49 results about "Hydroxypropyl Chitosan" patented technology

The invention provides a preparation method of a shape-adaptive hydrogel material for tissue repair. The method comprises the following steps: S1, preparing HPC (Hydroxypropyl Chitosan); s2, preparation of phenylboronic acid functional chitosan PHPC (Polyhydroxyalkanoate); s3, preparing a PHPC solution; s4, preparing a polyvinyl alcohol (PVA) solution; and S5, preparing the dynamic covalent bond hydrogel. According to the invention, a dynamic covalent bond-boric acid ester bond with stimulation response capability is introduced on the basis of common dual-network CS-PVA hydrogel; on the premise of not changing the biocompatibility and biodegradability of the original dual-network hydrogel, the hydrogel is endowed with response capability under physical and chemical stimulation, and the diversity of application scenes is expanded; the dynamic mechanical behavior changes of the PCA hydrogel at four different strain rates of 0.05 mm / s, 0.5 mm / s, 5 mm / s and 50 mm / s are explored, and the passive shape adaptability of the PCA hydrogel along with tissue growth is studied; meanwhile, changes of hydrogel creep deformation and stress relaxation caused by addition of dynamic covalent bonds are researched.

The invention relates to bone paste for repairing bone wounds and a preparation method of the bone paste, and belongs to the technical field of biomedical material manufacturing. The bone paste is prepared from nanoscale calcium-phosphorus biphase ceramic, biomimetic mineralized collagen fiber, biodegradable polymer, modified hyaluronic acid, beta-cyclodextrin coated recombinant human bone morphogenetic protein-7, an angiogenesis accelerant and an immunoregulation additive according to a certain proportion. The nano-scale calcium-phosphorus dual-phase ceramic is hydroxyapatite and beta-tricalcium phosphate dual-phase ceramic; the biomimetic mineralized collagenous fiber is prepared by mixing type I collagen freeze-dried fiber with hydroxypropyl chitosan and performing mineralization; the modified hyaluronic acid is hyaluronic acid-sulfydryl and hyaluronic acid-hydrazide; the angiogenesis accelerant is a polylactic acid sustained release microsphere loaded with tanshinone and hydroxyl polyethylene glycol biotin; the immunoregulation additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction capacity, promote vascularization generation and reduce the immunogenicity risk.

The invention relates to the technical field of medicines, in particular to a medical dressing for promoting healing of a diabetic wound and a preparation method of the medical dressing. The medical dressing for promoting healing of the diabetic wound surface is prepared from the following raw materials in percentage by mass: 0.008 to 0.012 percent of stem cell exosome, 0.002 to 0.005 percent of oligopeptide-1, 0.004 to 0.01 percent of jasminin, 0.03 to 0.07 percent of modified CaSi2 nanosheets, 2 to 6 percent of hydroxypropyl chitosan, 0.1 to 0.5 percent of xanthan gum, 0.5 to 5 percent of glycerol and the balance of water. The medical dressing not only can promote wound healing, but also is beneficial to scar repair after wound healing.

The embodiment of the invention provides a preparation method of a sodium-ion battery negative plate and a sodium-ion battery. The preparation method comprises the following steps: soaking a pretreated light aluminum foil in an acidic mixed aqueous solution of hydroxypropyl chitosan and a pyrrole monomer; adding an oxidizing agent into the acidic mixed aqueous solution to form a hydroxypropyl chitosan / polypyrrole composite conductive polymer coating on the surface of the optical aluminum foil to obtain a negative electrode current collector; the method comprises the following steps: dissolving hard carbon, a conductive agent and a binder in a solvent according to a preset proportion to prepare slurry; and coating the slurry on the surface of the negative current collector, and baking and drying to obtain the negative plate. According to the method, the hydroxypropyl chitosan can be applied to the negative electrode binder so as to at least partially replace a traditional binder system; the technical scheme of'bonding-interface collaborative optimization 'is formed, the adhesion of hard carbon and the aluminum foil is improved, the internal resistance of an electrode plate is reduced, the structural stability of the electrode is improved, and the cycle life of the battery is prolonged.

