20 results about "Hydroxypropyl Chitosan" patented technology

The application discloses a non-metallic mineral powder ball preparation method for loading plant nutrient factors, and comprises the following steps: kaolin is added into hydrochloric acid and stirred, washed with water, calcined at 400-460 DEG C for 1-2h, then added into water with gelatinized starch and stirred, added with silane coupling agent KH560 and continuously stirred, filtered, washed, dried, added with polyvinyl alcohol and pH regulator and stirred to obtain premix; fly ash and refined sugar are uniformly mixed and formed to obtain pretreated fly ash; potassium hydroxide is added into sodium silicate solution and stirred uniformly, then hydroxypropyl chitosan is added and stirred to obtain a precursor solution; the precursor solution is uniformly poured on the surface of the pretreated fly ash, and then placed, solidified, ultrasonic washed and dried to obtain a sponge-like carrier; field soil, organic fertilizer and plant fermented straw are added into a high-speed pulverizer and pulverized, and sieved to obtain granules; the premix and the sponge-like carrier are added and uniformly mixed, and then formed to obtain a seedling raising substrate.

The invention discloses oral multi-effect analgesic and anti-inflammatory gel and a preparation method thereof, and belongs to the technical field of medical gel. The gel is prepared from mussel mucin grafted hydroxypropyl chitosan, a poly (N-isopropylacrylamide)-co-acrylic acid copolymer, quercetin-zinc coordination nanoparticles, a local anesthetic compound wrapped by temperature-sensitive lipidosome, a gamma-polyglutamic acid-catechin gel matrix, aloe polysaccharide, dipotassium glycyrrhizinate, and sodium hyaluronate and potassium sorbate which can be selectively added, wherein the local anesthetic compound is prepared from the mussel mucin grafted hydroxypropyl chitosan, the poly (N-isopropylacrylamide)-co-acrylic acid copolymer, the quercetin-zinc coordination nanoparticles, the temperature-sensitive lipidosome, the gamma-polyglutamic acid-catechin gel matrix, the aloe polysaccharide and the dipotassium glycyrrhizinate. During preparation, part of the components and water are stirred to obtain a mixed solution, and then the other components are added and stirred into gel. According to the gel, the leakage rate of local anesthetics is reduced by stabilizing the liposome through the zinc ions, the quercetin adjusts the phase transition temperature of the liposome to realize preferential drug release at the pain part, the mussel mucin and the copolymer form a reversible hydrogen bond network to enhance the mucous membrane adhesive force, and the inflammatory environment triggers the gel permeation drug release, so that the gel has the advantages of multiple-effect synergy, strong adhesion and the like; the problems that existing oral gel is short in analgesia time and insufficient in anti-inflammation can be effectively solved.

The invention relates to the technical field of high polymer materials, in particular to high-substitution-degree hydroxypropyl chitosan and a preparation method thereof. The raw materials comprise chitosan, sodium hydroxide, epoxypropane and isopropanol; the method comprises the following steps: pretreating chitosan; the preparation method comprises the following steps: mixing chitosan with isopropanol, and adding a sodium hydroxide solution for alkalization treatment to obtain alkalized chitosan; the alkalized chitosan is placed in a cooling device to be subjected to a hydroxypropylation reaction; by taking glacial acetic acid as a neutralizer, dropwise adding glacial acetic acid into the reaction liquid to carry out neutralization reaction; adding absolute ethyl alcohol into the reaction liquid, separating out a precipitate of hydroxypropyl chitosan from the reaction liquid, and treating the precipitate to obtain crude hydroxypropyl chitosan; carrying out purification treatment on the crude hydroxypropyl chitosan, and drying to obtain a hydroxypropyl chitosan product with a high substitution degree; through the mode, accurate regulation and control of the substitution degree of the hydroxypropylation reaction are realized, and the performance stability of the product is improved.

The application provides a high-efficiency hemostatic dressing, a preparation method and application thereof. The hemostatic dressing is a crosslinked product containing hydroxypropyl chitosan and low molecular weight eucommia ulmoides gum. The hemostatic dressing has a high swelling rate, can better absorb water-soluble exudates, and is beneficial to rapid hemostasis. The hemostatic dressing has better mechanical strength, which indicates that the hemostatic dressing has excellent compression resistance and high-load impact resistance, so that appropriate eucommia ulmoides gum-based dressing can be selected according to specific application scenes and wound characteristics, so as to improve the treatment effect.

