35 results about "Bone Paste" patented technology

The invention relates to bone paste for repairing bone wounds and a preparation method of the bone paste, and belongs to the technical field of biomedical material manufacturing. The bone paste is prepared from nanoscale calcium-phosphorus biphase ceramic, biomimetic mineralized collagen fiber, biodegradable polymer, modified hyaluronic acid, beta-cyclodextrin coated recombinant human bone morphogenetic protein-7, an angiogenesis accelerant and an immunoregulation additive according to a certain proportion. The nano-scale calcium-phosphorus dual-phase ceramic is hydroxyapatite and beta-tricalcium phosphate dual-phase ceramic; the biomimetic mineralized collagenous fiber is prepared by mixing type I collagen freeze-dried fiber with hydroxypropyl chitosan and performing mineralization; the modified hyaluronic acid is hyaluronic acid-sulfydryl and hyaluronic acid-hydrazide; the angiogenesis accelerant is a polylactic acid sustained release microsphere loaded with tanshinone and hydroxyl polyethylene glycol biotin; the immunoregulation additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction capacity, promote vascularization generation and reduce the immunogenicity risk.

The present invention relates to a bone trauma repair bone paste and a preparation method thereof, belonging to the technical field of biomedical material manufacturing. The bone paste of the present invention is prepared by mixing nano calcium phosphate biphasic ceramics, biomimetic mineralized collagen fibers, biodegradable polymers, modified hyaluronic acid, β-cyclodextrin-coated recombinant human bone morphogenetic protein-7, angiogenesis promoters and immunomodulatory additives in a certain proportion; the nano calcium phosphate biphasic ceramics are hydroxyapatite and β-tricalcium phosphate biphasic ceramics; the biomimetic mineralized collagen fibers are prepared by mineralizing freeze-dried fibers of type I collagen admixed with hydroxypropyl chitosan; the modified hyaluronic acid is hyaluronic acid-thiol and hyaluronic acid-hydrazide; the angiogenesis promoter is a polylactic acid sustained-release microsphere loaded with tanshinone and hydroxy polyethylene glycol biotin; the immunomodulatory additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction ability, promote angiogenesis and reduce the risk of immunogenicity.

The invention discloses a spine minimally invasive combined type interbody fusion cage and an interbody fixing device.The spine minimally invasive combined type interbody fusion cage comprises an interbody fusion cage body, the interbody fusion cage body is arranged in a fan shape, a distance adjusting supporting structure is arranged on one side of the interbody fusion cage body, and the distance adjusting supporting structure is arranged on the other side of the interbody fusion cage body. The interbody fusion cage body comprises a fusion cage supporting base, a fan-shaped containing plane groove is formed in the upper surface of the fusion cage supporting base, distance adjusting supporting plates consistent in shape and size are placed on the inner side of the containing plane groove, and two symmetrical penetrating jacking grooves are formed in the positions, located at the bottom of the containing plane groove, of the fusion cage supporting base. The interbody fusion cage and the interbody fixing device are combined and fixed, so that after bone paste is injected, the whole interbody fusion cage is fixed to the interbody fixing device, the interbody fusion cage is more stable to use and not prone to deviation, the jacking height of the interbody fusion cage can be accurately adjusted, and adaptability is higher.

1.The name of the design product: packaging box (depicting the grass muscle paste). 2.The use of the design product: for packaging muscle paste. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best indicates the design points: perspective view. 5.The design for which protection is sought contains color.

The present application relates to the technical field of preparation of ox bone ointment, and particularly relates to a purification and separation device and process for preparing ox bone ointment, which can continuously work and centrally collect impurities when cleaning impurities in the prior art, and provides a purification and separation device for preparing ox bone ointment, which comprises a vertical plate, a filter barrel is arranged in the support frame, a scraper assembly comprises a scraper capable of rotating, when the scraper rotates, the impurities on the upper end of the filter plate can be pushed into the collection groove of the filter area, when the rotating table rotates, the impurities in the filter area can be pushed into the slag discharge area, a material gathering cylinder is arranged at the lower end of the slag discharge area, a sealing door is arranged at the bottom of the material gathering cylinder, a briquetting machine matched with the material gathering cylinder is arranged at the upper end of the slag discharge area, when the briquetting machine moves downward, the impurities in the material gathering cylinder can be extruded, and when the briquetting machine moves upward, the sealing door can be opened; the impurities can be removed without stopping the machine, and the impurities can be further extruded, so that the impurities can be centrally collected.

