Ophthalmic material and method for preparing contact lenses from same

Abstract

Disclosed in the present invention are an ophthalmic material and a method for preparing contact lenses from same, relating to the field of materials of contact lenses. Specifically disclosed is an ophthalmic material, comprising the following components in percentage by mass: 0.01-0.5% of methyldopa, 99.1-99.5% of an acrylate compound and 0.2-0.8% of a cross-linking agent. The present invention has the advantages of improving properties and the comfort of wearing of contact lenses and improving eye health.

Description

Ophthalmic material and method for manufacturing contact lens using the same TECHNICAL FIELD

[0001] The present application relates to the technical field of contact lenses, and in particular to an ophthalmic material and a method for manufacturing a contact lens using the same. BACKGROUND

[0002] Dopamine (DA) is a substance belonging to the catecholamine family and is one of the important neurotransmitters in the central nervous system. It is also an important active substance secreted by the retina. Dopamine metabolism and release in the retina are related to many physiological activities of the visual system. In recent years, the application of dopamine in the field of contact lenses has attracted widespread attention and research.

[0003] Through dopamine coating and material modification, the hydrophilicity, protein adsorption resistance and infection resistance of contact lenses can be improved, thereby improving the comfort and safety of wearers. In addition, dopamine can also regulate visual function and ocular surface health, improve the visual effect of contact lenses and the health status of the eyes.

[0004] Dopamine and its analogues can be used to synthesize quinone polymers, which can form chelates with calcium, iron, copper and other ions in the human body and produce active oxygen, and have excellent antibacterial performance. Therefore, dopamine and its analogues have a wide range of applications, and related products can utilize the antibacterial performance of dopamine materials to improve the eye hygiene of users and improve safety.

[0005] However, the selection and research of various dopamine derivatives are still at the macro level, and with the increasing functional demand for contact lenses, there is an urgent need for contact lens materials that are more excellent in hydrophilicity, protein adsorption resistance and infection resistance, and also have other effects. SUMMARY

[0006] In view of the deficiencies in the prior art, the purpose of the present application is to provide an ophthalmic material and a method for manufacturing a contact lens using the same.

[0007] The above-mentioned purpose of the present application is achieved by the following technical solutions:

[0008] An ophthalmic material comprising the following components in mass percentage: methyl dopa 0.01-0.5%; acrylate compound 99.1-99.5%; crosslinking agent 0.2-0.8%.

[0009] The molecular formula of methyl dopa is:

[0010] In the present application, the acrylate compound and the crosslinking agent are main components of the contact lens. The present application also adds methyldopa as an additive into the contact lens material. The methyldopa has both carboxyl and amino groups, and has the characteristics of amphiphilicity, which can significantly increase the wettability of the contact lens surface, more effectively reduce protein adsorption, so that the lens surface can effectively retain more moisture, reduce the amount of protein deposition, prevent tear film evaporation and dry eye, and improve the wearing comfort. Secondly, the trace amount of methyldopa component is delivered into the blood vessels in the eye by slow release, and is delivered to the central nervous system with the blood, thereby playing a role in reducing blood pressure.

[0011] Further, the crosslinking agent is selected from one or more of trimethylolpropane trimethacrylate, trihydroxypropane trimethacrylate, ethylene glycol dimethacrylate or ethylene glycol diacrylate.

[0012] Further, the acrylate compound includes a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is selected from one or more of hydroxyethyl methacrylate, hydroxyethyl acrylate or monoglyceride acrylate; the hydrophobic monomer is selected from one or more of ethoxyethyl methacrylate, methyl methacrylate or lauryl methacrylate.

[0013] Further, the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 1-8:1.

[0014] Further, the ophthalmic material also adds 0.001-0.03% of rare earth element-tyrosine complex by mass ratio.

[0015] Further, the rare earth element is selected from one or more of europium, samarium and dysprosium.

[0016] In the present application, the addition of the rare earth element-tyrosine complex in addition to methyldopa has good antibacterial property, and its presence in the contact lens is more stable, which can play a long-acting antibacterial role.

[0017] Further, the ophthalmic material also adds 0.01-0.1% of menthol and / or menthol ester by mass ratio.

[0018] The present application also adds menthol and / or menthol ester in the ophthalmic material. When the tear fluid infiltrates the contact lens, the menthol ester can slowly decompose to release menthol, and the menthol can be slowly released from the contact lens, thereby achieving the effect of ice cooling and relieving the eyes, reducing fatigue. Secondly, the methyldopa has an amino group therein, which can promote the decomposition of the menthol ester in the tear fluid environment, thereby improving the release capacity of menthol, so that the menthol ester can decompose and release more menthol in the case of more tear secretion such as tearing, thereby more effectively and quickly relieving the eyes from heat and eye fatigue.

