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28 results about "Aloe Polysaccharide" patented technology

Aloe polysaccharides comes from the aloe vera plant and is used for skin-wound healing.. Hydrocortisone is a steroid. It prevents the release of substances in the body that cause inflammation. Iodoquinol is an antibiotic and antifungal medication that fights infection caused by bacteria or fungus.. The combination of aloe polysaccharides, hydrocortisone, and iodoquinol topical (for the skin ...

Application of aloe polysaccharide in regulation and control of energy metabolism of mitochondria

The invention discloses application of aloe polysaccharide in regulation and control of mitochondrial energy metabolism, and belongs to the field of new application of aloe polysaccharide. The aloe polysaccharide can regulate mitochondrial energy metabolism to be converted into anabolism, promote the content of protein and amino acid in cells and promote wound healing. The preparation method of the aloe polysaccharide comprises the following steps: removing two ends of fresh aloe barbadensis leaves, and soaking the fresh aloe barbadensis leaves with pure water for 1-2 days; washing with water and removing skin to obtain aloe gel to be ground; shearing the aloe vera gel to be ground in an automatic gel grinding device to finish gel grinding, so as to obtain aloe polysaccharide feed liquid; and putting the aloe polysaccharide feed liquid into a stirring tank, stirring at 4-15 DEG C, carrying out light treatment for at least 24 hours, and then collecting the aloe polysaccharide pervaporation membrane on the surface of the liquid in a high-temperature membrane forming tank at 75-95 DEG C, thereby obtaining the aloe polysaccharide pervaporation membrane.
Owner:广州市东源药业科技有限公司 +1

Multi-effect analgesic and anti-inflammatory gel for oral cavity and preparation method thereof

PendingCN121265525AOrganic active ingredientsPeptide/protein ingredientsDipotassium GlycyrrhizateQuercitrin
The invention discloses oral multi-effect analgesic and anti-inflammatory gel and a preparation method thereof, and belongs to the technical field of medical gel. The gel is prepared from mussel mucin grafted hydroxypropyl chitosan, a poly (N-isopropylacrylamide)-co-acrylic acid copolymer, quercetin-zinc coordination nanoparticles, a local anesthetic compound wrapped by temperature-sensitive lipidosome, a gamma-polyglutamic acid-catechin gel matrix, aloe polysaccharide, dipotassium glycyrrhizinate, and sodium hyaluronate and potassium sorbate which can be selectively added, wherein the local anesthetic compound is prepared from the mussel mucin grafted hydroxypropyl chitosan, the poly (N-isopropylacrylamide)-co-acrylic acid copolymer, the quercetin-zinc coordination nanoparticles, the temperature-sensitive lipidosome, the gamma-polyglutamic acid-catechin gel matrix, the aloe polysaccharide and the dipotassium glycyrrhizinate. During preparation, part of the components and water are stirred to obtain a mixed solution, and then the other components are added and stirred into gel. According to the gel, the leakage rate of local anesthetics is reduced by stabilizing the liposome through the zinc ions, the quercetin adjusts the phase transition temperature of the liposome to realize preferential drug release at the pain part, the mussel mucin and the copolymer form a reversible hydrogen bond network to enhance the mucous membrane adhesive force, and the inflammatory environment triggers the gel permeation drug release, so that the gel has the advantages of multiple-effect synergy, strong adhesion and the like; the problems that existing oral gel is short in analgesia time and insufficient in anti-inflammation can be effectively solved.
Owner:BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV

Method for detecting aloe polysaccharide effective component in aloe raw material

This application relates to the field of chemical analysis technology, specifically to a method for detecting the effective components of aloe polysaccharides in aloe vera raw materials. The method includes: obtaining a chromatogram of an aloe vera sample hydrolysate; determining the chromatographic peak corresponding to acetic acid from multiple chromatographic peaks based on the retention time and peak shape characteristics of each chromatographic peak; determining the amount of acetic acid in the aloe vera sample hydrolysate based on the hydrolysis completeness at a current moment and the peak area of ​​the chromatographic peak corresponding to acetic acid at that current moment, wherein the hydrolysis completeness at a given moment is used to characterize the degree of hydrolysis of the aloe vera sample at that moment; and determining the content of the effective polysaccharide components in the aloe vera sample based on the amount of acetic acid. This method can obtain an accurate amount of acetic acid, and based on this accurate amount of acetic acid, the content of the effective polysaccharide components in the aloe vera sample can be accurately detected.
Owner:SHANXI AGRI UNIV