The invention discloses a muscle and bone patch for treating lumbago. The traditional Chinese medicine is prepared from the following raw materials by weight: 5 to 7 grams of prepared kusnezoff monkshood root, 5 to 7 grams of radix aconiti, 5 to 7 grams of herba asari, 14 to 16 grams of cassia twig, 14 to 16 grams of cortex eucommiae, 14 to 16 grams of radix dipsaci, 14 to 16 grams of rhizoma drynariae, 14 to 16 grams of radix angelicae pubescentis, 14 to 16 grams of radix clematidis, 14 to 16 grams of radix achyranthis bidentatae, 9 to 11 grams of frankincense, 9 to 11 grams of myrrh, 9 to 11 grams of flos carthami, 17 to 19 grams of caulis spatholobi, 17 to 19 grams of herba lycopodii, 17 to 19 grams of herba speranskiae tuberculatae and 11 to 13 grams of herba lycopi. The ointment is prepared by the following steps: weighing and preparing the raw materials according to the proportion, crushing the medicines, sieving with a 120-mesh sieve to obtain fine powder, blending honey, egg white, wine for treating cold symptoms, vinegar and the fine powder into thick paste, and coating the thick paste on a dressing to prepare the ointment. The traditional Chinese medicine has the effects of warming channels and expelling cold, activating meridians to stop pain, tonifying kidney and strengthening waist, strengthening bones and benefiting spines, clearing damp and dispersing blood stasis, activating meridians to stop pain, penetrating channels and inducing meridians and relieving swelling and urgency, has a good treatment effect on lumbago, does not have side effects, and has a good popularization prospect and a good medical economic value.

The utility model discloses an adjustable interbody fusion cage which comprises a group of fusion blocks which are symmetrically arranged up and down and further comprises a front propelling block, a rear propelling block and an adjusting assembly, the adjusting assembly is connected with the front propelling block and the rear propelling block and can adjust the distance between the front propelling block and the rear propelling block, and the front propelling block comprises a group of combined plates of the same structure. And the two combined plates are connected through sunk screws. The distance between the upper fusion block and the lower fusion block is adjusted through the arranged adjusting assembly, then the range of the practical gap of the fusion device is adjusted, and continuous height adjustment of the fusion device is achieved. Meanwhile, the bone paste injection channel is arranged, so that the artificial bone paste can be conveniently injected after the fusion cage is implanted, and different amounts of artificial bone paste can be implanted according to different operation conditions.

The utility model belongs to the field of medical instruments, particularly relates to a bone cement push rod, and provides the following scheme aiming at the problem that the bone cement push rod is extremely inconvenient to operate due to the existence of a G-arm machine: the bone cement push rod comprises a guide cylinder and an injection tube, a guide tube is inserted into the guide cylinder, and the top of the guide tube is fixedly connected with a communicated connecting box; the bottom of the connecting box is fixedly connected and communicated with a connecting pipe, and a flexible hose is in threaded connection between the connecting pipe and the discharge end of the bottom of the injection pipe; according to the utility model, the bone paste is guided by using the hose, so that a worker can perform a PKP surgery operation more conveniently under a G-arm machine, and meanwhile, the one-way tube is arranged at the bottom of the injection tube, so that the operation is more convenient, and the operation is more convenient. According to the bone paste injection device, a worker can conveniently add bone paste which is treated in advance into the injection pipe, more air is prevented from entering the injection pipe, the exhaust time is shortened, and the working efficiency is improved.

The invention discloses a multi-cutting-edge bone grinding head, which belongs to the technical field of medical instruments, and comprises a drill body of a cylindrical structure; the drill body is provided with a spiral tool bit which is integrally machined and formed by a plurality of cutting blades which are spirally distributed along the axial direction of the drill body; the connecting handle and the drill body are coaxially arranged, and the connecting handle is connected with the drill body; the marking unit is arranged on the periphery of the drill body and used for indicating the drilling depth; wherein the helix angle of the spiral cutter head is 15-25 degrees, so that bone substances are crushed in the cutting process, and bone-forming paste is conveyed upwards. By arranging the spiral cutter head with the spiral cutting angle ranging from 58 degrees to 62 degrees and combining the equidistant annular concave point depth marking unit structure, fine smashing, extraction and depth control over bone tissue in a cavity are achieved, and the quality and the use efficiency of bone paste in an operation are effectively improved.

