121 results about "Matrine" patented technology

The invention discloses a carrier-free nano-particle with pH / ROS dual response as well as a preparation method and application of the carrier-free nano-particle. The preparation method comprises the following steps: enabling quinolizidine alkaloid and flavonol to be subjected to self-assembly, so as to prepare quinolizidine alkaloid-flavonol carrier-free nano particles; modifying the quinolizidine alkaloid-flavonol carrier-free nano particles by adopting a phenylboronic acid-hyaluronic acid conjugate, so as to prepare nano particles modified by the phenylboronic acid-hyaluronic acid conjugate; and coating the surfaces of the nano-particles modified by the phenylboronic acid-hyaluronic acid conjugate with a pH sensitive polymer to prepare the pH / ROS dual-response carrier-free nano-particles. The sophocarpidine-kaempferol carrier-free nanoparticles with pH / ROS dual response, prepared by the invention, have the advantages of good targeting property, high biocompatibility, small toxicity and adverse reaction and the like, meanwhile, the nanoparticles have a good anti-inflammatory effect, and a new choice is provided for the treatment of ulcerative colitis.

The invention discloses matrine-oleanolic acid ionic liquid and a preparation method and application thereof.The preparation method comprises the steps that matrine and oleanolic acid are dissolved in an organic solvent, heating and stirring are conducted, then rotary evaporation is conducted, and the matrine-oleanolic acid ionic liquid is obtained; wherein the mass ratio of the sum of the matrine and the oleanolic acid to the organic solvent is 1: (5-30), and the molar ratio of the matrine to the oleanolic acid is (3-10): 1. The ionic liquid disclosed by the invention not only can effectively improve the water solubility of oleanolic acid, but also can effectively inhibit the activity of 5 alpha-reductase and prevent the 5 alpha-reductase from catalyzing testosterone to be converted into DHT, so that the problems of rapid entry into a retrogression period, miniaturization, hair loss and the like caused by the fact that DHT acts on hair follicles after being combined with an androgen receptor are prevented. Meanwhile, expression of IL-1beta and TNF-alpha inflammatory factors in skin hair follicles can be inhibited, and the purposes of preventing alopecia and promoting hair growth are achieved. The effects of controlling oil, resisting inflammation, relieving, removing dandruff, relieving itching and the like are also achieved.

The invention discloses a tripterine-sophocarpidine self-assembled nanoparticle and application thereof in preparation of an anti-tumor drug, and belongs to the field of biological medicine. The nanoparticles are formed by self-assembly of the tripterine and the sophocarpidine through supramolecular interaction, the molar ratio of the tripterine to the sophocarpidine is 1: 1-1: 3, and the self-assembly system effectively solves the problems of low Cst solubility, poor bioavailability, rapid in-vivo removal and the like; the inhibition effect on triple negative breast cancer (TNBC) is remarkably enhanced through the synergistic effect of Cst and Mar, and a new strategy is provided for expanding the application of a traditional Chinese medicine carrier-free self-assembly nano drug delivery system in the anti-tumor field.

The invention discloses a gynecological antibacterial nursing gel containing hydrolyzed collagen and a preparation method thereof. Comprising the following raw materials in parts by weight: 4 to 12 parts of hydrolyzed collagen, 1 to 3 parts of glutathione, 2 to 4 parts of sophocarpidine, 0.2 to 0.5 part of resveratrol, 1 to 3 parts of hydroxybutyl chitosan, 15 to 20 parts of a traditional Chinese medicine extract, 0.5 to 1.5 parts of sodium hyaluronate, 0.1 to 0.25 part of plant essential oil, 1 to 3 parts of triethanolamine, 0.8 to 1.5 parts of lactic acid, 1 to 2 parts of carboxymethylcellulose, 1 to 1.5 parts of glycerol, 1 to 2 parts of carbomer and 0.5 to 1.5 parts of an emulsifier, 1-3 parts of a pH regulator, 10-15 parts of an irradiation improver, and the balance of purified water, totaling 100 parts; the invention relates to the technical field of gynecological gel. According to the gynecological antibacterial nursing gel containing the hydrolyzed collagen and the preparation method, the antibacterial effect of the gel is enhanced by adding the hydrolyzed collagen, so that the antibacterial effect is more durable, and the hydrolyzed collagen has relatively small molecular weight, is easily absorbed by skin, and can quickly permeate into vaginal mucosa to play nourishing and repairing roles.