Novel beverage and preparation method thereof

The invention relates to a novel beverage and a preparation method thereof. Comprising the following components in percentage by weight: 0.05%-0.6% of a double-petal red rose distillation extracting solution, 0.05%-0.6% of food-grade hyaluronic acid, 0.05%-0.6% of xylitol or erythritol, 0.1%-0.3% of a butterfly bean flower extracting solution, 0.05%-0.2% of a turmeric root extracting solution, 0.03%-0.1% of mint leaf essence, 0.1%-0.4% of chia seed powder, 0.2%-0.5% of aloe juice, 0.1%-0.3% of a pomegranate extracting solution, 0.05%-0.2% of a green tea extracting solution, 0.02%-0.1% of citric acid and the balance of water. Hyaluronic acid and rose hydrolat are added, so that the oral liquid has the effects of moisturizing, resisting aging, soothing liver-qi stagnation and relieving and reducing pressure after being orally taken, aloe polysaccharide and chia seeds form a stable colloidal network, satiety and skin repair capacity are improved, low sugar and low burden are achieved, pomegranate ellagic acid has the effects of resisting inflammation, natural color matching with butterfly bean flowers is achieved, visual interest is enhanced, green tea catechin and curcumin are compounded to resist oxidation, promote metabolism and strengthen immunity, and the oral liquid has the effects of promoting metabolism and improving immunity. And the defects of irritation, single nutrition and the like of the traditional beverage are overcome.
Owner:HONGHE NATURE WATER IND CO LTD

Application of aloe polysaccharide in improving solubility and storage stability of insoluble substances

The invention discloses application of aloe polysaccharide to improvement of solubility and storage stability of insoluble substances. The aloe polysaccharide can be used as a solubilizer of insoluble substances, and the preparation method of the aloe polysaccharide comprises the following steps: removing two ends of fresh aloe barbadensis leaves, and soaking the fresh aloe barbadensis leaves in pure water for 1-2 days; washing with water and removing skin to obtain aloe gel to be ground; the aloe gel to be ground is ground, and aloe polysaccharide feed liquid is obtained; and putting the aloe polysaccharide feed liquid into a stirring tank, stirring at 4-15 DEG C, carrying out light treatment for at least 24 hours, and then collecting the aloe polysaccharide pervaporation membrane on the surface of the liquid in a high-temperature membrane forming tank at 75-95 DEG C, thereby obtaining the aloe polysaccharide pervaporation membrane. According to the present invention, the aloe polysaccharide pervaporation membrane can be used for improving the solubility and the stability of the insoluble substance (such as fumaric acid) at the normal temperature so as to avoid the storage precipitation;
Owner:广州市东源药业科技有限公司 +1

Low-sensitivity high-taste nicotine buccal preparation and preparation method thereof

The invention provides a low-sensitivity and high-taste nicotine buccal preparation and a preparation method thereof. The nicotine buccal preparation comprises an inner layer, a middle layer and an outer layer, wherein the middle layer and the outer layer sequentially coat the inner layer from inside to outside; the outer layer comprises nicotine salt, a plant source carrier and a film-forming agent; the components of the middle layer comprise nicotine salt and a hydrophilic high polymer material; the inner layer comprises nicotine salt, silicon dioxide nanoparticles, a plant source carrier and a film-forming agent; the plant source carrier comprises any one or a combination of at least two of aloe polysaccharide, inulin or pea protein peptide. Through design and compatibility of a three-layer composite structure, the release rate and the release amount of nicotine are cooperatively controlled and controlled within a reasonable range, and the nicotine sustained release tablet has relatively low oral irritation and relatively high taste characteristics, can meet instant requirements and maintenance requirements of nicotine and ensure fresh breath, and is suitable for people with sensitive oral cavities and social scenes.
Owner:CHINA TOBACCO JIANGSU INDAL

