75 results about "Matrine" patented technology

The present application relates to the application of traditional Chinese medicine active ingredient composition and its preparation in synergistic anti-tumor of PD-1 inhibitor. The traditional Chinese medicine active ingredient composition is a composition of oxymatrine and astragaloside B. The combination of the two can improve the anti-tumor effect of PD-1 inhibitor. In addition, it can also be used in the form of preparation to realize in vivo drug delivery in cooperation with its pharmaceutically acceptable carrier. The carrier can be selected from iron-based MOF and liposome, etc. to realize the co-loading of oxymatrine and astragaloside B with different polarity and efficient drug delivery. The iron-based MOF carrier has the advantages of high drug loading capacity and Fe ion which can cooperate with astragaloside B to improve the activity of tumor infiltrating T cells. The ferromagnetism and platelet membrane modification can also precisely target tumor tissue. The preparation technology of liposome is mature, which is conducive to industrialized production and has broad prospects for clinical transformation. The combination of the two with PD-1 inhibitor can significantly improve the anti-tumor effect of PD-1 inhibitor.

The invention discloses a matrine slow-release agent as well as a preparation method and application thereof, and belongs to the technical field of pesticides. The preparation method comprises the following steps: firstly, dissolving matrine in an acidic aqueous solution, then sequentially adding carboxyl cellulose and fatty amine into the solution, stirring and emulsifying to obtain a dispersion liquid, and finally, adding the dispersion liquid into vegetable oil, and carrying out secondary emulsification to obtain the W / O / W Pickering emulsion. The sophocarpidine is combined and self-assembled through non-covalent bonds to form the drug-loaded gel, a wrapping structure is formed, the stability of the drug-loaded gel is effectively improved, and meanwhile the slow release performance of drug molecules is achieved through the non-covalent bond combination form; and vegetable oil is used for encapsulation, so that the stability of matrine molecules is further ensured, the matrine has better affinity with the plant surface, and the wettability is improved.

The invention relates to the technical field of drug carriers, in particular to a mesoporous nanomaterial coupled with a CCR2 antibody and a preparation method and application of the mesoporous nanomaterial. According to the invention, the aminated mesoporous material is used for loading the drug and is coupled with the CCR2 antibody, so that the obtained CCR2 antibody coupled mesoporous nano material can target CCR2 + macrophages, the bioavailability of drugs such as matrine is improved, and the side effect is reduced. According to the invention, leading-edge technical elements such as a mesoporous nano-carrier, CCR2 antibody targeted modification and macrophage precise delivery are introduced, so that a carrier-drug-antibody ternary innovative combination system is formed.

The invention relates to the technical field of medicinal chemistry, and particularly discloses application of echinacoside in preparation of a medicine for improving autism social and cognitive impairment, and the application comprises the following steps: constructing a recombinant saccharomyces cerevisiae strain, and knocking out a precursor competition pathway gene; performing metabolic flow reprogramming fermentation on the recombinant strain; centrifuging the fermentation liquor at 7000-9000 r / min and pretreating the fermentation liquor with an 8-12 kDa ultrafiltration membrane; carrying out dual-targeting affinity chromatography purification on the pretreatment liquid; the preparation method comprises the following steps: preparing echinacoside into a liposome containing pH sensitive poly-histidine; and adding a freeze-drying protective agent into the suspension to carry out gradient pre-freezing and vacuum freeze-drying. According to the application, a mode of combining recombinant saccharomyces cerevisiae strain construction and metabolic flow reprogramming fermentation is adopted, targeted enrichment of echinacoside is realized through affinity chromatography coupled with autism brain region specific double ligands, then the echinacoside is prepared into the liposome containing pH sensitive poly-histidine, the double ligands are modified, and the effects of precise targeting and efficient effect are achieved.

