7 results about "Pharmacological action" patented technology

The present invention relates to novel synthetic lipidic alkynylcarbinols, in particular as antibacterial agents, preferably against mycobacteria, and more preferably against species from the Mycobacterium tuberculosis complex, and also to therapeutic uses thereof. The present invention also relates to said compounds for use for the treatment of bacterial infections. The present invention further relates to the discovery of the pharmaceutical mechanism and bioactivity of these novel synthetic lipidic alkynylcarbinols.

The invention discloses a novel radial artery compression hemostasis device combining traditional Chinese medicine and western medicine methods, belongs to the technical field of medical instruments, and aims at solving the problems that an existing radial artery inflatable compressor is low in hemostasis efficiency, the pain of a patient is obvious, and the risk of complications is high. The device comprises an air bag, an inflation pipeline, a traditional Chinese medicine patch and a wrist strap, a Qihuang paste traditional Chinese medicine patch composed of safflower, radix arnebiae seu lithospermi, radix astragali, radix angelicae sinensis, dragon's blood, pollen typhae and musk is pasted to the center of the pressing face of the air bag, detachable wrist straps are symmetrically connected to the two sides of the air bag, and the inflation pipeline is communicated with the air bag to achieve inflation and pressurization. Through combination of physical compression and pharmacological action of traditional Chinese medicine, hemostasis and healing of a wound at a puncture position of the radial artery can be accelerated, analgesic and anti-inflammatory effects are achieved, compression time can be shortened, pain of a patient is relieved, infection is prevented, risks of complications such as stenosis and occlusion of the radial artery are reduced, and the hemostasis device is suitable for hemostasis nursing after puncture of the radial artery.

The invention discloses a michelia alba SSR (Simple Sequence Repeat) molecular marker primer group and application thereof. Belongs to the technical field of molecular markers. According to the method, high-throughput transcriptome sequencing data of michelia alba leaves is taken as a material, SSR marker sites are explored by utilizing MISA, corresponding primers are designed by utilizing Primer3 software, 34 parts of michelia alba germplasm are subjected to genetic diversity analysis by utilizing 47 pairs of screened polymorphic SSR primers, and the 34 parts of michelia alba germplasm is divided into three subgroups by clustering analysis. At present, research on michelia alba is mainly in the aspects of chemical components and pharmacological action, and previous research fully proves the development value of michelia alba. 47 pairs of SSR highly-polymorphic primers developed by the invention are suitable for michelia alba, the number of SSR molecular markers of michelia alba is enriched, a basis is provided for michelia alba genetic diversity research and germplasm resource analysis, and a theoretical basis is provided for michelia alba resource protection and utilization and other works.

The present application relates to a kind of mint taste heating cigarette, the preparation method of the mint taste heating cigarette includes: (1) after cutting Chinese medicine composition and tobacco raw material are mixed to obtain mixture, then the mixture is sequentially carried out microbial treatment and supercritical extraction, obtain supercritical material;(2) after supercritical material, mint additive and smoke agent are mixed, tobacco section is prepared by machine to obtain;(3) after filter tip section and tobacco section are wrapped by wrapping paper and formed, the mint taste heating cigarette is obtained;The Chinese medicine composition includes radix puerariae, radix scrophulariae and rhizoma coptidis;The mint additive includes any one or at least two combinations of mint leaf, mint class cooling agent or mint blasting bead.The heating cigarette of the present application is easy to stimulate gastrointestinal and other problems caused by mint additive, by adding suitable traditional Chinese medicine ingredients, combined with the pharmacological action of active ingredient, targetedly relieve this kind of gastrointestinal irritation, and will not cause additional burden to human body.

The invention discloses a camellia pollen total flavone extract as well as a preparation method and application thereof, and belongs to the technical field of medicines. According to the method, the optimal process for ultrasonically extracting the total flavonoids of the camellia pollen is explored, the influence of three single factors, namely the ethanol concentration, the ultrasonic time and the liquid-solid ratio, on the extraction rate of the total flavonoids of the camellia pollen is explored, and finally the three optimal single factors are selected. On the basis, through design of Design-Expert software, extraction conditions are optimized through a response surface method, and the optimal process is obtained as follows: the ethanol concentration is 73%, the ultrasonic time is 31 min, and the liquid-solid ratio is 31: 1 (mL.g <-1 >). Meanwhile, the extract is used for blood fat reduction research, and experiments prove that the camellia pollen total flavonoids have the drug effects of reducing the fat rate and improving hyperlipidemia. The method lays a foundation for extraction, separation and pharmacological action research of the camellia pollen total flavonoids.

The present invention relates to a polymorphic form of a nepicastat acid addition salt, a preparation method therefor and a use thereof. The acid addition salt is selected from hydrochloride, sulfate, phosphate, mesylate, benzenesulfonate, p-toluenesulfonate, hydrobromate, maleate, tartrate, citrate, and fumarate, preferably hydrochloride. The nepicastat acid addition salt has high polymorphic form stability, high solubility, high plasma concentration, high bioavailability, and excellent pharmacological action, and therefore is suitable for pharmaceutical preparations.

The present invention relates to novel synthetic lipidic alkynylcarbinols, in particular as antibacterial agents, preferably against mycobacteria, and more preferably against species from the Mycobacterium tuberculosis complex, and also to therapeutic uses thereof. The present invention also relates to said compounds for use for the treatment of bacterial infections. The present invention further relates to the discovery of the pharmaceutical mechanism and bioactivity of these novel synthetic lipidic alkynylcarbinols.