PH self-adaptive private care lotion based on composite biological bacteriostatic system and preparation method

The invention discloses a pH self-adaptive private care lotion based on a composite biological antibacterial system. The pH self-adaptive private care lotion is prepared from 8 to 12 parts of cocamidopropyl betaine, 0.5 to 1.5 parts of polylysine hydrochloride, 0.3 to 0.8 part of tea tree essential oil, 1.2 to 2.0 parts of lactic acid-sodium lactate buffer agent, 0.1 to 0.3 part of dipotassium glycyrrhizinate, 0.5 to 1.2 parts of chamomile extract, 0.3 to 0.7 part of lactobionic acid, 1.0 to 2.0 parts of aloe polysaccharide and the balance of deionized water. During preparation, the tea tree essential oil and beta-cyclodextrin are subjected to clathration for 30 minutes at 35 DEG C to form a clathrate compound, so that the volatile loss is reduced by 80%; dissolving polylysine hydrochloride in deionized water at 4 DEG C, and adding a lactic acid-sodium lactate buffer solution; lactobionic acid and a chamomile extract are added; homogenizing for 3 minutes by using a homogenizer at the speed of 2000rpm; and carrying out vacuum defoaming under 0.08 MPa. Dynamic pH buffering is achieved, and a lactic acid-lactobionic acid double-buffering layer resists secreta impact; a preservative-free process is adopted, and vacuum defoaming and PES membrane filtration are used for replacing chemical preservatives; and gender differentiation adaptation: cranberry polyphenol, female adhesion prevention and succinic acid buffer male pH adaptation.
Owner:MIAOWANG PHARMACEUTICAL (GUANGZHOU) CO LTD

Method for determining free mannose and total mannose in biological sample based on LC-MS / MS (Liquid Chromatography-Mass Spectrometry / Mass Spectrometry) method

The invention belongs to the technical field of analytical chemistry, and particularly relates to a method for determining free mannose and total mannose in a biological sample based on an LC-MS / MS (Liquid Chromatography-Mass Spectrometry / Mass Spectrometry) method. According to the method provided by the invention, endogenous mannose and exogenous mannose of a biological sample can be distinguished, and the existence form (monosaccharide or polysaccharide) of mannose introduced into aloe polysaccharide is further identified. The method has the advantages of simplicity and convenience in operation, high specificity, high sensitivity, good precision and accuracy and the like, not only overcomes the limitation of insufficient sensitivity of HPLC and spectrophotometry, but also meets the requirements of respective detection of monosaccharide and polysaccharide in a biological sample.
Owner:GUANGDONG LEWWIN PHARM RES INST CO LTD

Extraction method of aloe polysaccharide

PendingCN121319240AFiberCrude fibre
The invention provides an extraction method of aloe polysaccharide, and belongs to the technical field of extraction of chemical components of aloe. The preparation method comprises the following steps: peeling aloe vera, dicing, soaking in cold water, stirring and crushing to form aloe juice; further heating the aloe juice to homogenize the aloe juice; filtering to remove crude fibers after homogenization, adding granular active carbon into the filtrate for decoloration, filtering to obtain a clear solution, adding ammonia water into the solution, and adjusting the pH value to be alkaline; continuously heating and concentrating the obtained clear solution; adding ethanol into the concentrated solution, adding an ammonium chloride coagulant, standing and precipitating; and centrifugally separating the obtained mixture with the precipitate, and washing and drying the obtained precipitate to obtain the aloe polysaccharide. Compared with a traditional extraction process, the aloe polysaccharide extraction method has the advantages that the process flow is simple, the process condition control operability is high, and the extraction rate of the aloe polysaccharide in the separation process is high. An experiment result shows that the extraction rate of the aloe polysaccharide is up to 11.23% and is obviously higher than that of the traditional extraction process.
Owner:EAST CHINA UNIV OF TECH

A kind of dynamic covalent hydrogel dressing of aconite leaf nanoparticles and its preparation and application