The invention provides a piezoelectric phase change six-layer moisture-proof corrugated board. The corrugated board is of a six-layer structure sequentially compounded from outside to inside, wherein an antistatic piezoelectric layer is formed by lead zirconate titanate nanoparticles and polyvinylidene fluoride through electrostatic spinning; the moisture-proof functional layer is formed by compounding a polyurethane emulsion, a fluorine-containing compound with the carbon atom number larger than or equal to 6 and hydroxypropyl chitosan, the hydrophobic adhesive interface layer is formed by mixing acrylic resin and TiO2 nanoparticles and then conducting UV curing, and the contact angle is larger than or equal to 110 degrees; the fine honeycomb composite corrugated layer is formed by arranging G corrugations, F corrugations and V-shaped compression-resistant corrugations in a staggered manner, gaps among corrugation teeth are filled with nano silicon dioxide aerogel containing more than or equal to 30% of regenerated cellulose, and the water absorption rate is less than or equal to 1.5%; the phase change temperature control layer is composed of a paraffin / expanded graphite shape-stabilized phase change material, and the paraffin adsorption rate is larger than or equal to 90%; the nano reinforced base material layer is prepared from 60% of softwood pulp, 40% of hibiscus cannabinus stem pulp and red seaweed gel modified nano calcium carbonate. A dynamic damp-proof, compression-resistant and temperature-control cooperative system is realized, and the comprehensive cost is effectively reduced.

The invention relates to a preparation method of a high-stability low-wear disc brake friction plate, which comprises the following steps of: mixing a resin-assistant-hydroxypropyl chitosan compound which is obtained by special modification of phenolic resin and is used as an effective component with other raw materials and auxiliary materials, pressing into a green body, and carrying out graded curing. Through particle size matching of the components, a complete particle size chain from coarse to fine is formed, hardness change uniformity is improved, wear resistance is guaranteed, the contradiction between wear resistance and protection of mating plates can be balanced, through graded curing treatment, it is guaranteed that the mechanical property and wear resistance of a blank are stable, a stable'resin-hard phase 'bonding interface is constructed, and the service life of the blank is prolonged. The heat conductivity is larger than or equal to 18 W / (m.K), the friction coefficient fluctuation ratio is smaller than or equal to 0.04, and the normal-temperature abrasion rate is smaller than or equal to 0.5 * 10 <-7 > cm / (N.m).

The application relates to the technical field of veterinary drugs, and discloses a compound vitamin preparation, a preparation method thereof and application.The compound vitamin preparation comprises a water phase and an oil phase; the water phase comprises the following components in parts by weight: 1-3 parts of hydroxypropyl chitosan, 0.5-2 parts of vitamin C and 50 parts of water; and the oil phase comprises the following components in parts by weight: 1.1-5.5 parts of fat-soluble vitamins and 27.6-41.4 parts of an emulsifying system.The above technical scheme solves the problem that vitamin C in the vitamin preparation in the prior art is easy to be oxidized.

The invention relates to an asymmetric adhesion bionic hydrogel dressing and a preparation method thereof. The preparation method is characterized by comprising the following steps: (1) dissolving acrylamide and acrylic acid in water; then adding N, N '-methylene bisacrylamide and N, N, N', N '-tetramethylethylenediamine, then adding FeCl3 and ammonium persulfate, and carrying out crosslinking to obtain upper-layer hydrogel; (2) adding protocatechuic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide into the hydroxypropyl chitosan solution, so as to obtain an adhesive layer; and (3) coating one surface of the upper-layer hydrogel with the adhesion layer, and curing at room temperature to obtain the asymmetric adhesion bionic hydrogel dressing. The asymmetric adhesion bionic hydrogel dressing has the advantages that one surface of the prepared asymmetric adhesion bionic hydrogel dressing has good adhesion performance and is used for being adhered to a wound, and the other surface of the asymmetric adhesion bionic hydrogel dressing is low in adhesion performance; the adhesive composition can be firmly adhered to tissues and can prevent the generation of bad adhesion.

The invention provides a sea cucumber peptide microsphere compound. The sea cucumber peptide microsphere compound is nanoparticles formed by wrapping sea cucumber peptide with chitosan analogues, and the chitosan analogue is any one of chitosan, carboxymethyl chitosan and hydroxypropyl chitosan. The HP-CS-NPS (or HPStide-N) provided by the invention provides an innovative active ingredient solution for developing efficient, stable and multifunctional gynecological nursing, cosmetics and skin care products, and is particularly suitable for nursing and repairing sensitive skin and acne skin.

This invention relates to the field of veterinary drug formulation and new feed additive technology, and proposes a compound emulsion based on hydroxypropyl chitosan-encapsulated essential oil-phytosterols, its preparation method, and its application. The compound emulsion is composed of the following raw materials in weight percentages: 10%–15% hydroxypropyl chitosan essential oil-encapsulated emulsion, 6%–9% phytosterol liposome dispersion, 6%–10% medium-chain triglycerides, 1.5%–2.5% beeswax, 2%–3% hydrogenated soybean lecithin, 3%–4% polysorbate 80, 0.3%–0.5% xanthan gum, 5%–7% glycerol, 3%–5% glucose, 0.05%–0.1% potassium sorbate, 0.005%–0.008% antioxidant, and the balance being water. This technical solution solves the problem of poor treatment efficacy for bacterial diseases in calves in related technologies.

