145 results about "Matrine" patented technology

The invention discloses a carrier-free nano-particle with pH / ROS dual response as well as a preparation method and application of the carrier-free nano-particle. The preparation method comprises the following steps: enabling quinolizidine alkaloid and flavonol to be subjected to self-assembly, so as to prepare quinolizidine alkaloid-flavonol carrier-free nano particles; modifying the quinolizidine alkaloid-flavonol carrier-free nano particles by adopting a phenylboronic acid-hyaluronic acid conjugate, so as to prepare nano particles modified by the phenylboronic acid-hyaluronic acid conjugate; and coating the surfaces of the nano-particles modified by the phenylboronic acid-hyaluronic acid conjugate with a pH sensitive polymer to prepare the pH / ROS dual-response carrier-free nano-particles. The sophocarpidine-kaempferol carrier-free nanoparticles with pH / ROS dual response, prepared by the invention, have the advantages of good targeting property, high biocompatibility, small toxicity and adverse reaction and the like, meanwhile, the nanoparticles have a good anti-inflammatory effect, and a new choice is provided for the treatment of ulcerative colitis.

The invention discloses an indole sophocarpidine derivative photoaffinity active molecular probe which is formed by connecting an active group and a reactive group, the active group is a sophocarpidine derivative, the reactive group is a substance containing a diaziridine group and an alkyne group, and the chemical formula of the sophocarpidine derivative is as shown in the formula I. The invention further discloses a preparation method of the indole sophocarpidine derivative photoaffinity active molecular probe. After Spodoptera frugiperda Sf9 cells are treated by the indole sophocarpidine derivative photoaffinity active molecular probe for 72 hours, the inhibition rate can reach 86.33%, potential target protein when the sophocarpidine derivative acts on the Sf9 cells can be determined by utilizing the indole sophocarpidine derivative photoaffinity active molecular probe, targeted modification of sophocarpidine is facilitated, and the application range of the indole sophocarpidine derivative photoaffinity active molecular probe is widened. Further, matrine pesticides with excellent insecticidal activity are efficiently synthesized, and agricultural pests are better prevented and controlled.

The invention discloses an anti-tumor matrine hydrazine thiazole derivative and a preparation method and application thereof.The preparation method comprises the steps that NaH is added into a first reaction container, then a DMF solution is added, thiosemicarbazide is added into the first reaction container, and the solution is stirred; adding sophocarpidine into the stirred solution to perform reflux reaction, performing quenching reaction after the reaction is finished, and performing extraction, concentration drying and column chromatography separation to obtain a thiosemicarbazide sophocarpidine intermediate; adding the obtained thiosemicarbazide matrine intermediate into a reaction container II, and adding a dissolving solvent ethanol for dissolving; adding alpha-bromo-R-ethyl ketone into the dissolved solution for reaction, concentrating and drying after the reaction is finished, and performing column chromatography separation to obtain the anti-tumor matrine hydrazine thiazole derivative. The anti-tumor matrine hydrazine thiazole derivative is high in anti-tumor activity, the preparation method is simple and convenient, and reaction conditions are easy to control.

The invention discloses matrine-oleanolic acid ionic liquid and a preparation method and application thereof.The preparation method comprises the steps that matrine and oleanolic acid are dissolved in an organic solvent, heating and stirring are conducted, then rotary evaporation is conducted, and the matrine-oleanolic acid ionic liquid is obtained; wherein the mass ratio of the sum of the matrine and the oleanolic acid to the organic solvent is 1: (5-30), and the molar ratio of the matrine to the oleanolic acid is (3-10): 1. The ionic liquid disclosed by the invention not only can effectively improve the water solubility of oleanolic acid, but also can effectively inhibit the activity of 5 alpha-reductase and prevent the 5 alpha-reductase from catalyzing testosterone to be converted into DHT, so that the problems of rapid entry into a retrogression period, miniaturization, hair loss and the like caused by the fact that DHT acts on hair follicles after being combined with an androgen receptor are prevented. Meanwhile, expression of IL-1beta and TNF-alpha inflammatory factors in skin hair follicles can be inhibited, and the purposes of preventing alopecia and promoting hair growth are achieved. The effects of controlling oil, resisting inflammation, relieving, removing dandruff, relieving itching and the like are also achieved.