The present invention relates to a bone trauma repair bone paste and a preparation method thereof, belonging to the technical field of biomedical material manufacturing. The bone paste of the present invention is prepared by mixing nano calcium phosphate biphasic ceramics, biomimetic mineralized collagen fibers, biodegradable polymers, modified hyaluronic acid, β-cyclodextrin-coated recombinant human bone morphogenetic protein-7, angiogenesis promoters and immunomodulatory additives in a certain proportion; the nano calcium phosphate biphasic ceramics are hydroxyapatite and β-tricalcium phosphate biphasic ceramics; the biomimetic mineralized collagen fibers are prepared by mineralizing freeze-dried fibers of type I collagen admixed with hydroxypropyl chitosan; the modified hyaluronic acid is hyaluronic acid-thiol and hyaluronic acid-hydrazide; the angiogenesis promoter is a polylactic acid sustained-release microsphere loaded with tanshinone and hydroxy polyethylene glycol biotin; the immunomodulatory additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction ability, promote angiogenesis and reduce the risk of immunogenicity.

The invention belongs to the field of biological materials, and particularly relates to hydroxyapatite nanofiber / biopolymer composite hemostatic sponge capable of rapidly absorbing liquid and expanding as well as a preparation method and application of the hydroxyapatite nanofiber / biopolymer composite hemostatic sponge. The hemostatic sponge is formed by cross-linking and compounding hydroxyapatite nanofibers and biopolymers, the chemical composition of the hydroxyapatite nanofiber is hydroxyapatite, the diameter of the hydroxyapatite nanofiber is 10-100 nm, and the length of the hydroxyapatite nanofiber is 10-500 [mu] m; the biopolymer is one or more of chitosan, carboxymethyl chitosan, hydroxypropyl chitosan, chitosan quaternary ammonium salt, chitosan hydrochloride, hyaluronic acid, alginic acid, gelatin and collagen; the hydroxyapatite nanofiber in the hemostatic sponge accounts for 10wt%-90wt% of the total mass of the sponge. The hemostatic sponge disclosed by the invention has excellent imbibition expansion capacity, relatively high imbibition expansion pressure, good erythrocyte and platelet adsorption capacity and good blood compatibility and biocompatibility.

The application discloses a non-metallic mineral powder ball preparation method for loading plant nutrient factors, and comprises the following steps: kaolin is added into hydrochloric acid and stirred, washed with water, calcined at 400-460 DEG C for 1-2h, then added into water with gelatinized starch and stirred, added with silane coupling agent KH560 and continuously stirred, filtered, washed, dried, added with polyvinyl alcohol and pH regulator and stirred to obtain premix; fly ash and refined sugar are uniformly mixed and formed to obtain pretreated fly ash; potassium hydroxide is added into sodium silicate solution and stirred uniformly, then hydroxypropyl chitosan is added and stirred to obtain a precursor solution; the precursor solution is uniformly poured on the surface of the pretreated fly ash, and then placed, solidified, ultrasonic washed and dried to obtain a sponge-like carrier; field soil, organic fertilizer and plant fermented straw are added into a high-speed pulverizer and pulverized, and sieved to obtain granules; the premix and the sponge-like carrier are added and uniformly mixed, and then formed to obtain a seedling raising substrate.

