95 results about "Pentanone" patented technology

The invention discloses a mixed fire extinguishing agent and a testing method thereof, and the mixed fire extinguishing agent comprises 2-bromo-3, 3, 3-trifluoropropene and perfluoro-2-methyl-3-pentanone; the test method comprises the following steps: S100, mixing the 2-bromo-3, 3, 3-trifluoropropene and the perfluoro-2-methyl-3-pentanone according to a preset mass ratio, and adding the 2-bromo-3, 3, 3-trifluoropropene and the perfluoro-2-methyl-3-pentanone into the mixture, s200, controllable flames are generated; s300, a mixture of the 2-bromine-3, 3, 3-trifluoropropene and the perfluoro-2-methyl-3-pentanone is adopted to carry out fire extinguishing on the controllable flame, and a mixture of the 2-bromine-3, 3, 3-trifluoropropene and the perfluoro-2-methyl-3-pentanone is adopted to carry out fire extinguishing on the controllable flame And S400, the minimum fire extinguishing concentration of the mixture is measured. The mixed fire extinguishing agent and the testing method thereof have the advantage that the mixed fire extinguishing agent capable of effectively extinguishing fire and the testing method thereof are provided.

The invention provides a preparation method of 2-pentyl-2-cyclopentenone, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: carrying out a first-stage isomerization reaction on 2-pentylidene cyclopentanone and a first composite catalyst in a first atmosphere to obtain an intermediate, carrying out a second-stage isomerization reaction on the intermediate and a second composite catalyst in a second atmosphere, and controlling the volume ratio of nitrogen to hydrogen in the first atmosphere and the second atmosphere to obtain the 2-pentylidene cyclopentanone. In the first-stage isomerization reaction, the conversion rate of converting 2-pentylidene cyclopentanone into 2-pentyl-2-cyclopentenone is increased, and in the second-stage isomerization reaction, the use amount of hydrogen in the second atmosphere is reduced, the temperature of the second-stage isomerization reaction is increased, generation of by-products is inhibited, and the yield of 2-pentylidene cyclopentanone is increased. Further, the yield and the purity of the 2-pentyl-2-cyclopentenone can be improved. According to the preparation method, the first-stage isomerization reaction and the second-stage isomerization reaction are continuous reactions, intermittent reactions are not needed, and the preparation method is more suitable for industrial application.

The invention provides a method for extracting, rectifying and separating an ethano-2-pentanone azeotropic system by using a tetramethylammonium chloride eutectic solvent, and relates to the technical field of extracting, rectifying and separating the ethano-2-pentanone azeotropic system, which comprises the following steps: taking an ethano-2-pentanone mixture as a raw material to be separated; the method comprises the following steps: mixing and stirring a hydrogen bond acceptor and a hydrogen bond donor according to a certain proportion and temperature to obtain the eutectic solvent, firstly heating a material S01 to be separated by a heat exchanger E101 and then entering the middle part of a T101 tower, adjusting a eutectic solvent material flow S02 to a proper temperature and then entering the upper part of the T101 tower, carrying out heat exchange on a tower top ethanol material flow S03, enabling a part of material flow S05 to flow back to the tower top, and carrying out heat exchange on a tower top ethanol material flow S03; according to the method, a specific eutectic solvent is adopted as an extracting agent, an extractive distillation process is matched, an ethano-2-pentanone azeotropic system can be effectively broken, the yields of ethanol and 2-pentanone can reach 99% or above finally, the purities of ethanol and 2-pentanone can reach 99.5% (mass percent) or above finally, and efficient separation is achieved.

