68 results about "Pentanone" patented technology

The invention provides a preparation method of 2-pentyl-2-cyclopentenone, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: carrying out a first-stage isomerization reaction on 2-pentylidene cyclopentanone and a first composite catalyst in a first atmosphere to obtain an intermediate, carrying out a second-stage isomerization reaction on the intermediate and a second composite catalyst in a second atmosphere, and controlling the volume ratio of nitrogen to hydrogen in the first atmosphere and the second atmosphere to obtain the 2-pentylidene cyclopentanone. In the first-stage isomerization reaction, the conversion rate of converting 2-pentylidene cyclopentanone into 2-pentyl-2-cyclopentenone is increased, and in the second-stage isomerization reaction, the use amount of hydrogen in the second atmosphere is reduced, the temperature of the second-stage isomerization reaction is increased, generation of by-products is inhibited, and the yield of 2-pentylidene cyclopentanone is increased. Further, the yield and the purity of the 2-pentyl-2-cyclopentenone can be improved. According to the preparation method, the first-stage isomerization reaction and the second-stage isomerization reaction are continuous reactions, intermittent reactions are not needed, and the preparation method is more suitable for industrial application.

A preparation method of N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate enzyme belongs to the field of medical intermediates, and comprises the following steps: step 1, preparing a buffer solution of a compound enzyme preparation; step 2, adding (2S)-2-benzyloxy-3-pentanone into a solvent A, and then adding a buffer solution of the compound enzyme preparation for reaction; 3, filtering, and carrying out an activation reaction on the filtrate; 4, filtering, removing the solvent, adding the obtained solid into a solvent B, and then adding formylhydrazine for reaction; 5, filtering, removing the solvent, adding the obtained solid into a solvent C, and then adding oxalic acid for reaction; and 6, drying the solid obtained by filtering to obtain the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate. According to the method, the yield of the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate can be increased, and the production cost is effectively reduced.

This invention discloses a method for producing 4-methyl-2-pentanone, which is implemented using a 4-methyl-2-pentanone production apparatus. The apparatus includes a reactive distillation column, a condenser connected to the top of the reactive distillation column, and a reboiler connected to the bottom of the column. The reactive distillation column has a rectification section, a reaction section, and a stripping section arranged sequentially from top to bottom. During operation, a catalyst is placed in the reaction section, and 4-methyl-2-pentanol is introduced into the reaction section. The temperature of the reaction section is controlled at 180–280°C. The gas phase produced by the reaction is condensed by the condenser to produce 4-methyl-2-pentanone. This production method features high conversion rate, stable product quality, and low energy consumption.

The invention belongs to the technical field of aliphatic ketone preparation, and particularly relates to a preparation method and device of 2-pentylidene cyclopentanone. The method comprises the following steps: by taking activated solid alkali as a catalyst, carrying out catalytic synthesis reaction on cyclopentanone and n-valeraldehyde in a fixed bed reactor to obtain a catalytic synthesis reaction solution; the solid alkali comprises a carrier and an active component loaded on the carrier; the catalytic synthesis reaction liquid is separated and purified through a concentration tower, and 2-pentylidene cyclopentanone and fractions containing n-valeraldehyde, cyclopentanone and water are obtained respectively; and carrying out oil-water separation on the fraction containing n-valeraldehyde, cyclopentanone and water to obtain n-valeraldehyde and cyclopentanone, and circularly carrying out catalytic synthesis reaction on the n-valeraldehyde and cyclopentanone as raw materials. The activated solid alkali is used as the catalyst, the use of an alkaline aqueous solution is avoided, the discharge of wastewater is reduced, the raw material conversion rate is high, and the product yield is high.

The invention discloses an exhaled gas VOC (volatile organic compound) marker for detecting inflammatory bowel diseases and a detection system thereof. The marker is a combination of one or more of the following components: methyl propyl sulfide, propionaldehyde, cyclohexanone, allyl methyl sulfide, octanal, 2-pentanone, phenol, butyric acid, propionic acid and 3-methylheptane. The detection system comprises an exhaled air sampling module, a sample preprocessing module, a detection analysis module and a data analysis module. The marker provided by the invention has the advantages of high specificity and good stability, can realize accurate noninvasive diagnosis of IBD, and can assist in realizing early screening and dynamic monitoring in a clinical environment.