The application discloses a kind of antifungal matrine derivatives and preparation method and application, with sophocarpine and thiourea reaction;The lone pair of electrons on the nitrogen atom of thiourea attacks C13 in matrine, and a series of antifungal matrine derivatives are synthesized by nucleophilic addition of thiourea matrine intermediate, with thiourea matrine and alpha-brominated R group ketone as reactant to synthesize a series of antifungal matrine derivatives with ethanol as solvent.The application not only enhances the bacteriostatic activity of matrine derivatives, but also has simple preparation method and easy control of reaction conditions.

The application provides an imidazo[1,2-a]pyrimidine matrine / sophoridine derivative, which has the chemical structural formula as shown in the description. 1 R is alpha-hydrogen or beta-hydrogen; and R 2 is selected from phenyl, substituted phenyl and naphthyl. Compared with the parent matrine and sophoridine, the acaricidal activity of the imidazo[1,2-a]pyrimidine matrine / sophoridine derivative is significantly improved, and the imidazo[1,2-a]pyrimidine matrine / sophoridine derivative can be used for preparing a plant source acaricide which is high in efficiency, environmental protection and low in toxicity.

The invention relates to the technical fields of medicines, daily chemicals and the like, in particular to a baicalin-based ternary eutectic solvent as well as a preparation method and application thereof. The baicalin is used as a bridge between the matrine and the grape seed oil, and the matrine and the grape seed oil are combined to form a uniform and stable ternary eutectic solvent through weak interaction force such as hydrogen bonds. The problem of solubility of the baicalin is remarkably solved, and the solubility of the baicalin in water and grease is greatly improved. In order to improve the bioavailability of baicalin, baicalin with an efficient anti-inflammatory effect and grape seed oil with a strong anti-oxidation effect are co-dissolved. On the basis of retaining the original anti-inflammatory effect and the like of the baicalin, free radicals can be more effectively cleared, and the ultra-strong antioxidant capacity is exerted, so that a foundation is laid for application of the baicalin in the technical fields of medicines, daily chemicals and the like.

This invention discloses a biocontrol agent for controlling sesame wilt, belonging to the field of pesticide technology. The raw materials of this biocontrol agent for controlling sesame wilt, by weight, include: 8-15 parts of a pyrimidine nucleoside antibiotic, 0.5-5 parts of matrine, 0.5-2 parts of an antioxidant, 1-5 parts of a dispersant, 1-3 parts of an adhesive, and 2000 parts of water. This invention utilizes a mixture of the pyrimidine nucleoside antibiotic and matrine to achieve a synergistic effect. The mixed product system allows matrine to enter the plant more easily, further improving its rapid action and systemic absorption. Furthermore, by simultaneously utilizing the different bactericidal mechanisms of the pyrimidine nucleoside antibiotic and matrine, the problem of the slow onset of action of the pyrimidine nucleoside antibiotic is addressed, thus enabling faster and more effective control of sesame wilt.

The invention belongs to the technical field of medicines and the field of acne treatment, and particularly relates to application of amorphous salt in preparation of a medicine for treating acne and the medicine. The amorphous salt is prepared by reacting ursodesoxycholic acid and matrine, preferably, the ursodesoxycholic acid and the matrine are dissolved in a proper solvent according to the molar ratio of 1: (0.5-2), then the solvent is rapidly removed, and remaining solids are further dried and crushed to obtain the ursodesoxycholic acid / matrine amorphous salt. The solubility and the percutaneous penetration rate of the propionibacterium acnes are remarkably improved, the propionibacterium acnes can be inhibited, the expression of IL-1beta, IL-6, IL-8 and TNF-alpha can be reduced, P65 protein nucleus translocation can be inhibited, and an efficient and safe new scheme is provided for acne treatment.