[0019] Further, the menthol ester is menthyl lactate.

[0020] A method for preparing a contact lens using the above ophthalmic material, comprising the following steps:

[0021] S1: according to the amount of each component, configure the solution;

[0022] S2: fill the solution into a sandwich mold made of stainless steel and Teflon, and put it into an irradiation device or an oven at 100 DEG C for 24 hours to obtain a sample;

[0023] S3: immerse the sample and its mold in water, and subject them to a 65 DEG C water bath for 48 hours, with water change every 12 hours, and then demold.

[0024] Further, in the S1 step, the configured solution is first heated to 45-50 DEG C, and the heating time is 20-40 min.

[0025] Compared with the prior art, the present application has the following beneficial effects:

[0026] By using methyldopa as an additive to prepare the ophthalmic material, the hydrophilicity of the contact lens is significantly improved, protein adsorption is reduced, and the anti-infection ability is enhanced, thereby improving the comfort and safety of the wearer. In addition, methyldopa can also be delivered to the blood vessels of the eye through sustained release, thereby playing a role in reducing blood pressure. The further addition of the rare earth element-tyrosine complex has long-acting bacteriostatic properties, and the addition of menthol and / or menthol ester can release menthol in the tear environment, thereby achieving the effect of relieving eye fatigue. These improvements, taken together, not only improve the material properties of the contact lens, but also provide significant improvements in wearing comfort and eye health. DETAILED DESCRIPTION

[0027] The present application will be described in detail below with reference to the embodiments.

[0028] Embodiment 1

[0029] The ophthalmic material disclosed in the present application comprises the following components in mass percentage: methyldopa 0.01%; acrylate compound 99.49%; crosslinking agent 0.5%.

[0030] The molecular formula of methyldopa is:

[0031] The crosslinking agent is trimethylolpropane trimethacrylate.

[0032] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is hydroxyethyl methacrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate.

[0033] A method for preparing a contact lens by using an ophthalmic material, comprising the following steps:

[0034] S1: according to the amount of each component, a solution is configured;

[0035] S2: the solution is filled into a sandwich mold made of stainless steel and a tetrafluoro sheet, the sandwich mold has a reservoir cavity of 10*0.3*5 cm, and is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0036] S3: the sample and the mold are immersed in water, and are subjected to a water bath at 65 DEG C for 48 hours, the water is replaced every 12 hours, and the sample is demolded.

[0037] Example 2

[0038] The ophthalmic material disclosed by the application comprises the following components in percentage by mass: methyl dopa 0.5%, acrylate compound 99.1%, and crosslinking agent 0.4%.

[0039] The crosslinking agent is trimethylolpropane trimethacrylate.

[0040] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is hydroxyethyl methacrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate. The mass ratio between the hydrophilic monomer and the hydrophobic monomer is 6:1.

[0041] A method for preparing a contact lens by using an ophthalmic material, comprising the following steps:

[0042] S1: according to the amount of each component, a solution is configured;

[0043] S2: the solution is filled into a sandwich mold made of stainless steel and a tetrafluoro sheet, the sandwich mold has a reservoir cavity of 10*0.3*5 cm, and is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0044] S3: the sample and the mold are immersed in water, and are subjected to a water bath at 65 DEG C for 48 hours, the water is replaced every 12 hours, and the sample is demolded.

[0045] Example 3

[0046] The ophthalmic material disclosed by the application comprises the following components in percentage by mass: methyldopa 0.3%; acrylate compound 99.5%; crosslinking agent 0.2%.

[0047] The crosslinking agent is trimethylolpropane trimethacrylate.

[0048] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is hydroxyethyl methacrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 6:1.

[0049] A method for preparing a contact lens by using the ophthalmic material comprises the following steps:

[0050] S1: according to the amount of each component, a solution is prepared;

[0051] S2: the solution is filled into a sandwich mold made of stainless steel and a Teflon sheet, the cavity of the liquid storage tank of the sandwich mold is 10*0.3*5 cm, and the sandwich mold is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0052] S3: the sample and the mold are immersed in water, and the water is replaced every 12 hours in a 65 DEG C water bath for 48 hours, and then the sample is demolded.

[0053] Example 4

[0054] The ophthalmic material disclosed by the application comprises the following components in percentage by mass: methyldopa 0.2%; acrylate compound 99.3%; crosslinking agent 0.5%.

