16 results about "HYDROGENATED SOYBEAN LECITHIN" patented technology

The invention relates to the technical field of nano-material drug delivery, in particular to a loaded peptide and doxorubicin hydrochloride liposome as well as a preparation method and application thereof. Comprising the following steps: (1) dissolving hydrogenated soybean lecithin and cholesterol in ethanol, and filtering with a filter membrane for later use; (2) dissolving peptide CH3 (CH2) 6CO-GIIKKIIKKI-NH2 and doxorubicin hydrochloride into pure water, and filtering with a filter membrane for later use; and (3) taking the phospholipid-cholesterol ethanol solution and the peptide-doxorubicin hydrochloride aqueous solution prepared in the step (2) as organic phases, and preparing the liposome loaded with peptide and doxorubicin hydrochloride by adopting a microfluidic method and controlling the total flow velocity and the flow velocity ratio of the aqueous phase to the organic phase. The prepared liposome is spherical, uniform in particle size, and good in biocompatibility and biodegradability. And no surfactant or dispersant is added in the preparation process, so that the toxicity to the body is further reduced.

The invention discloses a preparation method of an external skin care product, belongs to the technical field of cosmetics, and aims to solve the problems of weak effect of a single target spot, poor transdermal permeability of active ingredients and easy inactivation in the prior art. The method comprises the following steps: preparing a composition containing an A-phase licorice extract and a B-phase bearberry extract, wherein the mass ratio of the A phase to the B phase is 1: (1.5-3); the preparation method comprises the following steps: preparing a liposome suspension of which the entrapment rate is greater than or equal to 88% and the particle size is 50-200nm by using a hydrogenated soybean lecithin-phytosterol-ceramide composite membrane material through a membrane dispersion-high-pressure homogenization method; mixing with auxiliary materials to prepare essence or emulsion; and smearing according to 0.5-1mg / cm < 2 > to realize double-target synergistic blackening inhibition. According to the scheme, the melanin inhibition rate reaches 54%-62% through the double-target design in cooperation with composite membrane material liposome delivery, the active ingredient retention rate is larger than or equal to 89% after storage at 45 DEG C for 6 months, the transdermal rate is increased to 40%-48%, and the method is mild, low in irritation and remarkable in application value.

The invention provides an essential oil delivery system based on bionic lipidosome and a preparation method thereof, and belongs to the technical field of cosmetics and pharmaceutical preparations, a membrane material of the bionic lipidosome delivery system contains a component similar to skin cuticle lipid, and an inclusion compound formed by cyclodextrin and volatile active ingredients is encapsulated in the membrane material; the volatile active component is selected from plant essential oil or active components thereof with anti-aging, analgesic, anti-inflammatory or anti-allergy effects; the membrane material is prepared from hydrogenated soybean lecithin, cholesterol, ceramide, phytosphingosine, phytosterol and an antioxidant; according to the bionic liposome delivery system provided by the invention, the volatility of active ingredients can be remarkably reduced, the stability of the active ingredients can be improved, and slow release and synergistic infiltration promotion effects can be realized, so that the effects of the bionic liposome delivery system in anti-aging, pain relieving and other applications can be greatly enhanced.

The invention relates to irinotecan liposome combined administration for treating colorectal cancer. Specifically, the invention relates to application of irinotecan lipidosome combined with oxaliplatin, 5-fluorouracil, calcium folinate and bevacizumab in preparation of medicines for treating colorectal cancer, and the irinotecan lipidosome contains hydrogenated soybean lecithin, polyethylene glycol 2000-distearoyl phosphatidyl ethanolamine and cholesterol.

A lipid nanoparticle (liposome) comprising: (i) an outer shell comprising a lipid formulation; and (ii) one or more therapeutic agents which prevent apoptosis of a target cell is provided. The therape

The invention provides a propylthiouracil liposome injection and a preparation method thereof. The propylthiouracil liposome injection comprises the following components: propylthiouracil, hydrogenated soybean lecithin, cholesterol, distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000, alpha-tocopherol, a phosphate buffer solution and cane sugar. The preparation process comprises the steps of lipid film preparation, hydrated active drug loading, high-pressure homogenization, concentration and purification, sterilization and filtration, subpackaging and freeze-drying. The prepared propylthiouracil injection has the advantages of being fast in redissolution, good in stability, low in toxic and side effect, fast in clinical use effect and the like, is suitable for industrial large-scale production, can be used by patients who have hyperthyroidism emergency, coma, dysphagia and the like and cannot take oral liquid as the injection, and fills the blank in the current clinical treatment field.

