586 results about "Matrine" patented technology

Compositions and methods for treating patients suffering from a proliferation disorder characterized by an increased voltage gated ion-channel uptake are described. Included are compositions comprised of a compound selected from the group consisting of matrine, oxymatrine, artemisinin, agmatine, and vinpocetine.

The invention relates to a disinsection composition containing a matrine and a neonicotinoid insecticide, and application thereof. The composition mainly uses the matrine and the neonicotinoid insecticide and is prepared by an auxiliary agent and an excipient to form microemulsion, emulsion in water, suspending agent, water dispersible granule, wetting powder and missible oil, wherein the mass percentage of the matrine and the neonicotinoid insecticide is 30:1-1:100. The disinsection composition has higher synergy effect, prevents pests from becoming resistant to drugs, prolongs the service life of pesticides and reduces pesticide residue. The composition can be used for preventing and treating homoptera, lepidoptera, thysanoptera, coleopteran and diptera on crops, particular for rice planthopper, trialeurodes vaporariorum, aphid, tryporyza incertulas, chilo suppressalis, thrips, paddy weevil and gall midge.

The production process features that dried and crushed flavescent sophora root is processed through extraction, concentration, alkalization, reduction, solvent extraction, acid reverse extraction, deposition and separation to produce coarse matrine product and coarse sophoridine product; coarse matrine product and coarse sophoridine product are recrystallized and dried to obtain matrine product and sophoridine product; and matrine is further processed through oxidation with hydrogen peroxide, decompression distillation, crystallization, filtering, re-crystallization and drying to obtain oxymatrine product. The said three products are material for producing medicine for treating hepatitis B, hepatitis C, leucopenia, arrhythmia, cancer and other diseases.The production process of the present invention is simple, low in cost, high in product purity and suitable for industrial production.

The invention discloses camptothecin and a self-emulsifying medicine precursor of a derivative thereof. The self-emulsifying medicine precursor is prepared by the covalent union of medicine molecules and hydrophilic radicals, wherein the medicine molecules are camptothecin molecules or camptothecin derivative molecules, and the medicine carrying quantity of the precursor is as high as more than 50%. The invention also discloses application of the self-emulsifying medicine precursor. The self-emulsifying medicine precursor can form micelles or vesicles with nano size in water, can be used as a medicine carrier used for loading one or a plurality of other anticancer medicines, such as CPT derivatives, yew alcohol, turmeric essence, methotrexate, irinotecan, danshinolic acid, matrine, doxorubicine and the like, can form a nano medicine carrying a plurality of medicines and can realize the synergic treatment of the medicines.

The invention relates to an action of ferulic acid on enhancing the drug effect of some medicaments and a purpose thereof, wherein the medicaments mainly comprise alkaloid medicaments including matrine, kushenin, sophocarpine, hyoscyamine, narceine, hanfangchin A, jamaicin, morphine, codeine, evodiamine, strychnine, catharanthine, vincristine, taxol, verticine, peimine, peiminine, ephedrine, pseudoephedrine, wilfordine, triptolide, tripdiolide and the like, and flavonoid medicaments including puerarin, ginsenoside, ginsengenin, mangiferin, scutelloside, alkannin, meletin, rutin, hesperidin, daidzin, soybean isoflavone, daidzein, carthamin, catechin and the like. The ferulic acid and the medicaments can form a compound or a medicament compound, or the ferulic acid and the medicaments can generate a chemical reaction (including salification, esterification, amidation, ketonization, etherification and the like), and/or the ferulic acid and the medicaments can generate a synergistic effect and an additive effect.

An agricultural chemical composition for controlling pests including armyworm and bacteria contains berberine (0.5-2.5%) and matrine (0.1-2.0%). Its advantages are high effect, no environmental pollution, and low toxicity to people and livestock.