The application discloses an anti-tumor matrine hydrazine thiazole derivative and a preparation method and application thereof, NaH is added into a reaction container one, then a DMF solution is added, and then aminothiourea is added into the reaction container one to stir the solution; sophoridine is added into the stirred solution to perform a reflux reaction, after the reaction is completed, a quenching reaction is performed, and then extraction, concentration drying and column chromatography separation are performed to obtain an aminothiourea matrine intermediate; the obtained aminothiourea matrine intermediate is added into a reaction container two, and an ethanol dissolving solvent is added to dissolve; the dissolved solution is added with alpha-bromo R base ethanone to perform a reaction, after the reaction is completed, concentration drying and column chromatography separation are performed to obtain the anti-tumor matrine hydrazine thiazole derivative. The anti-tumor matrine hydrazine thiazole derivative has strong anti-tumor activity, and the preparation method is simple and the reaction condition is easy to control.

The invention relates to a double-drug liposome co-carrying oxymatrine and an STING agonist prodrug as well as a preparation method and application of the double-drug liposome. The double-drug liposome comprises a drug carrier and oxymatrine, wherein the drug carrier consists of a membrane material; the oxymatrine is loaded in a hydrophilic inner cavity of the carrier; the membrane material is prepared from distearoyl phosphatidylcholine, distearoyl phosphatidyl ethanolamine-polyethylene glycol and a cholesterol-STING agonist prodrug conjugate; the cholesterol-STING agonist prodrug conjugate is a conjugate formed by coupling an STING agonist prodrug with cholesterol through a chemical bond. According to the invention, the traditional Chinese medicine active component oxymatrine and the STING agonist prodrug are creatively integrated into the same liposome, so that synergistic controlled release and mechanism complementation can be realized; wherein the STING prodrug is embedded into the carrier in a chemical bond coupling manner, so that drug leakage caused by physical entrapment is avoided, the acute toxicity of the free STING agonist is remarkably reduced, and meanwhile, the innate immune activation capability of the free STING agonist is enhanced.

The invention provides an antibacterial dressing composition and a medical gynecological protection pad, and belongs to the technical field of medical dressings. The composition is prepared from 70 to 90 parts of water, 8 to 10 parts of polyethylene glycol, 4 to 6 parts of glycerol, 0.3 to 0.7 part of carbomer, 0.06 to 0.15 part of L-cysteine, 4 to 8 parts of chitosan quaternary ammonium salt, 0.3 to 0.8 part of panthenol, 0.4 to 0.7 part of tocopheryl acetate, 0.2 to 0.4 part of sodium hyaluronate, 0.1 to 0.3 part of chlorhexidine digluconate, 3 to 4 parts of polyvinylpyrrolidone, 1 to 5 parts of sodium alginate, 0.1 to 0.3 part of polysorbate, 0.6 to 0.9 part of luteoloside, 0.1 to 0.2 part of quercetin and 0.05 to 0.2 part of sophocarpidine. Chitosan quaternary ammonium salt and chlorhexidine digluconate are used as bactericidal components, quercetin and sophocarpidine are added to serve as bacteriostatic agents, and the bactericidal components, active components such as panthenol, tocopheryl acetate and galuteolin and a film-forming agent form a dispersion system. The antibacterial facial mask has remarkable antibacterial property, and has the effects of resisting inflammation, preserving moisture, promoting tissue repair and the like. The gynecological protection pad acts on the surface of vulva inflammation, and the exact treatment effect can be achieved.

The invention relates to the technical field of natural active ingredient extraction, and particularly discloses a method for extracting flavonoid compounds from sophora alopecuroide matrine production waste liquid, and the method comprises the following steps: sequentially adding a reducing agent and a chelating agent into alkaline water waste liquid, uniformly stirring, standing, and filtering to obtain pretreated filtrate; dropwise adding organic acid into the pretreated filtrate to adjust the pH to obtain a suspension; standing and curing the suspension, centrifugally collecting precipitate, washing, and freeze-drying to obtain flavone powder. According to the method, the reducing agent and the chelating agent are combined for use, the precipitation efficiency and purity of the flavonoid compounds are remarkably improved and the impurity content is reduced through the dual effects of chemical reduction and physical adsorption, the yield of the flavonoid compounds is improved through the synergistic reaction of the reducing agent and the chelating agent, and the dosage of chemicals and the complexity of waste liquid treatment in the production process are effectively reduced; and energy conservation, environmental protection and economic benefits are improved.

