrophilic monomer, a siloxane monomer, a cross-linking agent and an initiator, injecting the mixed solution into a contact lens mold, and carrying out polymerization reaction to obtain a contact lens material; mixing the chitosan solution, the shellac acid solution, the hyaluronic acid solution and the vitamin E succinate solution to obtain a hyaluronic acid mixed solution; and soaking the contact lens material in the hyaluronic acid mixed solution, adding a cross-linking agent, curing, and drying to obtain the moisturizing contact lens containing the hyaluronic acid coating. The contact lens disclosed by the invention has excellent moisture retention, good light transmission performance, swelling performance and excellent mechanical property, the wearing comfort is remarkably improved, and the contact lens is suitable for being worn for a long time; the preparation method disclosed by the invention is environment-friendly and easy to industrialize.

The invention provides a preparation process of a hyaluronic acid-chitosan coating and a contact lens with the hyaluronic acid-chitosan coating, and belongs to the technical field of surface coatings of contact lenses. The preparation method comprises the following steps: carrying out surface grafting treatment on a bare contact lens with high oxygen permeation rate, and alternately coating a chitosan solution and a hyaluronic acid solution with certain concentrations, so as to form a composite coating consisting of discontinuous single layers on the surface of the contact lens; the obtained contact lens with the hyaluronic acid-chitosan coating has high oxygen permeation rate, good antibacterial effect and moisturizing capacity, and has important significance.

The invention relates to the technical field of preparation of contact lens materials, in particular to a high-weather-resistance silicone hydrogel contact lens material and a preparation method thereof. The preparation method of the contact lens material comprises the following steps: S1, adding a polymeric monomer, a weather-proof additive and a functional additive into absolute ethyl alcohol, and stirring in a dark place to obtain a premixed solution; and S2, adding nano silver and nano titanium dioxide into the premixed solution, performing ultrasonic dispersion, adding a cross-linking agent and an initiator, performing uniform mixing, injecting the mixture into a contact lens mold, performing photo-initiation polymerization reaction under the protection of inert gas, and performing washing with deionized water and equilibrium with a boric acid buffer solution to obtain the high-weather-resistance silicon hydrogel contact lens material. The prepared contact lens material not only has high oxygen permeability and high light transmittance, but also can effectively ensure that the cornea obtains sufficient oxygen, and is also excellent in weather resistance and not easy to deform or damage.

The present invention belongs to the field of medical device technology and discloses a suture-free ocular surface repair device and its preparation method. The suture-free ocular surface repair device comprises a main body layer and a biofilm; the main body layer is a structure obtained by solidifying invisible contact lens material and having a curvature consistent with the ocular surface; the biofilm is disposed on the inner side of the main body layer; before the main body layer solidifies, the invisible contact lens material partially penetrates into the biofilm and solidifies to form a permeable layer, which connects the biofilm to the main body layer via the permeable layer. The technical solution provided by the suture-free ocular surface repair device and its preparation method can ensure a stable and non-detachable bond between the biofilm and the main body layer, while also ensuring that the side of the biofilm closest to the ocular surface is flat, reducing foreign body sensation, improving wearing comfort, and maintaining the biological activity of the biofilm, resulting in good clinical therapeutic effects.

The present invention provides a hard contact lens that has high oxygen permeability and a large bending deformation capacity, making it resistant to breakage from bending deformation, and a hard contact lens material that can be used to manufacture such a hard contact lens. [Solution] According to one aspect of the present invention, a hard contact lens material is provided, comprising a substituted methacrylate (A) having a molecular structure in which the ratio of the number of fluorine atoms to the number of carbon atoms is 0.6 or more and 0.9 or less, a substituted styrene (B), a methacryloyl group-containing silicone monomer (C), a (meth)acryloyl group-containing monomer (D), an unsaturated double bond-containing hydrophilic monomer (E), and a methacryloyl group-containing monomer (F), wherein the molar ratio of (meth)acryloyl group-containing monomer (D) to methacryloyl group-containing monomer (F) is 0.12 or more and 0.2 or less.

