852 results about "P phosphate" patented technology

The invention discloses a carbon-coated sodium ferrous sulfate phosphate positive electrode material as well as a preparation method and application thereof. The carbon-coated sodium ferrous sulfate phosphate positive electrode material is square flaky particles formed by coating sodium ferrous sulfate phosphate with a conductive carbon material and irregular aggregates of the square flaky particles. The molecular formula of the sodium ferrous sulfate phosphate is Na (6-2x + y) Fex( SO4) (3-y) (PO4) y, x is more than 0 and less than 3, and y is more than 0 and less than or equal to 0.5. The invention also discloses a preparation method and application of the carbon-coated sodium ferrous sulfate phosphate positive electrode material. The positive electrode material has the advantages of phosphate and sulfate positive electrode materials, the voltage platform is high, the conductivity is excellent, the air stability is good, and the assembled battery has excellent chemical sodium storage performance, high discharge specific capacity, highly reversible charge-discharge reaction and good cycle performance. The method is simple in process, high in feasibility, low in raw material cost and easy to realize industrial production through a solution system.

The present application belongs to the technical field of battery materials. Disclosed are a doped iron (III) phosphate, a method for preparing same, and use thereof. The chemical formula of the doped iron (III) phosphate is (MnxFe1−x)@FePO4·2H2O, wherein 0<x<1. According to the present application, ferromanganese phosphate is used as a template agent for preparing the doped iron (III) phosphate. The doped iron (III) phosphate is regular in morphology and good in fluidity, facilitates washing and conveying, and can improve the electrochemical performance of the subsequently prepared LiFePO4 / C. When the doping amount of Mn is 11000 ppm, the specific discharge capacity of LiFePO4 / C at room temperature at 0.1 C rate can reach 165 mAh / g; the retention rate of the discharge capacity of 1000 cycles at 45° C. at 1 C rate can reach 97.4%; and at a low temperature of −15° C. the specific discharge capacity at 0.1 C rate is still 134 mAh / g.

The invention belongs to the field of modified self-repairing calcium aluminate cement 3D printing, and particularly relates to a phosphate modified self-repairing calcium aluminate cement 3D printing material and a preparation method thereof. The phosphate modified self-repairing calcium aluminate cement 3D printing material prepared by the invention is prepared from the following raw materials in parts by mass: 60 to 70 parts of calcium aluminate cement, 3 to 7 parts of silica fume, 2 to 4 parts of metakaolin, 0.5 to 3.5 parts of double-template modified calcium bentonite, 0.8 to 1.5 parts of amino modified sodium polyphosphate and 0.15 to 0.8 part of basalt fiber. The invention relates to a concrete anti-microbial agent, which is prepared from the following raw materials in parts by weight: 20-30 parts of water, 20-30 parts of water, 20-30 parts of water, 20-30 parts of nano calcium carbonate, 20-30 parts of nano calcium carbonate, 20-30 parts of magnesium phosphate cement coated bacteria-loaded porous microspheres, 20-30 parts of a polycarboxylate superplasticizer, 20-30 parts of an organic silicon defoaming agent and 25-35 parts of mixing water. The technical-economic cooperation requirement of building 3D printing under complex working conditions is met, and various indexes of phosphate modified calcium aluminate cement applied to the 3D printing technology are met.

The invention provides a safe lithium ion battery gel electrolyte as well as a preparation method and application thereof. The safe lithium ion battery gel electrolyte is prepared from the following raw materials: lithium salt, an organic solvent, a film-forming agent, a thermal initiator and a gel polymer monomer, the gel polymer monomer comprises an acrylic ester compound and a phosphate ester compound. According to the gel electrolyte provided by the invention, through cooperation and compounding of all the components, especially introduction of the phosphate ester compound, the electrolyte has relatively good safety performance; the acrylate compound has an acrylate functional group and plays a role of a cross-linking agent, the phosphate compound plays a flame-retardant role, and through thermal polymerization, phosphate with the flame-retardant role is distributed among battery pole pieces and among active particles of the pole pieces in a three-dimensional network manner along with the acrylate cross-linking agent; thermal runaway among active particles can be uniformly and effectively blocked, so that the safety of the battery can be improved.