The invention discloses a tripterine-sophocarpidine self-assembled nanoparticle and application thereof in preparation of an anti-tumor drug, and belongs to the field of biological medicine. The nanoparticles are formed by self-assembly of the tripterine and the sophocarpidine through supramolecular interaction, the molar ratio of the tripterine to the sophocarpidine is 1: 1-1: 3, and the self-assembly system effectively solves the problems of low Cst solubility, poor bioavailability, rapid in-vivo removal and the like; the inhibition effect on triple negative breast cancer (TNBC) is remarkably enhanced through the synergistic effect of Cst and Mar, and a new strategy is provided for expanding the application of a traditional Chinese medicine carrier-free self-assembly nano drug delivery system in the anti-tumor field.

The invention provides a matrine-natural polyphenol amorphous substance as well as a preparation method and application thereof, and relates to the technical field of polyphenol and alkaloid pharmacy, in the matrine-natural polyphenol amorphous substance, the molar ratio of matrine to natural polyphenol is (1-2): (1-2), through strong interaction between matrine and polyphenol substances, the matrine-natural polyphenol amorphous substance can be used for preparing the natural polyphenol, and the matrine-natural polyphenol amorphous substance can be used for preparing the natural polyphenol. The physicochemical properties of the medicine in the amorphous substance, such as solubility, polarity and lipid-water partition coefficient, are changed, the slow release of the medicine is realized, and the IC50 value of the amorphous substance is reduced; in addition, matrine and polyphenol substances exert synergistic anti-oxidative stress capability, the ROS (reactive oxygen species) level of cells is reduced, and the toxicity of natural polyphenols to the cells is further reduced.

The invention discloses a gynecological antibacterial nursing gel containing hydrolyzed collagen and a preparation method thereof. Comprising the following raw materials in parts by weight: 4 to 12 parts of hydrolyzed collagen, 1 to 3 parts of glutathione, 2 to 4 parts of sophocarpidine, 0.2 to 0.5 part of resveratrol, 1 to 3 parts of hydroxybutyl chitosan, 15 to 20 parts of a traditional Chinese medicine extract, 0.5 to 1.5 parts of sodium hyaluronate, 0.1 to 0.25 part of plant essential oil, 1 to 3 parts of triethanolamine, 0.8 to 1.5 parts of lactic acid, 1 to 2 parts of carboxymethylcellulose, 1 to 1.5 parts of glycerol, 1 to 2 parts of carbomer and 0.5 to 1.5 parts of an emulsifier, 1-3 parts of a pH regulator, 10-15 parts of an irradiation improver, and the balance of purified water, totaling 100 parts; the invention relates to the technical field of gynecological gel. According to the gynecological antibacterial nursing gel containing the hydrolyzed collagen and the preparation method, the antibacterial effect of the gel is enhanced by adding the hydrolyzed collagen, so that the antibacterial effect is more durable, and the hydrolyzed collagen has relatively small molecular weight, is easily absorbed by skin, and can quickly permeate into vaginal mucosa to play nourishing and repairing roles.

The invention relates to a temperature-sensitive gel nose drop and a preparation method and application thereof, and belongs to the technical field of biological medicines.The temperature-sensitive gel nose drop is composed of a temperature-sensitive gel matrix, active ingredients and pharmaceutic adjuvants, the temperature-sensitive gel matrix comprises poloxamer 407 and poloxamer 188, the active ingredients comprise matrine and oxymatrine, and the pharmaceutic adjuvants comprise the temperature-sensitive gel matrix, the active ingredients and the pharmaceutic adjuvants. The pharmaceutic adjuvants comprise one or more of a solvent, a humectant, an antioxidant, a preservative, a wetting agent, a thickening agent, a coloring agent, a wetting agent and a buffering agent. The temperature-sensitive gel nose drop disclosed by the invention is simple in preparation process, controllable in cost and suitable for large-scale production. The thermo-sensitive gel nose drop can improve the expression level of serum IgE, IL-4 and IFN-gamma, improves the symptom of allergic rhinitis by correcting Th1 / Th2 imbalance, is suitable for clinical treatment and prevention of allergic rhinitis, and has a remarkable clinical application prospect.