The invention belongs to the technical field of organic matter preparation, and particularly relates to a preparation method of 2-pentylcyclopentyl-2-ketene. According to the method, methanol is used as a solvent, sulfonic acid type resin doped with lewis acid is used as a catalyst to catalyze the isomerization reaction of 2-pentylidene cyclopentanone, the catalyst and the methanol solvent can jointly promote the isomerization reaction of 2-pentylidene cyclopentanone, and the catalytic efficiency is high, so that the reaction yield is remarkably increased, and the catalyst cost is reduced; in addition, a fixed bed reactor continuous production mode is adopted, waste salt is prevented from being generated when the acid catalyst is quenched by processes such as HCl / HBr / p-toluenesulfonic acid, and methanol is used as a solvent, so that the byproduct dimethyl ether is simply separated from water and the solvent methanol. In addition, when the sulfonic acid type resin doped with the lewis acid is used for catalyzing the isomerization reaction of 2-pentylidene cyclopentanone, the stability is high, and the service life is long.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a process method for producing 3-pentanone by dehydrogenation of 3-pentanol. According to the method, 3-pentanol is used as a raw material, a supported copper-based catalyst is used, 3-pentanol is fed into a dehydrogenation reactor for dehydrogenation reaction, 3-pentanol reaction liquid is subjected to continuous rectification, light components are removed in a light component removal tower, and high-purity 3-pentanone is obtained at the top of the heavy component removal tower. The specific catalyst is adopted for preparing the 3-pentanone through dehydrogenation of the 3-pentanol, so that the dehydrogenation efficiency of the 3-pentanol is remarkably improved, and the selectivity of the 3-pentanone is 99.5% or above, so that the single-pass preparation of the 3-pentanone from the 3-pentanol is remarkably improved, and meanwhile, the production energy consumption cost is greatly reduced. According to the method, normal-pressure multi-tower continuous rectification is adopted, separation and purification of the product are achieved, and the 3-pentanone product meeting the standard is obtained.

A preparation method of N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate enzyme belongs to the field of medical intermediates, and comprises the following steps: step 1, preparing a buffer solution of a compound enzyme preparation; step 2, adding (2S)-2-benzyloxy-3-pentanone into a solvent A, and then adding a buffer solution of the compound enzyme preparation for reaction; 3, filtering, and carrying out an activation reaction on the filtrate; 4, filtering, removing the solvent, adding the obtained solid into a solvent B, and then adding formylhydrazine for reaction; 5, filtering, removing the solvent, adding the obtained solid into a solvent C, and then adding oxalic acid for reaction; and 6, drying the solid obtained by filtering to obtain the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate. According to the method, the yield of the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate can be increased, and the production cost is effectively reduced.

This invention discloses a method for producing 4-methyl-2-pentanone, which is implemented using a 4-methyl-2-pentanone production apparatus. The apparatus includes a reactive distillation column, a condenser connected to the top of the reactive distillation column, and a reboiler connected to the bottom of the column. The reactive distillation column has a rectification section, a reaction section, and a stripping section arranged sequentially from top to bottom. During operation, a catalyst is placed in the reaction section, and 4-methyl-2-pentanol is introduced into the reaction section. The temperature of the reaction section is controlled at 180–280°C. The gas phase produced by the reaction is condensed by the condenser to produce 4-methyl-2-pentanone. This production method features high conversion rate, stable product quality, and low energy consumption.

The invention belongs to the technical field of aliphatic ketone preparation, and particularly relates to a preparation method and device of 2-pentylidene cyclopentanone. The method comprises the following steps: by taking activated solid alkali as a catalyst, carrying out catalytic synthesis reaction on cyclopentanone and n-valeraldehyde in a fixed bed reactor to obtain a catalytic synthesis reaction solution; the solid alkali comprises a carrier and an active component loaded on the carrier; the catalytic synthesis reaction liquid is separated and purified through a concentration tower, and 2-pentylidene cyclopentanone and fractions containing n-valeraldehyde, cyclopentanone and water are obtained respectively; and carrying out oil-water separation on the fraction containing n-valeraldehyde, cyclopentanone and water to obtain n-valeraldehyde and cyclopentanone, and circularly carrying out catalytic synthesis reaction on the n-valeraldehyde and cyclopentanone as raw materials. The activated solid alkali is used as the catalyst, the use of an alkaline aqueous solution is avoided, the discharge of wastewater is reduced, the raw material conversion rate is high, and the product yield is high.

The invention discloses an exhaled gas VOC (volatile organic compound) marker for detecting inflammatory bowel diseases and a detection system thereof. The marker is a combination of one or more of the following components: methyl propyl sulfide, propionaldehyde, cyclohexanone, allyl methyl sulfide, octanal, 2-pentanone, phenol, butyric acid, propionic acid and 3-methylheptane. The detection system comprises an exhaled air sampling module, a sample preprocessing module, a detection analysis module and a data analysis module. The marker provided by the invention has the advantages of high specificity and good stability, can realize accurate noninvasive diagnosis of IBD, and can assist in realizing early screening and dynamic monitoring in a clinical environment.