This invention relates to "an efficient and safe method for synthesizing perfluoropentanone," belonging to the field of organic chemical synthesis. The method for synthesizing perfluoropentanone is characterized by the following steps: under the action of hexafluoropropylene CF2=CF-CF3, fluorophosgene CF2O, and trifluorobromomethane CF3Br, perfluoropentanone (C5F) is generated in the gas phase. 10 O. The raw materials of this invention are inexpensive and readily available; the product separation and purification are simple; it is easy to industrialize; and it produces less industrial waste.

The application discloses a preparation method of an amido pyrazole compound and a method for preparing sildenafil by using the same. The amido pyrazole compound is shown as formula I. The compound of formula I is prepared by using 2-pentanone as an industrial chemical, and can be used for synthesizing sildenafil which is a selective inhibitor of type 5 phosphodiesterase (PDE5). The method has the advantages of easy availability of raw materials, simple operation, avoidance of nitration reaction, avoidance of safety hidden dangers caused by the nitration reaction from a technical source, and avoidance of environmental protection pressure caused by a large amount of nitration waste liquid, and is suitable for development into a green and sustainable production process of sildenafil bulk drug.

This invention belongs to the field of chemical technology, specifically relating to a method for preparing glutaric acid. The method includes: reacting cyclopentanone with an oxygen-containing gas in the presence of a solvent and a catalyst, and separating the glutaric acid; the contact is carried out in the presence of an auxiliary, wherein the auxiliary is a C5-C6 alcohol and / or a C6 ketone. This invention, by adding a suitable auxiliary to the cyclopentanone oxidation catalytic reaction, improves the conversion rate of cyclopentanone, enhances the selectivity of glutaric acid, reduces the occurrence of side reactions, and alleviates the burden of impurities in the synthesis liquid, achieving better technical results.

The application relates to the technical field of alpha-olefin preparation, and discloses a method for preparing 4-methyl-1-pentene from 4-methyl-2-pentanone, which comprises the following steps: (1) mixing 4-methyl-2-pentanone with hydrogen in the presence of a hydrogenation catalyst to perform a hydrogenation reaction, so as to obtain a 4-methyl-2-pentanol-containing stream; (2) performing ketone removal on the 4-methyl-2-pentanol-containing stream, so as to obtain 4-methyl-2-pentanone and 4-methyl-2-pentanol crude products; and (3) performing dehydration reaction on the 4-methyl-2-pentanol crude products obtained in the step (2) in the presence of a dehydration catalyst, so as to obtain a 4-methyl-1-pentene-containing stream. The method for preparing 4-methyl-1-pentene from 4-methyl-2-pentanone can be simply and effectively used for preparing 4-methyl-1-pentene products, 4-methyl-2-pentanone raw materials are easy to obtain, the reaction conditions are relatively mild, the product distribution is simple, and high-purity 4-methyl-1-pentene products can be prepared.

The invention relates to a method for a palladium-catalyzed cyclization extension reaction of butadienes. Specifically, under the condition that tert-butyl nitrite is oxidized under the catalysis of palladium, the cyclopentanone compound is obtained through a ring extension reaction of butyl fulvene and water. According to the invention, green and rich water is used as a raw material, and a series of cyclopentanone compounds are obtained under mild conditions.

The application belongs to the technical field of organic chemical synthesis and heterogeneous catalysis, and particularly relates to a catalyst for preparing 2,4-dimethyl-3-pentanone from isobutyric acid or isobutyric anhydride and a preparation method thereof. The application overcomes key technical bottlenecks in the existing gas-phase ketonization reaction, such as serious cracking side reactions, quick deactivation of the catalyst due to carbon deposition, and low selectivity of the target product. The application provides a method for efficiently preparing 2,4-dimethyl-3-pentanone from isobutyric acid or isobutyric anhydride. The method innovatively constructs a modified HZSM-5 molecular sieve catalyst with a micropore-mesopore multi-level pore structure, and introduces specific metal oxide active components to construct acid-base synergistic active centers, thereby realizing directional regulation of the reaction path. The method not only significantly inhibits the competitive monomolecular cracking reaction, greatly improves the selectivity of the bimolecular coupling ketonization reaction for generating 2,4-dimethyl-3-pentanone, but also effectively eliminates the diffusion resistance of macromolecular products by using mesoporous channels, thereby fundamentally solving the problem of easy carbon deposition and deactivation of the catalyst, and having excellent industrial application prospects and technical progress.

