66 results about "Effervescent vaginal tablet" patented technology

The invention discloses a preparation method of a vagina effervescent tablet containing matrine, and application thereof. The invention belongs to the new technical field of medicaments and relates to a new preparation formulation of the matrine, which is used for curing colpitis, chronic cervicitis and cervical erosion caused by various bacteria and preventing and treating cervical carcinoma; moreover, the new preparation formulation can also be used as the medicament preparations of senile vaginitis and pelvic inflammation and used in the preparation methods thereof. The new preparation formulation is characterized in that after the effervescent tablet is dissolved, the pH value of the liquid thereof is between 2.5 and 5.5 and the best PH value is between 3.8 and 4.2 which approach the physiological environments of human bodies.

The vagina effervescent tablet has the salt or ester of clindamycin and metronidazole as active component and is prepared via a common tablet making process. The present invention features that the said effervescent tablet contains hydroxypropyl methyl cellulose as adhesive. Compared with conventional effervescent tablet, the present invention has the advantages of greater foam amount, fine and lasting foams, homogeneous distribution of effective medicine component, long duration, raised medicine curative effect, simple preparation process, stable quality and being suitable for industrial production.

The present invention discloses a Chinese medicine Lifukang preparation for curing vaginopathy. Said Lifukang medicine preparation can be used for effectively curing various vaginitises of gyneco logical disease, pruritus vulvae and vulvitis, etc. with obvious therapeutic effect. Said invention is made up by using 11 Chinese medicinal materials of flavescent sophora root, phellodendron bark, cnidium seed, dictamnus root bark, coptis root and others through a certain preparation process. It can be made into suppository, lotion, gels and vaginal effervescent tablet, etc.

A vaginal effervescent tablet for treating gynecologic inflammation, such as vaginitis, cervicitis, cervical erosion, etc is prepared from rhubard, arnebia root, catechu, borneol, and the auxiliary chosen from organic acid, carbonate, filler, adhesive, disintegrant and lubricant.

The present invention is compound preparation for treating womení»s inflammation, and belongs to the field of medicine technology. Each 1000 application units of the compound preparation consists of ornidazole 100-1000 g, butoconazole nitrate 10-500 g and policresulen 50-300 g. The compound preparation may be prepared into different forms, including vaginal suppository, vaginal effervescent tablet, vaginal tablet, vaginal gel, etc. The compound preparation has the functions of resisting anaerobic bacteria, resisting protoplasm, resisting mildew and resisting aerobion, and may be used in treating various womení»s infectious diseases, such as bacterial vaginitis, mycotic vaginitis, protozoal vaginitis, non-specific vaginitis, mixed infectious vaginitis, pruritus vulvae, etc.

The invention relates to a method for preparing a new gynecological anti-bacterial anti-inflammatory drug, namely dithiazole vaginal effervescent tablet and a method for quality control. The dithiazole vaginal effervescent tablet is used for treating gynecopathy, anorectal diseases and skin commonly-encountered diseases such as pelvic inflammatory disease, cervical erosion, vaginitis and the like caused by anaerobic bacteria, aerobic bacteria, trichomoniasis, pure or mixed fungal infections. The dithiazole vaginal effervescent tablet is characterized in that lactic acid and a calcium lactate buffer system are added to the formulation so that the pH value of the drug is between 3.5 and 4.0 similar to the vaginal physiological pH and is advantageous to remove pathogen and infusorian, provide living conditions suitable for vaginal beneficial bacterium group of lactic acid bacteria, and promote the illness rehabilitation. Besides, the dithiazole vaginal effervescent tablet uses pharmaceutical acceptable water-soluble polymer materials such as water-soluble polymer polyethylene glycol, polyvidone K30 and the like to enwrap acidic or alkaline components of an effervescent disintegrant so as to avoid the occurrence of hidden spots or even collapsing phenomenon on the surface of the tablet caused by gas production reaction resulted from small amount of water in the storage process, and uses a ethanol solution with adhesives and surface-active agents for granulation so that the hydrolysis of clotrimazole can be prevented, the infiltration of moisture is promoted in use, the uniform collapse is accelerated, and gas bubbles are homogeneous and stable.