The invention provides a phosphate of a compound shown in a formula (I) and a polymorphic substance of the phosphate, and the phosphate and the polymorphic substance of the phosphate have excellent hygroscopicity, solubility and stability, have excellent druggability and are suitable for industrial production and storage. In addition, the phosphate and the polymorph thereof have excellent pharmacokinetic properties.

The present invention belongs to the technical field of battery materials, and particularly relates to a composite phosphate-based positive electrode material, and a preparation method therefor and the use thereof. The composite phosphate-based positive electrode material comprises a phosphate-based active core, wherein the outer surface of the phosphate-based active core is sequentially coated with a carbon coating layer, a nitrogen-doped carbon coating layer and a nitrogen-phosphorus co-doped carbon coating layer from inside to outside, wherein the carbon coating layer can improve the electronic and ionic conductivity of the composite positive electrode material, and optimize the particle size and morphology of the composite positive electrode material. The nitrogen-doped carbon coating layer improves the consistency and integrity of coating; and nitrogen-atom-doped carbon further enhances the electronic conductivity and lithium-ion diffusion of the carbon coating layer. Electron-rich clouds of P and N atoms in the nitrogen-phosphorus co-doped carbon coating layer can provide a rich conductive network, mutual contact is formed among different particles to form a series network, thus promoting the interfacial electron transport of the composite material during a charging and discharging process, and improving the cycling and rate performance of the composite phosphate-based positive electrode material during the charging and discharging process.

The invention relates to the technical field of medical materials, in particular to an injection composition for endoscopic submucosal dissection and a preparation method and application thereof. The injection composition is prepared from the following raw materials: 1 to 5 w / v percent of sodium hydroxymethyl starch, 0.1 to 10 w / v percent of acetylcysteine, 0.2 to 4 w / v percent of polyvinylpyrrolidone, 0.001 to 0.1 w / v percent of coloring agent and the balance of phosphate buffer solution. The injection composition disclosed by the invention can be directly injected under mucous membranes, plays a role in upheaving diseased regions, has the advantages of long maintenance time and high upheaving degree, and has the effects of stopping bleeding and promoting wound healing.

The invention belongs to the technical field of pharmaceutical analysis, and relates to a method for detecting the content of povidone K30. According to the method, the content of povidone K30 in the medicinal preparation is detected by adopting a high performance liquid chromatography; detection conditions of the high performance liquid chromatography are as follows: a chromatographic column is a C18-AQ column; a mobile phase is a phosphate solution. The method has the characteristics of high accuracy, strong specificity and the like for detecting the content of povidone K30 in the pharmaceutical preparation, can overcome the interference of other auxiliary materials in the pharmaceutical preparation, and has important application value in development and consistency evaluation of the pharmaceutical preparation.

The invention relates to a betaine phosphate-containing feed additive for improving net energy level and a preparation method and application thereof, and belongs to the technical field of feed additives, the preparation method comprises the following steps: preparing composite betaine phosphate, preparing composite zinc methionine, and mixing; the preparation of the composite betaine phosphate comprises the following steps: preparing a betaine phosphate crude product, preparing a composite silicon dioxide carrier, and crystallizing; the preparation of the compound zinc methionine comprises the following steps: preparing an activated silicon dioxide carrier, adsorbing starch and adsorbing the zinc methionine; in the step of mixing, the compound betaine phosphate and the compound zinc methionine are mixed and then stirred at room temperature, and the betaine phosphate-containing feed additive capable of improving the net energy level is obtained. The feed additive prepared by the invention has a strong effect of improving the net energy level of broiler chickens, is not easy to have the problems of bonding and clustering, and is good in storage resistance.

