749 results about "Pharmacological action" patented technology

The invention provides a traditional Chinese medicinal dendrobium officinale preparation and a preparation method thereof. In the preparation method, by adopting freeze-drying and ultra-fine pulverization methods, dendrobium officinale is frozen to a brittle point or below vitreous temperature so that the dendrobium officinale is in a brittle state, then the dendrobium officinale is dried and pulverized in mechanical and pneumatic modes so that cell walls are broken, and finally ultra-fine powder is obtained. The preparation method has the beneficial effects of increasing specific surface area of the preparation, improving dissolution rate and bioavailability of effective ingredients, increasing absorption rate and absorption capacity for human body, enhancing pharmacological action and improving medicament effect up to 3-10 times as that of the traditional dendrobium officinale decoction pieces, thus reducing medicament consumption and saving medicinal materials.

This invention describes the large-scale fermentation and processing of Chinese caterpillar fungus. In this invention, hirsutella sinensis strains are used as the fermentation strain and cultivated in the inclined plate and shaking-bottle. 3-5% of potato, 0.5-2% of soybean powders, 0.01-0.02% of soifnum muicfun, 0.01-0.02% of Chinese yam, 0.5-2% of protein, 0.5-5% of glucose, a small amount of dipotassium hydrogen phosphorus and magnesium sulfate, and water culture medium are successively directed into all levels of fermenter for fermentation and processing. The yield of the fermented product is 20% higher than that in the present processes, the fermentation periodic time is 12 days shorter, the cost is 20% lower and the pollution rate is 2% lower. Through the DNA molecular sequence examination by the institute of microbes, Chinese Academy of Sciences, the constitution of the fermented product is the same with that of natural Chinese caterpillar fungus, and the content of cordycepin, adenosine, Chinese caterpillar fungus polyoses, sterol, biological base, amino acids and trace elements is much higher than that in natural Chinese caterpillar fungus. The pharmacological action of the fermented product is better than that of natural Chinese caterpillar fungus.

There is provided an FGF2 substitute containing medicinal composition which comprises, as an active ingredient, a chimeric protein comprising the amino acid sequence of an FGF1 protein in which a partial sequence including a sequence of at least positions 62-83 within a sequence of positions 41-83 is substituted with a partial sequence at the corresponding positions in the amino acid sequence of an FGF2 protein; and the remaining region is formed of the amino acid sequence of FGF1. In particular, this medicinal composition is used for wound healing and for the prevention and treatment of radiation-induced damage, and it exhibits a pharmacological action superior to that of an FGF2 medicinal composition, and further, it can be easily formulated into a preparation.

The invention discloses a salvianolic acid A for injection and its preparing process, wherein high efficiency liquid chromatography method is employed to determine salvianolic acid A in the raw material medicaments, the content of salvianolic acid A is between 92% and 100%, two foreign substances are present. The mass ratio of salvianolic acid A and anti-oxidizing agent in the preparation is 2-50:1, the pH of the injection is controlled to 3-7.

The invention discloses a total bufogenin extract with antitumor function and also discloses a preparation method of the extract and application thereof in the preparation of antitumor medicines. The total bufogenin extract of the invention is prepared by organic solvent extraction, column chromatography separation and purification of dried toadskin; the content of total bufogenin is over 80 percent, wherein the content of resibufogenin is over 12 percent, the content of cinobufagin is over 4 percent, and the content of bufotalin is over 10 percent. Compared with the prior art, the invention eliminates bufotenine alkaloid which has irritation, is easy to cause hypersensitivity but has no antitumor activity, efficiently collects the effective part of total bufogenin which has significant antitumor activity, therefore pharmacological action is stronger, the clinical curative effect is higher and the toxic and side effect is lower. The total bufogenin extract can be prepared into various pharmaceutical preparations for clinical application, therefore the invention has the functions of killing tumor cells, inducing differentiation and apoptosis of tumor cells, inhibiting the neovascularization of tumor cells and lowering the neoplasm metastasis rate, etc.