The invention belongs to the technical field of contact lens materials, and discloses a high-moisture-retention contact lens material and a preparation method thereof. The raw materials of the invention comprise 50-70 parts of a silicon-based monomer, 40-60 parts of a hydrophilic monomer, 5-15 parts of hyaluronic acid, 3-10 parts of water-soluble collagen, 2-8 parts of modified chitosan, 1-5 parts of a moisturizing aid, 0.5-3 parts of a cross-linking agent, 0.1-1 part of a photoinitiator and 10-20 parts of water. The contact lens material prepared by the invention is low in water loss rate, long in moisturizing time, excellent in biocompatibility, excellent in oxygen permeability, simple in preparation process and easy to industrialize.

The invention relates to the technical field of contact lens materials, in particular to a high-moisturizing cosmetic contact lens material based on natural raw materials and a low-irritation preparation method thereof.The high-moisturizing cosmetic contact lens material is prepared from, by mass, 25%-38% of hyaluronic acid-chitosan compound, 12%-22% of plant extract and 6%-12% of natural moisturizing factors; 0.3%-1.5% of a natural cross-linking agent, and the balance deionized water with the conductivity less than or equal to 1 [mu] S / cm; the mass ratio of hyaluronic acid to chitosan in the hyaluronic acid-chitosan compound is (3: 1)-(5: 1); the plant extract comprises a mixture of aloe polysaccharide and seaweed gel, and the mass ratio of the aloe polysaccharide to the seaweed gel is (2: 1)-(4: 1); the natural moisturizing factor comprises a mixture of glyceryl laurate and betaine in a mass ratio of (1: 1)-(2: 1). Natural synergistic moisturizing is realized through electrostatic net formation of the hyaluronic acid-chitosan compound and combination of aloe polysaccharide and mucoprotein, glutaraldehyde is replaced by genipin, a low-irritation process is realized through dialysis and impurity removal, and the effects of high moisturizing, low irritation, good oxygen permeability and good biocompatibility are realized by combining a double-layer structure and natural moisturizing factors.

The invention discloses a high-light-transmittance contact lens silicone hydrogel material and a preparation method thereof, and relates to the technical field of contact lens materials, the high-light-transmittance contact lens silicone hydrogel material comprises the following raw materials by weight: 25-35 parts of a silane monomer, 20-25 parts of a functional monomer, 0.6-1.0 part of a cross-linking agent, 0.3-0.5 part of an initiator, and 40-50 parts of a solvent. The silane monomer, the functional monomer and the cross-linking agent are combined for use, so that the high light transmittance of the prepared silicon hydrogel material meets the use requirement. The functional monomer is prepared from 4-nitrophenyl-beta-D-glucuronic acid sodium salt, 2-cyano-5-(dimethylamino)-3-ethoxy penta-2, 4-dienoic acid ethyl ester, 5-chloro-2-pentanone and the like through a reaction, and the contact lens silicon hydrogel material is endowed with relatively high water content and relatively strong antibacterial property.

The present invention discloses a contact lens material, which comprises: a hydrophilic monomer, a crosslinking agent, an initiator, and a siloxane monomer. Based on the total weight of the contact lens material being 100 parts by weight, a dosage range of the siloxane monomer is between 5 parts by weight and 50 parts by weight. And, a chemical formula of the siloxane monomer is: C a H b O c N d Si e . Wherein, C represents a carbon atom, a is a positive number between 12 and 55; H represents a hydrogen atom, b is a positive number between 29 and 121; O represents an oxygen atom, c is a positive number between 4 and 17; N represents a nitrogen atom, d is a positive number between 0 and 5; Si represents a silicon atom, e is a positive number between 1 and 9. The contact lens material of the present invention can be prepared into a silicone hydrogel contact lens, which has the advantages of low cost, mass production, and simple manufacturing process, etc.