The invention discloses a method for separating 2-pentanone and 2-pentanol by using a symmetric conjugated column [5] arene derivative crystalline non-porous material, which is characterized in that the symmetric conjugated column [5] arene derivative crystalline non-porous material is used as an adsorbent to selectively adsorb and separate 2-pentanone from a 2-pentanone / 2-pentanol mixture so as to realize adsorption separation of 2-pentanone and 2-pentanol. Industrial rectification is not needed in the adsorption separation process, the energy consumption is low, and the separation cost of the 2-pentanone and the 2-pentanol is reduced. The selected crystalline non-porous material is simple to prepare, has good economic feasibility and stability, and is short in adsorption separation time, low in equipment requirement and good in separation effect.

This invention relates to "an efficient and safe method for synthesizing perfluoropentanone," belonging to the field of organic chemical synthesis. The method for synthesizing perfluoropentanone is characterized by the following steps: under the action of hexafluoropropylene CF2=CF-CF3, fluorophosgene CF2O, and trifluorobromomethane CF3Br, perfluoropentanone (C5F) is generated in the gas phase. 10 O. The raw materials of this invention are inexpensive and readily available; the product separation and purification are simple; it is easy to industrialize; and it produces less industrial waste.

The application discloses a preparation method of an amido pyrazole compound and a method for preparing sildenafil by using the same. The amido pyrazole compound is shown as formula I. The compound of formula I is prepared by using 2-pentanone as an industrial chemical, and can be used for synthesizing sildenafil which is a selective inhibitor of type 5 phosphodiesterase (PDE5). The method has the advantages of easy availability of raw materials, simple operation, avoidance of nitration reaction, avoidance of safety hidden dangers caused by the nitration reaction from a technical source, and avoidance of environmental protection pressure caused by a large amount of nitration waste liquid, and is suitable for development into a green and sustainable production process of sildenafil bulk drug.

The present invention provides a preparation method of a posaconazole intermediate. In this method, 3-pentanone is used as the starting material, and the posaconazole intermediate is prepared through an asymmetric catalytic oxidation reaction, a substitution reaction and an asymmetric reductive amination reaction. The product obtained by this method has high purity and good yield. The preparation method has fewer steps, the raw materials are cheap and easily available, the operation is simple, the total yield is high, and it is more suitable for industrial production.

This invention belongs to the field of chemical technology, specifically relating to a method for preparing glutaric acid. The method includes: reacting cyclopentanone with an oxygen-containing gas in the presence of a solvent and a catalyst, and separating the glutaric acid; the contact is carried out in the presence of an auxiliary, wherein the auxiliary is a C5-C6 alcohol and / or a C6 ketone. This invention, by adding a suitable auxiliary to the cyclopentanone oxidation catalytic reaction, improves the conversion rate of cyclopentanone, enhances the selectivity of glutaric acid, reduces the occurrence of side reactions, and alleviates the burden of impurities in the synthesis liquid, achieving better technical results.

The application relates to the technical field of alpha-olefin preparation, and discloses a method for preparing 4-methyl-1-pentene from 4-methyl-2-pentanone, which comprises the following steps: (1) mixing 4-methyl-2-pentanone with hydrogen in the presence of a hydrogenation catalyst to perform a hydrogenation reaction, so as to obtain a 4-methyl-2-pentanol-containing stream; (2) performing ketone removal on the 4-methyl-2-pentanol-containing stream, so as to obtain 4-methyl-2-pentanone and 4-methyl-2-pentanol crude products; and (3) performing dehydration reaction on the 4-methyl-2-pentanol crude products obtained in the step (2) in the presence of a dehydration catalyst, so as to obtain a 4-methyl-1-pentene-containing stream. The method for preparing 4-methyl-1-pentene from 4-methyl-2-pentanone can be simply and effectively used for preparing 4-methyl-1-pentene products, 4-methyl-2-pentanone raw materials are easy to obtain, the reaction conditions are relatively mild, the product distribution is simple, and high-purity 4-methyl-1-pentene products can be prepared.