The invention discloses a muscle and bone patch for treating knee pain. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 14-16g of kadsura pepper stem, 14-16g of Chinese starjasmine stem, 11-13g of notopterygium root, 11-13g of radix angelicae pubescentis, 11-13g of radix saposhnikoviae, 9-11g of cortex acanthopanacis, 11-13g of safflower, 11-13g of radix dipsaci, 9-11g of sappan wood, 9-11g of herba lycopi, 5-7g of radix aucklandiae, 14-16g of rheum officinale, 14-16g of lycopodium clavatum, 14-16g of garden balsam stem, 9-11g of radix angelicae, 9-11g of cortex moutan, 5-7g of prepared kusnezoff monkshood root and 5-7g of radix aconiti. The ointment is prepared by the following steps: weighing and preparing the raw materials according to the proportion, crushing the medicines, sieving with a 120-mesh sieve to obtain fine powder, blending the honey, the egg white, the wine for treating the cold symptom, the vinegar and the fine powder into thick paste, and coating a dressing with the thick paste to prepare the ointment. The ointment has the effects of dispelling wind, eliminating dampness, dredging collaterals, promoting blood circulation, removing blood stasis, relieving pain, relieving swelling and pain and warming channels, eliminating cold and relieving pain; the traditional Chinese medicine composition has a good treatment effect on knee pain, has no side effect, and has a good popularization prospect and medical economic value.

1. The name of the design product: packaging box set (bone ointment with musk). 2. The use of the design product: packaging of external use type external application medicine. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: set 1 perspective view. 5. The design claimed contains color. 6. The packaging bag shown in set 2 is a planar product, and other views are omitted. 7. Other circumstances that need to be explained: set 2 is a packaging bag, set 1 is a packaging box, and set 2 is placed in set 1.

The invention belongs to the technical field of nutritional food processing, and particularly relates to a nutritional and healthy meat and bone tea drink and a preparation method thereof.The nutritional and healthy meat and bone tea drink is prepared from, by weight, 10-50% of basic soup, 50-90% of purified water, 0-3% of tea leaves, 0-3% of roasted coffee beans and 0.1-0.3% of ginger slices, the basic soup is prepared by treating meat and bone raw materials, compound organic acid and double protease, the preparation method comprises five steps of bone soup boiling, meat and bone slurry enzymolysis, base soup deoiling and blending, original soup extraction and filtration, and packaging and sterilization. The formula and the process are synergistically matched, full release of nutritional ingredients is achieved through organic acid boiling and double-enzyme enzymolysis, and the prepared beverage is free of any additive, rich in nutritional ingredients such as small molecular protein and delicious polypeptide, clear in soup, pleasant in flavor, long in normal-temperature shelf life and suitable for industrial production.

The application relates to the technical field of biomedical materials, in particular to a calcium sulfate-based bionic bone repair material and a preparation method and application thereof. The preparation method comprises the following steps: stirring and mixing calcium sulfate dihydrate mixture into a collagen solution; performing suction filtration on the mixed solution to obtain bone paste, and performing shaping and drying to obtain a pre-shaped bone block; heating the pre-shaped bone block under vacuum conditions to obtain a dehydrated bone block; and finally rehydrating the dehydrated bone block and solidifying under the condition that the relative humidity is greater than or equal to 90% to obtain a bone repair material; the calcium sulfate dihydrate mixture is composed of calcium sulfate dihydrate and inorganic particles. The material is densified through suction filtration, collagen cross-linking and the conversion of calcium sulfate dihydrate into calcium sulfate hemihydrate are simultaneously completed through vacuum heating, and then the rehydration and high-humidity solidification are performed to obtain a bone repair material with an interpenetrating network structure. The material has excellent mechanical properties, a controllable degradation rate and is suitable for bone defect repair.