This invention relates to the field of pharmaceutical technology, specifically to a dynamic covalent hydrogel dressing loaded with moxa nanoparticles, its preparation method, and its application. The dynamic covalent hydrogel dressing loaded with moxa nanoparticles is composed of a dispersion of moxa nanoparticles made from moxa, aloe polysaccharides, and tea saponins, and a hydrogel matrix made from chitosan, polyvinyl alcohol, ε-polylysine, and 4-formylphenylboronic acid. This invention provides a multifunctional traditional Chinese medicine nanocomposite hydrogel dressing integrating intelligent response, antibacterial membrane-breaking, antioxidant, cell repair promotion, and wound healing promotion. It can provide a safe, efficient, and targeted novel solution for the clinical treatment of deep burns complicated with drug-resistant bacterial infections, and provides an experimental basis and technical reference for the formulation development and application of active ingredients of traditional Chinese medicine in wound repair.
Owner:GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE

Chloroplast storage liquid and application thereof

PendingCN121942677AEffectively maintain activityDead plant preservationFermentationBiotechnologyGlycan
The invention provides chloroplast storage liquid and application thereof. The chloroplast storage solution disclosed by the invention is prepared from the following components in parts by mass: 5 to 30 parts of aloe polysaccharide ABPA1, 5 to 30 parts of aloe acetylmannan ABPA2, 2 to 15 parts of red algae colloid extract and 25 to 88 parts of water. The invention also provides an application method of the chloroplast storage liquid. According to the chloroplast storage solution, the plant polysaccharide and the red algae colloid extract are applied to an in-vitro chloroplast storage system, so that the activity of chloroplast can be effectively maintained for a long time, and a stable and reliable in-vitro research window is provided for deeply analyzing a fine mechanism of photosynthesis; moreover, it is possible to serve as a high-efficiency biological light energy converter.
Owner:东源药业科技(昆明)有限公司 +1

Active delivery microcapsules, methods of making and using the same

The application provides an active substance delivery microcapsule, a preparation method and application thereof, a wall material of the active substance delivery microcapsule comprises polylysine, plant polysaccharide and polyethylene glycol; the plant polysaccharide comprises any one or a combination of at least two of bletilla striata polysaccharide, aloe polysaccharide, dendrobium polysaccharide, tremella polysaccharide, seaweed polysaccharide, medlar polysaccharide, tricholoma matsutake polysaccharide and ganoderma polysaccharide or beta-glucan; and a core material of the active substance delivery microcapsule comprises an active substance. Wall material components form a dense and stable high-molecular crosslinked network through electrostatic interaction and hydrogen bond interaction, significantly improve the efficacy stability of the active substance of the core material, and play excellent skin care efficacy.
Owner:GUANGZHOU RIDGEPOLE BIOLOGICAL TECH CO LTD

Method for detecting effective components of aloe polysaccharide in aloe raw material

The invention relates to the technical field of chemical analysis, in particular to a method for detecting effective components of aloe polysaccharide in an aloe raw material, and the method comprises the following steps: acquiring a chromatogram of aloe sample hydrolysate; based on the peak retention time and the peak shape characteristic of each chromatographic peak, determining a chromatographic peak corresponding to acetic acid from the plurality of chromatographic peaks; based on the hydrolysis completeness at the current moment and the peak area of the chromatographic peak corresponding to the acetic acid at the current moment, the amount of the acetic acid in the aloe sample hydrolysate is determined, and the hydrolysis completeness at one moment is used for representing the hydrolysis degree of the aloe sample at the moment; and determining the content of polysaccharide active ingredients in the aloe sample based on the acetic acid amount. According to the method, the accurate acetic acid amount can be obtained, and based on the accurate acetic acid amount, the content of polysaccharide active ingredients in the aloe sample can be accurately detected.
Owner:SHANXI AGRI UNIV

Application of phagocytic macrophages for in-vitro regulation and control of aloe polysaccharide in promotion of wound healing

