The invention discloses a dexheptane structure
prostacyclin-loaded nano
transdermal patch and a preparation method, the dexheptane structure
prostacyclin-loaded nano
transdermal patch comprises 10-30 parts of dexheptane precursor
liposome, 10-20 parts of a
prostacyclin nano-structure lipid carrier and 50-70 parts of an
acrylate pressure-sensitive
adhesive, the dexheptane precursor
liposome comprises 8-12 parts of dexheptane and 36-54 parts of hydrogenated
soya bean lecithin, and the prostacyclin nano-structure lipid carrier comprises a prostacyclin nano-structure lipid carrier and an
acrylate pressure-sensitive
adhesive. The prostacyclin injection comprises the following components in parts by weight: 36-54 parts of
mannitol, 80-240 parts of absolute ethyl
alcohol, 150-450 parts of
purified water, 0.150-0.200 part of prostacyclin, 80-150 parts of
glyceryl monostearate, 20-50 parts of
oleic acid, 10-30 parts of
soybean lecithin and the balance of
purified water, wherein the total amount of the prostacyclin injection, the
glyceryl monostearate, the
oleic acid, the
soybean lecithin and the
purified water is 1000 parts. According to the invention, the dextroheptane is used as a functional penetration enhancing component in transdermal
drug delivery, the dextroheptane and the prostacyclin are synergistically integrated in the nano-lipid carrier, the
transdermal penetration rate and the cumulative penetration amount of the prostacyclin are improved, the
treatment effect is improved, and continuous and stable release of the prostacyclin is realized under the combined action of the nano-structure lipid carrier and the patch matrix.