The invention provides a preparation method and application of chicken bone active peptide powder of Xuefeng black-bone chickens, and belongs to the technical field of food processing. The preparation method comprises the following steps: (1) crushing chicken bones of Xuefeng black-bone chickens, and mixing the crushed chicken bones with water to obtain bone slurry; (2) adding a compound enzyme preparation into the bone slurry for enzymolysis and enzyme deactivation to obtain enzymatic hydrolysate; and (3) filtering the enzymatic hydrolysate, performing gradient dialysis, performing separation and purification by adopting a gel chromatography column, collecting eluent, and performing spray drying on the eluent to obtain the active peptide powder of the chicken bones of the Xuefeng black-bone chickens. The Xuefeng black-bone chicken bone active peptide powder and the preparation method thereof have the advantages that the Xuefeng black-bone chicken bone is subjected to enzymolysis by adopting the compound enzyme preparation, and the production cost is reduced and the process is simple and controllable by optimizing the enzyme type, the dosage and the enzymolysis condition and adopting a specific purification process, so that the obtained Xuefeng black-bone chicken bone active peptide powder has a relatively strong anti-oxidation characteristic.

The invention discloses a pet molar rod composition capable of removing dental plaque, the pet molar rod composition comprises an inner core layer and a coating layer wound on the inner core layer, and the inner core layer comprises fresh bone paste, edible montmorillonite, plant powder, animal oil, meat meal, cationic glucan, starch and water. The invention also discloses a preparation method. The tooth cleaning rod has the advantages that the tooth cleaning rod is divided into the inner layer and the outer layer, the outer layer is hard, the inner layer is soft, the mouth feel is good, the chewing interest of pets is strong, and the oral health of the pets is maintained by combining the double effects of physical tooth grinding of chicken and duck intestines and biological method dental plaque removal of cationic dextran; the addition of the montmorillonite powder helps to promote the digestion ability of pets, and the addition of the related anti-inflammatory plant powder helps to improve the immunity of pets and reduce the morbidity of pets.

1. Name of the designed product: packing box (bone paste). 2. Use of the designed product: for packing products. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: front view.

The invention belongs to the technical field of food enzymolysis engineering, and particularly relates to a compound protein flavor base material rich in gamma-glutamyl peptide, a stock solution, a concentrated solution and powder of the compound protein flavor base material, and preparation and application of the compound protein flavor base material. The compound protein flavoring base material rich in gamma-glutamyl peptide is obtained by carrying out transpeptidation reaction on compound protein enzymatic hydrolysate, and the compound protein enzymatic hydrolysate is obtained by mixing bone paste enzymatic hydrolysate of livestock and / or aquatic products and yeast extract according to the weight ratio of (2-7): 1; according to the transpeptidation reaction, 0.5-1.3 U / g gamma-glutamine transpeptidase is added into the compound protein enzymatic hydrolysate to carry out the transpeptidation reaction on the basis of the unit enzyme amount U added into each g of the compound protein enzymatic hydrolysate. According to the invention, livestock and / or aquatic product meat by-products and yeast extracts are taken as substrates, the enzyme method oriented synthesis preparation is utilized, the production process is simple, the reaction condition is mild, the generation of Maillard reaction products with toxic and carcinogenic characteristics is avoided, the safety of the reaction products is higher, and the method is suitable for industrial production, green, safe and low in cost.

The invention belongs to the technical field of medical instruments, and provides a handheld orthopedic sander capable of absorbing bone paste, comprising a body, the bottom of the body is fixedly connected with a sleeving column, and the side, away from the body, of the sleeving column is in transmission connection with a grinding head; the water jacket is detachably connected to the sleeving column in a sleeving mode, the water jacket communicates with normal saline supply equipment, and a plurality of water outlet holes used for spraying normal saline to the grinding head are formed in the end, close to the grinding head, of the water jacket; the bone paste adsorption assembly comprises a liquid suction annular pipe, the liquid suction annular pipe is arranged close to the grinding head, a plurality of negative pressure openings used for absorbing bone paste are formed in the liquid suction annular pipe, the liquid suction annular pipe communicates with liquid pumping equipment, and the liquid suction annular pipe is detachably connected to the machine body through a limiting connecting assembly. The limiting connecting assembly is used for enabling the liquid suction annular pipe to be attached to the bone tissue of the ground area. During grinding, normal saline is continuously sprayed to a grinding area for cooling, and meanwhile generated bone paste can be automatically and timely absorbed and removed.