The invention belongs to the technical field of organic synthesis, and provides a method for synchronously preparing 3-methyl-2-butanone and 3-pentanone, butanone, methanol, ion exchange resin and a catalyst are mixed for alcohol ketone condensation reaction, and 3-methyl-2-butanone and 3-pentanone are obtained at the same time. Methanol and butanone are used as raw materials and react under the action of ion exchange resin and an activated carbon supported metal catalyst. According to the method, directional control of the molar ratio of 3-methyl-2-butanone to 3-pentanone is realized by accurately regulating and controlling reaction conditions, and generation of other by-products in the reaction process is relatively low. Specifically, when anion exchange resin is added into reactants, alpha-H at the edge of butanone is strong in acidity and small in steric hindrance, so that 3-pentanone is a main product (selectivity is greater than or equal to 75%); when cation exchange resin is added into reactants, alpha-H in butanone is good in stability, and 3-methyl-2-butanone is a main product (selectivity is greater than or equal to 70%).

According to the method for recovering the PGME and the PGIE from the HPPO process wastewater, the HPPO process wastewater is concentrated through the membrane separation device, the content of the PGME and the PGIE in the wastewater is greatly increased, and compared with the prior art, the energy consumption can be greatly reduced, the recovery efficiency can be improved, and the recovery cost can be reduced; 2-pentanone or 3-pentanone and a mixture of 2-pentanone and 3-pentanone are used as an azeotropic solvent to replace benzene, and the solvent circulation amount in the dehydration process can be reduced by 50% under the same pressure, so that the dehydration energy consumption is remarkably reduced, and the green and environment-friendly process requirements are met; the water layer of the dehydrated fraction is recycled into the HPPO process wastewater and then is subjected to membrane separation, so that the loss of trace PGME entrained in the dehydrated fraction can be avoided, and the yield of the PGME is increased; according to the technical scheme, the recovery rates of the PGME and the PGIE can reach 99%.

The application relates to a synthesis method of 2-hydroxy-2-methylcyclopentanone compounds and belongs to the technical field of organic synthesis. The 2-hydroxy-2-methylcyclopentanone compounds are prepared from cyclobutanone compounds through protection of carbonyl groups, deprotection and rearrangement reaction; the application does not need to use expensive metal catalysts, has mild reaction conditions, does not need high-pressure equipment, is high in safety and easy to be industrialized, is high in atomic economy, is simple in operation, avoids use of highly toxic or high-pollution reagents, and is low in mercury salt consumption.

This invention provides a method for preparing squalene. The method involves reacting 1,4-dihalobutane and magnesium powder via a Grignard reaction to obtain the corresponding Grignard reagent, which is then reacted with 5-chloro-2-pentanone via an addition reaction and acidification to prepare 1,12-dichloro-4,9-dimethyldodecyl-4,8-diene. The obtained 1,12-dichloro-4,9-dimethyldodecyl-4,8-diene and magnesium powder are then reacted with the Grignard reagent to obtain the corresponding Grignard reagent, which is then reacted with 6-methyl-5-hepten-2-one via an addition reaction and acidification to prepare squalene. The raw materials used in this invention are inexpensive and readily available. Only two Grignard and addition reactions are required to obtain the target product, making the steps simple. The reaction conditions are mild, the equipment is simple, the cost is low, and it is easy to industrialize. Wastewater generation is low, making it green, safe, and environmentally friendly. The reaction has high selectivity, few byproducts, and high yield and purity of the target product, making it suitable for green industrial production.

The application provides a positive photoresist composition, which comprises a phenolic resin, a photosensitive compound and a mixed solvent, wherein the mixed solvent comprises a first solvent and a second solvent, the first solvent is selected from at least one of ethyl lactate, ethyl 3-ethoxypropionate, 4-methyl-2-pentanone and 2-heptanone; and the second solvent is selected from at least one of ethylene glycol monomethyl ether, propylene glycol monomethyl ether, diethylene glycol monomethyl ether, diethylene glycol dimethyl ether, propylene glycol methyl ether acetate, ethyl acetate and n-butyl acetate. The photoresist composition provided by the application has better stability than a photoresist composition using a single solvent, and can be better applied to an organic electroluminescent display.