The invention discloses a medicine for treating pruritus caused by dermatitis, eczema and insect bite, and applications thereof. The medicine is a preparation prepared by the following components according to weight percentage: 0.1 percent to 90 percent of glycyrrhizic acid or physically acceptable salt of glycyrrhizic acid or glycyrrhetic acid or physically acceptable salt of glycyrrhetic acid, 0 percent to 90 percent of total matrines or physically acceptable salt of total matrines or oxymatrine or physically acceptable salt of oxymatrine or matrine or physically acceptable salt of matrine, 0 percent to 90 percent of hibiscus syriacus acid or physically acceptable salt of hibiscus syriacus acid or pseudolaric acid B or physically acceptable salt of pseudolaric acid B or osthole or total coumarins of fructus cnidii, and 1 percent to 5 percent of menthol or borneol. The medicine has the effect of anti-inflammatory, bacteriostasis and relieving itching, has unique therapeutic effect on pruritus caused by dermatitis, eczema and insect bite. The raw materials used by the medicine are nontoxic and cheap with low cost.

A matrine vagina gel is prepared from matrine (5-50 wt. portions) Kapomu (5-50), glycerine (25-500) and distilled water (400-4500). Its advantages are high curative effect, long stay time, no damage to vagina and no pollution to clothes.

The invention discloses a method for measuring effective component content in kuhuang injection on line by near-infrared spectroscopy quickly. Effective components in kuhuang injection mainly comprise aloe-emodin, rhein, emodin, chrysophanol, physcion, sophocarpine and matrine so on. Near-infrared absorption spectroscopy collecting kuhuang injection make data of effective component content relate with near-infrared spectroscopy by HPLC method. Calibration model is built by partial least-squares regression method. Quick on-line measurement for effective component in injection can be accomplished. Studying result shows that near-infrared spectroscopy analyzing method can measure effective component in kuhuang injection effectively. The method is provided with simple pretreatment for sample, quick measurement and measuring multiple components at the same time. It can be used in on-line analysis and on-line quality control in tcm manufacture process.

The invention discloses a piperine deinsectization bactericidal agent by taking the piperine as an effective component and is prepared by mixing piperine, natural pyrethrin, matrine, hodorine, nicotine, synergistic agent, preservative, emulsifier, surface active agent, stabilizer, pH regulator, defoamer and solvent. The invention belongs to a plant source deinsectization bactericidal agent with the advantages of unambiguous effective components and easily controlled product quality, which adopts a proper accessory ingredient such as the emulsifier and stabilizer, etc., to solve the key problems of degradation and unstable quality and has no toxicity and residue, environment-friendliness and broad-spectrum effective deinsectization bactericidal effect. The invention has remarkable killing and controlling effects on various pests and germs in wheat, rice, fruit trees, vegetables, flowers, storehouses, houses as well as forests, has remarkable controlling effects on sanitary insect pests and germs like mosquito, fries, black beetles, ants, bedbugs, moth flies and fleas, etc, which is used for controlling pests and various germs for grains like paddy, wheat, corn, broomcorn, etc., during a storage period with a remarkable effect.

The invention relates to high-effective mosquito repelling liquid medicine which is characterized by comprising the following components by weight percent: 2%-7% of N, N-Diethyl-m-toluamide, 0.2%-2% of glycyrrhiza extract (0.1%-90% of glycyrrhizinic acid or glycyrrhetinic acid or physiologically acceptable salt thereof), 0.2%-2% of flavescens extract (0%-90% of matrine or oxymatrine or physiologically acceptable salt thereof), 0%-50% of menthol or borneol and 0.01%-2% of plant essential oil. The high-effective mosquito repelling liquid medicine is the hormone-free preparation made of pure Chinese herbal medicine for external application and is prepared by uniquely combining the high-effective repellent with the components having the anti-inflammatory, the antibacterial and the antipruritic effect, thereby being innovative. The high-effective mosquito repelling liquid medicine of the invention has the function of repelling the mosquito, relieving the itching, refreshing the consciousness and protecting the skin from the insect bite and can repel the mosquito for 5-7 hours. The high-effective mosquito repelling liquid medicine of the invention is non-toxic to the skin and mucous membrane, can not cause the allergic reaction and has higher stability.