The invention belongs to the technical field of contact lenses, and provides a bionic protein contact lens material capable of being degraded by tear enzyme. The biomimetic protein contact lens material capable of being degraded by the tear enzyme comprises the following raw materials in specific parts by mass: a siloxane monomer, a hydrophobic acrylic monomer, a hydrophilic monomer, a biomimetic material, a biocompatibility agent, a cross-linking agent, an initiator and a solvent. On the basis of a siloxane monomer and a hydrophilic monomer, a hydrophobic acrylic monomer is added and compounded with the siloxane monomer to form a hydrophobic and high-oxygen-permeability system; by controlling the dosage of the biomimetic material, the biomimetic material forms a self-crosslinking body, so that the light transmittance of the contact lens material is prevented from being influenced; due to the addition of the biomimetic material, the contact lens material is endowed with high biocompatibility and biodegradability; the biological compatibilizer has good hydrophilicity and biocompatibility, and is matched with the hydrophilic monomers, so that the hydrophilic effect is remarkably improved, and the compatibility among the raw material monomers is improved; the film has the characteristics of high oxygen and light permeability, strong hydrophilicity and biodegradability.

A contact lens material includes: a hydrophilic monomer, a crosslinking agent, an initiator, and a siloxane monomer. Based on a total weight of the contact lens material being 100 parts by weight, an amount of the siloxane monomer is between 5 parts by weight and 50 parts by weight. A chemical empirical formula of the siloxane monomer is: CaHbOcNdSie, in which C represents carbon atoms, a is a positive number between 12 and 55, H represents hydrogen atoms, b is a positive number between 29 and 121, O represents oxygen atoms, c is a positive number between 4 and 17, N represents nitrogen atoms, d is a positive number between 0 and 5, Si represents silicon atoms, and e is a positive number between 1 and 9.

The application discloses a kind of hydrophilic rigid gas-permeable contact lens materials and its surface grafting modified preparation method, comprising the following steps: using the monomer containing isocyanate group or epoxy group and the copolymerization of silane monomer and methyl methacrylate to prepare rigid contact lens;The above-mentioned rigid contact lens is immersed into the solution containing hydrophilic macromolecule of hydroxyl or amino, and the covalent reaction of epoxy group and amino or isocyanate group and hydroxyl or amino is carried out at high temperature, and the hydrophilic macromolecule is grafted on the surface of lens;The present application is simple and easy to operate, and the product after grafting is stable, which can significantly improve the hydrophilicity of the lens without affecting the transparency of the lens.

The invention belongs to the technical field of contact lenses, and discloses a long-lasting fragrance-retaining contact lens material and a preparation method thereof. The invention discloses a light-sensitive adhesive which is prepared from the following raw materials: hydroxyethyl methylacrylate, N-vinyl pyrrolidone, acrylamide, glycidyl methacrylate, methacryloyloxypropyl tri (trimethylsiloxane) silane, a cross-linking agent, a modified essential oil microcapsule and a photoinitiator. According to the modified essential oil microcapsule, gelatin-Arabic gum serves as a capsule wall to wrap the essential oil, fragrance can be continuously released, the capsule wall material is high in hydrophilicity, good in biocompatibility and free of irritation to the cornea, and the wearing comfort is improved. Meanwhile, modification is carried out, through surface functionalization of the silane coupling agent, the essential oil microcapsule can be well connected with a contact lens base material, the compatibility with the base material is good, falling of the essential oil microcapsule is avoided, fragrance can be kept for a long time, and pleasant sensory experience is brought to consumers.