The invention relates to a temperature-sensitive gel nose drop and a preparation method and application thereof, and belongs to the technical field of biological medicines.The temperature-sensitive gel nose drop is composed of a temperature-sensitive gel matrix, active ingredients and pharmaceutic adjuvants, the temperature-sensitive gel matrix comprises poloxamer 407 and poloxamer 188, the active ingredients comprise matrine and oxymatrine, and the pharmaceutic adjuvants comprise the temperature-sensitive gel matrix, the active ingredients and the pharmaceutic adjuvants. The pharmaceutic adjuvants comprise one or more of a solvent, a humectant, an antioxidant, a preservative, a wetting agent, a thickening agent, a coloring agent, a wetting agent and a buffering agent. The temperature-sensitive gel nose drop disclosed by the invention is simple in preparation process, controllable in cost and suitable for large-scale production. The thermo-sensitive gel nose drop can improve the expression level of serum IgE, IL-4 and IFN-gamma, improves the symptom of allergic rhinitis by correcting Th1 / Th2 imbalance, is suitable for clinical treatment and prevention of allergic rhinitis, and has a remarkable clinical application prospect.

The present application relates to the application of traditional Chinese medicine active ingredient composition and its preparation in synergistic anti-tumor of PD-1 inhibitor. The traditional Chinese medicine active ingredient composition is a composition of oxymatrine and astragaloside B. The combination of the two can improve the anti-tumor effect of PD-1 inhibitor. In addition, it can also be used in the form of preparation to realize in vivo drug delivery in cooperation with its pharmaceutically acceptable carrier. The carrier can be selected from iron-based MOF and liposome, etc. to realize the co-loading of oxymatrine and astragaloside B with different polarity and efficient drug delivery. The iron-based MOF carrier has the advantages of high drug loading capacity and Fe ion which can cooperate with astragaloside B to improve the activity of tumor infiltrating T cells. The ferromagnetism and platelet membrane modification can also precisely target tumor tissue. The preparation technology of liposome is mature, which is conducive to industrialized production and has broad prospects for clinical transformation. The combination of the two with PD-1 inhibitor can significantly improve the anti-tumor effect of PD-1 inhibitor.

The invention relates to the technical field of pesticides, in particular to an environment-friendly composite pesticide based on marine microorganisms and a preparation method thereof.The environment-friendly composite pesticide is prepared from, by weight, 40%-52% of functional microspheres, 5%-6% of matrine, 2%-3% of rotenone, 3%-4% of rhamnolipid, 1%-1.5% of sodium alginate, 30%-35% of kieselguhr, 1%-2% of zinc sulfate, 2%-4% of hydroxyapatite and the balance water. Natural marine materials such as algin, sodium alginate and kieselguhr are used as carriers, plant source active ingredients and a biological surfactant are matched, matrine serves as a cholinesterase inhibitor, rotenone serves as a mitochondrial compound I inhibitor, a dual-action mechanism is formed, and meanwhile pollution caused by chemical pesticide residues is avoided.

The present invention relates to the technical field of compounds for medicine and cosmetics, and particularly relates to an mandelic acid ionic liquid, a preparation method and an application thereof. The present invention combines matrine and mandelic acid through an ionic bond to obtain the mandelic acid ionic liquid, which increases the water solubility and percutaneous permeability of the two monomers. The mandelic acid ionic liquid simultaneously improves the low solubility of matrine and the permeability of mandelic acid. While increasing the available range of the two substances, the mandelic acid ionic liquid simultaneously has the advantages of both matrine and mandelic acid; moreover, the mandelic acid ionic liquid has good permeability, cell and biocompatibility, good solubility and no irritation, and has the characteristics of oil control, soothing, high bioavailability and stable properties when applied to cosmetics.