The utility model relates to the technical field of 3-pentanone, in particular to a 3-pentanone storage container which comprises a storage box, an annular groove is formed in the storage box, two containing grooves are formed in the bottom of the inner wall of the annular groove, one side of the top of the storage box is connected with an upper cover through a hinge, and two transmission grooves are formed in the upper cover. Electric fans are rotatably connected to the interiors of the transmission grooves, a heater is fixedly connected to the top of the upper cover and located outside one transmission groove, a refrigerator is fixedly connected to the top of the upper cover and located outside the other transmission groove, and a temperature detector is in threaded connection to one side of the storage box; the detection end of the temperature detector extends into the annular groove. The device has the beneficial effects that the temperature of a storage environment can be kept constant, and decomposition reaction is reduced, so that the chemical stability of 3-pentanone is improved, the purity of 3-pentanone is kept, and compared with a traditional device, the operation quality and the use efficiency are greatly improved.

The invention belongs to the field of chemical synthesis, and particularly relates to an industrial production and synthesis method of spice 5-methyl-2-heptene-4-ketone, which comprises the following steps: reacting butanone serving as a raw material with 2-methylbutyryl chloride under alkaline conditions, creating an alkaline environment by using a solid base catalyst, filtering and separating the catalyst after the reaction is finished, and purifying filtrate by using a molecular sieve to obtain the spice 5-methyl-2-heptene-4-ketone. The preparation method comprises the following steps: taking 3-methyl-2-pentanone as a raw material to obtain an intermediate 3-methyl-2-pentanone, then reacting the intermediate 3-methyl-2-pentanone with acetaldehyde under an acidic condition, creating an acidic environment by using a solid acid catalyst, and carrying out a continuous flow reaction in a microchannel reactor to obtain the spice 5-methyl-2-heptene-4-ketone. By adjusting the process and raw materials, the yield and purity of the product are improved, the catalyst can be recycled, the emission of three wastes is less, the reaction is efficient, and the energy consumption is low.

This invention belongs to the field of ketoxime synthesis technology and provides a method for synthesizing 3-pentanone oxime. The method uses 3-pentanone, hydrogen peroxide, and ammonia as raw materials, adds a catalyst, and reacts in a closed system. After the reaction, the mixture is filtered and distilled under reduced pressure to obtain 3-pentanone oxime. The catalyst is a fluorine-modified Ti-MOR molecular sieve, obtained by reacting the Ti-MOR molecular sieve with an NH4F-alcohol solution. The method provided by this invention features high yield, high purity, and low waste, with a single-pass yield ≥96% and purity ≥99.0%. The catalyst can be recycled up to 6 times without significant activity decline. The entire process involves no organic solvent discharge and low salt content in the wastewater, meeting the requirements of green production.

The application discloses a kind of metal organic framework UiO-66 modified terahertz super surface detection lung cancer marker 2-pentanone method.The method is based on a kind of terahertz multi-resonance super surface sensor, and its unit structure is composed of two S-shaped open resonant ring and an antenna, produces three independent resonant valleys.To improve detection selectivity and structural stability, the application is functionalized to super surface using three-layer modification strategy: APTES is introduced in sequence to form stable interface layer, spin-coated amino-rich PEI layer is provided with additional adsorption sites to interact with ketone molecules, and finally spin-coated metal organic framework UiO-66 is used as sensing layer to realize effective pre-enrichment of 2-pentanone.During detection, three resonant valleys show linear red shift with the increase of 2-pentanone concentration, and the lowest test concentration is 20 ppm.The application uses multi-resonance characteristics combined with multi-dimensional response mode to realize rapid, high-sensitivity and high-selectivity non-contact detection of lung cancer marker 2-pentanone.

This invention relates to the field of chemical synthesis technology, specifically a method for preparing 2,3,3,5-tetramethylindole. The method comprises using p-methylphenylhydrazine hydrochloride and 3-pentanone as raw materials, generating 2,3,3,5-tetramethylindole through a one-step condensation-cyclization reaction in acetic acid medium, followed by further processing steps. This synthetic method offers significant advantages: First, it is highly efficient, with a one-step condensation-cyclization reaction, a molar yield of 60-68%, HPLC endpoint control, and a total processing time of one day, making it suitable for industrial production. Second, it operates under mild conditions, using acetic acid as both solvent and catalyst, with a reaction temperature of 112℃, allowing the use of ordinary enamel-lined reactors and avoiding corrosion from traditional strong acid equipment. Third, it achieves excellent purity, with no isomers and a purity exceeding 99%, offering flexible purification at low cost. Fourth, it is more environmentally friendly, with a dichloromethane recovery rate ≥90%, and wastewater with a near-neutral pH for easy treatment. Fifth, it is easily scaled up, with quantitative formulas for parameters and flexible process adjustments, adaptable to various production fields.