The present invention belongs to the technical field of batteries. Disclosed are an iron(III) phosphate material, a preparation method therefor, and a use thereof. The iron(III) phosphate material comprises a carbon quantum dot core located internally and an iron(III) phosphate shell formed on the surface of the carbon quantum dot core, and the surface of the iron(III) phosphate shell is provided with a carbon coating layer formed from a carbon-containing dispersing agent. The iron(III) phosphate material is nanoscale iron(III) phosphate and has a uniform crystal size. The preparation method therefor comprises the following steps: mixing a first mixed solution containing a divalent iron salt and carbon quantum dots, a second mixed solution containing a phosphate and a dispersing agent, and an oxidizing agent to undergo a reaction to obtain iron(III) phosphate dihydrate; and annealing and calcining the iron(III) phosphate dihydrate. The iron(III) phosphate material can be further used for preparing a lithium iron phosphate positive electrode material and a battery.

A method for preparing exosomes is provided. The method includes preparing a human platelet, treating the human platelet with a buffer to obtain a platelet solution, centrifuging the platelet solution, and collecting supernatant of the centrifuged platelet solution to obtain an exosome solution. The buffer is calcium ion buffer, phosphate buffered saline (PBS), tris(hydroxymethyl)aminomethane hydrochloride (Tris-HCl) buffer, or 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES) buffer.

Engineering bacteria for expressing an alpha-glucose phosphate mutase gene, a glucose phosphate mutase gene, a difunctional enzyme glucose phosphate isomerase / mannose 6-phosphate isomerase gene and a mannose 6-phosphate phosphatase gene are used as a whole-cell catalyst, starch or a starch derivative is used as a substrate, phosphate and Mg < 2 + > are added, and the whole-cell engineering bacteria are obtained. A whole-cell catalysis system is constructed, and starch or starch derivatives can be efficiently catalyzed to synthesize D-mannose. According to the method, the D-mannose is prepared through whole-cell catalysis, and the method has the advantages of being low in cost, low in pollution, high in yield and the like and is suitable for industrial production of the D-mannose.

The application specifically discloses a phosphate-based positive electrode material and a preparation method and application thereof. The phosphate-based positive electrode material comprises base particles and a carbon coating layer coated on the surface of the base particles; the chemical formula of the base particles is Li x M y PO4, 0.96≤x≤1.08, 0.96≤y≤1, M comprises at least one of Fe and Mn; wherein, the M site is doped with a first metal element, the first metal element comprises at least one of Ti, V, Cr, Co, Ni, Nb, Mo and W; and / or, the Li site is doped with a second metal element, the second metal element comprises at least one of Mg and Zr; the carbon coating layer comprises a carbon material, and the degree of disorder I D / I G of the carbon material is ≤1.2. The application has the advantages of improving the electrochemical performance of the phosphate-based positive electrode material and reducing the ion elution rate thereof.

The invention discloses an iron-based phosphate material, a preparation method thereof and a sodium ion positive electrode material. The preparation method of the iron-based phosphate material comprises the following steps: S1, mixing raw materials containing a sodium source, an iron source, a phosphorus source and a carbon source to obtain a precursor mixture; s2, granulating the precursor mixture to obtain precursor particles; s3, carrying out fluidized roasting on the precursor particles in a circulating fluidized bed reactor in a fluidizing medium to obtain iron-based phosphate material particles; and S4, the iron-based phosphate material particles are subjected to powder making treatment, and iron-based phosphate material powder is obtained. Precursor granulation and fluidized roasting are carried out, and the influence of the reaction heat effect on the purity and performance of the iron-based phosphate polyanion type sodium ion battery positive electrode material is solved; and by using the carbon source gas, the defects of a carbon coating layer of the material are reduced, the performance of the iron-based phosphate polyanionic sodium ion battery positive electrode material is improved, and the positive electrode material has remarkable beneficial effects.

The present invention discloses a method for detecting MPL in a sample and its related applications, relating to the field of biological detection. The adsorbent includes aluminum phosphate or a product obtained by mixing aluminum hydroxide and a phosphate solution, which can effectively adsorb free MPL in the sample, thereby achieving effective separation of free MPL and MPL bound to liposomes in the sample. By detecting the difference in MPL content in the sample before and after adsorption, the proportion of free MPL and MPL bound to liposomes in the sample can be determined. This method has the advantages of being easy to implement, low cost, and high efficiency. It does not require expensive reagents and instruments, and can quickly and accurately calculate the encapsulation rate of MPL in liposomes, providing a new approach for quality control of adjuvants or vaccines containing MPL.