The invention discloses a matrine slow-release agent as well as a preparation method and application thereof, and belongs to the technical field of pesticides. The preparation method comprises the following steps: firstly, dissolving matrine in an acidic aqueous solution, then sequentially adding carboxyl cellulose and fatty amine into the solution, stirring and emulsifying to obtain a dispersion liquid, and finally, adding the dispersion liquid into vegetable oil, and carrying out secondary emulsification to obtain the W / O / W Pickering emulsion. The sophocarpidine is combined and self-assembled through non-covalent bonds to form the drug-loaded gel, a wrapping structure is formed, the stability of the drug-loaded gel is effectively improved, and meanwhile the slow release performance of drug molecules is achieved through the non-covalent bond combination form; and vegetable oil is used for encapsulation, so that the stability of matrine molecules is further ensured, the matrine has better affinity with the plant surface, and the wettability is improved.

The invention belongs to the technical field of cell culture, discloses a multiplication culture method of peripheral blood gamma delta T cells, and particularly discloses application of matrine in multiplication culture of gamma delta T cells. Matrine is alkaloid which is extracted from traditional Chinese medicines and has various pharmacological activities, and has wide anti-tumor and anti-inflammatory activities. Matrine with a proper concentration is added into the gamma delta T cell culture medium, so that the amplification quantity of gamma delta T cells can be effectively increased, and the cell culture cost is reduced; meanwhile, the matrine component in the culture medium can effectively improve the killing activity of the gamma delta T cells on tumor cells, and the clinical immunotherapy effect is further improved.

The invention relates to the technical field of drug carriers, in particular to a mesoporous nanomaterial coupled with a CCR2 antibody and a preparation method and application of the mesoporous nanomaterial. According to the invention, the aminated mesoporous material is used for loading the drug and is coupled with the CCR2 antibody, so that the obtained CCR2 antibody coupled mesoporous nano material can target CCR2 + macrophages, the bioavailability of drugs such as matrine is improved, and the side effect is reduced. According to the invention, leading-edge technical elements such as a mesoporous nano-carrier, CCR2 antibody targeted modification and macrophage precise delivery are introduced, so that a carrier-drug-antibody ternary innovative combination system is formed.

The invention relates to the technical field of medicinal chemistry, and particularly discloses application of echinacoside in preparation of a medicine for improving autism social and cognitive impairment, and the application comprises the following steps: constructing a recombinant saccharomyces cerevisiae strain, and knocking out a precursor competition pathway gene; performing metabolic flow reprogramming fermentation on the recombinant strain; centrifuging the fermentation liquor at 7000-9000 r / min and pretreating the fermentation liquor with an 8-12 kDa ultrafiltration membrane; carrying out dual-targeting affinity chromatography purification on the pretreatment liquid; the preparation method comprises the following steps: preparing echinacoside into a liposome containing pH sensitive poly-histidine; and adding a freeze-drying protective agent into the suspension to carry out gradient pre-freezing and vacuum freeze-drying. According to the application, a mode of combining recombinant saccharomyces cerevisiae strain construction and metabolic flow reprogramming fermentation is adopted, targeted enrichment of echinacoside is realized through affinity chromatography coupled with autism brain region specific double ligands, then the echinacoside is prepared into the liposome containing pH sensitive poly-histidine, the double ligands are modified, and the effects of precise targeting and efficient effect are achieved.

The application discloses a kind of antifungal matrine derivatives and preparation method and application, with sophocarpine and thiourea reaction;The lone pair of electrons on the nitrogen atom of thiourea attacks C13 in matrine, and a series of antifungal matrine derivatives are synthesized by nucleophilic addition of thiourea matrine intermediate, with thiourea matrine and alpha-brominated R group ketone as reactant to synthesize a series of antifungal matrine derivatives with ethanol as solvent.The application not only enhances the bacteriostatic activity of matrine derivatives, but also has simple preparation method and easy control of reaction conditions.