The invention discloses lincomycin hydrochloride compound vaginal effervescent tablets and a preparation method thereof. The effervescent tablets comprise the following western medicine effective ingredients in parts by weight: 4-6 parts of lincomycin hydrochloride and 1-3 parts of domiphen bromide; and the effervescent tablets comprise the following raw medicinal materials of traditional Chinese medicine active ingredients in parts by weight: 20-25 parts of densefruit pittany root-bark, 22-27 parts of tuber fleeceflower root, 18-25 parts of Chinese waxgourd seed, 30-35 parts of argy wormwood leaf, 21-25 parts of herb of red-knees, 18-24 parts of plantain seed, 17-20 parts of villous amomum fruit, 25-28 parts of largehead atractylodes rhizome, 22-26 parts of Chinese angelica (stir-fried with wine), and 20-25 parts of medicinal auxiliary materials. The preparation method of the effervescent tablets comprises the steps of preparing materials, extracting active ingredients of the traditional Chinese medicines, performing granulation, and tabletting. The lincomycin hydrochloride compound vaginal effervescent tablets disclosed by the invention effectively overcome adverse reactions caused by oral administration of lincomycin hydrochloride, directly act on affected parts by adopting an external method for local treatment of vaginitis, take effect quickly, are good in curative effect, and are convenient to use.

The invention provides a vaginal effervescent tablet composition that comprises 100 weight portions of active drug ingredients and 20-1000 weight portions of solid lipid. The vaginal effervescent tablet composition of the invention can be released in vagina slowly and continuously, ensuring that the sufferer feels comfortable, and generates foams that can ensure fine drug powder to be uniformly distributed, leading the drug to be uniformly distributed in the inner wall mucosa of the vagina; meanwhile, the foams last for a long time, which prolongs dramatically the even contact time of the drug and the mucosa of the vagina and extends the effect of the drug; furthermore, the vaginal effervescent tablet composition is easily washed out and more beneficial to the health of sufferers.

The invention relates to a effervescent preparation for treating women's vaginitis, which is prepared from raw material herbs of goldthread root, seed of nuxvomica, smilax China root, zedoary, oak-apple, pomegranate bark, beta cyclodextrin, sodium hydrogen carbonate, polyethylene glycol, lactose, citric acid, magnesium stearate and sodium carboxymethylstarch.

The invention discloses a compound norfloxacin vaginal effervescent tablet and a preparation method thereof. The compound norfloxacin vaginal effervescent tablet consists of a Western medicine, a Chinese medicine and a medicinal auxiliary material, wherein the Western medicine comprises the following active components in parts by weight: 4-6 parts of norfloxacin and 10-20 parts of borneol; the Chinese medicine comprises the following raw herbs in parts by weight: 70-80 parts of liquorice, 145-155 parts of viola mandshurica, 125-135 parts of dandelion, 115-125 parts of sophorae flavescentis and 80-90 parts of catechu; the parts of the medicinal auxiliary material by weight is 30-40. The compound vaginal effervescent norfloxacin tablet is a combination of Chinese and Western medicines, is used for topical treatment, is convenient to use, and can increase a contact surface of a medicine and a human body after effervescing so as to improve the medicinal efficacy; through a traditional therapeutic method that the Chinese medicine treats root causes and the Western medicine treats symptoms, the compound norfloxacin vaginal effervescent tablet can treat urinary tract infection, leukorrhagia and yellow leucorrhea caused by sensitive bacteria and other gynaecological diseases.

The invention relates to effervescent tablets for treating vaginal inflammation, wherein the preparation is prepared from Ainsliasa fragrans Champ. through extraction, then mixing the obtained dried concrete with auxiliary materials by a weight ratio of 1:1-6, and the auxiliary materials include effervescent excipient, bulking agent, surface active agent, crumbling agent, lubricating agent and bonding agent.

The present invention relates to a kind of viginal effervescent dragoní»s blood tablet, which is prepared with dragoní»s blood in effective dosage as main medicine, acid and alkali disintegrating agent and other supplementary material, and through tabletting directly or after pelletizing or coating. The effervescent dragoní»s blood tablet has acid and alkali disintegrating agent capable of generating CO2 gas after reacting with water, and thus can foam and disintegrate inside vagina for dragoní»s blood to disperse fast inside vagina. It is used in treating pelvic inflammatory disease, uterine appendages cyst, cervicitis, vaginitis, hysteromyoma and other womení»s diseases.

The invention discloses a Chinese medicinal external composition for curing gynecological diseases and a preparation method thereof. The composition is prepared from amur corktree bark, hairyvein agrimonia herb and bud, common cnidium fruit, climbing groundsel herb, dried alum and borneol in a certain ratio. The composition is prepared into clinically acceptable external formulations such as suppository, external capsules, gel, ointments, vaginal tablets, vaginal effervescent tablets, vaginal films, lotion, aerosol, foaming agent and the like by a pharmaceutical conventional method. The composition has good curative effects on cervical erosion, gynecological inflammation, and urinary tract infection of women. The composition is prepared into an external preparation and is not orally administrated so as to avoid first-pass effect on liver and physiological screening effects of gastrointestinal tracts and reduce untoward effect. The external preparation can directly act on afflicted parts, and has the advantages of strong pertinence, general actions through skin and mucosa, quick medicinal absorption, less interference to internal environment of body, non-traumatic treatment mode, simple operation, good safety of clinical use, high cure rate, base strengthening of Chinese medicaments, and less side effect. The composition can effectively eliminate cause of diseases, can safely and effectively cure diseases under guidance of doctors and is easy to popularize.