The invention discloses a bemisia tabaci control agent and a preparation method thereof, and belongs to the technical field of bemisia tabaci control, the effective components of the control agent are matrine and dinotefuran, and the matrine and dinotefuran are compounded to solve the problem that drug resistance is easily generated when single dinotefuran is applied; the auxiliary material components in the control agent comprise gelatin, humic acid and the like, the gelatin is adopted as an embedding material to embed the effective components to prepare the slow-release control agent with immediate and constant-speed drug release, the drug loss and decomposition are inhibited, the stability of the effective components is improved, the action time of the control agent is prolonged, the effect of the control agent is improved, and the control effect of the control agent is improved. The efficient control on the bemisia tabaci is realized, and a good application prospect is realized.

The application relates to the technical field of biological control, and specifically discloses application of Streptomyces rochei YHLC-1 in prevention and treatment of pepper blight. The Streptomyces rochei YHLC-1 is preserved in the China General Microbiological Culture Collection Center, has a preservation number of CGMCC No. 35491, and is preserved on August 1, 2025; the application also provides a composite biological agent which comprises the following components in the following amounts: 1-5% of Streptomyces rochei YHLC-1 spore powder, 0.1-1% of matrine, 2-8% of a surfactant, 1-5% of a stabilizer, 2-6% of an antifreezing agent, 0.5%-3% of a synergist, 10-20% of a filler, and the rest of solvent. The composite biological agent can prevent and treat pepper blight and has a remarkable promoting effect on the growth of peppers.

The invention provides a hair-growing traditional Chinese medicine preparation and a preparation method thereof. The hair-growing traditional Chinese medicine preparation is prepared from the following components in parts by weight: 400 to 500 parts of fermented radix polygoni multiflori, 100 to 200 parts of radix rehmanniae preparata, 100 to 200 parts of radix angelicae sinensis, 20 to 30 parts of fructus chaenomelis lagenariae, 20 to 30 parts of flos carthami, 1 to 5 parts of rhizoma zingiberis recens, 0.03 to 0.05 part of L-selenium-methyl selenocysteine, 50 to 100 parts of inulin and 60 to 90 parts of matrine-chitosan conjugate. Uniformly mixing the fermented polygonum multiflorum, prepared rehmannia root, angelica sinensis, pawpaw, safflower carthamus, ginger, L-selenium-methyl selenocysteine, inulin and matrine-chitosan conjugate to obtain the hair-growing traditional Chinese medicine preparation which has the effects of preventing hair loss and growing hair.

The invention relates to the technical field of traditional Chinese medicine active component extraction and raw material medicine purification, in particular to a staged extraction and purification method of traditional Chinese medicine active component raw material medicine. Wherein the raw material medicine of the active component of the traditional Chinese medicinal materials is a matrine raw material medicine, and the preparation method comprises the following steps: S1, carrying out contact extraction on the matrine-containing traditional Chinese medicinal materials and an acidic ethanol aqueous solution to obtain a total alkaloid extracting solution; s2, obtaining a first-time segmented extraction solution; s3, obtaining a desalted enrichment solution; s4, obtaining a matrine fumarate crystal; s5, obtaining a matrine organic phase; and S6, obtaining the matrine bulk drug. By constructing a series purification technical scheme of ethanol-phosphate aqueous two-phase segmented enrichment, nanofiltration dialysis replacement desalination, fumaric acid selective salification crystallization, free alkali release extraction and displacement anti-solvent crystallization, segmented selective enrichment and purification of matrine in the total alkaloid extracting solution are realized.