The invention relates to the field of biological pharmacy, in particular to application of matrine in preparation of an intestinal microbiota regulator and an anti-escherichia coli medicine. The invention provides application of matrine in preparation of an intestinal microbiota regulator and an anti-Escherichia coli medicine, and matrine has the following advantages in application: (1) an active compound of a plant source has the characteristics of specificity and naturalness, and is friendly to the ecological environment; (2) the chemical structure and chemical characteristics are known, and the compound plays a role together with the immune system and the like of a host; (3) the main mode of acting on pathogens is a weakening and inhibiting mechanism or a synergistic effect with other substances, so that the drug resistance of pathogenic microorganisms is not easily caused, and the effectiveness of long-term use is ensured; and (4) pathogenic bacteria cannot be directly and completely killed generally, and corresponding pathogenic microorganisms are inhibited in a way of controlling an ecological steady state, so that the survival, replication and proliferation of the microbial community cannot be seriously influenced.

The present application relates to the application of traditional Chinese medicine active ingredient composition and its preparation in synergistic anti-tumor of PD-1 inhibitor. The traditional Chinese medicine active ingredient composition is a composition of oxymatrine and astragaloside B. The combination of the two can improve the anti-tumor effect of PD-1 inhibitor. In addition, it can also be used in the form of preparation to realize in vivo drug delivery in cooperation with its pharmaceutically acceptable carrier. The carrier can be selected from iron-based MOF and liposome, etc. to realize the co-loading of oxymatrine and astragaloside B with different polarity and efficient drug delivery. The iron-based MOF carrier has the advantages of high drug loading capacity and Fe ion which can cooperate with astragaloside B to improve the activity of tumor infiltrating T cells. The ferromagnetism and platelet membrane modification can also precisely target tumor tissue. The preparation technology of liposome is mature, which is conducive to industrialized production and has broad prospects for clinical transformation. The combination of the two with PD-1 inhibitor can significantly improve the anti-tumor effect of PD-1 inhibitor.

The invention relates to the technical field of pesticides, in particular to an environment-friendly composite pesticide based on marine microorganisms and a preparation method thereof.The environment-friendly composite pesticide is prepared from, by weight, 40%-52% of functional microspheres, 5%-6% of matrine, 2%-3% of rotenone, 3%-4% of rhamnolipid, 1%-1.5% of sodium alginate, 30%-35% of kieselguhr, 1%-2% of zinc sulfate, 2%-4% of hydroxyapatite and the balance water. Natural marine materials such as algin, sodium alginate and kieselguhr are used as carriers, plant source active ingredients and a biological surfactant are matched, matrine serves as a cholinesterase inhibitor, rotenone serves as a mitochondrial compound I inhibitor, a dual-action mechanism is formed, and meanwhile pollution caused by chemical pesticide residues is avoided.

The present invention relates to the technical field of compounds for medicine and cosmetics, and particularly relates to an mandelic acid ionic liquid, a preparation method and an application thereof. The present invention combines matrine and mandelic acid through an ionic bond to obtain the mandelic acid ionic liquid, which increases the water solubility and percutaneous permeability of the two monomers. The mandelic acid ionic liquid simultaneously improves the low solubility of matrine and the permeability of mandelic acid. While increasing the available range of the two substances, the mandelic acid ionic liquid simultaneously has the advantages of both matrine and mandelic acid; moreover, the mandelic acid ionic liquid has good permeability, cell and biocompatibility, good solubility and no irritation, and has the characteristics of oil control, soothing, high bioavailability and stable properties when applied to cosmetics.