[0055] The crosslinking agent is trimethylolpropane trimethacrylate.

[0056] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is hydroxyethyl methacrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 6:1.

[0057] A method for preparing a contact lens by using the ophthalmic material comprises the following steps:

[0058] S1: according to the amount of each component, a solution is prepared;

[0059] S2: the solution is filled into a sandwich mold made of stainless steel and a Teflon sheet, the cavity of the liquid storage tank of the sandwich mold is 10*0.3*5 cm, and the sandwich mold is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0060] S3: immerse the sample and its mold in water, and undergo 65 DEG C water bath for 48 hours, replace water every 12 hours, and then demold.

[0061] Example 5

[0062] The ophthalmic material disclosed in the application comprises the following components in percentage by mass: methyldopa 0.1%; acrylate compound 99.1%; crosslinking agent 0.8%.

[0063] The crosslinking agent is trimethylolpropane trimethacrylate.

[0064] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is hydroxyethyl methacrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 6:1.

[0065] A method for preparing a contact lens by using the ophthalmic material comprises the following steps:

[0066] S1: configure a solution according to the dosages of components;

[0067] S2: pour the solution into a sandwich mold made of stainless steel and Teflon, the sandwich mold has a liquid storage cavity with a size of 10*0.3*5 cm, and then place the sandwich mold into an oven for reaction at 100 DEG C for 24 hours to obtain a sample;

[0068] S3: immerse the sample and its mold in water, and undergo 65 DEG C water bath for 48 hours, replace water every 12 hours, and then demold.

[0069] Example 6

[0070] The ophthalmic material disclosed in the application comprises the following components in percentage by mass: methyldopa 0.1%; acrylate compound 99.1%; crosslinking agent 0.8%.

[0071] The crosslinking agent is trimethylolpropane trimethacrylate.

[0072] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is hydroxyethyl methacrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 6:1.

[0073] A method for preparing a contact lens by using the ophthalmic material comprises the following steps:

[0074] S1: configure a solution according to the dosages of components;

[0075] S2: The solution is filled into a sandwich mold made of stainless steel and Teflon sheet, the sandwich mold liquid storage cavity is 10*0.3*5cm, and the sample is obtained by being placed into an oven at 100°C for 24 hours;

[0076] S3: The sample and the mold are immersed in water, and the water is replaced every 12 hours in a 65°C water bath for 48 hours, and the sample is demolded.

[0077] Example 7

[0078] The ophthalmic material disclosed in the application comprises the following components by mass percentage: methyldopa 0.3%; acrylate compound 99.5%; crosslinking agent 0.2%.

[0079] The crosslinking agent is ethylene glycol dimethacrylate.

[0080] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is acrylic acid monoglyceride, and the hydrophobic monomer is selected from lauryl methacrylate; and the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 6:1.

[0081] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0082] S1: A solution is prepared according to the amount of each component;

[0083] S2: The solution is filled into a sandwich mold made of stainless steel and Teflon sheet, the sandwich mold liquid storage cavity is 10*0.3*5cm, and the sample is obtained by being placed into an oven at 100°C for 24 hours;

[0084] S3: The sample and the mold are immersed in water, and the water is replaced every 12 hours in a 65°C water bath for 48 hours, and the sample is demolded.

[0085] Example 8

[0086] The ophthalmic material disclosed in the application comprises the following components by mass percentage: methyldopa 0.2%; acrylate compound 99.3%; crosslinking agent 0.5%.

[0087] The crosslinking agent is trimethylolpropane trimethacrylate.

[0088] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a mixture with a mass ratio of 1:1 of hydroxyethyl methacrylate and hydroxyethyl acrylate; and the hydrophobic monomer is selected from ethoxyethyl methacrylate; and the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0089] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0090] S1: according to the amount of each component, configure the solution;

[0091] S2: the solution is filled into a sandwich mold made of stainless steel and Teflon sheet, the storage tank cavity of the sandwich mold is 10*0.3*5cm, and the sandwich mold is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0092] S3: the sample and the mold are immersed in water, and the water is replaced every 12 hours after being subjected to a 65 DEG C water bath for 48 hours, and the sample can be demolded.

[0093] Example 9

[0094] The ophthalmic material disclosed in the application comprises the following components in mass percentage:

[0095] The crosslinking agent is trimethylolpropane trimethacrylate.

