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589 results about "Matrine" patented technology

Matrine is an alkaloid found in plants from the genus Sophora. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism. Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait.

Matrine composition

The invention relates to a disinsection composition containing a matrine and a neonicotinoid insecticide, and application thereof. The composition mainly uses the matrine and the neonicotinoid insecticide and is prepared by an auxiliary agent and an excipient to form microemulsion, emulsion in water, suspending agent, water dispersible granule, wetting powder and missible oil, wherein the mass percentage of the matrine and the neonicotinoid insecticide is 30:1-1:100. The disinsection composition has higher synergy effect, prevents pests from becoming resistant to drugs, prolongs the service life of pesticides and reduces pesticide residue. The composition can be used for preventing and treating homoptera, lepidoptera, thysanoptera, coleopteran and diptera on crops, particular for rice planthopper, trialeurodes vaporariorum, aphid, tryporyza incertulas, chilo suppressalis, thrips, paddy weevil and gall midge.
Owner:SHENZHEN NOPOSION AGROCHEM

Prepn of matrine, oxymatrine and sophoxidine from flavescent sophora root

The production process features that dried and crushed flavescent sophora root is processed through extraction, concentration, alkalization, reduction, solvent extraction, acid reverse extraction, deposition and separation to produce coarse matrine product and coarse sophoridine product; coarse matrine product and coarse sophoridine product are recrystallized and dried to obtain matrine product and sophoridine product; and matrine is further processed through oxidation with hydrogen peroxide, decompression distillation, crystallization, filtering, re-crystallization and drying to obtain oxymatrine product. The said three products are material for producing medicine for treating hepatitis B, hepatitis C, leucopenia, arrhythmia, cancer and other diseases.The production process of the present invention is simple, low in cost, high in product purity and suitable for industrial production.
Owner:王答祺 +2

Camptothecin, self-emulsifying medicine precursor of derivative thereof and application thereof

The invention discloses camptothecin and a self-emulsifying medicine precursor of a derivative thereof. The self-emulsifying medicine precursor is prepared by the covalent union of medicine molecules and hydrophilic radicals, wherein the medicine molecules are camptothecin molecules or camptothecin derivative molecules, and the medicine carrying quantity of the precursor is as high as more than 50%. The invention also discloses application of the self-emulsifying medicine precursor. The self-emulsifying medicine precursor can form micelles or vesicles with nano size in water, can be used as a medicine carrier used for loading one or a plurality of other anticancer medicines, such as CPT derivatives, yew alcohol, turmeric essence, methotrexate, irinotecan, danshinolic acid, matrine, doxorubicine and the like, can form a nano medicine carrying a plurality of medicines and can realize the synergic treatment of the medicines.
Owner:ZHEJIANG UNIV

Action of ferulic acid on enhancing drug effect of some medicaments and purpose thereof

The invention relates to an action of ferulic acid on enhancing the drug effect of some medicaments and a purpose thereof, wherein the medicaments mainly comprise alkaloid medicaments including matrine, kushenin, sophocarpine, hyoscyamine, narceine, hanfangchin A, jamaicin, morphine, codeine, evodiamine, strychnine, catharanthine, vincristine, taxol, verticine, peimine, peiminine, ephedrine, pseudoephedrine, wilfordine, triptolide, tripdiolide and the like, and flavonoid medicaments including puerarin, ginsenoside, ginsengenin, mangiferin, scutelloside, alkannin, meletin, rutin, hesperidin, daidzin, soybean isoflavone, daidzein, carthamin, catechin and the like. The ferulic acid and the medicaments can form a compound or a medicament compound, or the ferulic acid and the medicaments can generate a chemical reaction (including salification, esterification, amidation, ketonization, etherification and the like), and / or the ferulic acid and the medicaments can generate a synergistic effect and an additive effect.
Owner:QINGDAO QIYUAN BIO TECH CO LTD

Aqueous berberine-matrine fungicidal and insecticidal solution

InactiveCN1401235AGood killing effectBroad-spectrum insecticidal actionBiocideAnimal repellantsBerberineChemical composition
An agricultural chemical composition for controlling pests including armyworm and bacteria contains berberine (0.5-2.5%) and matrine (0.1-2.0%). Its advantages are high effect, no environmental pollution, and low toxicity to people and livestock.
Owner:北京阳光露雨生物科技有限公司

Composition of natural herb extract for treating cardiovascular disease and its method of preparation thereof