The invention discloses a matrine slow-release agent as well as a preparation method and application thereof, and belongs to the technical field of pesticides. The preparation method comprises the following steps: firstly, dissolving matrine in an acidic aqueous solution, then sequentially adding carboxyl cellulose and fatty amine into the solution, stirring and emulsifying to obtain a dispersion liquid, and finally, adding the dispersion liquid into vegetable oil, and carrying out secondary emulsification to obtain the W / O / W Pickering emulsion. The sophocarpidine is combined and self-assembled through non-covalent bonds to form the drug-loaded gel, a wrapping structure is formed, the stability of the drug-loaded gel is effectively improved, and meanwhile the slow release performance of drug molecules is achieved through the non-covalent bond combination form; and vegetable oil is used for encapsulation, so that the stability of matrine molecules is further ensured, the matrine has better affinity with the plant surface, and the wettability is improved.

The invention belongs to the technical field of cell culture, discloses a multiplication culture method of peripheral blood gamma delta T cells, and particularly discloses application of matrine in multiplication culture of gamma delta T cells. Matrine is alkaloid which is extracted from traditional Chinese medicines and has various pharmacological activities, and has wide anti-tumor and anti-inflammatory activities. Matrine with a proper concentration is added into the gamma delta T cell culture medium, so that the amplification quantity of gamma delta T cells can be effectively increased, and the cell culture cost is reduced; meanwhile, the matrine component in the culture medium can effectively improve the killing activity of the gamma delta T cells on tumor cells, and the clinical immunotherapy effect is further improved.

The invention relates to the technical field of drug carriers, in particular to a mesoporous nanomaterial coupled with a CCR2 antibody and a preparation method and application of the mesoporous nanomaterial. According to the invention, the aminated mesoporous material is used for loading the drug and is coupled with the CCR2 antibody, so that the obtained CCR2 antibody coupled mesoporous nano material can target CCR2 + macrophages, the bioavailability of drugs such as matrine is improved, and the side effect is reduced. According to the invention, leading-edge technical elements such as a mesoporous nano-carrier, CCR2 antibody targeted modification and macrophage precise delivery are introduced, so that a carrier-drug-antibody ternary innovative combination system is formed.

The invention relates to the technical field of medicinal chemistry, and particularly discloses application of echinacoside in preparation of a medicine for improving autism social and cognitive impairment, and the application comprises the following steps: constructing a recombinant saccharomyces cerevisiae strain, and knocking out a precursor competition pathway gene; performing metabolic flow reprogramming fermentation on the recombinant strain; centrifuging the fermentation liquor at 7000-9000 r / min and pretreating the fermentation liquor with an 8-12 kDa ultrafiltration membrane; carrying out dual-targeting affinity chromatography purification on the pretreatment liquid; the preparation method comprises the following steps: preparing echinacoside into a liposome containing pH sensitive poly-histidine; and adding a freeze-drying protective agent into the suspension to carry out gradient pre-freezing and vacuum freeze-drying. According to the application, a mode of combining recombinant saccharomyces cerevisiae strain construction and metabolic flow reprogramming fermentation is adopted, targeted enrichment of echinacoside is realized through affinity chromatography coupled with autism brain region specific double ligands, then the echinacoside is prepared into the liposome containing pH sensitive poly-histidine, the double ligands are modified, and the effects of precise targeting and efficient effect are achieved.

The application discloses a kind of antifungal matrine derivatives and preparation method and application, with sophocarpine and thiourea reaction;The lone pair of electrons on the nitrogen atom of thiourea attacks C13 in matrine, and a series of antifungal matrine derivatives are synthesized by nucleophilic addition of thiourea matrine intermediate, with thiourea matrine and alpha-brominated R group ketone as reactant to synthesize a series of antifungal matrine derivatives with ethanol as solvent.The application not only enhances the bacteriostatic activity of matrine derivatives, but also has simple preparation method and easy control of reaction conditions.