The application provides an imidazo[1,2-a]pyrimidine matrine / sophoridine derivative, which has the chemical structural formula as shown in the description. 1 R is alpha-hydrogen or beta-hydrogen; and R 2 is selected from phenyl, substituted phenyl and naphthyl. Compared with the parent matrine and sophoridine, the acaricidal activity of the imidazo[1,2-a]pyrimidine matrine / sophoridine derivative is significantly improved, and the imidazo[1,2-a]pyrimidine matrine / sophoridine derivative can be used for preparing a plant source acaricide which is high in efficiency, environmental protection and low in toxicity.

The invention relates to the technical fields of medicines, daily chemicals and the like, in particular to a baicalin-based ternary eutectic solvent as well as a preparation method and application thereof. The baicalin is used as a bridge between the matrine and the grape seed oil, and the matrine and the grape seed oil are combined to form a uniform and stable ternary eutectic solvent through weak interaction force such as hydrogen bonds. The problem of solubility of the baicalin is remarkably solved, and the solubility of the baicalin in water and grease is greatly improved. In order to improve the bioavailability of baicalin, baicalin with an efficient anti-inflammatory effect and grape seed oil with a strong anti-oxidation effect are co-dissolved. On the basis of retaining the original anti-inflammatory effect and the like of the baicalin, free radicals can be more effectively cleared, and the ultra-strong antioxidant capacity is exerted, so that a foundation is laid for application of the baicalin in the technical fields of medicines, daily chemicals and the like.

This invention discloses a biocontrol agent for controlling sesame wilt, belonging to the field of pesticide technology. The raw materials of this biocontrol agent for controlling sesame wilt, by weight, include: 8-15 parts of a pyrimidine nucleoside antibiotic, 0.5-5 parts of matrine, 0.5-2 parts of an antioxidant, 1-5 parts of a dispersant, 1-3 parts of an adhesive, and 2000 parts of water. This invention utilizes a mixture of the pyrimidine nucleoside antibiotic and matrine to achieve a synergistic effect. The mixed product system allows matrine to enter the plant more easily, further improving its rapid action and systemic absorption. Furthermore, by simultaneously utilizing the different bactericidal mechanisms of the pyrimidine nucleoside antibiotic and matrine, the problem of the slow onset of action of the pyrimidine nucleoside antibiotic is addressed, thus enabling faster and more effective control of sesame wilt.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to application of matrine combined with medroxyprogesterone acetate in preparation of antitumor drugs. According to the invention, matrine and medroxyprogesterone are combined for use, and the matrine and medroxyprogesterone are used for developing products such as drugs, preparations, kits and the like for treating endometrial cancer. Experimental results prove that after sophocarpidine and medroxyprogesterone acetate are combined for medication, the composition shows relatively strong activity of inhibiting endometrial cancer and relatively good synergistic inhibition effect, so that the composition has relatively good practical application value. Experimental results prove that the dosages of the two can be remarkably reduced after drug combination, and the anti-tumor effect is remarkably improved. Animal experiments show that in-vivo anti-tumor effects of sophocarpidine and medroxyprogesterone acetate can be improved by combined medication compared with that of single medication. In conclusion, the combined medication of the matrine and the medroxyprogesterone can become a new method for treating endometrial cancer patients.

The invention belongs to the technical field of medicines and the field of acne treatment, and particularly relates to application of amorphous salt in preparation of a medicine for treating acne and the medicine. The amorphous salt is prepared by reacting ursodesoxycholic acid and matrine, preferably, the ursodesoxycholic acid and the matrine are dissolved in a proper solvent according to the molar ratio of 1: (0.5-2), then the solvent is rapidly removed, and remaining solids are further dried and crushed to obtain the ursodesoxycholic acid / matrine amorphous salt. The solubility and the percutaneous penetration rate of the propionibacterium acnes are remarkably improved, the propionibacterium acnes can be inhibited, the expression of IL-1beta, IL-6, IL-8 and TNF-alpha can be reduced, P65 protein nucleus translocation can be inhibited, and an efficient and safe new scheme is provided for acne treatment.