The utility model belongs to the technical field of medical bone paste processing, and particularly relates to a mixing mechanism for bone paste processing, which comprises a mixing tank, a rotating shaft is rotatably connected to the upper part in the mixing tank, a rotating plate is fixedly connected to the bottom of the rotating shaft, a stirring rod is rotatably connected to one side in the rotating plate, and sliding plates are slidably connected to two sides in the mixing tank. Overturning plates are fixedly connected to the bottoms of the two sliding plates, and cleaning strips are fixedly connected to the two sides of the outer portions of the sliding plates; the utility model provides a mixing mechanism for bone paste processing, and solves the problems that in the prior art, when bone paste and other raw materials are mixed and processed, the bone paste and other raw materials are generally injected into a stirring tank and are uniformly mixed through stirring of a stirring rod, but if the bone paste is relatively thick and is not turned over, the bone paste cannot be uniformly mixed. The problems of poor mixing quality and further influence on the processing efficiency due to the fact that the stirring and mixing effect of a single stirring rod is common and part of bone paste accumulated at the bottom and raw materials are difficult to fully mix only through the stirring rod in the prior art are solved.

The invention discloses a preparation method and application of sea cucumber polysaccharide, and belongs to the field of food and medicine. According to the method, the sea cucumber intestines are used as raw materials, only the sea cucumber intestines are simply washed in the pretreatment stage, on one hand, polysaccharide loss caused by excessive treatment is avoided, on the other hand, a natural grinding medium is provided for subsequent use of bone paste grinding homogenate, and tissue breaking is facilitated; and then the sand grains and the tissue homogenate are separated through standing. On the basis, polysaccharide extraction is performed by fully utilizing the autolysis characteristic of sea cucumber intestines, and a NaCl solution with a specific concentration is key added in the autolysis stage to inhibit polysaccharide degradation, so that the yield of total sugar and sulfated polysaccharide is increased. Furthermore, a synergistic treatment process of alkaline hydrolysis and enzymolysis is adopted, so that polysaccharide components in the sea cucumber intestines are fully released. Experiments show that the obtained polysaccharide can effectively relieve immunosuppression and intestinal barrier injury caused by cyclophosphamide, and the whole immune function of the body is recovered by adjusting intestinal flora and metabolites thereof.

The invention relates to the technical field of preparation of ox bone paste, in particular to a purification and separation device and process for preparing ox bone paste, and provides a purification and separation device for preparing ox bone paste to solve the problem that existing equipment cannot continuously work during impurity cleaning and cannot treat and collect impurities in a centralized mode. A filtering barrel is arranged in the supporting frame, the scraping assembly comprises a scraper capable of rotating, when the scraper rotates, impurities at the upper end of a filtering plate can be pushed into a collecting groove in the filtering area, and when the rotating table rotates, the impurities in the filtering area can be pushed into the slag discharging area; a material gathering barrel is arranged at the lower end of the slag discharging area, a sealing door is arranged at the bottom of the material gathering barrel, a pressing block matched with the material gathering barrel is arranged at the upper end of the slag discharging area, when the pressing block moves downwards, impurities in the material gathering barrel can be extruded, and when the pressing block moves upwards, the sealing door can be opened; impurities can be removed in a non-stop state, and further extrusion treatment can be performed on the impurities, so that centralized collection is facilitated.

1. The name of the design product: packaging box set (bone ointment with musk). 2. The use of the design product: packaging of external use type external application medicine. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: set 1 perspective view. 5. The design claimed contains color. 6. The packaging bag shown in set 2 is a planar product, and other views are omitted. 7. Other circumstances that need to be explained: set 2 is a packaging bag, set 1 is a packaging box, and set 2 is placed in set 1.

1. The appearance design name: packaging box (Baicao bone ointment). 2. The use of the appearance design: for medicine packaging. 3. The design points of the appearance design: pattern. 4. The view that can best indicate the design points: front view.

1. The name of the design product: packaging box set (bone ointment with musk). 2. The use of the design product: packaging of external use type external application medicine. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: set 1 perspective view. 5. The design claimed contains color. 6. The packaging bag shown in set 2 is a planar product, and other views are omitted. 7. Other circumstances that need to be explained: set 2 is a packaging bag, set 1 is a packaging box, and set 2 is placed in set 1.