The present invention relates to the new use of narigenin and similar compounds in preparing medicines for treating cardiac and cerebral vascular diseases. These compounds include narigenin and its derivative, hesperidene and its derivative, isosakuranetin and its derivative, eriodictyol and its derivative, etc. These compounds may be used in preventing, diagnosing and treating cerebral infarction, myocardial infarction, cerebral ischemia-reperfusion injury, myocardial ischemia-reperfusion injury and other cardiac and cerebral vascular diseases as well as Alzheimer disease and its relevant diseases. These compounds have high pharmacological action, low toxicity, wide material source, low cost and other advantages.

The invention discloses a method for manufacturing salvianolic acid A of danshen root, which is characterized in that total salvianolic acid in the danshen root is transformed into salvianolic acid A by adopting a certain method. The method increases greatly the extraction yield of salvianolic acid A. The salvianolic acid A is prepared into tablets, capsule, granula, soft capsule, micro pill, dripping pill and oral liquid, which have good pharmacological action indicated by pharmacological experiments.

The invention discloses an ecological community structure layout method of healthcare gardens. The ecological community structure layout method of the healthcare gardens comprises performing strict classification, precision matching and reasonable application according to growth characteristics, functions and usages of all kinds of healthcare plants, and respectively mass-planting the plants in healthcare gardens of different forms according to needs through scientific design, consummate layout and corresponding compatibility; meanwhile, selecting relevant arbors which are vigorous, good in stress resistance and have pharmacological actions as a frame and utilizing healthcare plants of different varieties, clear functions and high ornamental values as a main body to build an ecological plant community. According to the ecological community structure layout method of the healthcare gardens, aesthetics, medicine pharmacology and environmental psychology are used as guidance, sightseeing gardens with healthcare effects are built through the application of biological measures, the healthcare plants, gardening architecture articles and the like, positive significance on public health maintenance, recreation and body-building, disease prevention and cure, wisdom development, tumor suppression and cancer prevention, body health and longevity, physical and mental health and the like can be obtained, and also social significance of energy saving and emission reduction, low carbon and environmental protection and ecological civilization promotion can be achieved.

The invention discloses a normal-temperature preparation method for ultrafine powder hawthorn. The method comprises the following steps of: cleaning hawthorn, and drying till the water content is less than or equal to 10 percent; smashing the hawthorn at the normal temperature to obtain coarse powder of which the granularity is 60-80 meshes; putting the coarse powder into a rod mill for smashing,conveying into the special bilateral airflow sieving machine through wind for sieving with a 500-mesh sieve, sieving to obtain powder of which the particle diameter is less than or equal to 25 micrometers, and conveying to a cyclone aggregator through airflow generated by a draught fan for collecting to obtain finished ultrafine powder coccidia powder; and collecting powder which is not sieved with the 500-mesh sieve with a funnel, and conveying to the rod mill through a pipeline for smashing circularly once again. The method has the advantages that: the entire preparation process is performed at the normal temperature without low temperature or special additional conditions; the particle diameter of prepared finished hawthorn micro powder is less than or equal to 25 micrometers, the cell-wall breaking rate and biological availability are greatly increased, and the pharmacological action of a medicament is enhanced; and due to the adoption of the bilateral airflow sieving machine, thepreparation process of ultrafine powder hawthorn is simplified, and the aim of controlling the quality standard of Chinese medicinal powder is fulfilled.

[Problem] To provide a compound which can be used for the prevention and/or treatment of diseases in which 5-HT_2B receptor and 5-HT₇ receptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS).

[Means for Resolution] It was found that an amide derivative characterized by the possession of a nitrogen-containing bicyclic hetero ring (e.g., an indole or the like), or a pharmaceutically acceptable salt thereof, has a strong antagonism for both of the 5-HT_2B receptor and 5-HT₇ receptor. In addition, the compound of the present invention having the antagonistic activity for both of the receptors showed a good pharmacological action in comparison with the case in which an antagonist selective for either one of the receptors was used alone. Based on the above, the compound of the present invention is useful for the prevention and/or treatment of diseases in which 5-HT_2B receptor and 5-HT₇ receptor are concerned, particularly for the treatment of irritable bowel syndrome (IBS).