The application provides an imidazo[1,2-a]pyrimidine matrine / sophoridine derivative, which has the chemical structural formula as shown in the description. 1 R is alpha-hydrogen or beta-hydrogen; and R 2 is selected from phenyl, substituted phenyl and naphthyl. Compared with the parent matrine and sophoridine, the acaricidal activity of the imidazo[1,2-a]pyrimidine matrine / sophoridine derivative is significantly improved, and the imidazo[1,2-a]pyrimidine matrine / sophoridine derivative can be used for preparing a plant source acaricide which is high in efficiency, environmental protection and low in toxicity.

The invention relates to the technical fields of medicines, daily chemicals and the like, in particular to a baicalin-based ternary eutectic solvent as well as a preparation method and application thereof. The baicalin is used as a bridge between the matrine and the grape seed oil, and the matrine and the grape seed oil are combined to form a uniform and stable ternary eutectic solvent through weak interaction force such as hydrogen bonds. The problem of solubility of the baicalin is remarkably solved, and the solubility of the baicalin in water and grease is greatly improved. In order to improve the bioavailability of baicalin, baicalin with an efficient anti-inflammatory effect and grape seed oil with a strong anti-oxidation effect are co-dissolved. On the basis of retaining the original anti-inflammatory effect and the like of the baicalin, free radicals can be more effectively cleared, and the ultra-strong antioxidant capacity is exerted, so that a foundation is laid for application of the baicalin in the technical fields of medicines, daily chemicals and the like.

This invention discloses a biocontrol agent for controlling sesame wilt, belonging to the field of pesticide technology. The raw materials of this biocontrol agent for controlling sesame wilt, by weight, include: 8-15 parts of a pyrimidine nucleoside antibiotic, 0.5-5 parts of matrine, 0.5-2 parts of an antioxidant, 1-5 parts of a dispersant, 1-3 parts of an adhesive, and 2000 parts of water. This invention utilizes a mixture of the pyrimidine nucleoside antibiotic and matrine to achieve a synergistic effect. The mixed product system allows matrine to enter the plant more easily, further improving its rapid action and systemic absorption. Furthermore, by simultaneously utilizing the different bactericidal mechanisms of the pyrimidine nucleoside antibiotic and matrine, the problem of the slow onset of action of the pyrimidine nucleoside antibiotic is addressed, thus enabling faster and more effective control of sesame wilt.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to application of matrine combined with medroxyprogesterone acetate in preparation of antitumor drugs. According to the invention, matrine and medroxyprogesterone are combined for use, and the matrine and medroxyprogesterone are used for developing products such as drugs, preparations, kits and the like for treating endometrial cancer. Experimental results prove that after sophocarpidine and medroxyprogesterone acetate are combined for medication, the composition shows relatively strong activity of inhibiting endometrial cancer and relatively good synergistic inhibition effect, so that the composition has relatively good practical application value. Experimental results prove that the dosages of the two can be remarkably reduced after drug combination, and the anti-tumor effect is remarkably improved. Animal experiments show that in-vivo anti-tumor effects of sophocarpidine and medroxyprogesterone acetate can be improved by combined medication compared with that of single medication. In conclusion, the combined medication of the matrine and the medroxyprogesterone can become a new method for treating endometrial cancer patients.

The invention belongs to the technical field of medicines and the field of acne treatment, and particularly relates to application of amorphous salt in preparation of a medicine for treating acne and the medicine. The amorphous salt is prepared by reacting ursodesoxycholic acid and matrine, preferably, the ursodesoxycholic acid and the matrine are dissolved in a proper solvent according to the molar ratio of 1: (0.5-2), then the solvent is rapidly removed, and remaining solids are further dried and crushed to obtain the ursodesoxycholic acid / matrine amorphous salt. The solubility and the percutaneous penetration rate of the propionibacterium acnes are remarkably improved, the propionibacterium acnes can be inhibited, the expression of IL-1beta, IL-6, IL-8 and TNF-alpha can be reduced, P65 protein nucleus translocation can be inhibited, and an efficient and safe new scheme is provided for acne treatment.