A composition of natural herb extract for treating cardiovascular disease or vascular disorder and its method of preparation and separation, and particularly to a composition prepared from natural herb extract comprising constituents of Danshensu, Tanshinone IIA, matrine, oxymatrine and puerarin for lowering the risk factors of heart disease or treating the heart disease that side effects are minimized. The working ranges of Danshensu, Tanshinone IIA, matrine, oxymatrine and puerarin are between 5 and 40 mg / kg per day and a ratio of Danshensu, Tanshinone IIA, matrine, oxymatrine, and puerarin is 1:1:1:1:1. The extraction and separation method of the five active ingredients are also illustrated. The composition can be exhibit in different forms for administration.
Owner:YOUNG JEFFREY

Matrine vaginal gel

A matrine vagina gel is prepared from matrine (5-50 wt. portions) Kapomu (5-50), glycerine (25-500) and distilled water (400-4500). Its advantages are high curative effect, long stay time, no damage to vagina and no pollution to clothes.
Owner:盛俊泰 +1

Method for quickly on-line detection of traditional Chinese medicine Kuhuang injection effective ingredient using near infra red spectrum

The invention discloses a method for measuring effective component content in kuhuang injection on line by near-infrared spectroscopy quickly. Effective components in kuhuang injection mainly comprise aloe-emodin, rhein, emodin, chrysophanol, physcion, sophocarpine and matrine so on. Near-infrared absorption spectroscopy collecting kuhuang injection make data of effective component content relate with near-infrared spectroscopy by HPLC method. Calibration model is built by partial least-squares regression method. Quick on-line measurement for effective component in injection can be accomplished. Studying result shows that near-infrared spectroscopy analyzing method can measure effective component in kuhuang injection effectively. The method is provided with simple pretreatment for sample, quick measurement and measuring multiple components at the same time. It can be used in on-line analysis and on-line quality control in tcm manufacture process.
Owner:常熟雷允上制药有限公司

Mode creature method for medicament toxicity research

A method for studying toxicity of drugs by using model organism zebra fish comprises the following steps of: selecting 100 to 200 adult zebra fishes, respectively disposing in bottles containing a solution of 30 to 50 mL, keeping the temperature in the bottles substantially constant at 22 to 25 DEG C, randomly grouping, each group containing 10 to 20 fishes, wherein the solution in one of the groups is pure water (blank), the solutions in other groups are medicinal solutions with different concentrations, and 0.5% to 2% dimethylsulfoxide (DMSO) can be added to assist dissolving a drug that has poor water solubility, when an additional solvent comparison group prepared by adding 0.5% to 2% DMSO into the pure water is needed; recording the death number of zebra fishes in the medicinal solutions of different concentrations within 24 h, and calculating the death rate (%); calculating median lethal dose-LD50 by Bliss method according to the experiment result; and representing the acute toxicity by the value of LD50. According to the method, the LD50s of zebra fish of triptolide, matrine and emodin are respectively 5.39*10<-3>, 112.3 and 1.08*10<3> mug / mL. The method can objectively reflect the toxicity of drugs.
Owner:CHINA PHARM UNIV

Deinsectization microbicide of piperine

The invention discloses a piperine deinsectization bactericidal agent by taking the piperine as an effective component and is prepared by mixing piperine, natural pyrethrin, matrine, hodorine, nicotine, synergistic agent, preservative, emulsifier, surface active agent, stabilizer, pH regulator, defoamer and solvent. The invention belongs to a plant source deinsectization bactericidal agent with the advantages of unambiguous effective components and easily controlled product quality, which adopts a proper accessory ingredient such as the emulsifier and stabilizer, etc., to solve the key problems of degradation and unstable quality and has no toxicity and residue, environment-friendliness and broad-spectrum effective deinsectization bactericidal effect. The invention has remarkable killing and controlling effects on various pests and germs in wheat, rice, fruit trees, vegetables, flowers, storehouses, houses as well as forests, has remarkable controlling effects on sanitary insect pests and germs like mosquito, fries, black beetles, ants, bedbugs, moth flies and fleas, etc, which is used for controlling pests and various germs for grains like paddy, wheat, corn, broomcorn, etc., during a storage period with a remarkable effect.
Owner:杜道林 +1