The invention discloses oral multi-effect analgesic and anti-inflammatory gel and a preparation method thereof, and belongs to the technical field of medical gel. The gel is prepared from mussel mucin grafted hydroxypropyl chitosan, a poly (N-isopropylacrylamide)-co-acrylic acid copolymer, quercetin-zinc coordination nanoparticles, a local anesthetic compound wrapped by temperature-sensitive lipidosome, a gamma-polyglutamic acid-catechin gel matrix, aloe polysaccharide, dipotassium glycyrrhizinate, and sodium hyaluronate and potassium sorbate which can be selectively added, wherein the local anesthetic compound is prepared from the mussel mucin grafted hydroxypropyl chitosan, the poly (N-isopropylacrylamide)-co-acrylic acid copolymer, the quercetin-zinc coordination nanoparticles, the temperature-sensitive lipidosome, the gamma-polyglutamic acid-catechin gel matrix, the aloe polysaccharide and the dipotassium glycyrrhizinate. During preparation, part of the components and water are stirred to obtain a mixed solution, and then the other components are added and stirred into gel. According to the gel, the leakage rate of local anesthetics is reduced by stabilizing the liposome through the zinc ions, the quercetin adjusts the phase transition temperature of the liposome to realize preferential drug release at the pain part, the mussel mucin and the copolymer form a reversible hydrogen bond network to enhance the mucous membrane adhesive force, and the inflammatory environment triggers the gel permeation drug release, so that the gel has the advantages of multiple-effect synergy, strong adhesion and the like; the problems that existing oral gel is short in analgesia time and insufficient in anti-inflammation can be effectively solved.

The invention relates to the technical field of high polymer materials, in particular to high-substitution-degree hydroxypropyl chitosan and a preparation method thereof. The raw materials comprise chitosan, sodium hydroxide, epoxypropane and isopropanol; the method comprises the following steps: pretreating chitosan; the preparation method comprises the following steps: mixing chitosan with isopropanol, and adding a sodium hydroxide solution for alkalization treatment to obtain alkalized chitosan; the alkalized chitosan is placed in a cooling device to be subjected to a hydroxypropylation reaction; by taking glacial acetic acid as a neutralizer, dropwise adding glacial acetic acid into the reaction liquid to carry out neutralization reaction; adding absolute ethyl alcohol into the reaction liquid, separating out a precipitate of hydroxypropyl chitosan from the reaction liquid, and treating the precipitate to obtain crude hydroxypropyl chitosan; carrying out purification treatment on the crude hydroxypropyl chitosan, and drying to obtain a hydroxypropyl chitosan product with a high substitution degree; through the mode, accurate regulation and control of the substitution degree of the hydroxypropylation reaction are realized, and the performance stability of the product is improved.

The invention belongs to the technical field of thermoplastic polyurethane elastomers, and relates to a high-damping modified thermoplastic polyurethane elastomer and a preparation method thereof, the high-damping modified thermoplastic polyurethane elastomer comprises the following components by weight: 85-95 parts of a thermoplastic polyurethane elastomer and 5-15 parts of a modifier; the hardness of the thermoplastic polyurethane elastomer is between Shore 55A and Shore 82D; the modifying agent is one or two of a polydopamine particle, a polydopamine-polyethyleneimine copolymer and hydroxypropyl chitosan. The thermoplastic polyurethane elastomer modified by adding the polymer modifier containing hydroxyl or amino has high damping property, the tensile strength of the modified thermoplastic polyurethane elastomer is reduced slightly, and the preparation process is simple and easy to operate.

The present invention discloses a Cu-MOF-based composite antibacterial hydrogel wound dressing and a preparation method thereof. The Cu-MOF-based composite antibacterial hydrogel wound dressing includes a hydrogel and a chlorogenic acid@Cu-MOF composite material dispersed in the hydrogel; the chlorogenic acid@Cu-MOF composite material includes chlorogenic acid and a Cu-MOF porous material in a mass ratio of 1:2 to 1:5; the hydrogel is a hydrogel with an interpenetrating network structure prepared from polyvinyl alcohol and catechol-modified hydroxypropyl chitosan. The Cu-MOF-based composite antibacterial hydrogel wound dressing of the present invention solves the problems of insufficient antibacterial property, short antibacterial action time, low adhesion strength and adverse effects on wound healing of the existing hydrogel wound dressing for infected wounds.