The invention relates to a metronidazole clotrimazole and chlorhexidine acetate vaginal effervescent tablet, which consists of a tablet core, an isolating layer and a filmcoating layer, wherein the tablet core of the metronidazole clotrimazole and chlorhexidine acetate vaginal effervescent tablet is firstly prepared, and then ethyl cellulose and polyethylene glycol are wrapped by the isolating layer and are finally wrapped by filmcoating. The appearance, foaming amount and other indicators of the vaginal effervescent tablet are stable during the storage process, and the storage requirement islow, so the use and curative effect of the medicine are ensured.

The invention relates to a nifungin-canstat vagina effervescent tablet. Wherein, it uses nifungin and canstat, with acid-alkali adding system, and stuff or directly being compressed into tablet or particles then to be compressed into tablet, or uses macrogol to cover the alkali, then to be compressed into tablet. The invention uses the acid alkali system which will generate carbon dioxide gas when meeting water as slaking agent; therefore, the tablet will foam and slake when adsorbs water in vagina, to disperse the elements into vagina completely, as uterine cervix, etc.

The present invention provides a kind of Anaer vagina cleaning effervescent tablet and its production process. The Anaer vagina cleaning effervescent tablet is produced with fenugreek seed, cnidium fruit, pricklyash, pomegranate rind, gallnut, borneol, coral, beta-cyclodextrin, sodium bicarbonate, polyglycol-6000, citric acid, lactose, magnesium stearate and polyvinyl pyrrolidon, and through one optimized process. It has unique effervescent effect in the vagina environment and high treating effect.

The invention belongs to the field of pharmacy, and particularly relates to a gynecological inflammation clearing vaginal effervescent tablet. The tablet is prepared from the following Chinese medicinal bulk pharmaceutical chemicals: 500g of sophora flavescens, 400g of quassia, 400g of common cnidium fruit, 100g of dried alum, 5g of pearl stratum powder, 10g of borneol, 4g of menthol, 40g of berberine hydrochloride and 60g of boric acid. The gynecological inflammation clearing vaginal effervescent tablet contains auxiliary components which comprise acid, alkali, a filler, a disintegrating agent, a lubricant and a coating agent.

The invention discloses vaginal effervescent tablets comprising starch, boric acid, a lubricant, and microencapsulated catechin-tea flavonoid crystals. The tablets have the advantages that: the microencapsulated catechin-tea flavonoid crystals are added, such that mould can be effectively killed, and effective antibacterial and antiviral effects can be provided; boric acid is adopted as a buffering liquid component, such that catechin bioactivity can be protected; tartaric acid is added as an antioxidant, such that catechin bioactivity can be further sufficiently protected; silver ions are added as a protective agent and disinfectant, such that disinfecting and antibacterial effects are provided, and antibacterial and antiviral effects of catechin can be better developed; silica gel micro-powder, castor oil, tea seed oil, perilla oil and sandalwood essential oil are adopted as the lubricant, adsorbents and flow aid, such that tablet press-molding is facilitated, and content is uniform.

The invention discloses an external gynecological drug compound which consists of an active ingredient butoconazole nitrate and other drug carriers acceptable in pharmacy. The external gynecological drug compound has the forms of suppositories, vaginal tablets and vaginal effervescent tablets and can be used for treating the fungal infection outside the vagina caused by mycotoruloides.

The invention discloses a Chinese medicinal composition for external use and a preparation method and application thereof. The composition consists of amur corktree bark, herba agrimoniae, common cnidium fruit, climbing groundsel herb, dried alum and borneol according to certain proportion; and according to a pharmaceutical conventional method, the composition is prepared into clinical acceptable formulae for external use, such as suppositories, capsules for external use, gelata, ointments, vaginal tablets, vaginal effervescent tablets, vaginal pellicles, washing liquor, aerosols, forming agents and the like. The composition has a better therapeutic effect of treating gynecologic diseases, such as cervical erosion, gynecologic inflammations and urinary tract infection; the composition is prepared into an external preparation and is not orally taken to avoid a liver first-pass effect and a gastrointestinal tract physiological checkpoint effect and reduce adverse reactions; the external preparation can directly act on sick parts, has strong pertinence, can act on a whole body through skins or mucous membranes, can be absorbed quickly, has small interference on the internal environment of an organism, is a non-invasive treatment mode, is simple and convenient to operate, has high safety and high curative ratio in clinical application, is a Chinese medicament for enhancing the body resistance, has small side effects, can effectively and thoroughly eradicate causes of diseases, can be used for performing safe and effective treatments under the guidance of doctors, and is favorable for popularization.