High-effective mosquito repelling liquid medicine

The invention relates to high-effective mosquito repelling liquid medicine which is characterized by comprising the following components by weight percent: 2%-7% of N, N-Diethyl-m-toluamide, 0.2%-2% of glycyrrhiza extract (0.1%-90% of glycyrrhizinic acid or glycyrrhetinic acid or physiologically acceptable salt thereof), 0.2%-2% of flavescens extract (0%-90% of matrine or oxymatrine or physiologically acceptable salt thereof), 0%-50% of menthol or borneol and 0.01%-2% of plant essential oil. The high-effective mosquito repelling liquid medicine is the hormone-free preparation made of pure Chinese herbal medicine for external application and is prepared by uniquely combining the high-effective repellent with the components having the anti-inflammatory, the antibacterial and the antipruritic effect, thereby being innovative. The high-effective mosquito repelling liquid medicine of the invention has the function of repelling the mosquito, relieving the itching, refreshing the consciousness and protecting the skin from the insect bite and can repel the mosquito for 5-7 hours. The high-effective mosquito repelling liquid medicine of the invention is non-toxic to the skin and mucous membrane, can not cause the allergic reaction and has higher stability.
Owner:TIANJIN HEERBO BIOLOGICAL TECH CO LTD

A plant pesticide including matrine and its preparing method as well as application

The invention relates to matrine containing vegetative insecticide, of which raw materials contain the following weight-portioned material medicines that: sophora flavescens is 9.0-10.0 parts, thunder god vine is 1.5-2.0 parts, black false hellebore is 3.2-3.5 parts, radix euphorbiae ebractealatae is 1.2-1.4 parts, conelike redpepper is 0.8-1.2 parts, tobacco leaf is 1.2-1.6 parts, chinaberry bark is 0.8-1.2 parts, and stemona is 0.8-1.2 parts. The vegetative insecticide of the invention is effective, low-toxic, and environment-friendly. The invention also relates to the preparation method and the application of the vegetative insecticide.
Owner:邯郸市建华植物农药厂

Matrine microcapsule suspension agent and preparation method thereof

The invention belongs to the technical field of biological pesticides, and more particularly relates to a matrine-containing pesticide and a preparation method thereof. The matrine-containing pesticide is characterized in that a suspension agent mainly comprises the following components in parts by weight: 1-25 parts of matrine, 5-20 parts of organic solvent, 1-25 parts of capsule wall material, 0.1-3 parts of colloid, 1-20 parts of emulsifier and the balance of de-ionized water to 100 parts. The matrine microcapsule suspension agent and the preparation method thereof aim to solve insufficient dosage form of biological pesticides in China, pollution to the environment and a poor control effect on insect pests. All active components in the scheme are naturally extracted from single-composition sophora flavescens plants, do not contain any chemical pesticides and are safe to natural enemies and the environment; and the novel matrine pesticide has the advantages of long duration of efficacy, anti-photolysis, improvement of utilization rate of pesticides and the like.
Owner:沈阳东大迪克化工药业有限公司

Matrine agent plant pesticide and preparation thereof

The invention discloses botanical bactericide of soluble matrine and a preparation method thereof, which aims at providing the botanical bactericide and a preparation method thereof which adopts Chinese herbal medicine as raw material and has high matrine content, low toxin and low cost but high efficiency and is harmless to human and livestock. The botanical bactericide comprises 17-25 portions of Chinese herbal medicine extract containing the matrine, 10-20 portions of emulsifier, 4-8 portions of penetrating agent, 0.1 portions of antioxidant and 48-56 portions of deionized water; the Chinese herbal medicine extract containing the matrine is extracted by mixing the following materials by weight portions: 30-35 portions of sophora flavescens ait, 20-35 portions of vietnamese sophora root, 10-15 portions of tea seed, 12-19 portions of common fibraurea stem, 7-10 portions of cubeb litsea, 6-9 portions of phellodendron, and 5-9 portions of magnolia officinalis. The bactericide comprises the matrine of super high content of about 2.6 percent and has special effect on killing pear scab, powerful penetrating performance that is in favor of absorption by plants, high efficiency, low toxin, no residue, no pollution and no drug resistance.
Owner:TIANJIN HENGYUAN BIOLOGICAL TECH DEV

Compound insecticidal main agent of destruxins and matrine and compound insecticide

The invention discloses a compound insecticidal main agent of destruxins and matrine and a compound insecticide. The compound insecticide comprises a main agent and an auxiliary agent, wherein the weight percentage content of the main agent is 1 to 30 percent and the weight percentage content of the auxiliary agent is 70 to 99 percent. The compound insecticidal main agent is a mixture prepared from the destruxins and the matrine in a weight ratio of 1:0.25-50. The destruxins is a pure substance or a mixture containing destruxins A, B, C, D and E, and the matrine is a pure substance or a mixture containing total matrines. The compound insecticide can be processed into emulsifiable solution, wettable powder, micro-emulsions, suspension emulsions or aqueous emulsions and the like. The compound insecticide is used for controlling vegetable foliar pests, in particular for controlling cotton aphids, and the effect is very remarkable.
Owner:SOUTH CHINA AGRI UNIV