The present application relates to nematode disease prevention and treatment agent technical field, especially to a kind of pine wood nematode disease prevention and treatment agent and preparation method thereof, by weight parts, including the following components: sophocarpidine 10-30 parts;Azadirachtin 5-20 parts;Turpentine 40-70 parts;Emulsifier 5-15 parts;Efficiency agent 1-5 parts;Stabilizer 0.5-3 parts, the synergistic effect of sophocarpidine and azadirachtin constitutes the core of the present application;Quinolone ring and pyridine ring structure in sophocarpidine molecule endow it with strong insecticidal activity, mainly by inhibiting acetylcholinesterase to interfere with the nerve conduction of nematode;And the complex triterpenoid structure of azadirachtin can interfere with the hormone system of nematode, inhibit its growth and development and reproduction.The two different mechanisms of action form complementation at molecular level, both can quickly kill nematode, and can long-term inhibit its population growth;Second, turpentine as natural terpene compound, the permeability of other active ingredients is enhanced.

The invention provides a plant extraction gel for improving vaginal elasticity and a preparation method and application thereof, and belongs to the technical field of biological medicine. The plant extraction gel is prepared from fructus evodiae extract, Chinese herbaceous peony root extract, rhodomyrtus tomentosa fruit extract, dogwood extract, lime peel extract, cyrtomium rhizome extract, zedoary turmeric oil, melaleuca alternifolia oil, rosemary leaf oil, matrine and auxiliary materials. According to the invention, the fructus evodiae extract increases the thickness, the wettability and the elasticity of a vaginal wall by simulating an estrogen function; the Chinese herbaceous peony root extract has anti-inflammatory and anti-oxidation effects. The rhodomyrtus tomentosa fruit extract can tighten tissues in time, the dogwood extract can improve microcirculation and provide nutrition, and the lime peel extract can protect the elastic fibers from oxidative damage. All the components in the plant extraction gel supplement each other, and the comprehensive effect of recovering and maintaining vagina elasticity is achieved together. The plant extract gel disclosed by the invention has obvious effects in balancing vaginal flora and improving vaginal elasticity.

The invention discloses application of combination of sophocarpidine and gallic acid in preparation of an additive for relieving intestinal injury of piglets, and relates to the technical field of molecular biology. The invention provides an application of combination of sophocarpidine and gallic acid in preparation of an additive for relieving intestinal injury of piglets, the concentration of sophocarpidine in the additive for relieving intestinal injury of piglets is 1-3 [mu] g / mL, and the concentration of gallic acid in the additive for relieving intestinal injury of piglets is 0.3-0.5 [mu] g / mL. The injury is the injury caused by enterotoxigenic escherichia coli. The matrine and gallic acid are combined for use, so that the epithelial barrier function can be improved, the budding efficiency of group-like organs is improved, the gene abundance of the closed protein Occludin, the gene abundance of the goblet cell marker MUC2 and the gene abundance of the absorption cell marker Villin are recovered to the level of a control group, and the effect is better than that of single use; the problems that enterotoxigenic escherichia coli damages intestinal tracts of piglets and the effect of an existing single additive is poor are effectively solved.

The application discloses a kind of biological source pesticides for preventing and treating aigan's root rot, it includes one or more than two combinations of berberine, ningnanmycin, Sophora flavescens extract, zhongshengmycin, allicin, polyoxin, matrine, osthol, lentinan.The application takes aigan's root and rhizome infected with root rot as research object, obtains a strain of pathogenic bacteria from disease-healthy boundary by separation, purification and pathogenicity determination, and is identified as bean shell ball spores by morphological observation, rDNA-ITS sequence analysis Macrophomina phaseolina Comprehensive indoor and field screening results, the most effective pesticide screened includes 3% zhongshengmycin, 0.5% berberine, 3.5% Sophora flavescens extract and 8% ningnanmycin, and all does not show plant adverse effect and phytotoxicity to aigan growth.Especially, it can significantly reduce malondialdehyde level, while increasing the activity of superoxide dismutase, catalase and peroxidase, so as to improve the disease resistance of aigan.