The invention discloses multifunctional injectable hydrogel as well as a preparation method and application thereof, and relates to conductive antibacterial hydrogel as well as preparation and application thereof. The technical problems that an existing hydrogel dressing is incomplete in covering and inaccurate in filling are solved. The multifunctional injectable hydrogel disclosed by the invention is double-network hydrogel formed by cross-linking dextran with hydroxypropyl chitosan through a reversible covalent bond and enhancing the mechanical strength of the hydrogel through an acrylamide network after the dextran is oxidized and modified; and FeCl3. 6H2O is uniformly distributed in a spatial framework of the hydrogel through coordinate bonds. The preparation method comprises the following steps: mixing oxidized dextran, acrylamide, N, N '-methylene bisacrylamide and FeCl3. 6H2O, and then quickly mixing the mixture with a mixed solution of a hydroxypropyl chitosan solution and a thermal initiator to obtain the multifunctional injectable hydrogel. The hydrogel can be used as a wound dressing or used for preparing a flexible sensor.

The application provides a high-efficiency hemostatic dressing, a preparation method and application thereof. The hemostatic dressing is a crosslinked product containing hydroxypropyl chitosan and low molecular weight eucommia ulmoides gum. The hemostatic dressing has a high swelling rate, can better absorb water-soluble exudates, and is beneficial to rapid hemostasis. The hemostatic dressing has better mechanical strength, which indicates that the hemostatic dressing has excellent compression resistance and high-load impact resistance, so that appropriate eucommia ulmoides gum-based dressing can be selected according to specific application scenes and wound characteristics, so as to improve the treatment effect.

The invention provides a piezoelectric phase change six-layer moisture-proof corrugated board. The corrugated board is of a six-layer structure sequentially compounded from outside to inside, wherein an antistatic piezoelectric layer is formed by lead zirconate titanate nanoparticles and polyvinylidene fluoride through electrostatic spinning; the moisture-proof functional layer is formed by compounding a polyurethane emulsion, a fluorine-containing compound with the carbon atom number larger than or equal to 6 and hydroxypropyl chitosan, the hydrophobic adhesive interface layer is formed by mixing acrylic resin and TiO2 nanoparticles and then conducting UV curing, and the contact angle is larger than or equal to 110 degrees; the fine honeycomb composite corrugated layer is formed by arranging G corrugations, F corrugations and V-shaped compression-resistant corrugations in a staggered manner, gaps among corrugation teeth are filled with nano silicon dioxide aerogel containing more than or equal to 30% of regenerated cellulose, and the water absorption rate is less than or equal to 1.5%; the phase change temperature control layer is composed of a paraffin / expanded graphite shape-stabilized phase change material, and the paraffin adsorption rate is larger than or equal to 90%; the nano reinforced base material layer is prepared from 60% of softwood pulp, 40% of hibiscus cannabinus stem pulp and red seaweed gel modified nano calcium carbonate. A dynamic damp-proof, compression-resistant and temperature-control cooperative system is realized, and the comprehensive cost is effectively reduced.

This application relates to the field of environmentally friendly PCB processing, disclosing an environmentally friendly film removal solution and its preparation method. The environmentally friendly film removal solution is prepared from the following raw materials in weight percentages: 2-4% alkaline hydroxide, 3-5% diethylene glycol butyl ether, 3.5-5.5% tetrahydrofurfuryl alcohol, 2-4% ethylene glycol hexyl ether, 3-5% accelerator, 4-6% stabilizer, and water as the balance; the stabilizer is prepared from hydroxypropyl chitosan, N-tris(hydroxymethyl)methylglycine, quaternary ammonium salt, and water. The environmentally friendly film removal solution of this application is suitable for high-precision PCB board processing, exhibiting good environmental friendliness and dry film removal efficiency, while reducing corrosion of the PCB board's circuit patterns.

The invention relates to a preparation method of a high-stability low-wear disc brake friction plate, which comprises the following steps of: mixing a resin-assistant-hydroxypropyl chitosan compound which is obtained by special modification of phenolic resin and is used as an effective component with other raw materials and auxiliary materials, pressing into a green body, and carrying out graded curing. Through particle size matching of the components, a complete particle size chain from coarse to fine is formed, hardness change uniformity is improved, wear resistance is guaranteed, the contradiction between wear resistance and protection of mating plates can be balanced, through graded curing treatment, it is guaranteed that the mechanical property and wear resistance of a blank are stable, a stable'resin-hard phase 'bonding interface is constructed, and the service life of the blank is prolonged. The heat conductivity is larger than or equal to 18 W / (m.K), the friction coefficient fluctuation ratio is smaller than or equal to 0.04, and the normal-temperature abrasion rate is smaller than or equal to 0.5 * 10 <-7 > cm / (N.m).

