Vaginal effervescent tablets for woman inflammation and their preparation

A technology for gynecological inflammation and effervescent tablets is applied in the field of Chinese patent medicine for treating gynecological inflammatory diseases and its preparation field, which can solve the problems of high cost, inconvenient transportation and storage, inability to extract, etc., and achieves increased utilization rate and improved drug efficacy. , the effect of reducing production costs

Inactive Publication Date: 2005-02-23
陈志成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are certain defects in the above-mentioned preparation process. For example, the rhubarb in the prescription is fried and extracted with more than 2 times the amount of sesame oil in the same pan. and other components are effectively extracted, and the water-soluble components of comfrey with antibacterial and anti-inflammatory effects are not utilized, so the therapeutic effects of rhubarb, comfrey and the formula cannot be fully exerted
In addition, after extracting rhubarb and comfrey with 650ml of sesame oil, the resulting medicinal oil was less than 365ml, indicating that more than 40% of the sesame oil was lost due to adsorption of medicinal residues and other reasons, resulting in waste; The prepared Fufuling suppository must be stored below 30°C, so it is inconvenient to transport and store, so it is necessary to improve the preparation process of the drug
On the other hand, from the perspective of dosage form, there is no report on the development of Kangfuling vaginal effervescent tablets.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of Medicinal Powder for the Treatment of Gynecological Inflammation

[0041] Raw material formula: rhubarb 248g, comfrey 100g, catechu 10g, borneol 7g.

[0042] Preparation method: (1) Take rhubarb and comfrey, extract them with 88% ethanol for 3 times, each time for 2 hours, filter, leave the dregs for later use, add β-cyclodextrin 60g, PVPk to the filtrate 30 60g and poloxamer 10g, mix well, recover ethanol under reduced pressure, and obtain the concentrated solution of alcohol extraction; take the dregs of the medicine and add water to decoct 2 times, each time for 1.5 hours, filter, and the filtrate is centrifuged at high speed, and the centrifugate is concentrated to a relative density of 1.23( 60°C), combined with the alcohol extraction concentrate, spray-dried and pulverized to obtain rhubarb and comfrey extract powder;

[0043] (2) Take borneol, 56g of β-cyclodextrin, and refer to the method [Song Hongtao, et al. Journal of Shenyang Pharm...

Embodiment 2

[0046] Example 2 Preparation of Medicinal Powder for Treatment of Gynecological Inflammation

[0047] Raw material formula: rhubarb 210g, comfrey 120g, catechu 12g, borneol 8g.

[0048] Preparation method: (1) get rhubarb, be crushed into coarse powder, sterilized, and ultrafinely pulverized into ultrafine powder with particle diameter≤10um to obtain rhubarb ultrafine powder;

[0049] (2) Get Comfrey, extract 2 times with 95% ethanol, each time for 2.5 hours, filter, the dregs are for subsequent use, add PVPk to the filtrate 30 70g, 30g of hydroxypropyl methylcellulose (HPMC-E5), 8g of soybean lecithin, stir well, recover ethanol under reduced pressure, concentrate to obtain alcohol extraction concentrate; take the dregs and add water to decoct twice, 1 hour each time , filtered, the filtrate was centrifuged at high speed, the centrifugate was concentrated to a relative density of 1.38, combined with the concentrated alcohol extraction solution, vacuum-dried at 60°C, and ult...

Embodiment 3

[0052] Example 3 Preparation of Medicinal Powder for Treatment of Gynecological Inflammation

[0053] Raw material formula: rhubarb 218g, comfrey 110g, catechu 13g, borneol 6g.

[0054] Preparation method: (1) get rhubarb, be crushed into coarse powder, sterilized, and ultrafinely pulverized into ultrafine powder with particle diameter≤10um to obtain rhubarb ultrafine powder;

[0055] (2) Take comfrey, extract 3 times with petroleum ether, each time for 1.5 hours, filter, use the dregs for later use, combine the filtrate, recover petroleum ether under reduced pressure, and add PEG to the residue 6000 80g, 30g of hydroxypropyl-β-cyclodextrin, 5g of lecithin, 550ml of ethanol, after heating to reflux for 40min, recover ethanol under reduced pressure, freeze-dry, and pulverize at low temperature to obtain fine powder of solubilized matter of fat-soluble extract of comfrey; take The dregs are decocted with water for 2 times, each time for 1.5 hours, filtered, the filtrate is cen...

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PUM

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Abstract

A vaginal effervescent tablet for treating gynecologic inflammation, such as vaginitis, cervicitis, cervical erosion, etc is prepared from rhubard, arnebia root, catechu, borneol, and the auxiliary chosen from organic acid, carbonate, filler, adhesive, disintegrant and lubricant.

Description

Technical field [0001] The invention belongs to the technical field of preparation of medicines, and in particular relates to a Chinese patent medicine for treating gynecological inflammatory diseases and a preparation method thereof. Background technique [0002] Gynecological inflammatory diseases such as adnexitis, pelvic inflammatory disease, vaginitis, cervicitis, cervical erosion, genital itching, and genital ulcers are common clinical diseases and frequently-occurring diseases. At present, there are many traditional Chinese medicine preparations for such diseases. However, due to factors such as slow or unstable curative effect, it still cannot meet the clinical needs. The variety "Fufuling Suppository" recorded in "Drug Standards of the Ministry of Health of the People's Republic of China" (eight volumes of traditional Chinese medicine preparations) is a suppository made from four traditional Chinese medicines, rhubarb, comfrey, catechu, and borneol. Dampness and in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/46A61P15/00A61P15/02
Inventor 陈志成
Owner 陈志成
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