Medicinal composition for treating skin itch, preparation method and application thereof

The invention provides a medicinal composition for treating skin itch, which is a preparation prepared from the raw material medicaments of cortex moutan radicis, densefruit pittany root-bark, lightyellow sophora root, liquorice root, borneol and menthol crystal. The invention also provides an external medicament which is prepared by taking paeonol extract used as active ingredients in the cortex moutan radicis, dictamnine extract used as active ingredients in the densefruit pittany root-bark, matrine extract used as active ingredients in the lightyellow sophora root, glycyrrhetinic acid extract used as active ingredients in the liquorice root, the borneol and the menthol crystal as active ingredients and adding pharmaceutically-acceptable auxiliary materials or auxiliary components. The invention also provides a preparation method of the medicinal composition. The medicament of the invention can treat the symptom of pruritus caused by accumulating evils of wind heat, moist heat and blood heat in the skin, comprising the pruritus caused by eczema. The medicinal composition of the invention has a refining formula of raw materials, definite material basis, definite curative effect and little toxic or side effect, and particularly has the unique curative effect on pruritus symptom of which the course of disease is lingering and repeated.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Matrine pure plant source pesticide

The invention relates to a matrine pure plant source pesticide which is characterized by comprising the following components in part by weight: 0.5-5 parts of banlangen, 5-25 parts of active emulsifier, 10-40 parts of organic solvent and 30-60 parts of purified water, wherein the part summation of four substances as basic components is 100. The matrine pure plant source pesticide is prepared from completely natural organic components without chemical pesticides, and has no harm to natural enemies and the environment.
Owner:沈阳东大迪克化工药业有限公司

Berberine insecticide and its preparation method

The invention discloses a berberine insecticide, which is characterized by comprising the following components by weight: 18 to 30 parts of berberine, 12 to 28 parts of matrine, 1 to 2 parts of polyacrylamide, 2 to 3 parts of methyl amyl alcohol and 70 to 80 parts of water; the formula is scientific and reasonable, the plant source insecticide is from nature, can be degraded in nature, generally may not pollute the environment and agricultural products, is relatively safe to people and livestock, small in harm to natural enemies of pests, and difficult for the pests to produce antibodies, and has the features of low toxicity and low residue.
Owner:李杰

Preparation method of matrine vagina effervescence tablet and use thereof

The invention discloses a preparation method of a vagina effervescent tablet containing matrine, and application thereof. The invention belongs to the new technical field of medicaments and relates to a new preparation formulation of the matrine, which is used for curing colpitis, chronic cervicitis and cervical erosion caused by various bacteria and preventing and treating cervical carcinoma; moreover, the new preparation formulation can also be used as the medicament preparations of senile vaginitis and pelvic inflammation and used in the preparation methods thereof. The new preparation formulation is characterized in that after the effervescent tablet is dissolved, the pH value of the liquid thereof is between 2.5 and 5.5 and the best PH value is between 3.8 and 4.2 which approach the physiological environments of human bodies.
Owner:BEIJING HOPE HUGE PHARM SCI

Plant-sourced medicinal fertilizer

The plant originated medicated fertilizer has pesticide components from plant or plant extract with pesticide function and nutritious components from industrial and agricultural wastes through harmless treatment. The plant originated medicated fertilizer consists of flavescent sophora root, matrine, castor, chicken excrement, brown coal, peanut shell, chestnut shell, bean cake, wheat bran, starch, etc. in certain proportion. It has the functions of increasing yield, killing pest, improving soil, etc. and is especially suitable for producing green agricultural products.
Owner:毕军

NO donor type matrine derivative and preparation method and medical application thereof

The invention relates to the field of medical chemistry and pharmacotherapeutics, and particularly relates to an NO donor type matrine derivative and a preparation method thereof and application in pharmacy. The compounds have an anti-tumor effect and can be used for preparing anti-tumor medicines. The invention also relates to a preparation method of the compounds.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Heat-sensitive gel containing matrine alkaloid and its preparing method

The present invention relates to a heat-sensitive gel preparation containing matrine alkaloid and its preparation method. Said preparation is composed of matrine alkaloid, hydroxypropyl methylcellulose, poloxamer 407, phosphate buffer solution whose pH value is 5.0-7.0, glycerin and preservative. It is flowable fluid at normal temperature, and when the temperature is 28-33 deg.C, it can produce phase change, and can be formed into gel, so that it can be conveniently applied to vagina, mucous membrane of external genitalia, skin and eye.
Owner:SHANGHAI HUATUO MEDICAL SCI CO LTD

Heterocyclic matrine derivatives and preparation methods and applications thereof