The invention provides a multi-effect balanced private care hydrogel film as well as a preparation method and application thereof, and belongs to the technical field of medical biological materials. By integrating traditional Chinese medicine antibacterial components, inactivated probiotics and a hydrogel slow release technology, the hydrogel film with a three-layer structure, which has the functions of inhibiting bacteria, repairing mucous membranes and maintaining pH balance, is developed, and matrine inhibits staphylococcus aureus (the diameter of an inhibition zone is greater than or equal to 15mm); inactivated bacteria competitively inhibit the adhesion of pathogenic bacteria (the in-vitro adhesion inhibition rate is greater than or equal to 70%); zinc hyaluronate promotes mucous membrane repair (the cell migration rate is increased by 40%), and through the multi-target-point synergistic effect, good nursing and postoperative repair effects are achieved.

The invention belongs to the field of medical technology, and specifically relates to an ultra-high performance liquid chromatography detection method for the active ingredient content and fingerprint of a compound sophora flavescens injection, wherein the method adopts ultra-high performance liquid chromatography for detection, and the ultra-high performance liquid chromatography conditions include a chromatographic column of ACQUITY UPLC CSH TM C 18 , with specifications of 1.7 μm and 2.1 mm×100 mm; the active ingredients are matrine, oxymatrine, methyl azoxymethanol primulin glycoside, sophocarpine, oxysophocarpine and sophoridine. The present invention can provide an improved detection method for compound sophora flavescens injection, which can simultaneously determine the six components in the compound sophora flavescens injection, and use the method to construct a chromatographic fingerprint, providing a fast and efficient technical method for quality control in the compound sophora flavescens injection, and reducing the inspection workload.

The application discloses an anti-tumor matrine hydrazine thiazole derivative and a preparation method and application thereof, NaH is added into a reaction container one, then a DMF solution is added, and then aminothiourea is added into the reaction container one to stir the solution; sophoridine is added into the stirred solution to perform a reflux reaction, after the reaction is completed, a quenching reaction is performed, and then extraction, concentration drying and column chromatography separation are performed to obtain an aminothiourea matrine intermediate; the obtained aminothiourea matrine intermediate is added into a reaction container two, and an ethanol dissolving solvent is added to dissolve; the dissolved solution is added with alpha-bromo R base ethanone to perform a reaction, after the reaction is completed, concentration drying and column chromatography separation are performed to obtain the anti-tumor matrine hydrazine thiazole derivative. The anti-tumor matrine hydrazine thiazole derivative has strong anti-tumor activity, and the preparation method is simple and the reaction condition is easy to control.

The invention relates to a double-drug liposome co-carrying oxymatrine and an STING agonist prodrug as well as a preparation method and application of the double-drug liposome. The double-drug liposome comprises a drug carrier and oxymatrine, wherein the drug carrier consists of a membrane material; the oxymatrine is loaded in a hydrophilic inner cavity of the carrier; the membrane material is prepared from distearoyl phosphatidylcholine, distearoyl phosphatidyl ethanolamine-polyethylene glycol and a cholesterol-STING agonist prodrug conjugate; the cholesterol-STING agonist prodrug conjugate is a conjugate formed by coupling an STING agonist prodrug with cholesterol through a chemical bond. According to the invention, the traditional Chinese medicine active component oxymatrine and the STING agonist prodrug are creatively integrated into the same liposome, so that synergistic controlled release and mechanism complementation can be realized; wherein the STING prodrug is embedded into the carrier in a chemical bond coupling manner, so that drug leakage caused by physical entrapment is avoided, the acute toxicity of the free STING agonist is remarkably reduced, and meanwhile, the innate immune activation capability of the free STING agonist is enhanced.