This invention discloses a method for producing 4-hydroxy-2-pentanone from acetone and acetaldehyde, belonging to the field of fine chemical intermediate synthesis technology. The method uses bio-based acetone and bio-based acetaldehyde as raw materials, and 1,8-diazabicyclo[5.4.0]undec-7-ene as a catalyst. In a DBU-H₂O catalytic system, high-purity 4-hydroxy-2-pentanone is obtained through a cross-aldol condensation reaction followed by separation and purification. This invention solves the technical problems of low product yield, numerous by-products, dark product color, strong odor, and difficulty in catalyst recovery in existing technologies by optimizing reaction parameters and selecting specific catalysts. The reaction conditions are mild, the operation is simple, and the energy consumption is low. The catalyst can be recycled, and all raw materials are bio-based, meeting the requirements of green chemical development. It is suitable for large-scale industrial production, and the product can be widely used in bakelite preparation, flavorings, pharmaceutical intermediates, and other fields.

The invention belongs to the technical field of chemistry and chemical engineering, and particularly relates to a preparation method of 3, 5-dichloro-2-pentanone. Through the synergistic effect of the photosensitizer and the solid catalyst, the one-pot direct chlorination of 2-pentanone is realized, and the separation and purification steps of the traditional multi-step reaction are avoided. By strictly controlling the dosage and the dropping speed of H2O2, the chlorination reaction is ensured to be complete, and the product yield can reach 84% or above. NaCl is used as a chlorine source, air is used as an oxygen source, and visible light catalysis is combined, so that the use of chlorine or a strong oxidant in a traditional chlorination process is avoided, and corrosive byproducts and three-waste pollution are reduced from the source. The Mn-Schiff base complex is loaded on the magnetic carrier, magnetic separation and recovery of the catalyst can be achieved, the yield is kept to be larger than 80% after 5 times of circulation, the phosphate buffer solution can be recycled, and the production cost is effectively reduced.

The invention belongs to the technical field of fermentation engineering, and particularly relates to Wickerhamomyces anomalus JG-WA1 and application thereof in aroma-enhancing fruit wine. A strain of aroma-enhanced Wickerhamomyces anomalus JG-WA1 is screened from distiller's yeast, apple juice is inoculated with the strain for primary fermentation, then saccharomyces cerevisiae is inoculated for secondary fermentation, and the aroma-enhanced fruit wine is prepared. The content of unpleasant odor substances such as acetone, 4-methyl-1-pentanol, 2-butanol, dimethyl disulfide, 3-hexanone and the like with pungent smell of alcohol or mildew odor and the like in the fruit wine is obviously reduced, while the content of 2-pentanol, ethyl propionate, propyl acetate, 3-methyl-2-pentanone, 3-pentene-2-ketone, hexyl hexanoate, ethyl hexanoate, methyl acetate, heptanal, 2-octanone, 2, 3-pentanone, ethyl hexanoate, ethyl hexanoate, methyl acetate, heptanal, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate, ethyl hexanoate and ethyl hexanoate is obviously reduced. The content of fruit flavor components such as 2, 3-dimethylpyrazine is greatly increased, the brewed apple wine is obvious in ester flavor and transparent and bright in color, and the flavor quality is obviously improved.

This invention discloses a method for preparing 1,2-pentanediol, comprising using 2-pentanone as a substrate, adding 2-keto reductase, linalool dehydratase, formate dehydrogenase, lysozyme, coenzyme NAD+, and water to react and obtain n-pentene. The obtained n-pentene is then thoroughly mixed with ethanol. This mixture is then fed into a reaction system containing olefin monooxygenase, epoxide hydrolase, formate dehydrogenase, lysozyme, coenzyme NAD+, MgSO4, and water using a fed-batch method. After the n-pentene and ethanol mixture has been completely added, the reaction continues for a period of time, followed by extraction to obtain 1,2-pentanediol. This preparation method uses 2-pentanone as a raw material, catalyzing the synthesis of 2-pentanol via 2-keto reductase. 2-pentanol is then catalyzed by a dehydrating enzyme to generate n-pentene, which is then catalyzed by an olefin monooxygenase to generate 1,2-epoxypentane. Finally, epoxide hydrolase ring-opens the 1,2-pentanediol. This process requires only four enzymatic catalytic reactions for efficient synthesis.