The invention relates to the technical field of preparation of contact lens materials, and particularly discloses a high-moisture-retention and antibacterial silicone hydrogel contact lens material and a preparation method thereof.The high-moisture-retention and antibacterial silicone hydrogel contact lens material is prepared through the following steps that S1, a silicon-containing component is prepared; s2, preparing a hydrogel contact lens material; the antibacterial dispersion liquid is added, the antibacterial dispersion liquid contains a sodium alginate structure, a chlorogenic acid structure, zinc glycinate and an aloe extract, on one hand, active hydroxyl contained in the molecular structure of the sodium alginate can be combined with water molecules through hydrogen bonds, and on the other hand, the active hydroxyl serves as an anchoring point to be subjected to esterification reaction with carboxyl of chlorogenic acid, so that the antibacterial effect is achieved. The zinc glycinate is used as a source of organic zinc, and the aloe extract is rich in aloe polysaccharide and anthraquinone compounds, so that the moisture retention, oxygen permeability and antibacterial property of the hydrogel contact lens material can be improved by introducing the aloe extract into the hydrogel contact lens material.

This invention belongs to the field of contact lens materials technology, specifically relating to 3D-printed hydrogel materials, their preparation methods, and their application in the fabrication of smart contact lenses. The 3D-printed hydrogel material comprises the following raw material components: hydroxyethyl methacrylate, polyethylene glycol diacrylate, 3-(trimethoxysilyl)propyl methacrylate, Pluronic F-127, poly(3,4-ethylenedioxythiophene):poly(p-phenylene sulfonate), and a photoinitiator. The 3D-printed hydrogel material provided by this invention can be directly molded into a contact lens substrate through high-precision 3D printing, thus providing a core material basis for developing next-generation comfortable, precise, and mass-producible personalized smart intraocular pressure monitoring contact lenses. This invention also provides its preparation method. Applying the hydrogel material of this invention to 3D-printed contact lenses meets the requirements for mechanical performance and comfort in contact lenses.

The invention belongs to the technical field of contact lens materials, and particularly relates to a 3D printing hydrogel material, a preparation method thereof and application of the 3D printing hydrogel material in preparation of intelligent contact lenses. The 3D printing hydrogel material is prepared from the following raw material components: hydroxyethyl methylacrylate, polyethylene glycol diacrylate, methacrylic acid-3-(trimethoxysilyl) propyl ester, PluronicF-127, poly (3, 4-ethylenedioxythiophene), poly (p-styrene sulfonate) and a photoinitiator. According to the 3D printing hydrogel material provided by the invention, the material can be directly formed into a contact lens matrix through high-precision 3D printing, so that a core material basis is provided for developing a next-generation comfortable and precise intelligent intraocular pressure monitoring contact lens which can be manufactured in a large-scale personalized manner, and the invention further provides a preparation method of the 3D printing hydrogel material. The hydrogel material disclosed by the invention is applied to 3D printed contact lenses, and the requirements of comfortable mechanical properties and the like of the contact lenses are met.

Disclosed in the present invention are an ophthalmic material and a method for preparing contact lenses from same, relating to the field of materials of contact lenses. Specifically disclosed is an ophthalmic material, comprising the following components in percentage by mass: 0.01-0.5% of methyldopa, 99.1-99.5% of an acrylate compound and 0.2-0.8% of a cross-linking agent. The present invention has the advantages of improving properties and the comfort of wearing of contact lenses and improving eye health.

The invention discloses a mixed solution and a method for extracting hard corneal contact lens protein from the mixed solution. The method comprises the following specific steps: preparing a lysozyme solution with the pH value range of 10-11.4; a certain amount of lysozyme solution is measured and placed in a container, a hard cornea contact lens is placed in the lysozyme solution in the container and cultured in a constant-temperature incubator for a period of time, and precipitable protein is deposited on the hard cornea contact lens; the lysozyme solution cultured in the container is moved out, the mixed solution is added into the container where the hard corneal contact lens is placed, oscillation is conducted for a certain time, and the protein content in the mixed solution is detected; wherein the mixed solution is composed of calcium chloride, ethanol and water. The mixed solution does not contain chemical substances which react with a hard cornea contact lens material, and does not contain chemical substances which interfere with detection, and the method for extracting the protein by using the mixed solution is convenient and effective, does not damage the hard cornea contact lens, and is high in repeatability.

