11 results about "HYDROGENATED SOYBEAN LECITHIN" patented technology

The invention discloses a preparation method of an external skin care product, belongs to the technical field of cosmetics, and aims to solve the problems of weak effect of a single target spot, poor transdermal permeability of active ingredients and easy inactivation in the prior art. The method comprises the following steps: preparing a composition containing an A-phase licorice extract and a B-phase bearberry extract, wherein the mass ratio of the A phase to the B phase is 1: (1.5-3); the preparation method comprises the following steps: preparing a liposome suspension of which the entrapment rate is greater than or equal to 88% and the particle size is 50-200nm by using a hydrogenated soybean lecithin-phytosterol-ceramide composite membrane material through a membrane dispersion-high-pressure homogenization method; mixing with auxiliary materials to prepare essence or emulsion; and smearing according to 0.5-1mg / cm < 2 > to realize double-target synergistic blackening inhibition. According to the scheme, the melanin inhibition rate reaches 54%-62% through the double-target design in cooperation with composite membrane material liposome delivery, the active ingredient retention rate is larger than or equal to 89% after storage at 45 DEG C for 6 months, the transdermal rate is increased to 40%-48%, and the method is mild, low in irritation and remarkable in application value.

The invention provides an essential oil delivery system based on bionic lipidosome and a preparation method thereof, and belongs to the technical field of cosmetics and pharmaceutical preparations, a membrane material of the bionic lipidosome delivery system contains a component similar to skin cuticle lipid, and an inclusion compound formed by cyclodextrin and volatile active ingredients is encapsulated in the membrane material; the volatile active component is selected from plant essential oil or active components thereof with anti-aging, analgesic, anti-inflammatory or anti-allergy effects; the membrane material is prepared from hydrogenated soybean lecithin, cholesterol, ceramide, phytosphingosine, phytosterol and an antioxidant; according to the bionic liposome delivery system provided by the invention, the volatility of active ingredients can be remarkably reduced, the stability of the active ingredients can be improved, and slow release and synergistic infiltration promotion effects can be realized, so that the effects of the bionic liposome delivery system in anti-aging, pain relieving and other applications can be greatly enhanced.

A lipid nanoparticle (liposome) comprising: (i) an outer shell comprising a lipid formulation; and (ii) one or more therapeutic agents which prevent apoptosis of a target cell is provided. The therape

The invention provides a propylthiouracil liposome injection and a preparation method thereof. The propylthiouracil liposome injection comprises the following components: propylthiouracil, hydrogenated soybean lecithin, cholesterol, distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000, alpha-tocopherol, a phosphate buffer solution and cane sugar. The preparation process comprises the steps of lipid film preparation, hydrated active drug loading, high-pressure homogenization, concentration and purification, sterilization and filtration, subpackaging and freeze-drying. The prepared propylthiouracil injection has the advantages of being fast in redissolution, good in stability, low in toxic and side effect, fast in clinical use effect and the like, is suitable for industrial large-scale production, can be used by patients who have hyperthyroidism emergency, coma, dysphagia and the like and cannot take oral liquid as the injection, and fills the blank in the current clinical treatment field.

The invention discloses doxorubicin lipidosome, a preparation method thereof and application of the doxorubicin lipidosome in a preparation, and belongs to the technical field of lipidosome drugs and preparations. The doxorubicin liposome comprises doxorubicin hydrochloride, hydrogenated soybean lecithin, cholesterol, fructo-oligosaccharide and glycine, the preparation method comprises the steps of premixing, blank liposome preparation, ammonium sulfate gradient establishment, multi-stage temperature incubation drug loading and post-treatment, and gradient temperature regulation is adopted in multi-stage incubation. According to the doxorubicin liposome, through the synergistic effect of all the components in the formula and the optimized preparation process, the performance of the liposome is improved, and the doxorubicin liposome can be used for preparing injections and has application value in the field of tumor treatment.

This invention relates to the field of veterinary drug formulation and new feed additive technology, and proposes a compound emulsion based on hydroxypropyl chitosan-encapsulated essential oil-phytosterols, its preparation method, and its application. The compound emulsion is composed of the following raw materials in weight percentages: 10%–15% hydroxypropyl chitosan essential oil-encapsulated emulsion, 6%–9% phytosterol liposome dispersion, 6%–10% medium-chain triglycerides, 1.5%–2.5% beeswax, 2%–3% hydrogenated soybean lecithin, 3%–4% polysorbate 80, 0.3%–0.5% xanthan gum, 5%–7% glycerol, 3%–5% glucose, 0.05%–0.1% potassium sorbate, 0.005%–0.008% antioxidant, and the balance being water. This technical solution solves the problem of poor treatment efficacy for bacterial diseases in calves in related technologies.