[Problem] To provide a pattern collapse inhibiting composition and a method for producing a pattern using the pattern collapse inhibiting composition. [Solution] A pattern collapse inhibiting composition comprising a solidifying component (A) and a solvent (B), wherein the solidifying component (A) is dicyclopropylketone oxime, 2,2,4,4-tetramethyl-3-pentanone oxime, or a mixture thereof. The pattern collapse inhibiting composition is a highly functional material that can be used in a semiconductor device production process of a nanotechnology process, for example, a semiconductor device production process for controlling a liquid crystal, quantum dot, or OLED display formed on a substrate.

The invention discloses durian essence and a preparation method thereof, and the durian essence is prepared from the following raw materials: 2.0 to 3.8 percent of methyl 2-methylbutyrate, 1.6 to 3.4 percent of ethyl 2-methylbutyrate, 0.8 to 1.6 percent of 3-mercaptohexyl acetate, 0.4 to 1.2 percent of dipropyl disulfide, 0.01 to 0.1 percent of 4-mercapto-4-methyl-2-pentanone, 0.8 to 2.0 percent of citral, 1.5 to 3.0 percent of hops tincture, 1.0 to 2.2 percent of 2, 6-dimethyl-5-heptenal and 80.0 to 88.0 percent of solvent. According to the durian essence, a certain amount of acetic acid 3-mercaptohexyl ester and citral are added into common durian essence components such as methyl 2-methylbutyrate and dipropyl disulfide, and on the basis that the storage stability of the durian essence is guaranteed, the pure and full aroma profile of durian can be highly restored.

The invention discloses a high-light-transmittance contact lens silicone hydrogel material and a preparation method thereof, and relates to the technical field of contact lens materials, the high-light-transmittance contact lens silicone hydrogel material comprises the following raw materials by weight: 25-35 parts of a silane monomer, 20-25 parts of a functional monomer, 0.6-1.0 part of a cross-linking agent, 0.3-0.5 part of an initiator, and 40-50 parts of a solvent. The silane monomer, the functional monomer and the cross-linking agent are combined for use, so that the high light transmittance of the prepared silicon hydrogel material meets the use requirement. The functional monomer is prepared from 4-nitrophenyl-beta-D-glucuronic acid sodium salt, 2-cyano-5-(dimethylamino)-3-ethoxy penta-2, 4-dienoic acid ethyl ester, 5-chloro-2-pentanone and the like through a reaction, and the contact lens silicon hydrogel material is endowed with relatively high water content and relatively strong antibacterial property.

The invention discloses a preparation method of non-grain bio-based pentamethylene diamine, and relates to the technical field of bio-based chemical preparation. The preparation method of the non-grain bio-based pentamethylene diamine comprises the following steps: adding furfural and a first catalyst into a first solvent, introducing hydrogen, carrying out a furfural hydrogenation reaction, and recovering the first catalyst to obtain a reaction liquid of cyclopentanone; adding ammonia water and a second catalyst into the reaction liquid of cyclopentanone, introducing oxygen, carrying out ammoxidation reaction on cyclopentanone, and recovering the second catalyst to obtain a reaction liquid of glutaronitrile; and adding the reaction liquid of the glutaraldehyde and a third catalyst into a second solvent, adding alkali liquor to adjust the pH value to 8-12, introducing hydrogen, carrying out a glutaraldehyde hydrogenation reaction, recovering the third catalyst, and carrying out rectification and purification to obtain the pentamethylene diamine. The preparation method disclosed by the invention does not depend on grain raw materials, the process is green and environment-friendly, the catalyst is stable in circulation, and industrial large-scale production and high-purity application scenarios can be met.

The invention provides a continuous separation system and process for glycerol-glycerol carbonate mixed liquid. The system comprises an extraction tower, an extraction phase extraction agent recovery rectifying tower and a raffinate phase extraction agent recovery rectifying tower, a first inlet, a second inlet and a third inlet are respectively formed in the tower bottom, the tower top and the middle part of the extraction tower, the third inlet of the extraction tower is used for receiving a glycerol-glycerol carbonate mixed solution, the first inlet of the extraction tower is used for receiving a first extraction agent, and the second inlet of the extraction tower is used for receiving a second extraction agent; the first extraction agent is methyl isobutyl ketone, cyclohexanone or 2-pentanone, and the second extraction agent is water; a tower top outlet of the extraction tower is connected with a feeding hole of the extraction phase extraction agent recovery rectifying tower, and a tower bottom outlet of the extraction tower is connected with a feeding hole of the raffinate phase extraction agent recovery rectifying tower. The system and the process thereof are simple in separation flow, wide in applicable concentration range and capable of realizing efficient separation of the glycerol-glycerol carbonate mixed solution.