The invention discloses an application of phagocytic macrophages regulated and controlled in vitro by aloe polysaccharide in promoting wound healing. According to the present invention, the aloe polysaccharide pervaporation membrane can be used for preparing phagocytic macrophages, the aloe polysaccharide pervaporation membrane is added into the macrophage culture medium, the result shows that the phagocytic ability of the macrophages is significantly improved, and the further experiment shows that the phagocytic macrophages are used for wound treatment, the inflammation level of the wound is obviously inhibited, and the healing speed of the wound is increased.
Owner:广州市东源药业科技有限公司 +2

Natural plant polyphenol alcohol-free washing-free gel and preparation method thereof

The invention provides a natural plant polyphenol alcohol-free wash-free gel and a preparation method thereof, and the natural plant polyphenol alcohol-free wash-free gel is prepared by mainly using natural plant polyphenol extracted from red raspberry leaves, dandelion flowers and pomegranate rind as a bacteriostatic agent and embedding the extracted natural plant polyphenol by using a polylactic acid-polyethylene glycol copolymer. The preparation method comprises the following steps: (1) raw material pretreatment, (2) polyphenol extraction, (3) polyphenol microsphere suspension preparation, (4) polyphenol microsphere collection, (5) aloe polysaccharide extract preparation, and (6) no-wash gel preparation. The invention provides a new path for high-valued utilization of agricultural and sideline products and upgrading of natural polyphenol industry, endows the gel with high efficiency and broad-spectrum antibacterial performance, avoids irritation of alcohols to skin, eliminates flammable hidden danger of alcohols, and can be used in places such as airports and stations. The stability of the polyphenol is remarkably improved and the shelf life is prolonged through copolymer embedding, long-acting bacteriostasis is achieved, and the hydrogel has good biocompatibility and wide market prospects.
Owner:NORTHEAST FORESTRY UNIV

Method for improving stability of aloe polysaccharide microsphere emulsion

PendingCN122356520ARos scavengingEmulsion
The application discloses a method for improving the stability of aloe polysaccharide microsphere emulsion. The method adds a specific parameter water bath ultrasonic treatment step on the basis of the existing aloe polysaccharide microsphere emulsion preparation process. The aloe polysaccharide microsphere emulsion is placed in an ultrasonic generator, purified water is added as a conducting medium, ultrasonic waves with a frequency of 35-45 kHz and a power of 200-300 W are used for water bath ultrasonic treatment, the treatment time is 0.5-3 hours, and the ultrasonic water temperature is controlled to be 45-55 DEG C. The method can significantly reduce the microsphere particle size, increase the microsphere quantity, and improve the absolute value of the surface potential, thereby improving the long-term storage stability of the emulsion. Meanwhile, the emulsion after treatment shows stronger ATP synthesis recovery, mitochondrial membrane potential stability and ROS scavenging capacity at the cell level, and has enhanced cell protection efficacy.
Owner:广州市东源药业科技有限公司 +1

Lung anti-inflammatory spray based on aloe polysaccharide and preparation method thereof

PendingCN121102264AOrganic active ingredientsAntipyreticLung alveolusDipotassium Oxalate
The invention relates to the technical field of medicines, and discloses a lung anti-inflammatory spray based on aloe polysaccharide, which realizes efficient anti-inflammatory (IL-6) and targeted delivery (deposition rate of 85%) by optimizing the proportion of natural components (8% of aloe polysaccharide, 1.5% of dipotassium glycyrrhizinate and 2% of andrographolide) and an atomization process (particle size of 2 mu m). According to the lung anti-inflammatory spray based on the aloe polysaccharide and the preparation method of the lung anti-inflammatory spray, through the synergistic effect of the aloe polysaccharide (8%) and natural anti-inflammatory components (1.5% of dipotassium glycyrrhizinate and 2% of andrographolide), the proinflammatory factor level (IL-6 is reduced by 60%, and TNF-alpha is reduced by 62%) is remarkably reduced, the inhibition rate on an LPS-induced mouse pneumonia model reaches 88% or above, and the lung anti-inflammatory spray has the advantages that the lung anti-inflammatory spray has a good application prospect. The effect of the dexamethasone spray is better than that of a single-component or chemically synthesized drug (such as dexamethasone), drug particles are efficiently deposited in an alveolar area through an optimized atomization process (the spraying particle size is 2 microns), the lung deposition rate is larger than or equal to 85% and far exceeds that of a conventional spray (generally smaller than or equal to 70%), and the bioavailability is remarkably improved.
Owner:SHANGHAI PULMONARY HOSPITAL (SHANGHAI OCCUPATIONAL DISEASE PREVENTION & CONTROL INSTITUTE) +1