The invention relates to matrine containing vegetative insecticide, of which raw materials contain the following weight-portioned material medicines that: sophora flavescens is 9.0-10.0 parts, thunder god vine is 1.5-2.0 parts, black false hellebore is 3.2-3.5 parts, radix euphorbiae ebractealatae is 1.2-1.4 parts, conelike redpepper is 0.8-1.2 parts, tobacco leaf is 1.2-1.6 parts, chinaberry bark is 0.8-1.2 parts, and stemona is 0.8-1.2 parts. The vegetative insecticide of the invention is effective, low-toxic, and environment-friendly. The invention also relates to the preparation method and the application of the vegetative insecticide.

The invention belongs to the technical field of biological pesticides, and more particularly relates to a matrine-containing pesticide and a preparation method thereof. The matrine-containing pesticide is characterized in that a suspension agent mainly comprises the following components in parts by weight: 1-25 parts of matrine, 5-20 parts of organic solvent, 1-25 parts of capsule wall material, 0.1-3 parts of colloid, 1-20 parts of emulsifier and the balance of de-ionized water to 100 parts. The matrine microcapsule suspension agent and the preparation method thereof aim to solve insufficient dosage form of biological pesticides in China, pollution to the environment and a poor control effect on insect pests. All active components in the scheme are naturally extracted from single-composition sophora flavescens plants, do not contain any chemical pesticides and are safe to natural enemies and the environment; and the novel matrine pesticide has the advantages of long duration of efficacy, anti-photolysis, improvement of utilization rate of pesticides and the like.

The invention discloses botanical bactericide of soluble matrine and a preparation method thereof, which aims at providing the botanical bactericide and a preparation method thereof which adopts Chinese herbal medicine as raw material and has high matrine content, low toxin and low cost but high efficiency and is harmless to human and livestock. The botanical bactericide comprises 17-25 portions of Chinese herbal medicine extract containing the matrine, 10-20 portions of emulsifier, 4-8 portions of penetrating agent, 0.1 portions of antioxidant and 48-56 portions of deionized water; the Chinese herbal medicine extract containing the matrine is extracted by mixing the following materials by weight portions: 30-35 portions of sophora flavescens ait, 20-35 portions of vietnamese sophora root, 10-15 portions of tea seed, 12-19 portions of common fibraurea stem, 7-10 portions of cubeb litsea, 6-9 portions of phellodendron, and 5-9 portions of magnolia officinalis. The bactericide comprises the matrine of super high content of about 2.6 percent and has special effect on killing pear scab, powerful penetrating performance that is in favor of absorption by plants, high efficiency, low toxin, no residue, no pollution and no drug resistance.

The invention provides a medicinal composition for treating skin itch, which is a preparation prepared from the raw material medicaments of cortex moutan radicis, densefruit pittany root-bark, lightyellow sophora root, liquorice root, borneol and menthol crystal. The invention also provides an external medicament which is prepared by taking paeonol extract used as active ingredients in the cortex moutan radicis, dictamnine extract used as active ingredients in the densefruit pittany root-bark, matrine extract used as active ingredients in the lightyellow sophora root, glycyrrhetinic acid extract used as active ingredients in the liquorice root, the borneol and the menthol crystal as active ingredients and adding pharmaceutically-acceptable auxiliary materials or auxiliary components. The invention also provides a preparation method of the medicinal composition. The medicament of the invention can treat the symptom of pruritus caused by accumulating evils of wind heat, moist heat and blood heat in the skin, comprising the pruritus caused by eczema. The medicinal composition of the invention has a refining formula of raw materials, definite material basis, definite curative effect and little toxic or side effect, and particularly has the unique curative effect on pruritus symptom of which the course of disease is lingering and repeated.

The invention relates to a matrine pure plant source pesticide which is characterized by comprising the following components in part by weight: 0.5-5 parts of banlangen, 5-25 parts of active emulsifier, 10-40 parts of organic solvent and 30-60 parts of purified water, wherein the part summation of four substances as basic components is 100. The matrine pure plant source pesticide is prepared from completely natural organic components without chemical pesticides, and has no harm to natural enemies and the environment.