The invention discloses doxorubicin lipidosome, a preparation method thereof and application of the doxorubicin lipidosome in a preparation, and belongs to the technical field of lipidosome drugs and preparations. The doxorubicin liposome comprises doxorubicin hydrochloride, hydrogenated soybean lecithin, cholesterol, fructo-oligosaccharide and glycine, the preparation method comprises the steps of premixing, blank liposome preparation, ammonium sulfate gradient establishment, multi-stage temperature incubation drug loading and post-treatment, and gradient temperature regulation is adopted in multi-stage incubation. According to the doxorubicin liposome, through the synergistic effect of all the components in the formula and the optimized preparation process, the performance of the liposome is improved, and the doxorubicin liposome can be used for preparing injections and has application value in the field of tumor treatment.

This invention relates to the field of veterinary drug formulation and new feed additive technology, and proposes a compound emulsion based on hydroxypropyl chitosan-encapsulated essential oil-phytosterols, its preparation method, and its application. The compound emulsion is composed of the following raw materials in weight percentages: 10%–15% hydroxypropyl chitosan essential oil-encapsulated emulsion, 6%–9% phytosterol liposome dispersion, 6%–10% medium-chain triglycerides, 1.5%–2.5% beeswax, 2%–3% hydrogenated soybean lecithin, 3%–4% polysorbate 80, 0.3%–0.5% xanthan gum, 5%–7% glycerol, 3%–5% glucose, 0.05%–0.1% potassium sorbate, 0.005%–0.008% antioxidant, and the balance being water. This technical solution solves the problem of poor treatment efficacy for bacterial diseases in calves in related technologies.

The invention discloses a fluralan drop as well as a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The fluralan drop is prepared from the following components in parts by weight: 5 to 15 parts of fluralan; 2-6 parts of hydrogenated soybean lecithin; 0.2 to 0.7 part of cholesterol; 1 to 4 parts of matrine C12-C16 fatty acid ionic liquid; 15 to 45 parts of short chain alcohol; and 30-70 parts of water. The sophocarpidine fatty acid ionic liquid of fatty acid with a specific carbon chain length is introduced into the ethosome, so that the surface charge of the ethosome is increased, and the stability of the ethosome and the encapsulation efficiency of the flurala sodium are improved. Moreover, due to the introduction of the matrine fatty acid ionic liquid, the transdermal permeation rate of the preparation and the medicine accumulation transdermal permeation amount are also enhanced, the medicine utilization rate is improved, the insecticidal activity of the preparation is remarkably prolonged, and the treatment effect on animal parasitic infection and the administration compliance are further improved.

The invention provides stem cell exosome freeze-dried powder as well as a preparation method and application thereof, and relates to the technical field of biology. The stem cell exosome freeze-dried powder comprises the following components: stem cell exosomes and a composite protective agent, the composite protective agent comprises trehalose, fucose, polyethylene glycol, an erythritol-hydrogenated soybean phospholipid composite material, human serum albumin and an antioxidant. The stem cell exosome freeze-dried powder provided by the invention can be applied to the field of medicine preparation or cosmetics, and the prepared stem cell exosome freeze-dried powder is beneficial to repairing skin injury, improving skin elasticity and reducing wrinkle depth.

The invention discloses a dexheptane structure prostacyclin-loaded nano transdermal patch and a preparation method, the dexheptane structure prostacyclin-loaded nano transdermal patch comprises 10-30 parts of dexheptane precursor liposome, 10-20 parts of a prostacyclin nano-structure lipid carrier and 50-70 parts of an acrylate pressure-sensitive adhesive, the dexheptane precursor liposome comprises 8-12 parts of dexheptane and 36-54 parts of hydrogenated soya bean lecithin, and the prostacyclin nano-structure lipid carrier comprises a prostacyclin nano-structure lipid carrier and an acrylate pressure-sensitive adhesive. The prostacyclin injection comprises the following components in parts by weight: 36-54 parts of mannitol, 80-240 parts of absolute ethyl alcohol, 150-450 parts of purified water, 0.150-0.200 part of prostacyclin, 80-150 parts of glyceryl monostearate, 20-50 parts of oleic acid, 10-30 parts of soybean lecithin and the balance of purified water, wherein the total amount of the prostacyclin injection, the glyceryl monostearate, the oleic acid, the soybean lecithin and the purified water is 1000 parts. According to the invention, the dextroheptane is used as a functional penetration enhancing component in transdermal drug delivery, the dextroheptane and the prostacyclin are synergistically integrated in the nano-lipid carrier, the transdermal penetration rate and the cumulative penetration amount of the prostacyclin are improved, the treatment effect is improved, and continuous and stable release of the prostacyclin is realized under the combined action of the nano-structure lipid carrier and the patch matrix.