Extraction method of aloe polysaccharide and application of aloe polysaccharide in cigarettes

PendingCN121800961ATobacco treatmentPhysical chemistryTetramethylammonium chloride
The invention relates to the technical field of aloe polysaccharides, and provides an extraction method of aloe polysaccharides and application of the aloe polysaccharides in cigarettes, the extraction method of the aloe polysaccharides comprises the following steps: S1, peeling, crushing and filtering aloe to obtain aloe juice and filter residues; s2, adding the aloe juice into a deep-eutectic solvent, performing ultrasonic extraction, and filtering to obtain an extracting solution; s3, concentrating the extracting solution, adding absolute ethyl alcohol, uniformly mixing, standing, filtering and drying to obtain aloe polysaccharide; the eutectic solvent comprises a substance A and a substance B; the substance B comprises tetramethylammonium chloride; the substance A comprises resorcinol. According to the technical scheme, the problems of insufficient extraction rate and purity of the aloe polysaccharide in the prior art are solved.
Owner:CHINA TOBACCO HEBEI INDUSTRIAL CO LTD

Composite probiotic composition as well as preparation method and application thereof

The invention discloses a compound probiotic composition, a preparation method and application, and relates to the technical field of probiotics, the compound probiotic composition comprises compound probiotics, compound polysaccharide and inorganic salt; wherein the compound polysaccharide is prepared from sodium alginate, phellinus igniarius polysaccharide and aloe polysaccharide according to the mass ratio of 1: (0.4-0.6): (0.4-0.6); the compound polysaccharide is crosslinked into gel under the action of inorganic salt so as to realize embedding of the compound probiotics; the preparation method of the compound probiotic composition comprises the following steps: S1, dispersing the compound polysaccharide into deionized water to prepare a compound polysaccharide solution; s2, adding compound probiotics into the compound polysaccharide solution in the step S1, and uniformly mixing; and S3, dropwise adding the uniformly mixed solution in the step S2 into an inorganic salt solution for crosslinking to prepare the composite probiotic composition. According to the invention, the compound polysaccharide is used for embedding the compound probiotics, so that the embedding rate of the probiotics is obviously improved; and the compound probiotics disclosed by the invention have a synergistic promotion effect on inhibiting harmful bacteria in the oral cavity.
Owner:TADPOLE JINGYAN BIOTECHNOLOGY (SUZHOU) CO LTD

Application of aloe polysaccharide in improving solubility and storage stability of poorly soluble substances

The application discloses application of aloe polysaccharide in improving solubility and storage stability of difficultly soluble substances. The aloe polysaccharide can be used as a solubilizer of the difficultly soluble substances. The preparation method of the aloe polysaccharide comprises the following steps: removing both ends of fresh Aloe barbadensis leaves, and soaking in pure water for 1-2 days; removing the epidermis after water washing to obtain aloe gel to be ground; grinding the aloe gel to be ground to obtain an aloe polysaccharide solution; placing the aloe polysaccharide solution in a stirring tank, stirring under the condition of 4-15 DEG C and performing light treatment for at least 24 hours, and then collecting aloe polysaccharide pervaporation membranes on the liquid surface in a high-temperature film forming tank under the condition of 75-95 DEG C to obtain the aloe polysaccharide pervaporation membranes. In the application, the aloe polysaccharide pervaporation membranes can be used to improve the solubility and stability of difficultly soluble substances (such as fumaric acid) at normal temperature, and storage precipitation is avoided.
Owner:广州市东源药业科技有限公司 +1