[0096] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate in a mass ratio of 1:1, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0097] The rare earth oxide is reacted with a proper excess of hydrochloric acid to generate a rare earth hydrochloride, and then the rare earth hydrochloride and tyrosine are added in a ratio of n (RECl3·nH2O) :n (Tyr) =1:3 (RE=Dy). A certain amount of rare earth salt and tyrosine are accurately weighed and dissolved in 95% ethanol solution, and the tyrosine is dissolved by adjusting the solution to pH=3 with 1 mol / L HCl. Then the rare earth chloride salt and the tyrosine solution are mixed, heated and stirred under reflux at 60-65 DEG C, and after about 3 hours of reaction, the mixture is transferred to a water bath for slow evaporation and concentration, and then vacuum dried to obtain a rare earth element-tyrosine complex.

[0098] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0099] S1: according to the amount of each component, configure the solution;

[0100] S2: the solution is filled into a sandwich mold made of stainless steel and Teflon sheet, the storage tank cavity of the sandwich mold is 10*0.3*5cm, and the sandwich mold is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0101] S3: the sample and the mold are immersed in water, and the water is replaced every 12 hours after being subjected to a 65 DEG C water bath for 48 hours, and the sample can be demolded.

[0102] Example 10

[0103] An ophthalmic material disclosed by the application comprises the following components by mass percentage:

[0104] The crosslinking agent is trimethylolpropane trimethacrylate.

[0105] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a 1:1 mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0106] The rare earth oxide is reacted with a proper excess of hydrochloric acid to generate a rare earth hydrochloride, and then the rare earth hydrochloride and tyrosine are added in a ratio of n (RECl3·nH2O) :n (Tyr) =1:3 (RE=Dy). A certain amount of the rare earth salt and tyrosine are accurately weighed and dissolved in a 95% ethanol solution, the tyrosine is dissolved by adjusting the solution to pH=3 with 1 mol / L HCl, then the rare earth chloride salt is mixed with the tyrosine solution, heated and stirred under reflux at 60℃, after about 3h of reaction, the solution is slowly concentrated by evaporation in a water bath and dried in vacuum to obtain a rare earth element-tyrosine complex.

[0107] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0108] S1: according to the amount of each component, a solution is prepared;

[0109] S2: the solution is filled into a sandwich mold made of stainless steel and Teflon, the sandwich mold has a liquid storage cavity of 10x0.3x5cm, and is placed in an oven at 100℃ for 24h to obtain a sample;

[0110] S3: the sample and the mold are immersed in water, and the water is replaced every 12h in a 65℃ water bath for 48h, and then the sample is demolded.

[0111] Example 11

[0112] An ophthalmic material disclosed by the application comprises the following components by mass percentage:

[0113] The crosslinking agent is trimethylolpropane trimethacrylate.

[0114] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a 1:1 mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0115] The rare earth oxide is reacted with a proper excess of hydrochloric acid to form a rare earth hydrochloride, and then the rare earth hydrochloride and tyrosine are mixed in a ratio of n (RECl3·nH2O) :n (Tyr) =1:3 (RE=Dy). A certain amount of the rare earth salt and tyrosine are accurately weighed and dissolved in 95% ethanol solution. When the tyrosine is dissolved, the solution is adjusted to pH=3 with 1 mol / L HCl. Then the rare earth chloride is mixed with the tyrosine solution, heated and stirred under reflux at 60-65 DEG C for about 3 hours. The sample is obtained by slow evaporation and concentration in a water bath and vacuum drying.

[0116] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0117] S1: according to the amount of each component, the solution is configured;

[0118] S2: the solution is injected into a sandwich mold made of stainless steel and tetrafluoro sheet, the sandwich mold liquid storage cavity is 10*0.3*5cm, and the sandwich mold is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0119] S3: the sample and the mold are immersed in water, and the water is replaced every 12 hours in a 65 DEG C water bath for 48 hours, and the sample is demolded.

[0120] Example 12

[0121] The ophthalmic material disclosed by the application comprises the following components in mass percentage:

[0122] The crosslinking agent is trimethylolpropane trimethacrylate.

[0123] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate in a mass ratio of 1:1, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0124] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0125] S1: according to the amount of each component, the solution is configured;

[0126] S2: the solution is injected into a sandwich mold made of stainless steel and tetrafluoro sheet, the sandwich mold liquid storage cavity is 10*0.3*5cm, and the sandwich mold is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0127] S3: the sample and the mold are immersed in water, and the water is replaced every 12 hours in a 65 DEG C water bath for 48 hours, and the sample is demolded.