The invention provides a multi-effect balanced private care hydrogel film as well as a preparation method and application thereof, and belongs to the technical field of medical biological materials. By integrating traditional Chinese medicine antibacterial components, inactivated probiotics and a hydrogel slow release technology, the hydrogel film with a three-layer structure, which has the functions of inhibiting bacteria, repairing mucous membranes and maintaining pH balance, is developed, and matrine inhibits staphylococcus aureus (the diameter of an inhibition zone is greater than or equal to 15mm); inactivated bacteria competitively inhibit the adhesion of pathogenic bacteria (the in-vitro adhesion inhibition rate is greater than or equal to 70%); zinc hyaluronate promotes mucous membrane repair (the cell migration rate is increased by 40%), and through the multi-target-point synergistic effect, good nursing and postoperative repair effects are achieved.

The application discloses an anti-tumor matrine hydrazine thiazole derivative and a preparation method and application thereof, NaH is added into a reaction container one, then a DMF solution is added, and then aminothiourea is added into the reaction container one to stir the solution; sophoridine is added into the stirred solution to perform a reflux reaction, after the reaction is completed, a quenching reaction is performed, and then extraction, concentration drying and column chromatography separation are performed to obtain an aminothiourea matrine intermediate; the obtained aminothiourea matrine intermediate is added into a reaction container two, and an ethanol dissolving solvent is added to dissolve; the dissolved solution is added with alpha-bromo R base ethanone to perform a reaction, after the reaction is completed, concentration drying and column chromatography separation are performed to obtain the anti-tumor matrine hydrazine thiazole derivative. The anti-tumor matrine hydrazine thiazole derivative has strong anti-tumor activity, and the preparation method is simple and the reaction condition is easy to control.

The invention relates to a double-drug liposome co-carrying oxymatrine and an STING agonist prodrug as well as a preparation method and application of the double-drug liposome. The double-drug liposome comprises a drug carrier and oxymatrine, wherein the drug carrier consists of a membrane material; the oxymatrine is loaded in a hydrophilic inner cavity of the carrier; the membrane material is prepared from distearoyl phosphatidylcholine, distearoyl phosphatidyl ethanolamine-polyethylene glycol and a cholesterol-STING agonist prodrug conjugate; the cholesterol-STING agonist prodrug conjugate is a conjugate formed by coupling an STING agonist prodrug with cholesterol through a chemical bond. According to the invention, the traditional Chinese medicine active component oxymatrine and the STING agonist prodrug are creatively integrated into the same liposome, so that synergistic controlled release and mechanism complementation can be realized; wherein the STING prodrug is embedded into the carrier in a chemical bond coupling manner, so that drug leakage caused by physical entrapment is avoided, the acute toxicity of the free STING agonist is remarkably reduced, and meanwhile, the innate immune activation capability of the free STING agonist is enhanced.

The invention provides an antibacterial dressing composition and a medical gynecological protection pad, and belongs to the technical field of medical dressings. The composition is prepared from 70 to 90 parts of water, 8 to 10 parts of polyethylene glycol, 4 to 6 parts of glycerol, 0.3 to 0.7 part of carbomer, 0.06 to 0.15 part of L-cysteine, 4 to 8 parts of chitosan quaternary ammonium salt, 0.3 to 0.8 part of panthenol, 0.4 to 0.7 part of tocopheryl acetate, 0.2 to 0.4 part of sodium hyaluronate, 0.1 to 0.3 part of chlorhexidine digluconate, 3 to 4 parts of polyvinylpyrrolidone, 1 to 5 parts of sodium alginate, 0.1 to 0.3 part of polysorbate, 0.6 to 0.9 part of luteoloside, 0.1 to 0.2 part of quercetin and 0.05 to 0.2 part of sophocarpidine. Chitosan quaternary ammonium salt and chlorhexidine digluconate are used as bactericidal components, quercetin and sophocarpidine are added to serve as bacteriostatic agents, and the bactericidal components, active components such as panthenol, tocopheryl acetate and galuteolin and a film-forming agent form a dispersion system. The antibacterial facial mask has remarkable antibacterial property, and has the effects of resisting inflammation, preserving moisture, promoting tissue repair and the like. The gynecological protection pad acts on the surface of vulva inflammation, and the exact treatment effect can be achieved.