The present invention relates to an ophthalmic preparation. The ophthalmic preparation comprises: penehyclidine hydrochloride, phosphate buffer, sodium chloride and hypromellose; wherein, based on the total volume of the ophthalmic preparation, the concentration of the phosphate buffer is not higher than 25 mM and not 0 mM, the mass-volume ratio of penehyclidine hydrochloride is 0.01% - 2%, and the mass ratio of penehyclidine hydrochloride to sodium chloride is (0.011 - 0.85):1. The ophthalmic preparation of the present invention has the advantages of low irritation and high stability.

The invention relates to an extraction method, a modification method and application of dendrobium nobile outer vesicles. The method comprises the following steps: placing dendrobium nobile leaves in a phosphate buffer solution, crushing and separating to ensure that plant cells are fully broken and outer vesicles are released; then a differential centrifugation method is combined with sucrose gradient centrifugation, finally, the outer vesicles in a sucrose solution with the mass concentration of 30-45% are selected, and the extracted dendrobium nobile outer vesicles are moderate in mass and high in purity. Then cholesterol structural analogues such as sterol compounds and triterpenoid saponin active molecules are embedded into a phospholipid bilayer of the dendrobium nobile outer vesicles to modify the dendrobium nobile outer vesicles, and the modification strategy can effectively improve the stability of the dendrobium nobile outer vesicles in a complex physiological environment; and the treatment effect can be enhanced through the synergism of active molecules and endogenous components of the vesicles.

Disclosed is a phosphate e precursor, which has a chemical formula of LixMy(PO4)(x+y) / 2Az·wH2O, where M is a transition metal element selected from one or more of Fe, Ti, V, Cr, Ni, Co, Mn, Al, Nb, Y, Zr, Sb, Mo, Sn, and Ce, A is one or more of F, OH, CO32−, C2O42−, and O2−; and 0.5≥x<1.2, 0.5<y≥1, 0≥z≥1, and 0.1≥w<8. The phosphate precursor has good uniformity, contains crystal water, and exhibits excellent structural stability, and can be used to prepare olivine-type phosphate cathode material through sintering at a low temperature of 260° C.-600° C.; and the phosphate precursor is blended with a carbon source and is subjected to heat treatment to obtain carbon-contained cathode material, which has good electrochemical properties.

The invention belongs to the technical field of batteries, and particularly relates to a doped phosphate positive electrode material and a preparation method and application thereof. The doped phosphate positive electrode material comprises a phosphate active material and a doped metal element doped in a crystal structure of the phosphate active material; according to the doped phosphate positive electrode material, under the condition that the pressure is 100-500 MPa, the maximum deformation quantity of particles is smaller than 50%, and the reversible deformation quantity is smaller than 10%. By doping the metal elements in the crystal structure of the phosphate-based active material, the structure of the doped phosphate-based positive electrode material is optimized, the structural stability of the doped phosphate-based positive electrode material is improved, the compression modulus of the positive electrode material is improved, and meanwhile, the chemical components and the electronic structure of the surface of the positive electrode material can be changed; therefore, the doped phosphate positive electrode material has the characteristics of relatively high ionic conductivity, electron conductivity, gram volume, cycling stability and the like.

The invention discloses a bone cement composition and application thereof, and relates to the technical field of bone cement. The bone cement composition comprises a solid phase component and a liquid phase component, wherein the solid phase component comprises 60-75 parts of composite calcium phosphate, 10-20 parts of strontium glass powder, 8-12 parts of a reinforcing agent and 3-7 parts of a solidification reaction regulator; the liquid phase component comprises 20-30 parts of a phosphate buffer solution, 3-8 parts of a sodium citrate solution, 5-15 parts of an anti-inflammatory agent and 1-5 parts of a hyaluronic acid solution. The preparation method comprises the following steps: reacting 1, 10-phenanthrene-2, 9-dicarboxylic acid with 2-aminomethyl furan to obtain an intermediate 1, and reacting the intermediate 1 with poly (ethylene glycol) maleimide to prepare the reinforcing agent. The prepared bone cement composition has good mechanical properties, self-repairing performance and anti-inflammatory performance, and has a good application prospect in the field of bone repairing.

