Preparation method of matrine vagina effervescence tablet and use thereof

The technology of effervescent tablet and matrine is applied in the new field of medicine, which can solve the problems of contaminated clothing and toxicity, and achieve the effect of increasing antibacterial and antibacterial, simple method and high quality.

Inactive Publication Date: 2009-05-06
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Toxicity; LD50 intraperitoneal injection of mice is 150mg / kg, and intraperitoneal injection of rats is 125mg / kg
Compared with ordinary suppositories, effervescent tablets can not only avoid the phenomenon of suppository softening and exudation caused by high temperature in summer, but also overcome the disadvantages of polluting clothes after medication and affecting normal activities.

Method used

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  • Preparation method of matrine vagina effervescence tablet and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: specification 1000 pieces

[0046] prescription:

[0047] Matrine 50g

[0048] Sodium bicarbonate 100g

[0049] Sodium carboxymethyl starch 40g

[0050] Tartaric acid 120g

[0051] Boric acid 100g

[0052] Lactic acid 10g

[0053] Compressible starch 40g

[0054] Starch 100g

[0055] Cysteine ​​Hydrochloride 2g

[0056] Sodium dodecyl sulfonate 1g

[0057] Preparation method:

[0058] (1) Pass the prescribed amount of matrine, sodium bicarbonate, and sodium carboxymethyl starch (half of the total amount) through an 80-mesh sieve and mix evenly.

[0059] (2) The prescription amount of tartaric acid, cysteine ​​hydrochloride, lactic acid, compressible starch, starch, sodium carboxymethyl starch (half of the total amount) is passed through an 80-mesh sieve, and mixed evenly.

[0060] (3) Configure 50% ethanol solution of 5% povidone as binder, add the above-mentioned mixed powder respectively to make soft material, and pass through a 24-mesh sieve ...

Embodiment 2

[0064] Embodiment 2: specification 10000 pieces

[0065] prescription:

[0066] Matrine 500g

[0067] Sodium bicarbonate 1000g

[0068] Sodium carboxymethyl starch 400g

[0069] Tartaric acid 1200g

[0070] Boric acid 1000g

[0071] Lactic acid 100g

[0072] Compressible starch 400g

[0073] Starch 1000g

[0074] Cysteine ​​Hydrochloride 20g

[0075] Sodium dodecyl sulfonate 10g

[0076] Preparation method:

[0077] (1) Pass the prescribed amount of matrine, sodium bicarbonate, and sodium carboxymethyl starch (half of the total amount) through an 80-mesh sieve and mix evenly.

[0078] (2) The prescription amount of tartaric acid, cysteine ​​hydrochloride, lactic acid, compressible starch, starch, sodium carboxymethyl starch (half of the total amount) is passed through an 80-mesh sieve, and mixed evenly.

[0079] (3) Configure 50% ethanol solution of 5% povidone as binder, add the above-mentioned mixed powder respectively to make soft material, and pass through a 24-...

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Abstract

The invention discloses a preparation method of a vagina effervescent tablet containing matrine, and application thereof. The invention belongs to the new technical field of medicaments and relates to a new preparation formulation of the matrine, which is used for curing colpitis, chronic cervicitis and cervical erosion caused by various bacteria and preventing and treating cervical carcinoma; moreover, the new preparation formulation can also be used as the medicament preparations of senile vaginitis and pelvic inflammation and used in the preparation methods thereof. The new preparation formulation is characterized in that after the effervescent tablet is dissolved, the pH value of the liquid thereof is between 2.5 and 5.5 and the best PH value is between 3.8 and 4.2 which approach the physiological environments of human bodies.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of matrine, which is used for treating vaginitis, chronic cervicitis, and cervical erosion caused by various bacteria, preventing and treating cervical cancer, and can also be used for senile vaginitis, Pharmaceutical preparations such as pelvic inflammatory disease and preparation methods thereof, specifically a preparation method and application of matrine vaginal effervescent tablets. Background technique [0002] Gynecological diseases refer to the general term for various diseases of reproductive organs in the non-pregnant state. Due to the particularity of female reproductive organs, gynecological diseases are common and frequently-occurring diseases in adult women. a serious complication. Common gynecological diseases include: cervicitis, vaginitis, pelvic inflammatory disease, uterine fibroids, ovarian tumors and other types of diseases. Since gyne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/20A61K9/46A61K47/36A61P15/00A61P15/02
Inventor 王翰斌闫艳立
Owner BEIJING HOPE HUGE PHARM SCI
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