A catalyst for preparing low-carbon alcohol mixture from synthetic gas contains Mo (2-40 %), Ni (4-10%), Mn (0.1-5.0%), K (5-15%), S (20-40%) and bentone, and is prepared through reaction of ammoniumsulfide solution or hydrogen sulfide gas on ammonium molybdate, adding concentrated acetic acid, thermal stirring, cooling for deposition, adding deionized water for dissolving doposit to obtain solution of ammonium thiomolybdate, dropping the solution along with the mixed solution of nickel acetate and manganese acetate in acetic acid to form black deposit, filtering, washing, baking, mixing with bentone, and tabletting. Its advantages are high resistance to S and no carbon deposit.