[0128] Example 13

[0129] The ophthalmic material disclosed in the present application comprises the following components by mass percentage:

[0130] The crosslinking agent is trimethylolpropane trimethacrylate.

[0131] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate in a mass ratio of 1:1, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0132] The method for preparing a contact lens from the ophthalmic material comprises the following steps:

[0133] S1: according to the amount of each component, a solution is prepared;

[0134] S2: the solution is filled into a sandwich mold made of stainless steel and a Teflon sheet, the sandwich mold has a liquid storage cavity of 10x0.3x5 cm, and is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0135] S3: the sample and the mold are immersed in water, and are subjected to a water bath at 65 DEG C for 48 hours, the water is replaced every 12 hours, and the sample is demolded.

[0136] Example 14

[0137] The ophthalmic material disclosed in the present application comprises the following components by mass percentage:

[0138] The crosslinking agent is trimethylolpropane trimethacrylate.

[0139] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate in a mass ratio of 1:1, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0140] The method for preparing a contact lens from the ophthalmic material comprises the following steps:

[0141] S1: according to the amount of each component, a solution is prepared;

[0142] S2: the solution is filled into a sandwich mold made of stainless steel and a Teflon sheet, the sandwich mold has a liquid storage cavity of 10x0.3x5 cm, and is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0143] S3: the sample and the mold are immersed in water, and are subjected to a water bath at 65 DEG C for 48 hours, the water is replaced every 12 hours, and the sample is demolded.

[0144] Example 15

[0145] The ophthalmic material disclosed in the application comprises the following components by mass percentage:

[0146] The crosslinking agent is trimethylolpropane trimethacrylate.

[0147] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate in a mass ratio of 1:1, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0148] The method for preparing a contact lens from the ophthalmic material comprises the following steps:

[0149] S1: according to the amount of each component, a solution is prepared;

[0150] S2: the solution is injected into a sandwich mold made of stainless steel and a Teflon sheet, the sandwich mold has a liquid storage cavity of 10*0.3*5 cm, and is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0151] S3: the sample and the mold are immersed in water, and are subjected to a water bath at 65 DEG C for 48 hours, the water is replaced every 12 hours, and the sample is demolded.

[0152] Example 16

[0153] The ophthalmic material disclosed in the application comprises the following components by mass percentage:

[0154] The crosslinking agent is trimethylolpropane trimethacrylate.

[0155] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate in a mass ratio of 1:1, and the hydrophobic monomer is selected from ethoxyethyl methacrylate; the mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0156] The method for preparing a contact lens from the ophthalmic material comprises the following steps:

[0157] S1: according to the amount of each component, a solution is prepared;

[0158] S2: the solution is injected into a sandwich mold made of stainless steel and a Teflon sheet, the sandwich mold has a liquid storage cavity of 10*0.3*5 cm, and is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0159] S3: the sample and the mold are immersed in water, and are subjected to a water bath at 65 DEG C for 48 hours, the water is replaced every 12 hours, and the sample is demolded.

[0160] Example 17

[0161] The ophthalmic material disclosed in the present application comprises the following components by mass percentage:

[0162] The crosslinking agent is trimethylolpropane trimethacrylate.

[0163] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a 1:1 mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate by mass ratio, and the hydrophobic monomer is selected from ethoxyethyl methacrylate. The mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0164] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0165] S1: According to the amount of each component, a solution is prepared, and the prepared solution is heated to 45 DEG C first, and the heating time is 40 min;

[0166] S2: The solution is filled into a sandwich mold made of stainless steel and Teflon, the sandwich mold storage tank cavity is 10*0.3*5 cm, and the sandwich mold is placed into an oven at 100 DEG C for 24 hours to obtain a sample;

[0167] S3: The sample and the mold are immersed in water, and the water is replaced every 12 hours after being placed in a water bath at 65 DEG C for 48 hours, and the sample can be demolded.

[0168] Comparative Example

[0169] Comparative Example 1

[0170] The ophthalmic material disclosed in the present application comprises the following components by mass percentage: acrylate compound 99.55%; crosslinking agent 0.5%;

[0171] The crosslinking agent is trimethylolpropane trimethacrylate.

[0172] The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is a 1:1 mixture of hydroxyethyl methacrylate and hydroxyethyl acrylate by mass ratio, and the hydrophobic monomer is selected from ethoxyethyl methacrylate. The mass ratio between the hydrophilic monomer and the hydrophobic monomer is 8:1.