The application relates to the technical field of veterinary drugs, and discloses a compound vitamin preparation, a preparation method thereof and application.The compound vitamin preparation comprises a water phase and an oil phase; the water phase comprises the following components in parts by weight: 1-3 parts of hydroxypropyl chitosan, 0.5-2 parts of vitamin C and 50 parts of water; and the oil phase comprises the following components in parts by weight: 1.1-5.5 parts of fat-soluble vitamins and 27.6-41.4 parts of an emulsifying system.The above technical scheme solves the problem that vitamin C in the vitamin preparation in the prior art is easy to be oxidized.

The utility model relates to the technical field of reaction kettles, in particular to a reaction kettle convenient to clean for producing hydroxypropyl chitosan, which comprises a reaction kettle barrel, a driving mechanism is arranged at the top end of the reaction kettle barrel, a cleaning mechanism is connected to the bottom end of the driving mechanism, and the driving mechanism comprises a protective shell. A driving motor is fixedly installed in the protective shell, the output end of the driving motor is fixedly connected with a driving rotating shaft, the driving rotating shaft is movably connected with a stirring shaft through a synchronous belt, the stirring shaft is of a hollow design, a water passing cavity is formed in the stirring shaft, and a rotating joint is installed at the top end of the stirring shaft; the top end of the stirring shaft is connected with a water inlet pipe through a rotary connector, and water spraying holes are formed in the two sides of the stirring shaft. The driving motor arranged on the driving mechanism drives the driving rotating shaft to rotate, and the driving rotating shaft is movably connected with the stirring shaft through the synchronous belt, so that the stirring shaft is driven to rotate synchronously, and the strip-shaped stirring rods and the semicircular stirring rods are further driven to rotate.

The application discloses an alkali polishing additive for single crystal silicon rapid polishing and a use method thereof, relates to the field of single crystal silicon etching technology, and comprises the following components: a reaction promoter, an anti-corrosion and anti-fouling agent, a PH regulator, a defoaming agent, 1,3-bis(2-hydroxyethyl)-2-imidazolidinone, 2,5-furan dimethyl alcohol, quinoline yellow, sodium glycyrrhizinate, melamine, hydroxypropyl chitosan and deionized water. The additive has the advantages of good alkali polishing effect, high efficiency, good stability, good appearance of a polishing surface and obvious gain effect on the light conversion efficiency of a solar cell under low weight reduction.

The present invention discloses a melanin-hydroxypropyl chitosan / hyaluronic acid-bisamino polyethylene glycol composite hydrogel and its preparation method and application. The present invention first improves the properties of CS, HA and melanin, grafts melanin onto HPCS to prepare M-HPCS to improve its solubility, and then mixes M-HPCS and HA-PEG to form a composite hydrogel, and soluble metal ions can be added. The two composite hydrogels prepared by the present invention have a strong degree of internal network cross-linking and better toughness; and have good photothermal properties and can be used for photothermal therapy of wound repair; have strong antioxidant properties and good free radical scavenging ability. The hydrogel is non-cytotoxic and has good biocompatibility; has good ability to promote cell growth; and can promote the formation of new blood vessels. After actual verification, the composite hydrogels prepared by the present invention can promote wound healing by promoting the formation of new blood vessels.