The invention discloses an anti-aging mask composition containing a supramolecular rhizoma polygonati extract and a preparation method of the anti-aging mask composition, and belongs to the technical field of cosmetics. The mask composition is prepared from the following components in parts by mass: 0.5 to 5.0 parts of rhizoma polygonati extract, 0.5 to 5.0 parts of sophocarpidine oxoglutaric acid supramolecular NaDES, 0.1 to 1.0 part of acetyl hexapeptide-8, 0.05 to 0.1 part of conopeptide, 8 to 16 parts of a moisturizing agent, 0.01 to 0.5 part of a preservative, 2 to 5 parts of a thickening agent and 40 to 90 parts of water. The supramolecular NaDES is prepared by reacting sophocarpidine and oxoglutaric acid in a molar ratio of 1: (0.2-5) at 50-80 DEG C for 3-12 hours, and the stability and transdermal absorption efficiency of active ingredients are remarkably improved. The preparation method comprises the steps of step-by-step mixing, homogenizing and aging, so that the synergistic interaction of the components is ensured. Experiments show that after the mask is used for 6 weeks, the wrinkle reduction rate reaches 61.68%-67.37%, and compared with a control group, the wrinkle reduction rate is remarkably improved. Through the synergistic effect of the supramolecular carrier and the polypeptide component, the technical problems that a traditional anti-aging mask is poor in transdermal absorption and active components are easy to degrade are solved, and the anti-aging mask has a good market application prospect.

The invention relates to the technical field of thrip prevention and control compositions, and particularly discloses a lotus root thrip prevention and control pharmaceutical composition and application, the technical key point is that the composition is composed of the following components by weight: 5%-20% of an active component, 5%-10% of an attractant, 1%-5% of a synergist, and the balance being an auxiliary agent; the active component is prepared from acetamiprid, guadipyr and epoxy thiacloprid; the attractant is prepared from methyl anthranilate, geraniol, lotus root essence and alcohol; the synergist is prepared from matrine and sesamin; the auxiliaries are a dispersing agent, an emulsifying agent and water. According to the composition disclosed by the invention, acetamiprid, guadipyr, cycolxylidin, sophocarpidine and sesamin are compounded for the first time, synergistic interaction is realized through dual mechanisms of inhibiting nerve conduction of thrips and damaging feeding behaviors of the thrips, and the sesamin which is a natural component is adopted for synergistic interaction, so that the risk of drug resistance is reduced, the cost of the composition is relatively low, and the synergistic effect is realized. And the thrip control effect is improved.

The invention relates to the technical field of natural active ingredient extraction, and particularly discloses a method for extracting flavonoid compounds from sophora alopecuroide matrine production waste liquid, and the method comprises the following steps: sequentially adding a reducing agent and a chelating agent into alkaline water waste liquid, uniformly stirring, standing, and filtering to obtain pretreated filtrate; dropwise adding organic acid into the pretreated filtrate to adjust the pH to obtain a suspension; standing and curing the suspension, centrifugally collecting precipitate, washing, and freeze-drying to obtain flavone powder. According to the method, the reducing agent and the chelating agent are combined for use, the precipitation efficiency and purity of the flavonoid compounds are remarkably improved and the impurity content is reduced through the dual effects of chemical reduction and physical adsorption, the yield of the flavonoid compounds is improved through the synergistic reaction of the reducing agent and the chelating agent, and the dosage of chemicals and the complexity of waste liquid treatment in the production process are effectively reduced; and energy conservation, environmental protection and economic benefits are improved.

The invention discloses a bemisia tabaci control agent and a preparation method thereof, and belongs to the technical field of bemisia tabaci control, the effective components of the control agent are matrine and dinotefuran, and the matrine and dinotefuran are compounded to solve the problem that drug resistance is easily generated when single dinotefuran is applied; the auxiliary material components in the control agent comprise gelatin, humic acid and the like, the gelatin is adopted as an embedding material to embed the effective components to prepare the slow-release control agent with immediate and constant-speed drug release, the drug loss and decomposition are inhibited, the stability of the effective components is improved, the action time of the control agent is prolonged, the effect of the control agent is improved, and the control effect of the control agent is improved. The efficient control on the bemisia tabaci is realized, and a good application prospect is realized.