The plant originated medicated fertilizer has pesticide components from plant or plant extract with pesticide function and nutritious components from industrial and agricultural wastes through harmless treatment. The plant originated medicated fertilizer consists of flavescent sophora root, matrine, castor, chicken excrement, brown coal, peanut shell, chestnut shell, bean cake, wheat bran, starch, etc. in certain proportion. It has the functions of increasing yield, killing pest, improving soil, etc. and is especially suitable for producing green agricultural products.

The present invention relates to a heat-sensitive gel preparation containing matrine alkaloid and its preparation method. Said preparation is composed of matrine alkaloid, hydroxypropyl methylcellulose, poloxamer 407, phosphate buffer solution whose pH value is 5.0-7.0, glycerin and preservative. It is flowable fluid at normal temperature, and when the temperature is 28-33 deg.C, it can produce phase change, and can be formed into gel, so that it can be conveniently applied to vagina, mucous membrane of external genitalia, skin and eye.

A synergistic composite insecticide contains matrine including oxymatrine, etc and methylamino Avermectin or its salt in the ratio of (0.01-100):1.

The invention discloses vegetable insecticide of soluble matrine special for killing plant louses and a preparation method thereof, which aims at providing the vegetable insecticide which adopts Chinese herbal medicine as raw material, has high matrine content and low toxin but high efficiency, is harmless to human and livestock as well as special for killing plant louses and the preparation method thereof. The invention comprises 11-13 portions of Chinese herbal medicine extract containing the matrine, 10-20 portions of emulsifier, 4-8 portions of penetrating agent, 0.1 portions of antioxidant and 57-64 portions of deionized water; the Chinese herbal medicine extract containing the matrine is the extract of the mixture by weight of 15-25 portions of sophora flavescens ait, 10-17 portions of chinaberry tree, 3-4 portions of argy wormwood leaf, 6-8 portions of celastrus angulatus maxim, 4-8 portions of derris, 2-4 portions of gardenia, 7-9 portions of herba artemisiae, 10-14 portions of gelsemium elegans, 5-7 portions of orange seed and 7-10 portions of Chinese wingnut leaf. The insecticide of the invention comprises the matrine with super high content about 1.3 percent and is special for killing the plant louses through scientific preparation of a plurality of Chinese herbal medicines and has powerful penetrating performance, high efficiency and insignificant toxin and is in favor of absorption by plants.

Aiming to provide an anti-acne skin care product characterized by good stability, small irritation and applicability to sensitive skin, the invention discloses a skin care product with soothing and anti-acne efficacy. The skin care product comprises an active component and a substrate, and the active component includes the following components by mass percentage: 0.5-2% of gellan gum, 0.3-2.5% of sodium shale oil sulfonate, 0.1-1% of glycerophosphoinositol choline, and 0.5-3% of acne removal agent, wherein the acne removal agent is composed of capryloyl glycine, capryloyl salicylic acid, tocopheryl phosphate, a Chinese trumpet creeper extract, matrine and pyridoxine in a mass ratio of 1:1.5:1:2:1:1. The skin care product belongs to the field of cosmetics.

The invention discloses a special seed dressing agent with effects of increasing the survival rate and invigorating seedlings for sweet corn. The seed dressing agent comprises gamma-aminobutyric acid, matrine, thiamethoxam, sedaxane, carboxin, amino-oligosaccharin, salicylic acid, glycine betaine, choline chloride, fulvic acid, starch grafted potassium acrylate, calcium chloride, a wetting dispersant, an emulsifier, gibberellin and microelement water soluble fertilizer mother liquor. Under normal conditions or adverse conditions of drought, low temperature and the like, the seed dressing agent has an obvious effect of improving the seed vigor and seedling quality of the sweet corn, can be used for effectively increasing the yield of the fresh spike of the sweet corn, also has effects of exterminating underground insects, protecting and invigorating seedlings and preventing and treating main plant diseases and insect pests of the corn, has control efficiency up to 70%-90% for plant diseases and insect pests in a seedling stage, has control efficiency up to 87%-96% for corn head smut, and not only can help farmers to save labor cost and seed cost greatly, but also can increase the yield by 15%-20%, thus having excellent social and economic benefits and application prospects.