The invention relates to the technical field of calcium lactate preparation, in particular to a method for preparing calcium lactate from shellfish and soothing protein polypeptide applied to the method. The invention discloses a method for preparing calcium lactate from shellfish, which comprises the following steps: firstly, removing attachments attached to the surface of the shellfish by combining physical scrubbing and magnetic composite biological enzyme solution soaking; secondly, calcium carbonate in the shell powder is extracted and purified through the steps of a calcination method, water dissolution, multi-stage precipitation adsorption impurity removal and the like; then, calcium lactate is generated through an acid-base neutralization reaction of lactic acid and calcium carbonate; secondly, carrying out specific chelating on calcium ions in the calcium lactate through disodium ethylene diamine tetraacetate; finally, a calcium-ethylenediamine tetraacetic acid chelate and the hydroxypropyl chitosan-acetylated collagen compound are subjected to electrostatic interaction and hydrogen bonding, a calcium-ethylenediamine tetraacetic acid-hydroxypropyl chitosan-acetylated collagen compound is formed, and the calcium-ethylenediamine tetraacetic acid-hydroxypropyl chitosan-acetylated collagen compound is marked as soothing protein polypeptide and can be prepared into essence, and the essence has a certain soothing effect.

The invention relates to an asymmetric adhesion bionic hydrogel dressing and a preparation method thereof. The preparation method is characterized by comprising the following steps: (1) dissolving acrylamide and acrylic acid in water; then adding N, N '-methylene bisacrylamide and N, N, N', N '-tetramethylethylenediamine, then adding FeCl3 and ammonium persulfate, and carrying out crosslinking to obtain upper-layer hydrogel; (2) adding protocatechuic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide into the hydroxypropyl chitosan solution, so as to obtain an adhesive layer; and (3) coating one surface of the upper-layer hydrogel with the adhesion layer, and curing at room temperature to obtain the asymmetric adhesion bionic hydrogel dressing. The asymmetric adhesion bionic hydrogel dressing has the advantages that one surface of the prepared asymmetric adhesion bionic hydrogel dressing has good adhesion performance and is used for being adhered to a wound, and the other surface of the asymmetric adhesion bionic hydrogel dressing is low in adhesion performance; the adhesive composition can be firmly adhered to tissues and can prevent the generation of bad adhesion.

The invention provides a sea cucumber peptide microsphere compound. The sea cucumber peptide microsphere compound is nanoparticles formed by wrapping sea cucumber peptide with chitosan analogues, and the chitosan analogue is any one of chitosan, carboxymethyl chitosan and hydroxypropyl chitosan. The HP-CS-NPS (or HPStide-N) provided by the invention provides an innovative active ingredient solution for developing efficient, stable and multifunctional gynecological nursing, cosmetics and skin care products, and is particularly suitable for nursing and repairing sensitive skin and acne skin.

This invention relates to the field of veterinary drug formulation and new feed additive technology, and proposes a compound emulsion based on hydroxypropyl chitosan-encapsulated essential oil-phytosterols, its preparation method, and its application. The compound emulsion is composed of the following raw materials in weight percentages: 10%–15% hydroxypropyl chitosan essential oil-encapsulated emulsion, 6%–9% phytosterol liposome dispersion, 6%–10% medium-chain triglycerides, 1.5%–2.5% beeswax, 2%–3% hydrogenated soybean lecithin, 3%–4% polysorbate 80, 0.3%–0.5% xanthan gum, 5%–7% glycerol, 3%–5% glucose, 0.05%–0.1% potassium sorbate, 0.005%–0.008% antioxidant, and the balance being water. This technical solution solves the problem of poor treatment efficacy for bacterial diseases in calves in related technologies.

This invention discloses a method for producing UV-protective fabric using biomass fibers, belonging to the field of textile materials technology. First, hydroxypropyl chitosan is modified with epoxy fatty acids and then combined with carboxymethyl cellulose and baicalin to prepare composite bio-based UV microcapsules via a complex coagulation method. Subsequently, these microcapsules are compounded with aqueous polyurethane to form a finishing solution, which is then coated onto Lyocell fibers to obtain microcapsule-loaded Lyocell fibers. Simultaneously, p-hydroxycinnamic acid is grafted onto PET fibers. Finally, WPU is applied and hot-pressed to form the two layers of fibers, resulting in the UV-protective fabric. This invention improves upon the problems of traditional fabrics, such as easy loss of function, easy peeling between layers, and a stiff feel, by constructing a two-layer composite structure of microcapsule-loaded Lyocell fibers and UV-grafted PET fibers. It achieves a balance between protective performance and wearing comfort, and is applicable to functional textiles such as outdoor sun-protective clothing and sunshade mesh.