The invention discloses bioactive gel for accelerating wound healing. The gel is prepared from the following raw materials in percentage by weight: 0.8%-1% of bomer 980, 5%-5.5% of glycerol, 15%-20% of white vaseline, 51.7%-55% of phosphate buffer, 1.8%-2% of nano royal jelly acid, 2%-3% of recombinant III type human collagen, 0.4%-0.5% of sodium hyaluronate, 1%-3% of sodium alginate, 20%-25% of polyethylene glycol-400, 1.5%-3% of dopamine-methacrylamide copolymer, 0.5%-0.8% of nano silver and 0.3%-0.5% of phenoxyethanol. The nano royal jelly acid and the nano silver have a synergistic antibacterial effect, so that the inhibition effect on drug-resistant bacteria such as MRSA and pseudomonas aeruginosa is remarkably improved, and meanwhile, the wound epithelization can be accelerated and scar formation can be reduced through the dual effects of the recombinant III type collagen and the acetylated sodium hyaluronate. The defects that a traditional dressing is narrow in antibacterial spectrum, single in repairing effect, poor in environmental adaptability and the like are overcome, and the dressing is particularly suitable for complicated wounds such as diabetic foot ulcer and second-degree burn.

A radioactive thermogel suspension, including a thermogel and a plurality of insoluble radioactive isotope phosphate particles, such as yttrium phosphate, suspended in the thermogel. The thermogel is PLGA-g-PEG. The thermogel contains less than 65 ppm stannous octanoate. The plurality of radioactive yttrium phosphate particles are between 0.03 μm and 10 μm in diameter. The plurality of radioactive yttrium phosphate particles are generally spherical. The YPO4 particle concentration is in the range of 3 mg / ml to 100 mg / ml.

According to the cell fixing liquid, phenol oxidase is used for catalyzing phenol to be oxidized into a quinone structure, the quinone structure reacts with protein amido to form light covalent immobilization, cell immobilization is achieved, a stable hydration environment and membrane protection are provided through the ionic liquid solvent choline dihydrogen phosphate, a phosphate-free buffer system is provided, and cell immobilization is achieved. Therefore, a novel cell fixing liquid is obtained, the cell structure integrity required by cell imaging analysis is effectively reserved, meanwhile, cell staining fluorescence signal interference is avoided, and therefore the accuracy of cell counting and cell imaging analysis is ensured.

The present invention relates to a nanomaterial for preventing tumor bone metastasis, a preparation method therefor, and use thereof. The present invention has discovered a spatiotemporal coupling interaction between tumor cells and osteoclasts, and provides a tumor-bone initial metastasis behavior-targeting strategy which can accurately prevent tumor metastasis on the basis of the source, and can avoid drug resistance and biochemical drug resistance. On this basis, the present invention designs a physical killing nanomaterial targeting tumor-osteoclast conjugates, the nanomaterial being a bone targeting group-modified nanovesicle encapsulating a carbonate compound and a phosphate compound. The nanomaterial can be effectively concentrated in bone tissue; when tumor cells are activated, the acid secretion function of tumor-related osteoclasts in nearby tumor-osteoclast conjugates which are in contact with the tumor cells triggers the carbonate compound to generate carbon dioxide gas and promotes the release of the phosphate compound, which forms calcium phosphate crystals with calcium ions so as to kill nearby tumor cells, thus achieving a specific very-early tumor metastasis inhibition effect.