Skin care composition and application thereof

The invention relates to a skin care composition which comprises a first active component and a second auxiliary component, the first active component is selected from tetrahydrocurcumin, ergothioneine, phloretin, arbutin, resveratrol, vitamin C, dipotassium glycyrrhizinate, ceramide, aloe polysaccharide, cactus polysaccharide, astragalus polysaccharide, dendrobe polysaccharide, cucumis metuliferus polysaccharide, fucoidan, micromolecular hyaluronic acid, pearl powder, collagen, tea tree essential oil, thearubigin, salicylic acid, retinol and tannin; one or more of carnosine; and the second auxiliary agent component is selected from one or more of tetrahydropiperine, laurocapram, PEG-75 shea butter glyceride, hydrogenated castor oil, glycerol, lauric acid, sucrose laurate, butanediol, polysorbate, hydroxyethyl cellulose, 1, 2-pentanediol and ethoxydiethylene glycol. The skin care composition can be used for whitening, resisting inflammation, resisting sugar, moisturizing, tightening skin, resisting bacteria and / or resisting ageing.
Owner:NANJING NUTRABUILDING BIO TECH CO LTD

Gel composition for repairing female genital tract as well as preparation process and application of gel composition

The invention discloses a gel composition for repairing female genital tracts as well as a preparation process and application of the gel composition. The composition comprises three functional core systems: a polysaccharide-enzyme compound A which is formed by self-assembly of superoxide dismutase and oxidative degradation modified aloe polysaccharide and has antioxidant and microenvironment regulation functions; a metal ion-polysaccharide slow-release antibacterial body B formed by coordination of zinc ions and low-molecular-weight chitosan provides instant and long-acting antibacterial protection; the plant polyphenol-protein tissue repair body C is formed by non-covalent binding of epigallocatechin gallate and hydrolyzed collagen, and tissue regeneration and functional reconstruction are promoted. The three components are compounded according to a mass ratio of (1-2): (0.5-1): (2-4), and are integrated with a carbomer matrix to form stable gel. The invention further provides a specific preparation process and a synergistic effect mechanism of all the components. The gel has good stability, biocompatibility and repairing efficiency, and is suitable for treating or improving female genital tract mucosa lesion, inflammation or flora imbalance.
Owner:SHAANXI YUANZHI PHARM BIOENGINEERING CO LTD

Swallowing oral care spray and preparation method thereof

The invention discloses a swallowable oral care spray and a preparation method thereof, and belongs to the technical field of oral care. The spray is composed of peculiar smell decomposition components (0.2-0.4% of persimmon fruit extract and 0.1-0.2% of emblic leafflower fruit extract according to the mass ratio of 2: 1), micro-ecological regulation components (0.3-0.6% of fructo-oligosaccharide, 0.2-0.4% of galactooligosaccharide and 0.08-0.15% of sugarcane polyphenol according to the mass ratio of 2: 1: 0.3), mucous membrane affinity components (0.08-0.15% of sodium hyaluronate, 0.03-0.06% of hydrolyzed hyaluronic acid and 0.08-0.15% of aloe polysaccharide) and a moisturizing and stabilizing matrix. All edible components conform to food related standards, all the components conform to Cosmetic Safety Technical Specifications, and the composition does not contain alcohol or traditional preservatives and can be swallowed. Through the triple synergistic effect of peculiar smell decomposition, micro-ecological regulation and mucous membrane affinity, the effects of radically improving oral cavity peculiar smell, mildly regulating flora balance and relieving mucous membrane discomfort are achieved. The preparation method comprises the steps of temperature-controlled dissolution, gradient feeding, hyaluronic acid pre-dispersion hydration, filtering and filling and the like, the process end point is clear, and the batch stability is good. Accelerated tests prove that the product has good normal-temperature storage stability.
Owner:BEIJING MINGYANG DENTAL CLINIC CO LTD

Starch film slow-release patch for promoting wound healing and preparation method of starch film slow-release patch