[0173] A method for preparing a contact lens from an ophthalmic material, comprising the following steps:

[0174] S1: According to the amount of each component, a solution is prepared;

[0175] S2: The solution is infused into a sandwich mold made of stainless steel and Teflon, the sandwich mold storage reservoir cavity is 10*0.3*5 cm, and the sample is obtained by placing in an oven at 100°C for 24 hours;

[0176] S3: The sample and its mold are immersed in water, and the water is changed every 12 hours after being placed in a 65°C water bath for 48 hours, and the sample is demolded.

[0177] Detection method

[0178] 1. Tensile property test: the tensile machine is Langshan LPS-20T, the elongation at break is tested at 35°C; the sample is cut into a rectangular sample of 0.3 cm*1 cm*10 cm and then the tensile property is tested;

[0179] 2. Refractive index test: refractometer: ATAGODR-M2, refractive index at 35 degrees;

[0180] 3. Water content test: balance Mettler MS-TS and oven constant DHG101-3A; the water content is calculated by the weight loss method, and the weight difference between 105°C for 24 hours and 65°C water for 48 hours is calculated;

[0181] 4. The contact lenses are placed in simulated tear fluid, the lenses are taken out at intervals, the concentrations of methyldopa and menthol in the solution are determined by ultraviolet spectrophotometry, and the cumulative release amounts of methyldopa and menthol after 48 hours are calculated, and the results are shown in Table 2.

[0182] 5. The contact lenses prepared from the ophthalmic material of Example 1 and Comparative Example 1 are used, and the VAS method (Visual Analogue Scale: visual evaluation scale) is used to evaluate the lubrication, comfort, cooling and wetness, etc. The average score of 3 (6 eyes) is calculated for each evaluation item, and the results are shown in Table 3.

[0183] Table 1

[0184] Table 2

[0185] Table 3

[0186] Conclusion: Through the above tests, it can be known that the ophthalmic material prepared by the application and the contact lenses prepared from the ophthalmic material have great improvement in comfort and cooling, and the sustained and effective release efficiency of the ophthalmic material is verified by the sustained and effective release of methyldopa and menthol.

[0187] The above merely describes the preferred embodiments of the present application, and the protection scope of the present application is not limited to the above-described embodiments. Any technical solution falling within the concept of the present application shall fall within the protection scope of the present application. It should be noted that, for ordinary skilled persons in the art, some improvements and refinements without departing from the principles of the present application shall also be considered as falling within the protection scope of the present application.

Claims

An ophthalmic material characterized in that, Comprise the following components by mass percentage: Methyldopa 0.01-0.5%; Acrylate compound 99.1-99.5%; Crosslinking agent 0.2-0.8%; The molecular formula of methyldopa is: An ophthalmic material according to claim 1, characterized in that: The crosslinking agent is selected from one or more of trimethylolpropane trimethacrylate, trihydroxypropane trimethacrylate, ethylene glycol dimethacrylate or ethylene glycol diacrylate. An ophthalmic material according to claim 1, characterized in that: The acrylate compound comprises a hydrophilic monomer and a hydrophobic monomer, the hydrophilic monomer is selected from one or more of hydroxyethyl methacrylate, hydroxyethyl acrylate or monoglyceride acrylate; the hydrophobic monomer is selected from one or more of ethoxyethyl methacrylate, methyl methacrylate or lauryl methacrylate. An ophthalmic material according to claim 3, characterized in that: The mass ratio between the hydrophilic monomer and the hydrophobic monomer is 1-8:

1. An ophthalmic material according to claim 1, characterized in that: The ophthalmic material further comprises 0.001-0.03% by mass of a rare earth element-tyrosine complex. An ophthalmic material according to claim 5, characterized in that: The rare earth element is selected from one or more of europium, samarium and dysprosium. An ophthalmic material according to claim 1, characterized in that: The ophthalmic material further comprises 0.01-0.1% by mass of menthol and / or menthol ester. An ophthalmic material according to claim 7, characterized in that: The menthol ester is menthyl lactate. A method for producing a contact lens using the ophthalmic material according to any one of claims 1 to 8, characterized by, Comprise the following steps: S1: configure a solution according to the amount of each component; S2: pour the solution into a sandwich mold made of stainless steel and Teflon, and place it in an irradiation device or oven at 100℃ for 24 hours to obtain a sample; S3: immerse the sample and its mold in water, and place it in a 65℃ water bath for 48 hours, changing the water every 12 hours, and then demold. A method of making a contact lens according to claim 9, wherein: In the S1 step, the configured solution is first heated to 45-50℃, and the heating time is 20-40 min.

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