The present invention relates to the technical field of daily chemical products, and specifically provides an essence containing osmanthus extract with soothing, firming and anti-wrinkle and light lines and a preparation method. The essence is measured by mass, including: 10 to 30 parts of osmanthus extract, 2 to 10 parts of frankincense seed extract, 2 to 10 parts of betaine, 2 to 10 parts of pentapeptide, 1 to 5 parts of hydrogenated soybean lecithin, 1 to 5 parts of xylitol, and 60 to 80 parts of water. Compared with the prior art, the essence containing osmanthus extract with soothing, firming and anti-wrinkle and light lines of the present invention not only has a good anti-inflammatory effect, but also can significantly reduce the content of MMP-1, thereby reducing the degradation of collagen, is conducive to increasing skin elasticity, improving skin firmness, repairing damaged skin, promoting healing, and has anti-aging and repairing effects.

The present invention relates to the field of biopharmaceutical technology, and specifically discloses a Grifola frondosa polysaccharide-protein complex with anti-tumor activity. The present invention also discloses a method for preparing the Grifola frondosa polysaccharide-protein complex with anti-tumor activity, including: extracting Grifola frondosa fruiting bodies by wet grinding, combining extracts, ultraviolet treatment for 1-2 minutes under stirring, the ultraviolet power is 13-17w, concentrating, and vacuum drying to obtain a crude product; purifying the crude product to obtain a purified material; adding dopamine hydrochloride and 2,2,6,6-tetramethylpiperidinoxide to an ethanol aqueous solution and stirring, adding 1,3,5-trimethylbenzene and continuing to stir, centrifuging, drying, washing, drying, and then mixing with the purified material and polyethylene glycol 400 and adding to chloroform, ultrasonication at room temperature, adding hydrogenated soybean lecithin, lecithin, and cholesterol to mix, rotary evaporation, adding phosphate buffer to hydrate, ultrasonication, and whole grains.

The present application relates to the field of cosmetic technology, in particular to a liposome for encapsulating ergothioneine, a preparation method and application thereof, comprising a phospholipid bilayer formed by compounding soybean lecithin and hydrogenated soybean lecithin, and ergothioneine encapsulated in the phospholipid bilayer; the mass ratio of the soybean lecithin to the hydrogenated soybean lecithin is 5:5-8:2; the intermembrane space of the phospholipid bilayer is filled with tocopherol and polyglycerol-10 laurate. The product is mild and can simultaneously solve the degradation odor of ergothioneine, balance the stability and transdermal permeability, meet the stringent requirements of edible grade safety standards for sensitive parts such as the lip mucosa, and has extremely high market promotion value.

The invention discloses an alligator penis active peptide and application thereof in thrombus treatment, and belongs to the technical field of biological medicine. The invention provides an active peptide extracted from alligator penis aiming at the problems of side effects of existing antithrombotic drugs and blank research on active substances of the alligator penis. The active peptide can effectively inhibit carrageenan-induced mouse tail thrombosis, the action mechanism of the active peptide is related to anti-platelet aggregation and anti-inflammatory dual pathways, and the active peptide shows good safety. The invention provides a phospholipid composite liposome containing the active peptide, the active peptide and hydrogenated soybean lecithin, cholesterol and the like in a specific proportion are constructed into a nano liposome, and a phospholipid combination with high and low phase transition temperatures is preferably adopted, so that the bioavailability and targeting property of a medicine are improved. According to the preparation, the synergistic effect of decrement and synergism and the synergistic effect of the same amount in an animal model is achieved, and a new candidate substance and preparation scheme is provided for developing novel, efficient and safe antithrombotic drugs or functional products.

The present application provides a liposome-encapsulated whitening composition, a preparation method and an application thereof, and belongs to the field of medical, dental or cosmetic preparations. The components of the present application are 4-butyl resorcinol, tranexamic acid, alpha-arbutin, coenzyme Q10, Ceylon cinnamon oil, sweep leaf Australian tea branch / leaf oil, hydrogenated soybean lecithin and a humectant. The present application is compounded with a variety of different whitening components, covering the three major pathways of "inhibiting tyrosinase activity, inhibiting melanin transfer and accelerating melanin metabolism" for melanin production; in line with the modern multi-target whitening trend. At the same time, the additional plant essential oil has the effect of promoting penetration and strengthening the inhibition of tyrosinase; at the same time, the liposome-encapsulated preparation solves the problem of mutual incompatibility between raw materials and increases the transdermal absorption rate and reduces the irritation. It can be added to a variety of different specific products, such as serums, creams, lotions, etc.