The invention belongs to the field of pharmaceutical chemistry, and relates to a furazan derivative which is prepared by combining a coumarin parent nucleus and an isomer of the coumarin parent nucleus with a furazan oxide through linking of groups with different lengths and structures. It is proved by the experiments that the furazan derivative has excellent effects on inhibiting sensitive human tumour cells and drug-resistant tumor strains, and on inhibiting activity of normal growth of HUVEC for measuring an inhibiting action of neovascularization, and on inhibiting activity of cell proliferation of cis-platinum-resistant A2780 cell strains and gemcitabine-resistant HM231 cell strains. It is shown by an initial pharmacological mechanism that by releasing nitric oxide with the high concentration, the furazan derivative can induce apoptosis of cancer cells, inhibits MEK activity, and obviously inhibits phosphorylation of MEK in an MAPK/ERK channel, thereby generating a significant effect on inhibiting growth of a tumor. According to the composition in the invention, excellent basis for obtaining candidate medicines having inhibition activity of sensitive and drug-resistant tumors and for illustrating the pharmacological action is provided.

A system for the controlled release of one or more physiologically or pharmacologically active substances, comprising compositions in the form of micro particles or granules, particularly for use in the zootechnical and/or veterinary field. The micro particles include a core which contains one or more substances having a pharmacological action, food supplements or diagnostic media, said one or more substances being characterized by the presence, within their chemical structure, of a basic functional group, specifically including an amine functional group. The core comprises also one or more carboxylic acids and/or their salts and eventually one or more excipients. Said core is coated by an outer layer of fats or waxes, and preferably by a mixture of glyceride of fatty acids.

By applying a compound selected from jasmonic acid represented by the following general formula (I) or 2-substituted form of jasmonic acid or derivatives thereof or salts thereof, the pharmacological action of a pesticide such as a microbicide or a herbicide applied to the plant is enhanced.

(wherein R¹ is an alkyl group or an alkenyl group, and R² is a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a hydroxyalkyl group).

The invention relates to a setwall extract with hypnotic sedative activity and the preparation thereof and also comprises the application of the extract in the pharmacy field. The extract essentially consists of setwall naphtha, valerienic acid, total valepotriate, etc. The pharmacodynamical experiment shows that the setwall extract made by the technology has the marked pharmacological actions of mitigation, hypnosis, anti-depression, spasmolysis, analgesis, the regulation of blood fat, anti-tumor, antibiosis, antivirus and the like and can be developed into medicine or food with health care function.

The invention relates to a novel long-acting glucagons like peptide-1 (GLP-1) analog and a synthesis method thereof. The synthesis method comprises the following steps: modifying the 8th, 23rd or 37th site of the natural GLP-1 to obtain the GLP-1 analog having longer pharmacological action time; quickly synthesizing a peptide chain by adopting a microwave-promoted solid-phase synthesis method; reacting cysteine residues with a 4-hydroxyl coumarin analog to obtain a target polypeptide; purifying the crude product; and carrying out freeze-drying to obtain the GLP-1 analog.

The invention relates to an aminosalicylic acid derivative. The structure of the aminosalicylic acid derivative accords with the following general formula (I). At least one of R1, R2, R3 and R5 is -OH; when R1, R2, R3 and R5 are not -OH, R1, R2, R3 and R5 are -H, -OCH3, -F, -Cl, -Br, -CF3 or -NO3; R4 is -OCH3, -F, -Cl, -Br, -CF3 or -NO3; R6 and R7 are -COOH or -OH. When R6 is -COOH, R7 is -OH; when R6 is -OH, R7 is -COOH. In the invention, target compounds have strong protection function on PC12 cell injuries caused by glutamate. And the target compounds block the coupling between PSD-95 and nNOS by specificity to develop the pharmacological action.

The invention relates to long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through adding a modified 37th amino acid to natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to obtain the GLP-1 analogues.