This invention discloses a method for producing UV-protective fabric using biomass fibers, belonging to the field of textile materials technology. First, hydroxypropyl chitosan is modified with epoxy fatty acids and then combined with carboxymethyl cellulose and baicalin to prepare composite bio-based UV microcapsules via a complex coagulation method. Subsequently, these microcapsules are compounded with aqueous polyurethane to form a finishing solution, which is then coated onto Lyocell fibers to obtain microcapsule-loaded Lyocell fibers. Simultaneously, p-hydroxycinnamic acid is grafted onto PET fibers. Finally, WPU is applied and hot-pressed to form the two layers of fibers, resulting in the UV-protective fabric. This invention improves upon the problems of traditional fabrics, such as easy loss of function, easy peeling between layers, and a stiff feel, by constructing a two-layer composite structure of microcapsule-loaded Lyocell fibers and UV-grafted PET fibers. It achieves a balance between protective performance and wearing comfort, and is applicable to functional textiles such as outdoor sun-protective clothing and sunshade mesh.

The invention provides a lactulose oral solution and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the oral solution comprises an active component lactulose, a solvent, a humectant, a stabilizer, a bacteriostatic agent and purified water; the stabilizing agent is prepared from hydroxypropyl chitosan and edetate disodium. The lactulose oral solution can overcome the defect of instability of lactulose through the cooperation of the stabilizer hydroxypropyl chitosan and edetate disodium, so that the lactulose oral solution has good stability.

The invention relates to the field of pharmaceutical preparations, in particular to a polypeptide composition for treating skin diseases and preventing aging and a preparation method thereof. The polypeptide composition is prepared from the following components: palmitoyl tetrapeptide-7, acetyl dipeptide-1 cetyl ester, acetyl heptapeptide-4, oligopeptide-1, hexapeptide-9, hexapeptide-11, hydroxypropyl chitosan, glycerol, bamboo leaf essential oil, squalane, modified nano cellulose, deionized water and other additives. A double-emulsion system is constructed through three different solvent systems of the hydroxypropyl chitosan, the squalane and the modified nanocellulose, a polypeptide channel of skin is opened by the squalane, and polypeptide is promoted to penetrate through a cuticle and permeate into deep skin tissue; hydroxypropyl chitosan and modified nanocellulose are connected through a Schiff base reaction after demulsification, in-situ crosslinking film forming is rapidly carried out on the skin surface, and the wound surface of the acne part can be effectively protected. The traditional Chinese medicine composition has the effects of soothing skin, treating acne and resisting aging.

The invention relates to the technical field of feed additives, and particularly discloses slow-release thiamine for acid decomposition as well as a preparation method and application of the slow-release thiamine. According to the slow-release thiamine for acid decomposition, provided by the invention, through long-acting acid decomposition of the core layer citric acid-sodium alginate modified dolomite, synergistic slow release of the coating layer polycaprolactone and hydroxypropyl chitosan and directional toxin capture of the betaine-alkyl glycoside modified attapulgite, the slow-release thiamine can be used for preparing the slow-release thiamine for acid decomposition; the problems that a traditional acidolysis product is short in action time and thiamine is easy to degrade are solved. When the slow-release thiamine for acid decomposition is applied to a ruminant feed, not only can subacute rumen acidosis be prevented, but also the early laminitis can be treated in an auxiliary manner, and the claudication rate and the chronic deformation hoof shell occurrence rate of ruminants can be effectively reduced.

The present invention relates to a tissue repair composition comprising nucleic acid and at least one substance selected from the group consisting of glycol chitosan, chitosan oligosaccharide lactate, trimethyl chitosan, methyl glycol chitosan, carboxymethyl chitosan, N-hydroxymethyl chitosan, N-hydroxypropyl chitosan, and N-hydroxypropyl ether chitosan.

The invention discloses chitosan-based nanoparticles capable of realizing targeted delivery of micrococcus oil mitochondria as well as a preparation method and application of the chitosan-based nanoparticles, and belongs to the technical field of biomedical materials. The nano particles are obtained by taking fenugreek gum, xylooligosaccharide, hydroxypropyl chitosan, fucoidin, mannose and (3-propyl carboxyl) triphenylphosphonium bromide as carriers, adding a phycocyanin-lactoferrin compound, and wrapping micrococcus oil and rhamnolipid. Chitosan-based nanoparticles with high drug loading rate and steady state are prepared, the nanoparticles have specific recognition and binding capacity to cells and mitochondria, active substances can be released at fixed points and accurately delivered, real-time tracking can be carried out, a new way is provided for accurate delivery of active ingredients such as micrococcus oil, and the application prospect is broad. The technical support is provided for the visual research of the functional component action mechanism.