The invention discloses an oral instant compound nystatin liniment and a preparation method thereof, the oral instant compound nystatin liniment comprises a powder agent and a mixed solvent which are separately packaged, and the powder agent comprises nystatin, vitamin B2, a diluent and an antioxidant; the mixed solvent comprises glycerol, a thickening agent, water or a phosphate buffer solution. The liniment is prepared by adopting a dry-wet separation method, one part of the liniment is mixture powder containing nystatin, the other part of the liniment is a mixed solvent capable of enabling medicine powder to be quickly dispersed and stably stored, and the mixture powder and the mixed solvent are respectively sealed and packaged and are automatically mixed before being used, so that long-term stable storage of the main component nystatin is facilitated; the alkalescent phosphate buffer solution is adopted, so that the stability after the suspension coating agent is prepared is improved. The liniment is simple in formula, convenient to use, capable of being stably stored for a long time and easy to convert and industrially produce.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

The invention relates to the technical field of water pollution treatment, and particularly discloses a preparation method of phosphorus removal polymer gel, which comprises the following steps: reacting sodium alginate, modified ferroferric oxide-hydroxyapatite, N-(hydroxymethyl) acrylamide, acrylamide and a cross-linking agent to obtain the phosphorus removal polymer gel; the nano-hydroxyapatite and the nano-ferroferric oxide in the polymer gel have rich micropores, specific surface area and adsorption sites, the sodium alginate can form a three-dimensional network structure, provide supporting and fixing effects and increase the specific surface area and the adsorption sites of the material, and through the synergistic effect of adsorption and precipitation of the polymer gel, the specific surface area and the adsorption sites of the material are increased. The method has the advantages that phosphate can be efficiently removed, nano ferroferric oxide has superparamagnetism, rapid separation and effective recovery can be realized through a magnetic separation method, the recovery process is simplified, the recovery cost is reduced, secondary pollution is reduced, and the method is green and environment-friendly.

2'-deoxycytidine-5'-monophosphate and an enzymatic synthesis method therefor, relating to the technical field of biosynthesis. The synthesis method comprises: constructing a first engineered strain and a second engineered strain; respectively carrying out fermentation culture and protein separation and purification on the first engineered strain and the second engineered strain to obtain high-purity deoxycytidine kinase and high-purity polyphosphate kinase; using 2'-deoxycytidine as a deoxycytidine substrate and adenosine triphosphate as a phosphate donor, cyclically feeding polyphosphate, and keeping the ratio of adenosine triphosphate to polyphosphate to a preset ratio to form an enzymatic reaction system; and performing an enzymatic reaction to obtain 2'-deoxycytidine-5'-monophosphate. High-concentration deoxycytidine monophosphate can be quickly and effectively produced, so that pollution hazards caused by a chemical synthesis method can be solved, and the input amount of adenosine triphosphate as a phosphate donor in a biosynthesis system can also be reduced, thereby reducing production costs.

The invention provides a method for detecting vitamin B6 related substances in a multivitamin preparation, and belongs to the field of analytical chemistry. According to the method, a high performance liquid chromatograph is adopted, and chromatographic conditions are as follows: an octadecyl silane bonded silica gel chromatographic column is adopted, a mobile phase is a phosphate buffered solution (containing sodium hexanesulfonate)-acetonitrile, and a mobile phase A and a mobile phase B are performed according to a gradient procedure; the flow velocity is 0.8 to 1.2 mL / min; the column temperature is 28-40 DEG C, the detection wavelength is 320-340nm, and the sample size is 20-50mu L. The detection method has the advantages of high sensitivity and good linear relationship, and is suitable for analysis and content determination of vitamin B6 related substances in various vitamin preparations.

The invention belongs to the technical field of sodium ion batteries, and mainly relates to a multifunctional site co-doped high-rate multi-element iron-based phosphate positive electrode material, a preparation method thereof and a sodium ion battery. The chemical formula of the multi-functional-site co-doped high-rate multi-element iron-based phosphate positive electrode material is Na [4-(3 + n) y] Fe (3-x) Mgx (PO4) 2-y (A) yP2O7 / C, x is more than 0.001 and less than 0.05, y is more than 0.001 and less than 0.5, n is the valence state of doped anions, and is-2 or-4, and y is the valence state of doped anions. The doped anion element A is selected from one or more of a group consisting of SiO4 < 4->, SO4 < 2-> and CO3 < 2->. According to the positive electrode material, iron ions are partially replaced by magnesium ions, the transmission rate of sodium ions is increased, the interface charge transfer resistance is reduced, phosphate radicals are replaced by doped anions, the crystal structure of the material is stabilized, the stability of crystal lattices is enhanced, and the high-power discharge capacity of the material is improved.