[Problem] To provide: a hard contact lens that has high oxygen permeability and, as a result of having a large bending deformation amount, is not easily damaged by bending deformation; and a hard contact lens material with which it is possible to manufacture the hard contact lens. [Solution] One aspect of the present invention provides a hard contact lens material which comprises a substituted methacrylate (A) having a molecular structure where the ratio of the number of fluorine atoms to the number of carbon atoms is 0.6-0.9, a substituted styrene (B), a methacryloyl group-containing silicone monomer (C), a (meth)acryloyl group-containing monomer (D), an unsaturated double bond-containing hydrophilic monomer (E), and a methacryloyl group-containing monomer (F), and in which the mole ratio of the (meth)acryloyl group-containing monomer (D) to the methacryloyl group-containing monomer (F) is 0.12-0.2.

The invention relates to the technical field of contact lens materials, in particular to a safe and non-irritant pure water ink printing cosmetic contact lens which comprises a base material layer made of silicone hydrogel, a pure water ink printing layer attached to the surface of the base material layer and a hydrophilic coating covering the surface of the printing layer. The ink of the pure water-based ink printing layer contains natural pigment, a water-soluble adhesive and a pH regulator; the hydrophilic coating is formed by compounding polyvinylpyrrolidone and hyaluronic acid; and the preparation method comprises the following steps: pretreating the base material, preparing the ink printing layer, curing at low temperature, coating the hydrophilic coating, sterilizing and packaging. According to the invention, pure water-based environment-friendly printing ink is adopted to replace traditional organic solvent printing ink to print patterns, and a substrate plasma activation pretreatment process, a low-temperature curing process and a PVP / hyaluronic acid composite hydrophilic coating process are combined, so that benzene-free solvent residual stimulation is realized, the oxygen permeability is improved, and the surface friction coefficient is reduced; finally, the safe cosmetic contact lens which is comfortable to wear for a long time and suitable for people with sensitive eyes is obtained.

The invention belongs to the technical field of contact lenses, and particularly discloses a fragrant UV (ultraviolet) photocuring contact lens material as well as a preparation method and application thereof. The contact lens material disclosed by the invention is prepared from 30 to 40 parts of a siloxane monomer, 50 to 80 parts of a hydrophilic monomer, 0.01 to 0.1 part of a nanocapsule, 0.5 to 1.5 parts of a cross-linking agent, 0.2 to 0.8 part of an ultraviolet light absorber and 0.5 to 1.5 parts of an initiator. Wherein the core material of the nano capsule is prepared from alpha-bisabolol, vanillin and apigenin. By adding the active components, xerophthalmia, eye inflammation and eye dryness can be relieved, and many problems caused by wearing contact lenses are avoided to a certain extent; the invention further discloses application of the nanocapsule, slow release of effective components is achieved, and stimulation to eyes is avoided. In addition, the mask also has the effects of emitting fragrance for a long time and making a wearer have physical and mental pleasure.

This invention discloses a method for preparing a photothermal controlled-release hydrogel contact lens material. The method involves chemically bonding ganciclovir with hydroxypropyltrimethylammonium chloride chitosan, then adding methacrylic anhydride to introduce double bonds. The resulting product is used as a crosslinking agent to crosslink and copolymerize with hydroxyethyl methacrylate (MXene) nanosheets to prepare the hydrogel material. The prepared photothermal controlled-release hydrogel contact lens material can bond drugs to the polymer chains of the hydrogel contact lens for drug loading, avoiding drug loss due to tear rinsing, thereby improving drug storage stability. Furthermore, it can be modulated with near-infrared light to generate a photothermal effect, raising the hydrogel temperature and triggering the breakage of thermosensitive azo bonds, releasing the drug into the contact lens matrix. When the lens is worn, the drug can be slowly released from the contact lens into the eye, potentially making it a multifunctional contact lens material for treating eye diseases.