The invention discloses a pig bone soup, a preparation method thereof and a food containing the pig bone soup, the preparation method comprises the following steps: adding pig bone paste and mushrooms into water to obtain a mixed solution, then adjusting the pH value of the mixed solution to 7-8, and sequentially adopting protease and lipase for step-by-step enzymolysis to obtain an enzymatic hydrolysate containing a flavor precursor; after enzymolysis is finished, reducing sugar and sulfur-containing amino acid or fresh and sweet amino acid are added into enzymatic hydrolysate to serve as a precursor compensator for flavor formation, then the mixture is put into high-pressure cooking equipment to be stewed, filtered and homogenized, and pig bone soup is obtained; the mass of the mushrooms is 0.5-1% of the mass of the pig bone paste. According to the invention, the mixed liquid of the pig bone paste and the mushroom is subjected to step-by-step enzymolysis to fully release flavor precursor substances in the pig bones, and specific precursor compensation and high-pressure cooking technologies are combined to directionally promote flavor formation ways such as Maillard reaction and the like; therefore, the pig bone soup which is rich in characteristic pork fragrance, outstanding in salty and delicious taste and mellow taste and rich in nutrition is efficiently prepared.

The invention discloses an automatic pretreatment system and process based on a pet food processing production line, and relates to the technical field of pet food processing, the system comprises: a mincing, chopping and grinding assembly comprising a meat mincer, a chopper mixer and a bone paste mill; the meat grinder is provided with a direct output end part, and is also provided with output end parts which are respectively communicated with the chopping and mixing machine and the bone paste grinder in a one-to-one correspondence manner; the premixing and storing mechanism is respectively communicated and connected with the direct output end part of the meat grinder, the output end part of the chopping and mixing machine and the output end part of the bone paste grinder; the vacuum stirring mechanism is communicated with the downstream position of the premixing storage mechanism; and the forming mechanism is communicated with the downstream position of the vacuum stirring mechanism. The technical problems that in the prior art, the operation efficiency is low, the automation degree is low, the quality stability is poor and potential food safety hazards exist in the pet food product pretreatment procedure are solved.

The invention relates to the technical field of pet food processing, and discloses a nutritional pet food based on a low-value seawater product and a preparation method thereof, and the preparation method comprises the following steps: desalting raw materials, and mechanically separating into a meat soft component and a hard calcium component; adding antioxidant such as rosemary extract into the soft meat component for pulping, and performing constant-temperature enzymolysis with compound protease to obtain enzymolysis meat pulp; the hard calcium component is subjected to high-temperature and high-pressure steaming and softening and multi-stage crushing to obtain ultramicro bone paste with the particle size D90 smaller than 50 [mu] m; and taking 60-80 parts of slurry and 15-30 parts of bone paste, adding sodium alginate and other structural stabilizers and nutrient supplements, mixing, and carrying out high-pressure homogenization, vacuum freeze-drying and nitrogen-filled packaging to obtain the bone paste. The processing contradiction of hard bones and soft meat of low-value marine products is solved through split-flow modification and texture structure recombination; the bioavailability of calcium is greatly improved by the micron-sized bone paste; in-situ antioxidation is combined with a freeze-drying technology, so that lipid rancidity is effectively inhibited, and the product is endowed with a crisp porous structure and excellent rehydration and palatability.

1. The name of the design product: packaging box (musk bone paste and joint pain paste). 2. The use of the design product: for packaging products. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: design 1 front view. 5. The design claimed contains color. 6. Design 1 is designated as the basic design.

The invention belongs to the technical field of organic fertilizer preparation, and particularly relates to a rabbit processing byproduct bio-organic fertilizer and a preparation method thereof. The rabbit processing byproduct bio-organic fertilizer is prepared from the following raw materials in parts by weight: 5 to 10 parts of humic acid, 10 to 20 parts of wheat bran, 10 to 15 parts of bone paste, 10 to 20 parts of modified nano-hydroxyapatite, 5 to 10 parts of red thick shell extract, 1 to 3 parts of microbial agent and 20 to 30 parts of water. A preparation method of the modified nano-hydroxyapatite comprises the following steps: adding nano-hydroxyapatite, maleic acid and carboxymethyl chitosan into a mixed solution of ethanol and water, carrying out reflux reaction, and purifying to obtain the modified nano-hydroxyapatite. The rabbit processing by-product bio-organic fertilizer provided by the invention not only fully utilizes rabbit processing by-product resources and realizes cyclic utilization and environmental protection value of the resources, but also can obviously improve the utilization rate of phosphorus elements by crops and improve the crop yield.