This invention discloses the use of LAPTM5 in the preparation of drugs regulating renal tubular epithelial-mesenchymal transition (EMT). Through bioinformatics analysis and multi-level experimental verification, this invention found that LAPTM5 is significantly upregulated in an aging kidney model and is positively correlated with renal aging and the severity of fibrosis. Mechanistic studies show that LAPTM5 interacts with the deubiquitinating enzyme USP10 and promotes its lysosomal degradation, weakening the deubiquitination effect of USP10 on PTEN. This leads to proteasomal degradation of PTEN via the K48-linked polyubiquitination pathway, thereby relieving PTEN's inhibition of the PI3K / AKT / mTOR signaling pathway, inhibiting autophagy activity, promoting renal tubular epithelial-mesenchymal transition, and accelerating the process of renal fibrosis. At the cellular level, PTEN overexpression can rescue LAPTM5-induced EMT; in animal models, the PTEN agonist matrine significantly improves D-galactose-induced renal fibrosis in aging mice and protects renal function by restoring autophagy.

The application relates to a preparation method of co-assembled nanoparticles, and belongs to the field of nanomaterials. A new type of nanoparticle (MUR NPs) is developed by taking hydrophobic core ursolic acid and hydrophilic shell matrine as a delivery system, aiming at improving the water solubility and bioavailability of resveratrol. And the NSMs compound with good biological activity but unable to be used for drug delivery can be applied. Scanning electron microscopy (SEM), x-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectrophotometry are used to characterize the properties and structure of the molecular interaction in the MUR NPs. In addition, the MUR NPs have good physicochemical stability, have sustained gastrointestinal digestion release characteristics, and improve in-vitro antioxidant and bioavailability. The study may contribute to the development of RES oral delivery systems and the application of hydrophobic active molecules in the field of functional foods.

This application relates to the field of personal care products, disclosing a no-rinse herbal skin-care bath liquid and its preparation method. The bath liquid raw materials include a herbal-eutectic precursor matrix, an aqueous solution of sodium cocoyl apple amino acid, deionized water, and a pH adjuster. The matrix is ​​made of betaine, matrine, dipotassium glycyrrhizate, and dimethyl isosorbide. The preparation method includes mixing the components and then adjusting the pH under negative pressure. During this process, the pH value and viscosity of the system are monitored in real time. When the instantaneous viscosity increases by a set proportion, the dropping rate of the acid adjuster is reduced and a high-speed shearing is initiated simultaneously. This invention utilizes the hydrogen bonding between specific matrix components to inhibit the crystallization and precipitation of herbal ingredients after water evaporation, improving the stickiness of residues. Simultaneously, by combining rheological feedback and negative pressure shearing technology, it alleviates the foaming and stratification problems of amino acid surfactant systems during the acid reduction adjustment process.

The invention discloses a theophylline alkaloid salt, a pharmaceutical composition thereof, a preparation method of the theophylline alkaloid salt, and an application of the theophylline alkaloid salt, and belongs to the technical field of pharmaceutical chemistry. Natural alkaloids with definite pharmacological activity, such as stachydrine, betaine, trigonelline, sophocarpidine, choline or berberine, are selected as saline-forming bases, and a series of novel theophylline alkaloid salts are developed. The functional salt formation strategy not only fundamentally changes the traditional theophylline salt formation mode, but also realizes a leap-through breakthrough from single improvement of solubility to synergistic interaction and active attenuation. Through inherent gastric mucosa protection, heart function regulation and other effects of alkaloid, an active attenuation mechanism is constructed, the core toxic and side effects of gastrointestinal irritation, heart excitability and the like caused by theophylline are effectively reduced, the risk of introduction of exogenous sensitizers is avoided, and the bioavailability of theophylline is improved. The clinical problems of narrow therapeutic window and large toxic and side effects of traditional theophylline and salt drugs thereof are effectively solved.