Provided is a method of producing a dry earthworm powder without deterioration in useful pharmacological action, by removing dirt on the skin of earthworms while allowing the earthworms to excrete the digest remaining in the digestive tracts efficiently without weakening the earthworms, which comprises the steps of: standing living earthworms under light for 10 to 50 hours, removing the dirt formed on the skin thereof, adding an organic acid to the living earthworms, diluting the acid rapidly with addition of water, adjusting the pH of the aqueous acidic solution to 2 to 5, standing the earthworm mixture for 3 to 180 minutes under the pH condition, washing the earthworms with water, grinding the earthworms into a homogenate, freezing the homogenate at −18° C to −35°0 C, keeping the frozen homogenate for 20 to 240 hours, and freeze-drying and degassing the frozen homogenate under vacuum simultaneously.

The invention discloses a thousand-mesh traditional Chinese medicine preparation used for controlling livestock and poultry diarrhea, and a preparation method thereof. The preparation is prepared from mixed Chinese herbal medicines of, by weight: 6 to 11 parts of amur corktree bark, 6 to 11 parts of pericarpium arecae, 6 to 11 parts of radix gentianae, 8 to 15 parts of tuckahoe, 8 to 15 parts of eclipta prostrate, 3 to 5 parts of asiatic plantain seed, 3 to 5 parts of purslane, and 2 to 4 parts of manyleaf meadowrue root. The preparation provided by the invention is characterized in that: the preparation is prepared from pure Chinese medicines, and the formulation is reasonable. The preparation is formulated according to the principles of heat clearing, detoxificating, dampness dissipating, and diarrhea relieving with astringents. Different formulations show different pharmacologic actions. With the medicine formula provided by the invention, effects of root cause and symptom treating, healthy energy supporting, evil eliminating, comprehensive regulating, and yin-yang balancing can be achieved. The preparation provided by the invention provides substantial effects on livestock and poultry diarrhea caused by various factors, and provides a curative effect greatly higher than those of simple recipe medicines and other western medicine preparations. The preparation has advantages of wide sources of raw materials of Chinese herbal medicines, low cost, high recovery rate, no drug residue, no toxic or side-effect, and wide application range.

The invention discloses a Chinese medicinal herb ointment for treating seborrhoeic dermatitis and eczema and a preparation method thereof. The Chinese medicinal herb ointment is prepared by a completely new formula, namely cortex dictamni, wild chrysanthemum flower, radix arnebiae, coptis root, radix sophorae flavescentis, tribulus terrestris, poria, cnidium fruit and other Chinese medicinal herbs, has the efficacies of clearing away heat and toxic materials, eliminating dampness and converging, dispelling wind and arresting itching as well as eliminating swelling and reducing stagnation, and has the advantages of simple preparation process, wide medicine sources, low cost, obvious pharmacological action, significant treatment effect and no toxic or side effect.

The invention relates to a preparation method of effective fractions of shining wintersweet leaf, a preparation method and a use of a preparation thereof, in particular to an application of the effective fractions of the shining wintersweet leaf and the preparation thereof in drugs used for preventing and treating respiratory system diseases as well as in anti-cold drugs, antimicrobial drugs, anti-inflammation drugs, antiviral drugs, antifungal drugs, etc. In the invention, the volatile effective fractions and non-volatile effective fractions are added to the crude drug of the shining wintersweet medicinal material with a weight ratio of the actual extraction amount of the shining wintersweet to the effective fractions being 1.0-2.6:0.5-3.5, thus the effective fractions of the shining wintersweet leaf are obtained. A preparation of the effective fractions of the shining wintersweet can be made into granules, soft capsules, capsules, drop pills, tablets, compound capsules, dispersible tablets, etc. In the invention, the preparation of the shining wintersweet is deeply developed, which ensures that the preparation is rich in active ingredients, has definite effective ingredients, obvious pharmacological action and significant improvement of drug action. Besides, the preparation has stable performance and controllable quality, is safe and reliable, has less dosage, and is favorable for transportation and storage of the medicine as well as for patients to take.

The invention discloses a freeze dry injection of hirudin and its preparation process. It is characterized in that hirudin is extracted from fresh leech, pharmaceutic adjuvant can be added or not added after purification to prepare freeze dry injection formulation of hirudin, the character also lies in not adopting any organic solvent in the preparation method, but adopting purification methods of ultra filtration, ion exchange column chromatography and reverse osmosis condensation to get hirudin with comparative highly purity. The pharmacody experiment result indicates that the freeze dry injection has a favorable pharmacological action.