The invention belongs to the technical field of pesticides, and particularly relates to a pesticide composition containing pydiflumetofen. The invention relates to a pesticide composition containing pydiflumetofen. The pesticide composition is prepared by compounding pydiflumetofen and matrine or phenazino-1-carboxylic acid. The pydiflumetofen and the sophocarpidine or the phenazino-1-carboxylic acid are reasonably compounded to be used for preventing and treating the crop diseases, and compared with a single component, the pesticide composition has the advantages that the disease prevention and treatment effect can be improved, the pesticide dosage is effectively reduced, the drug resistance risk is reduced, and the development speed of the drug resistance of the crop diseases is delayed; a thought can be provided for development and scientific use of medicaments.

The present invention disclosed a series of novel matrine α-ketoamine derivatives as shown in formula I, which could inhibit the overexpression of TNF-α and / or activate the immune killing function of the NK cells, thus could be used to treat autoimmune diseases, inflammatory diseases, neurodegenerative diseases and tumors mediated by the abnormal levels of TNF-α and / or NK cell dysfunction.

The invention provides an antibacterial dressing composition and a medical gynecological protection pad, and belongs to the technical field of medical dressings. The composition is prepared from 70 to 90 parts of water, 8 to 10 parts of polyethylene glycol, 4 to 6 parts of glycerol, 0.3 to 0.7 part of carbomer, 0.06 to 0.15 part of L-cysteine, 4 to 8 parts of chitosan quaternary ammonium salt, 0.3 to 0.8 part of panthenol, 0.4 to 0.7 part of tocopheryl acetate, 0.2 to 0.4 part of sodium hyaluronate, 0.1 to 0.3 part of chlorhexidine digluconate, 3 to 4 parts of polyvinylpyrrolidone, 1 to 5 parts of sodium alginate, 0.1 to 0.3 part of polysorbate, 0.6 to 0.9 part of luteoloside, 0.1 to 0.2 part of quercetin and 0.05 to 0.2 part of sophocarpidine. Chitosan quaternary ammonium salt and chlorhexidine digluconate are used as bactericidal components, quercetin and sophocarpidine are added to serve as bacteriostatic agents, and the bactericidal components, active components such as panthenol, tocopheryl acetate and galuteolin and a film-forming agent form a dispersion system. The antibacterial facial mask has remarkable antibacterial property, and has the effects of resisting inflammation, preserving moisture, promoting tissue repair and the like. The gynecological protection pad acts on the surface of vulva inflammation, and the exact treatment effect can be achieved.

The invention discloses an anti-aging mask composition containing a supramolecular rhizoma polygonati extract and a preparation method of the anti-aging mask composition, and belongs to the technical field of cosmetics. The mask composition is prepared from the following components in parts by mass: 0.5 to 5.0 parts of rhizoma polygonati extract, 0.5 to 5.0 parts of sophocarpidine oxoglutaric acid supramolecular NaDES, 0.1 to 1.0 part of acetyl hexapeptide-8, 0.05 to 0.1 part of conopeptide, 8 to 16 parts of a moisturizing agent, 0.01 to 0.5 part of a preservative, 2 to 5 parts of a thickening agent and 40 to 90 parts of water. The supramolecular NaDES is prepared by reacting sophocarpidine and oxoglutaric acid in a molar ratio of 1: (0.2-5) at 50-80 DEG C for 3-12 hours, and the stability and transdermal absorption efficiency of active ingredients are remarkably improved. The preparation method comprises the steps of step-by-step mixing, homogenizing and aging, so that the synergistic interaction of the components is ensured. Experiments show that after the mask is used for 6 weeks, the wrinkle reduction rate reaches 61.68%-67.37%, and compared with a control group, the wrinkle reduction rate is remarkably improved. Through the synergistic effect of the supramolecular carrier and the polypeptide component, the technical problems that a traditional anti-aging mask is poor in transdermal absorption and active components are easy to degrade are solved, and the anti-aging mask has a good market application prospect.