The invention discloses a starch film slow-release patch for promoting wound healing and a preparation method thereof.The method comprises the steps that 1, silymarin, centella asiatica extract, aescin, aloe polysaccharide, lithospermum erythrorhizon extract, olive oil, lecithin and cetostearyl alcohol polyether are taken and mixed to be uniform, phosphatidylinositol and deionized water are added, low-speed stirring and high-speed shearing are conducted in sequence at the temperature of 25-35 DEG C, and the starch film slow-release patch for promoting wound healing is obtained; the microcrystal nano-emulsion is obtained; 2, adding gelatin and starch into deionized water, heating for 5-15 minutes at 60-80 DEG C while stirring, cooling to 40-50 DEG C, adding citric acid, calcium citrate, glycerol, ethylene glycol and the crystal nano-emulsion, and uniformly mixing to obtain mixed paste liquid; 3, the mixed paste liquid is contained in a vacuumizing container, vacuumizing is conducted, and degassed mixed paste liquid is obtained; 4, carrying out roll forming on the mixed paste to obtain a starch film; and 5, cutting the starch film into the starch film slow-release patch. The starch film sustained-release patch prepared by the invention has good flexibility, viscosity and air permeability, and is capable of stopping bleeding, resisting inflammation and promoting wound healing.
Owner:XIANYANG VOCATIONAL TECHN COLLEGE

Antibacterial drug-hydrogel composite dressing for pressure sore nursing and preparation method thereof

The invention provides an antibacterial drug-hydrogel composite dressing for nursing pressure sores and a preparation method thereof. The dressing is formed by compounding a surface layer, a middle antibacterial hydrogel layer and a bottom layer, the middle layer takes a carboxymethyl chitosan-polyacrylic acid copolymer as a matrix and is loaded with an antibacterial agent compounded by surface modified nano zinc oxide and polyhexamethylene biguanide hydrochloride and a healing promoting component compounded by recombinant human epidermal growth factors and aloe polysaccharide. The preparation process comprises the steps of nitrogen protection, standing curing and the like, and the process is controllable. Tests show that the dressing has an antibacterial rate of more than or equal to 99.2%, excellent air permeability and water absorption performance, a wound healing time shortening rate of more than or equal to 38%, and good fitness and biocompatibility which are obviously superior to those of a contrast, can be adapted to I-IV stage pressure sore nursing, is suitable for hospitals, families and other scenes, has good clinical application value, and can be produced on a large scale.
Owner:HAIKOU THIRD PEOPLES HOSPITAL

Liquid dressing for skin repair and preparation method and application thereof

PendingCN121944206AImprove wound repair effectImprove liquidityAbsorbent padsBandagesSkin repairGiant salamander
The invention belongs to the technical field of functional dressings, and discloses a liquid dressing for skin repair as well as a preparation method and application thereof, the liquid dressing for skin repair is prepared from the following raw materials in percentage by weight: 1-5% of zinc hyaluronate, 2-10% of giant salamander collagen, 1-8% of aloe polysaccharide, 0.5-6% of L-lactic acid, 0.5-2% of carbomer, 0.1-0.5% of preservative, 0.1-2% of pH regulator and the balance of purified water. The components of the dressing are reasonably proportioned and synergistically gained, and the dressing has the effects of resisting bacteria, resisting oxidation, promoting angiogenesis and the like, can effectively promote skin wound repair, and also has good safety and use comfort.
Owner:GUANGZHOU HUAYAN FUXIN BIOMEDICAL TECHNOLOGY CO LTD

Plant extract combined with hydrogen-rich deuterium-depleted water and preparation method thereof

The invention relates to a plant extract combined with hydrogen-rich deuterium-depleted water and a preparation method thereof, belongs to the technical field of air purification and disinfection, and aims to solve the problems of low negative oxygen ion concentration and poor stability in the prior art. The extracting solution is prepared from 80 to 90 parts of hydrogen-rich water, 5 to 15 parts of deuterium-depleted water, 1.5 to 3.5 parts of aloe polysaccharide, 0.8 to 2.0 parts of green tea extract, 0.2 to 0.5 part of vegetable acid and 1.0 to 2.5 parts of purified water; the preparation method comprises the following steps: purifying the active components, mixing, adjusting the pH value to 6.0, filtering with a 0.22 mu m filter membrane, and the like. The extracting solution improves the concentration and half-life period of the negative oxygen ions through the synergistic effect of the components, is adaptive to air purification and disinfection equipment, is clear and controllable in preparation process, can realize large-scale production, and has relatively high practical application value.
Owner:GUANGDONG RENMANYI TECH DEV CO LTD