A vaginal effervescent tablet ''Funing'' contains active components (40-85 Wt%), acid source (5-35), CO2 source (5-25), lubricant (0.5-5) and adhesive (0-3). Its advantages are quickly taking its high curative effect, no damage to vaginal mucosa, and low by-effect.

The invention discloses a metronidazole, clotrimazole and chlorhexidine acetate effervescent tablet and a preparation method thereof. The compositions of the metronidazole, clotrimazole and chlorhexidine acetate effervescent tablet are 0.2 gram of metronidazole, 0.16 gram of clotrimazole, 0.008 gram of chlorhexidine acetate, 0.08 to 0.15 gram of sodium bicarbonate, 0.10 to 0.15 gram of tartaric acid, 0.10 to 0.20 gram of lactose, 0.015 to 0.035 gram of sodium dodecylsulfate, 0.01 to 0.05 gram of superfine silica gel powder, 0.01 to 0.02 gram of calcium hydrophosphate, 0.005 to 0.006 gram of magnesium stearate, 0.09 to 0.15 gram of 95 percent of alcohol and 0.004 to 0.006 gram of polyvidone K30. Compared with the prior art, the metronidazole, clotrimazole and chlorhexidine acetate effervescent tablet and the preparation method have the advantages that the sticking phenomenon is difficult to generate during the tabletting process and the operation is not difficult during the manufacturing process; a bag can not be expanded after packaging and the foaming amount is controlled to less than or equal to 10 milliliters within the guarantee period; and the tablet is difficult to break.

The invention discloses a vaginal effervescent tablet with biological adhesiveness and a preparation process thereof. The vaginal effervescent tablet with biological adhesiveness is characterized by comprising active pharmaceutical ingredients including terbinafine hydrochloride, an effervescent agent, tween-80, a biological adhesive, a filler and an emollient. The effervescent agent includes an acid-source component and an alkali-source component. The biological adhesive is composed one or multiple of chitosan, Carbomer, sodium carboxy methyl cellulose and hydroxypropyl methylcellulose. The effervescent tablet prepared by the preparation process can be distributed in the human body uniformly and easy to clean and has biological adhesiveness so as to adhere onto the vaginal wall for a long time and prevent from flowing out of the vagina within a short time, and accordingly therapeutic effect is improved further.

The invention relates to a ketoconazole vaginal tablet and a preparation method thereof. The prescription of the vaginal tablet comprises the following components according to the parts by weight: 1 of ketoconazole, 0.01-0.2 of carboxyrnethyl starch sodium, 0.01-0.2 of sodium bisulfite, 0.1-2 of lactose; 0.001-0.02 of polysorbate 80, 0.001-0.2 of polyvidone K30; 0.001-0.1 of magnesium stearate and 0.001-0.1 of talcum powder. Compared with the prior art, the ketoconazole vaginal tablet not only overcomes the defects of easy loss and clothing pollution of pessary, but also avoids the defects of demanding production conditions, inconvenient storage, and the like which are caused by a vaginal effervescent tablet using special accessories. Meanwhile, the ketoconazole vaginal tablet improves the cure effect in using ketoconazole to cure colpitis, reduces toxic and side effects, provides more choices for clinical doctors and patients and is one of ideal ketoconazole partial-vagina administration medicament forms.

The invention discloses a Shuangzuotai vagina effervescence tablet which is prepared from the following raw materials: 200 g of metronidazole, 160 g of mycosporin, 8 g of chlorhexidine acetate, 50-53 g of starch, 125 g of citric acid, 109.6 g of sodium bicarbonate, 102-106 g of lactose, 8-12 g of sodium dodecyl sulfate, 8 g of magnesium stearate, 25 g of 10 wt% starch slurry and 25 g of 4 wt% HPMC solution. According to the Shuangzuotai vagina effervescence tablet, as citric acid and sodium bicarbonate are used as an effervescing agent, a proper amount of sodium dodecyl sulfate is added to be used as a foaming agent, and starch which has good disintegration performance and is economical and easily available and a proper amount of lactose are used as a filler, the prepared tablet can reach the established clinical medication standard and general principles of the Chinese Pharmacopeia 2010 second section on tablets in various aspects such as appearance, foam volume, pH value and the like.