The present invention relates to the field of medical technology, and particularly to a medical dressing for promoting the healing of diabetic wounds and a preparation method thereof. The medical dressing for promoting the healing of diabetic wounds comprises the following raw materials in terms of mass percentage: 0.008-0.012% of stem cell exosomes, 0.002-0.005% of oligopeptide-1, 0.004-0.01% of jasminin, 0.03-0.07% of modified CaSi2 nanosheets, 2-6% of hydroxypropyl chitosan, 0.1-0.5% of xanthan gum, 0.5-5% of glycerol, and the balance being water. This medical dressing can not only promote wound healing, but also facilitate the repair of scars after wound healing.

The invention provides a lactulose oral solution and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the oral solution comprises an active component lactulose, a solvent, a humectant, a stabilizer, a bacteriostatic agent and purified water; the stabilizing agent is prepared from hydroxypropyl chitosan and edetate disodium. The lactulose oral solution can overcome the defect of instability of lactulose through the cooperation of the stabilizer hydroxypropyl chitosan and edetate disodium, so that the lactulose oral solution has good stability.

The invention relates to the field of pharmaceutical preparations, in particular to a polypeptide composition for treating skin diseases and preventing aging and a preparation method thereof. The polypeptide composition is prepared from the following components: palmitoyl tetrapeptide-7, acetyl dipeptide-1 cetyl ester, acetyl heptapeptide-4, oligopeptide-1, hexapeptide-9, hexapeptide-11, hydroxypropyl chitosan, glycerol, bamboo leaf essential oil, squalane, modified nano cellulose, deionized water and other additives. A double-emulsion system is constructed through three different solvent systems of the hydroxypropyl chitosan, the squalane and the modified nanocellulose, a polypeptide channel of skin is opened by the squalane, and polypeptide is promoted to penetrate through a cuticle and permeate into deep skin tissue; hydroxypropyl chitosan and modified nanocellulose are connected through a Schiff base reaction after demulsification, in-situ crosslinking film forming is rapidly carried out on the skin surface, and the wound surface of the acne part can be effectively protected. The traditional Chinese medicine composition has the effects of soothing skin, treating acne and resisting aging.

The invention discloses application of temperature-sensitive hydroxypropyl chitin hydrogel in preparation of a medicine for treating intervertebral disc degeneration, and belongs to the technical field of biological medicine. The temperature-sensitive hydroxypropyl chitin hydrogel has good biocompatibility and temperature sensitivity, is liquid in a low-temperature state, quickly forms transparent hydrogel after entering a human body, and can seal a damaged fibrous ring and prevent medicine leakage. The fibroblast has the functions of secreting extracellular matrix and inhibiting inflammation, and can maintain the height and stability of the intervertebral disc and relieve clinical symptoms. The combination of the temperature-sensitive hydroxypropyl chitin hydrogel and the fibroblast can promote the fibroblast to secrete an extracellular matrix, provide a stronger biomechanical function, give full play to the curative effect in a patient with a broken fibrous ring, and fill the gap of leakage type intervertebral disc cell therapy.

The invention relates to the technical field of feed additives, and particularly discloses slow-release thiamine for acid decomposition as well as a preparation method and application of the slow-release thiamine. According to the slow-release thiamine for acid decomposition, provided by the invention, through long-acting acid decomposition of the core layer citric acid-sodium alginate modified dolomite, synergistic slow release of the coating layer polycaprolactone and hydroxypropyl chitosan and directional toxin capture of the betaine-alkyl glycoside modified attapulgite, the slow-release thiamine can be used for preparing the slow-release thiamine for acid decomposition; the problems that a traditional acidolysis product is short in action time and thiamine is easy to degrade are solved. When the slow-release thiamine for acid decomposition is applied to a ruminant feed, not only can subacute rumen acidosis be prevented, but also the early laminitis can be treated in an auxiliary manner, and the claudication rate and the chronic deformation hoof shell occurrence rate of ruminants can be effectively reduced.