The present application relates to the technical field of biological medicine, in particular to a kind of tricyclic sophoridine compound and its preparation method and application, pharmaceutical composition.The tricyclic sophoridine compound provided in the present application has good potential in preventing and / or treating diseases with lipid metabolic disorder syndrome such as fatty liver disease, diabetes, obesity, etc., and the tricyclic sophoridine compound has low toxicity and high safety.As shown in the test results of examples, the tricyclic sophoridine compound provided in the present application can significantly reduce the body weight of MASLD model mice induced by high-fat feed, improve liver function, glucose-lipid metabolic disorder, insulin resistance index and liver steatosis and other pathological abnormalities, and no toxic side effects are observed for 6 weeks of 100mg / kg dose gavage, and acute toxicity test also shows that it has very high safety.

The application provides application of thiofungchinol and matrine in preparation of preparations for preventing and / or treating radiation-induced lung injury, and belongs to the technical field of medicines.The application effectively overcomes the defects of limited curative effect and large toxic and side effects of the radiation-induced lung injury prevention and treatment drugs in the prior art, and the thiofungchinol and the matrine can play a synergistic effect when being used in combination, so that the prevention and treatment effect on the radiation-induced lung injury is significantly improved, the single drug dosage is reduced, the toxic and side effects are reduced, and a new scheme is provided for clinical intervention of RILI.

The application relates to a preparation method of water-soluble alkaloid and terpenoid co-assembly nanoparticles, and belongs to the field of nanometer materials. Through a co-assembly strategy, a pure natural co-assembly nanometer transmission system, i.e. water-soluble alkaloid and terpenoid co-assembly nanoparticles, with novel morphological characteristics and multiple biological activities is prepared, and a NSMs compound with good biological activity but unable to be used for drug transmission can be applied. The terpenoid compound is dissolved in an organic phase, and the matrine and sophoridine are dissolved in water. The organic phase solution is added into the water phase, stirring, centrifugation, and the water-soluble alkaloid and terpenoid co-assembly nanoparticles are obtained. The water-soluble alkaloid and terpenoid co-assembly nanoparticles are prepared by a simple and convenient method, the toxic side effects are reduced, and the drug loading capacity is improved. Therefore, a carrier-free, biocompatible, biodegradable and low-cost nanometer self-assembly is constructed in the application.

The invention belongs to the technical field of matrine preparation, and particularly relates to a method for converting sophocarpine in radix sophorae flavescentis percolate into matrine. Comprising the following steps: adding Na2SO3 into the radix sophorae flavescentis percolate, reacting at the temperature of 20-25 DEG C, namely near room temperature, and converting sophocarpine in the radix sophorae flavescentis percolate into sophocarpine; the mass volume ratio of the Na2SO3 to the radix sophorae flavescentis percolate solution is (0.022 g to 0.024 g): 1 mL. According to the method, efficient conversion of sophocarpine into sophocarpidine can be achieved by accurately controlling the adding amount of Na2SO3, the whole conversion process is mild, a catalyst and a high-temperature environment do not need to be added, and the efficiency of converting sophocarpidine into sophocarpidine is effectively improved.

The invention discloses cocklebur fruit and perilla frutescens compound rhinitis oil and a preparation process thereof, and relates to the technical field of traditional Chinese medicine compound preparations. The essential components comprise 10-20 parts by weight of fructus xanthii, 30-50 parts by weight of perilla oil, 5-10 parts by weight of sea buckthorn fruit oil, 2-5 parts by weight of a dendrobium officinale flower extract, 1-3 parts by weight of a licoflavone extract, 0.5-1 part by weight of a Chinese prickly ash seed extract, 0.3 part by weight of vitamin C and beta-cyclodextrin, and the mass ratio of the beta-cyclodextrin to the perilla oil is 3: 1; the optional components comprise 0.2 part of matrine extract, 0.3 part of sodium hyaluronate and 0.1 part of natural limonene, the optional components can be added independently or in a combined mode, the proportion of necessary and optional components is optimized, the targeted preparation technology of all the extracts is combined, and the segmented extraction, microencapsulation and low-temperature homogenization technologies are matched, so that multi-component synergistic interaction is achieved, and the skin care effect is achieved. The problems that an existing preparation is limited in effect and poor in stability are solved, and the adaptability and use performance of the rhinitis oil are improved.