The invention relates to the technical field of gynecological medical treatment, in particular to a formula for erosion removal vaginal effervescent tablets.The erosion removal vaginal effervescent tablets comprise, by weight, 2.5-3 parts of radix arnebiae seu lithospermi extract, 10-12 parts of citric acid, 8-10 parts of sodium bicarbonate, 20-24 parts of lactose and 2-3 parts of lubricants.A process for preparing the erosion removal virginal effervescent tablets includes preparation steps of dividing the lactose into two portions; uniformly mixing one portion of the lactose with the radix arnebiae seu lithospermi extract and the citric acid to obtain a first mixture; uniformly mixing the other portion of the lactose with the sodium bicarbonate to obtain a second mixture; respectively granulating the first mixture and the second mixture by the aid of 5% PVP (polyvinyl pyrrolidone) absolute ethyl alcohol solution to obtain granules; drying the granules at the temperature of 50 DEG C and uniformly mixing the granules with PEG-6000 (polyethylene glycol-6000) to obtain third mixtures; tabletting and shaping the third mixtures to obtain the erosion removal virginal effervescent tablets.The 5% PVP absolute ethyl alcohol solution is used as adhesive.The formula and the process have the advantages that the virginal effervescent tablets are prepared after effective components in radix arnebiae seu lithospermi are extracted, so that patients can conveniently utilize the vaginal effervescent tablets, each erosion removal vaginal effervescent tablet in a prescription contains an acid source and a carbon dioxide source, each acid source and the corresponding carbon dioxide source can quickly react to each other to generate carbon dioxide gas when in contact with water, accordingly, the tablets can be disintegrated within a short time, principle medicines can be released, medicines can be uniformly released along with foam, and contact between the medicines and the vaginal mucous membranes of the patients can be improved.

The invention provides a method of applying a topical preparation containing triamcinolone acetonide in treating or preventing cervical erosion. The preparation can comprise triamcinolone acetonide and other accessories or be a composition of triamcinolone acetonide and one antibiotic or more antibiotics. According to the treatment method provided in the invention, a variety of topical dosage forms of the preparation containing triamcinolone acetonide can be used, e.g., vaginal cream, vaginal gelata, vaginal suppository, vaginal effervescent tablets, vaginal tablets, vaginal ointment, etc. The preparation used in the method has anti-inflammatory and vasoconstrictive effects, has effective action on reducing, shallowing and eliminating an erosion area and is effective in inhibiting recurrence of triamcinolone acetonide.

A vaginal IgY effervescent tablet specifically to kill Candida albicans for treating mycotic vaginitis of woman, even if gravida and puerpera, is disclosed.

The invention discloses miconazole nitrate compound vaginal extended-release effervescent tablets and a preparation method thereof. The effervescent tablets comprise miconazole nitrate, Corydalis tuber, Tricyrtis root, lightyellow Sophora root, cutch, Wilson's passion flower, root of Silene tenuis, root-bark of shaggy-fruited dittany, fleeceflower root, Chinese mugwort leaf, sodium alginate, polyoxyethylene, fumaric acid, sodium carbonate, sodium bicarbonate, lauryl sodium sulfate, powdered sugar, and polysorbate. The preparation method includes: preparing materials, extracting effective ingredients of herbal materials, and performing granulating and tableting. The miconazole nitrate compound vaginal extended-release effervescent tablets are a Chinese and western medicine mixture, the defect that miconazole nitrate is only capable of killing germs and diminishing inflammation is effectively overcome, and the herbs are good in synergistic effect. Hydrophilic gel extended-release material is used as a medicinal auxiliary material, acting time of the tablets and administering interval can be prolonged, and bioavailability of the tablets can be improved; the tablets directly act on an affected part, take effect fast, are good in effect, are convenient to use and allow higher patient compliance.

The invention discloses a female vagina effervescent tablets and a preparation method thereof. The drug solutions of the following traditional Chinese drugs are extracted by supercritical CO2 extraction to prepare the vaginal effervescent tablets, wherein the traditional Chinese drugs comprise, by weight, 2-6 parts of common cnidium fruit, 2-6 parts of Chinese mosla herb, 1-5 parts of flatspine pricklyash, and 1-3 parts of Chinese pulsatilla. The pH value of the care solution of the present invention is 6-7, and the vagina effervescent tablets of the present invention have significant effects of bacteriostasis, insect disinfestation, antiinflammatory, itching alleviating, regio pudendalis cleaning, and odor removing.