The invention provides stem cell exosome freeze-dried powder as well as a preparation method and application thereof, and relates to the technical field of biology. The stem cell exosome freeze-dried powder comprises the following components: stem cell exosomes and a composite protective agent, the composite protective agent comprises trehalose, fucose, polyethylene glycol, an erythritol-hydrogenated soybean phospholipid composite material, human serum albumin and an antioxidant. The stem cell exosome freeze-dried powder provided by the invention can be applied to the field of medicine preparation or cosmetics, and the prepared stem cell exosome freeze-dried powder is beneficial to repairing skin injury, improving skin elasticity and reducing wrinkle depth.

The invention discloses a dexheptane structure prostacyclin-loaded nano transdermal patch and a preparation method, the dexheptane structure prostacyclin-loaded nano transdermal patch comprises 10-30 parts of dexheptane precursor liposome, 10-20 parts of a prostacyclin nano-structure lipid carrier and 50-70 parts of an acrylate pressure-sensitive adhesive, the dexheptane precursor liposome comprises 8-12 parts of dexheptane and 36-54 parts of hydrogenated soya bean lecithin, and the prostacyclin nano-structure lipid carrier comprises a prostacyclin nano-structure lipid carrier and an acrylate pressure-sensitive adhesive. The prostacyclin injection comprises the following components in parts by weight: 36-54 parts of mannitol, 80-240 parts of absolute ethyl alcohol, 150-450 parts of purified water, 0.150-0.200 part of prostacyclin, 80-150 parts of glyceryl monostearate, 20-50 parts of oleic acid, 10-30 parts of soybean lecithin and the balance of purified water, wherein the total amount of the prostacyclin injection, the glyceryl monostearate, the oleic acid, the soybean lecithin and the purified water is 1000 parts. According to the invention, the dextroheptane is used as a functional penetration enhancing component in transdermal drug delivery, the dextroheptane and the prostacyclin are synergistically integrated in the nano-lipid carrier, the transdermal penetration rate and the cumulative penetration amount of the prostacyclin are improved, the treatment effect is improved, and continuous and stable release of the prostacyclin is realized under the combined action of the nano-structure lipid carrier and the patch matrix.

The present application relates to the field of cosmetic technology, in particular to a liposome for encapsulating ergothioneine, a preparation method and application thereof, comprising a phospholipid bilayer formed by compounding soybean lecithin and hydrogenated soybean lecithin, and ergothioneine encapsulated in the phospholipid bilayer; the mass ratio of the soybean lecithin to the hydrogenated soybean lecithin is 5:5-8:2; the intermembrane space of the phospholipid bilayer is filled with tocopherol and polyglycerol-10 laurate. The product is mild and can simultaneously solve the degradation odor of ergothioneine, balance the stability and transdermal permeability, meet the stringent requirements of edible grade safety standards for sensitive parts such as the lip mucosa, and has extremely high market promotion value.

The invention discloses an alligator penis active peptide and application thereof in thrombus treatment, and belongs to the technical field of biological medicine. The invention provides an active peptide extracted from alligator penis aiming at the problems of side effects of existing antithrombotic drugs and blank research on active substances of the alligator penis. The active peptide can effectively inhibit carrageenan-induced mouse tail thrombosis, the action mechanism of the active peptide is related to anti-platelet aggregation and anti-inflammatory dual pathways, and the active peptide shows good safety. The invention provides a phospholipid composite liposome containing the active peptide, the active peptide and hydrogenated soybean lecithin, cholesterol and the like in a specific proportion are constructed into a nano liposome, and a phospholipid combination with high and low phase transition temperatures is preferably adopted, so that the bioavailability and targeting property of a medicine are improved. According to the preparation, the synergistic effect of decrement and synergism and the synergistic effect of the same amount in an animal model is achieved, and a new candidate substance and preparation scheme is provided for developing novel, efficient and safe antithrombotic drugs or functional products.

The present application provides a liposome-encapsulated whitening composition, a preparation method and an application thereof, and belongs to the field of medical, dental or cosmetic preparations. The components of the present application are 4-butyl resorcinol, tranexamic acid, alpha-arbutin, coenzyme Q10, Ceylon cinnamon oil, sweep leaf Australian tea branch / leaf oil, hydrogenated soybean lecithin and a humectant. The present application is compounded with a variety of different whitening components, covering the three major pathways of "inhibiting tyrosinase activity, inhibiting melanin transfer and accelerating melanin metabolism" for melanin production; in line with the modern multi-target whitening trend. At the same time, the additional plant essential oil has the effect of promoting penetration and strengthening the inhibition of tyrosinase; at the same time, the liposome-encapsulated preparation solves the problem of mutual incompatibility between raw materials and increases the transdermal absorption rate and reduces the irritation. It can be added to a variety of different specific products, such as serums, creams, lotions, etc.