The invention discloses a carbonyl reductase mutant and application of the carbonyl reductase mutant in synthesis of a posaconazole intermediate. The mutant protein is a non-natural protein, and the mutant protein can significantly improve the activity of catalyzing reduction of carbonyl in (S)-2-benzyloxy-3-pentanone to generate R-configuration alcohol. When the carbonyl reductase mutant strain with improved activity is applied to the production process of a posaconazole intermediate, 100-200 g / L of a substrate can be completely converted, and (2S, 3R)-2-benzyloxy-3-pentanol is generated.

The invention relates to a method for a palladium-catalyzed cyclization extension reaction of butadienes. Specifically, under the condition that tert-butyl nitrite is oxidized under the catalysis of palladium, the cyclopentanone compound is obtained through a ring extension reaction of butyl fulvene and water. According to the invention, green and rich water is used as a raw material, and a series of cyclopentanone compounds are obtained under mild conditions.

The application belongs to the technical field of organic chemical synthesis and heterogeneous catalysis, and particularly relates to a catalyst for preparing 2,4-dimethyl-3-pentanone from isobutyric acid or isobutyric anhydride and a preparation method thereof. The application overcomes key technical bottlenecks in the existing gas-phase ketonization reaction, such as serious cracking side reactions, quick deactivation of the catalyst due to carbon deposition, and low selectivity of the target product. The application provides a method for efficiently preparing 2,4-dimethyl-3-pentanone from isobutyric acid or isobutyric anhydride. The method innovatively constructs a modified HZSM-5 molecular sieve catalyst with a micropore-mesopore multi-level pore structure, and introduces specific metal oxide active components to construct acid-base synergistic active centers, thereby realizing directional regulation of the reaction path. The method not only significantly inhibits the competitive monomolecular cracking reaction, greatly improves the selectivity of the bimolecular coupling ketonization reaction for generating 2,4-dimethyl-3-pentanone, but also effectively eliminates the diffusion resistance of macromolecular products by using mesoporous channels, thereby fundamentally solving the problem of easy carbon deposition and deactivation of the catalyst, and having excellent industrial application prospects and technical progress.

The invention belongs to the technical field of organic synthesis, and provides a method for synchronously preparing 3-methyl-2-butanone and 3-pentanone, butanone, methanol, ion exchange resin and a catalyst are mixed for alcohol ketone condensation reaction, and 3-methyl-2-butanone and 3-pentanone are obtained at the same time. Methanol and butanone are used as raw materials and react under the action of ion exchange resin and an activated carbon supported metal catalyst. According to the method, directional control of the molar ratio of 3-methyl-2-butanone to 3-pentanone is realized by accurately regulating and controlling reaction conditions, and generation of other by-products in the reaction process is relatively low. Specifically, when anion exchange resin is added into reactants, alpha-H at the edge of butanone is strong in acidity and small in steric hindrance, so that 3-pentanone is a main product (selectivity is greater than or equal to 75%); when cation exchange resin is added into reactants, alpha-H in butanone is good in stability, and 3-methyl-2-butanone is a main product (selectivity is greater than or equal to 70%).

According to the method for recovering the PGME and the PGIE from the HPPO process wastewater, the HPPO process wastewater is concentrated through the membrane separation device, the content of the PGME and the PGIE in the wastewater is greatly increased, and compared with the prior art, the energy consumption can be greatly reduced, the recovery efficiency can be improved, and the recovery cost can be reduced; 2-pentanone or 3-pentanone and a mixture of 2-pentanone and 3-pentanone are used as an azeotropic solvent to replace benzene, and the solvent circulation amount in the dehydration process can be reduced by 50% under the same pressure, so that the dehydration energy consumption is remarkably reduced, and the green and environment-friendly process requirements are met; the water layer of the dehydrated fraction is recycled into the HPPO process wastewater and then is subjected to membrane separation, so that the loss of trace PGME entrained in the dehydrated fraction can be avoided, and the yield of the PGME is increased; according to the technical scheme, the recovery rates of the PGME and the PGIE can reach 99%.