The application relates to the technical field of biological control, and specifically discloses application of Streptomyces rochei YHLC-1 in prevention and treatment of pepper blight. The Streptomyces rochei YHLC-1 is preserved in the China General Microbiological Culture Collection Center, has a preservation number of CGMCC No. 35491, and is preserved on August 1, 2025; the application also provides a composite biological agent which comprises the following components in the following amounts: 1-5% of Streptomyces rochei YHLC-1 spore powder, 0.1-1% of matrine, 2-8% of a surfactant, 1-5% of a stabilizer, 2-6% of an antifreezing agent, 0.5%-3% of a synergist, 10-20% of a filler, and the rest of solvent. The composite biological agent can prevent and treat pepper blight and has a remarkable promoting effect on the growth of peppers.

The invention provides a hair-growing traditional Chinese medicine preparation and a preparation method thereof. The hair-growing traditional Chinese medicine preparation is prepared from the following components in parts by weight: 400 to 500 parts of fermented radix polygoni multiflori, 100 to 200 parts of radix rehmanniae preparata, 100 to 200 parts of radix angelicae sinensis, 20 to 30 parts of fructus chaenomelis lagenariae, 20 to 30 parts of flos carthami, 1 to 5 parts of rhizoma zingiberis recens, 0.03 to 0.05 part of L-selenium-methyl selenocysteine, 50 to 100 parts of inulin and 60 to 90 parts of matrine-chitosan conjugate. Uniformly mixing the fermented polygonum multiflorum, prepared rehmannia root, angelica sinensis, pawpaw, safflower carthamus, ginger, L-selenium-methyl selenocysteine, inulin and matrine-chitosan conjugate to obtain the hair-growing traditional Chinese medicine preparation which has the effects of preventing hair loss and growing hair.

The invention relates to the technical field of traditional Chinese medicine active component extraction and raw material medicine purification, in particular to a staged extraction and purification method of traditional Chinese medicine active component raw material medicine. Wherein the raw material medicine of the active component of the traditional Chinese medicinal materials is a matrine raw material medicine, and the preparation method comprises the following steps: S1, carrying out contact extraction on the matrine-containing traditional Chinese medicinal materials and an acidic ethanol aqueous solution to obtain a total alkaloid extracting solution; s2, obtaining a first-time segmented extraction solution; s3, obtaining a desalted enrichment solution; s4, obtaining a matrine fumarate crystal; s5, obtaining a matrine organic phase; and S6, obtaining the matrine bulk drug. By constructing a series purification technical scheme of ethanol-phosphate aqueous two-phase segmented enrichment, nanofiltration dialysis replacement desalination, fumaric acid selective salification crystallization, free alkali release extraction and displacement anti-solvent crystallization, segmented selective enrichment and purification of matrine in the total alkaloid extracting solution are realized.

The present application relates to nematode disease prevention and treatment agent technical field, especially to a kind of pine wood nematode disease prevention and treatment agent and preparation method thereof, by weight parts, including the following components: sophocarpidine 10-30 parts;Azadirachtin 5-20 parts;Turpentine 40-70 parts;Emulsifier 5-15 parts;Efficiency agent 1-5 parts;Stabilizer 0.5-3 parts, the synergistic effect of sophocarpidine and azadirachtin constitutes the core of the present application;Quinolone ring and pyridine ring structure in sophocarpidine molecule endow it with strong insecticidal activity, mainly by inhibiting acetylcholinesterase to interfere with the nerve conduction of nematode;And the complex triterpenoid structure of azadirachtin can interfere with the hormone system of nematode, inhibit its growth and development and reproduction.The two different mechanisms of action form complementation at molecular level, both can quickly kill nematode, and can long-term inhibit its population growth;Second, turpentine as natural terpene compound, the permeability of other active ingredients is enhanced.