The invention discloses heterocyclic matrine derivatives and preparation methods and applications thereof. Structural formulas of the heterocyclic matrine derivatives are as shown in a formula (I). Two obtained matrine derivatives have an obvious inhibition effect on tumor cells or insect cells, the technical disadvantages in the field are filled, and the matrine derivatives can be applied to research and development of anti-tumor drugs or insecticides. Therefore, a candidate compound is provided for development of novel anti-tumor matrine derivatives or matrine derivatives with insecticidal activity, and the matrine derivatives are of great significance in overall development of the medical activity and the agricultural activity of matrine. The invention further provides preparation methods of the two derivatives. Indole or cyclohexane heterocyclic ring is introduced to the 13th key of a lead compound matrine, so that the biological activity of the matrine is significantly improved; and the preparation method is mild, simple and feasible. The formula is as shown in the specification.
Owner:ZHONGKAI UNIV OF AGRI & ENG

Matrine agent plant pesticide special for killing aphids and preparation thereof

The invention discloses vegetable insecticide of soluble matrine special for killing plant louses and a preparation method thereof, which aims at providing the vegetable insecticide which adopts Chinese herbal medicine as raw material, has high matrine content and low toxin but high efficiency, is harmless to human and livestock as well as special for killing plant louses and the preparation method thereof. The invention comprises 11-13 portions of Chinese herbal medicine extract containing the matrine, 10-20 portions of emulsifier, 4-8 portions of penetrating agent, 0.1 portions of antioxidant and 57-64 portions of deionized water; the Chinese herbal medicine extract containing the matrine is the extract of the mixture by weight of 15-25 portions of sophora flavescens ait, 10-17 portions of chinaberry tree, 3-4 portions of argy wormwood leaf, 6-8 portions of celastrus angulatus maxim, 4-8 portions of derris, 2-4 portions of gardenia, 7-9 portions of herba artemisiae, 10-14 portions of gelsemium elegans, 5-7 portions of orange seed and 7-10 portions of Chinese wingnut leaf. The insecticide of the invention comprises the matrine with super high content about 1.3 percent and is special for killing the plant louses through scientific preparation of a plurality of Chinese herbal medicines and has powerful penetrating performance, high efficiency and insignificant toxin and is in favor of absorption by plants.
Owner:TIANJIN HENGYUAN BIOLOGICAL TECH DEV

Skin care product with soothing and anti-acne efficacy

Aiming to provide an anti-acne skin care product characterized by good stability, small irritation and applicability to sensitive skin, the invention discloses a skin care product with soothing and anti-acne efficacy. The skin care product comprises an active component and a substrate, and the active component includes the following components by mass percentage: 0.5-2% of gellan gum, 0.3-2.5% of sodium shale oil sulfonate, 0.1-1% of glycerophosphoinositol choline, and 0.5-3% of acne removal agent, wherein the acne removal agent is composed of capryloyl glycine, capryloyl salicylic acid, tocopheryl phosphate, a Chinese trumpet creeper extract, matrine and pyridoxine in a mass ratio of 1:1.5:1:2:1:1. The skin care product belongs to the field of cosmetics.
Owner:GUANGDONG BAWEI BIOLOGICAL TECH CO LTD

Special seed dressing agent with effects of increasing survival rate and invigorating seedlings for sweet corn

ActiveCN105660701AStrong seedlingWell-developed root system at seedling stageBiocidePlant growth regulatorsBetaineInsect pest
The invention discloses a special seed dressing agent with effects of increasing the survival rate and invigorating seedlings for sweet corn. The seed dressing agent comprises gamma-aminobutyric acid, matrine, thiamethoxam, sedaxane, carboxin, amino-oligosaccharin, salicylic acid, glycine betaine, choline chloride, fulvic acid, starch grafted potassium acrylate, calcium chloride, a wetting dispersant, an emulsifier, gibberellin and microelement water soluble fertilizer mother liquor. Under normal conditions or adverse conditions of drought, low temperature and the like, the seed dressing agent has an obvious effect of improving the seed vigor and seedling quality of the sweet corn, can be used for effectively increasing the yield of the fresh spike of the sweet corn, also has effects of exterminating underground insects, protecting and invigorating seedlings and preventing and treating main plant diseases and insect pests of the corn, has control efficiency up to 70%-90% for plant diseases and insect pests in a seedling stage, has control efficiency up to 87%-96% for corn head smut, and not only can help farmers to save labor cost and seed cost greatly, but also can increase the yield by 15%-20%, thus having excellent social and economic benefits and application prospects.
Owner:深圳市一个玉米科技有限公司
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