The application relates to a synthesis method of 2-hydroxy-2-methylcyclopentanone compounds and belongs to the technical field of organic synthesis. The 2-hydroxy-2-methylcyclopentanone compounds are prepared from cyclobutanone compounds through protection of carbonyl groups, deprotection and rearrangement reaction; the application does not need to use expensive metal catalysts, has mild reaction conditions, does not need high-pressure equipment, is high in safety and easy to be industrialized, is high in atomic economy, is simple in operation, avoids use of highly toxic or high-pollution reagents, and is low in mercury salt consumption.

The present invention discloses a carbonyl reductase mutant and its application in the synthesis of posaconazole intermediates. The mutant protein is a non-natural protein and has significantly improved catalysis ( S )-2-benzyloxy-3-pentanone is reduced to form R The carbonyl reductase mutant strain with enhanced activity in the present invention is applied to the production process of posaconazole intermediates, and 100-200 g / L substrate can be completely converted to produce (2 S ,3 R )-2-benzyloxy-3-pentanol.

This invention provides a method for preparing squalene. The method involves reacting 1,4-dihalobutane and magnesium powder via a Grignard reaction to obtain the corresponding Grignard reagent, which is then reacted with 5-chloro-2-pentanone via an addition reaction and acidification to prepare 1,12-dichloro-4,9-dimethyldodecyl-4,8-diene. The obtained 1,12-dichloro-4,9-dimethyldodecyl-4,8-diene and magnesium powder are then reacted with the Grignard reagent to obtain the corresponding Grignard reagent, which is then reacted with 6-methyl-5-hepten-2-one via an addition reaction and acidification to prepare squalene. The raw materials used in this invention are inexpensive and readily available. Only two Grignard and addition reactions are required to obtain the target product, making the steps simple. The reaction conditions are mild, the equipment is simple, the cost is low, and it is easy to industrialize. Wastewater generation is low, making it green, safe, and environmentally friendly. The reaction has high selectivity, few byproducts, and high yield and purity of the target product, making it suitable for green industrial production.

The present invention relates to the technical field of chemical synthesis reactions and distillation equipment, and particularly to a distillation device for the production of 3,5-dichloro-2-pentanone and its control method; the distillation device for the production of 3,5-dichloro-2-pentanone includes: a hydrochloric acid storage tank; a raw material storage tank; a first distillation furnace body, in which a first liquid level sensor is connected; a first connecting pipe, the first connecting pipe is connected between a sulfuric acid storage tank and the first distillation furnace body, the first connecting pipe is connected with a first electric control valve and a first flowmeter, and the first flowmeter and the first electric control valve are electrically connected; the first connecting pipe is connected with a second electric control valve, and the second electric control valve is electrically connected with the first liquid level sensor; etc. Through improvement, it can realize large-scale industrialized and automated preparation of 3,5-dichloro-2-pentanone, and can alleviate the problem that by-products block the channel and are difficult to clean due to the change of the ratio of raw materials and hydrochloric acid in the first distillation furnace.

The application provides a positive photoresist composition, which comprises a phenolic resin, a photosensitive compound and a mixed solvent, wherein the mixed solvent comprises a first solvent and a second solvent, the first solvent is selected from at least one of ethyl lactate, ethyl 3-ethoxypropionate, 4-methyl-2-pentanone and 2-heptanone; and the second solvent is selected from at least one of ethylene glycol monomethyl ether, propylene glycol monomethyl ether, diethylene glycol monomethyl ether, diethylene glycol dimethyl ether, propylene glycol methyl ether acetate, ethyl acetate and n-butyl acetate. The photoresist composition provided by the application has better stability than a photoresist composition using a single solvent, and can be better applied to an organic electroluminescent display.

The utility model relates to the technical field of 3-pentanone, in particular to a 3-pentanone storage container which comprises a storage box, an annular groove is formed in the storage box, two containing grooves are formed in the bottom of the inner wall of the annular groove, one side of the top of the storage box is connected with an upper cover through a hinge, and two transmission grooves are formed in the upper cover. Electric fans are rotatably connected to the interiors of the transmission grooves, a heater is fixedly connected to the top of the upper cover and located outside one transmission groove, a refrigerator is fixedly connected to the top of the upper cover and located outside the other transmission groove, and a temperature detector is in threaded connection to one side of the storage box; the detection end of the temperature detector extends into the annular groove. The device has the beneficial effects that the temperature of a storage environment can be kept constant, and decomposition reaction is reduced, so that the chemical stability of 3-pentanone is improved, the purity of 3-pentanone is kept, and compared with a traditional device, the operation quality and the use efficiency are greatly improved.