This application relates to the field of water-soluble biomaterials, specifically disclosing a hydroxypropyl chitosan, its preparation process, and its applications. The preparation process of hydroxypropyl chitosan includes the following steps: dispersing chitosan in purified water, adding acetic acid under stirring to dissolve and purify, obtaining purified chitosan; adding the purified chitosan to a mixture of salicylaldehyde and 95% ethanol, reacting, filtering, and washing to obtain salicylaldehyde chitosan wet material; mixing the salicylaldehyde chitosan wet material with isopropanol, maintaining the pH at 10-13, adding propylene oxide / 1-chloro-2-propanol dropwise, reacting, filtering, and washing to obtain amino-protected hydroxypropyl chitosan; immersing the amino-protected hydroxypropyl chitosan in an HCl / ethanol solution to deprotect, dialyzing, and freeze-drying to obtain hydroxypropyl chitosan. The hydroxypropyl chitosan of this application has water solubility at all pH levels and a high amino retention rate, laying an ideal material foundation for subsequent medical, pharmaceutical, and cosmetic applications.

This invention discloses an AB-type bimicrosphere powder capable of in-situ liquid absorption and self-assembly, as well as its preparation and application. The preparation method includes: preparing photocrosslinkable hydroxypropyl chitosan and photocrosslinkable oxidized sodium alginate, respectively; using microfluidic technology and ultraviolet light curing to obtain chitosan microspheres loaded with polyphenols and antibacterial agents, and sodium alginate microspheres, respectively; and adsorbing Fe2+ onto the sodium alginate microspheres. 2+ Two types of microspheres were freeze-dried into powder and then mixed in a specific ratio to obtain AB-type dual microsphere powder capable of in-situ liquid absorption and self-assembly. This invention utilizes microfluidic shearing and freeze-drying processes, combined with the synergistic effect of borate ester bonds and carbon-carbon double bonds, to simultaneously achieve the construction of a microsphere cross-linking network and the interaction of polyphenols and Fe. 2+ The loading allows the AB-type bimicrosphere powder, which can absorb liquid in situ and self-assemble, to rapidly absorb liquid upon contact with blood or body fluids and then self-assemble in situ through a Schiff base and a metal-polyphenol network, thereby constructing a stable microsphere scaffold.

The invention discloses a hypoallergenic aluminum phosphate agent for human as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutic adjuvants. The aluminum phosphate agent is of a core-shell structure, the core is aluminum phosphate nanoparticles, the shell layer is a hydroxypropyl chitosan-polyethylene glycol cross-linked compound, and a modification layer is loaded with vitamin E succinate; the particle size of the composite particle is 80-150nm, the zeta potential is-8 to-3mV, and the composite particle comprises the following components in percentage by mass: 75-80% of aluminum phosphate, 17-22% of cross-linked compound, 0.5-2% of anti-inflammatory molecule and 0-3% of optional mannitol stabilizer. The preparation method adopts a precipitation-ultrasonic-assisted microfluidic modification-freeze-drying process. The aluminum phosphate agent can be used for human hypoallergenic vaccine adjuvants or drug carriers, and the problems that traditional aluminum phosphate is high in allergenicity and single in function are solved.

The invention discloses a 4-carboxyl-3-fluorophenylboronic acid modified hydroxypropyl chitosan microneedle patch and a preparation method of the 4-carboxyl-3-fluorophenylboronic acid modified hydroxypropyl chitosan microneedle patch. The preparation method comprises the following steps: dissolving 4-carboxyl-3-fluorophenylboronic acid modified hydroxypropyl chitosan in deionized water, adding polyvinyl alcohol, mixing to form gel, adding the anti-inflammatory drug colchicine and the uric acid reducing drug urate oxidase, and uniformly mixing; a two-step injection molding centrifugal method is adopted, firstly, non-drug-loaded gel is injected into a microneedle mold for centrifugal drying, then, drug-loaded gel is injected into the microneedle mold and placed in a centrifugal machine to be centrifuged to remove bubbles, and the microneedle patch with pH responsiveness is obtained after the microneedle patch is dried to constant weight in a dryer. The microneedle responds to the pH change of the gouty arthritis part, so that the medicine is intelligently released, a series of side effects caused by abnormal plasma medicine concentration are avoided, the effective utilization rate of the medicine can be increased through the microneedle design that only the needle point carries the medicine, medicine waste is avoided, and disease management of gout patients is simplified.