The invention belongs to the field of chemical synthesis, and particularly relates to an industrial production and synthesis method of spice 5-methyl-2-heptene-4-ketone, which comprises the following steps: reacting butanone serving as a raw material with 2-methylbutyryl chloride under alkaline conditions, creating an alkaline environment by using a solid base catalyst, filtering and separating the catalyst after the reaction is finished, and purifying filtrate by using a molecular sieve to obtain the spice 5-methyl-2-heptene-4-ketone. The preparation method comprises the following steps: taking 3-methyl-2-pentanone as a raw material to obtain an intermediate 3-methyl-2-pentanone, then reacting the intermediate 3-methyl-2-pentanone with acetaldehyde under an acidic condition, creating an acidic environment by using a solid acid catalyst, and carrying out a continuous flow reaction in a microchannel reactor to obtain the spice 5-methyl-2-heptene-4-ketone. By adjusting the process and raw materials, the yield and purity of the product are improved, the catalyst can be recycled, the emission of three wastes is less, the reaction is efficient, and the energy consumption is low.

This invention belongs to the field of ketoxime synthesis technology and provides a method for synthesizing 3-pentanone oxime. The method uses 3-pentanone, hydrogen peroxide, and ammonia as raw materials, adds a catalyst, and reacts in a closed system. After the reaction, the mixture is filtered and distilled under reduced pressure to obtain 3-pentanone oxime. The catalyst is a fluorine-modified Ti-MOR molecular sieve, obtained by reacting the Ti-MOR molecular sieve with an NH4F-alcohol solution. The method provided by this invention features high yield, high purity, and low waste, with a single-pass yield ≥96% and purity ≥99.0%. The catalyst can be recycled up to 6 times without significant activity decline. The entire process involves no organic solvent discharge and low salt content in the wastewater, meeting the requirements of green production.

The application discloses a kind of metal organic framework UiO-66 modified terahertz super surface detection lung cancer marker 2-pentanone method.The method is based on a kind of terahertz multi-resonance super surface sensor, and its unit structure is composed of two S-shaped open resonant ring and an antenna, produces three independent resonant valleys.To improve detection selectivity and structural stability, the application is functionalized to super surface using three-layer modification strategy: APTES is introduced in sequence to form stable interface layer, spin-coated amino-rich PEI layer is provided with additional adsorption sites to interact with ketone molecules, and finally spin-coated metal organic framework UiO-66 is used as sensing layer to realize effective pre-enrichment of 2-pentanone.During detection, three resonant valleys show linear red shift with the increase of 2-pentanone concentration, and the lowest test concentration is 20 ppm.The application uses multi-resonance characteristics combined with multi-dimensional response mode to realize rapid, high-sensitivity and high-selectivity non-contact detection of lung cancer marker 2-pentanone.

The invention discloses plant-based water-based ink and a preparation method thereof, and relates to the field of water-based ink. When the plant-based water-based ink is prepared, microcrystalline cellulose is subjected to formylation, then is grafted with 2-mercaptoethylamine and then is bonded with nano-silver to prepare modified cellulose; the preparation method comprises the following steps: reacting octamethylcyclotetrasiloxane, 2-methyl ester ethyl dimethoxy methylsilane and pentamethyldisiloxane, and grafting hydrazine hydrate to prepare modified silicone oil; uniformly mixing poly (butylene adipate), castor oil, isophorone diisocyanate and the modified silicone oil to obtain a modified polyurethane emulsion; the preparation method comprises the following steps: reacting aminomalonic acid with 3, 5-di-tert-butyl-4-hydroxybenzaldehyde, and uniformly mixing with carbon black powder and 1, 5-dihydroxy-3-pentanone to obtain modified carbon black; uniformly mixing the modified polyurethane emulsion, the color paste, the flatting agent and the modified cellulose to obtain the plant-based water-based ink. The prepared plant-based water-based ink has excellent antistatic property, wear resistance and durability.