423 results about "Bioactive glass" patented technology

The invention discloses bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement. The bone cement for orthopedic repair comprises solid-phase powder and a liquid-phase component, the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate, 10-15 parts of bioactive glass, 2-3 parts of a developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of a modified toughening agent and 2-3 parts of nano cellulose fibers; the liquid phase component is prepared from the following components in parts by weight: 40 to 50 parts of a sodium alginate solution, 10 to 20 parts of methacrylated gelatin, 0.5 to 1 part of transglutaminase, 30 to 60 parts of a citric acid buffer solution and 1 to 2 parts of an antibacterial agent. The preparation method comprises the following steps: reacting pentaerythritol with 12-oxododecanoic acid to obtain an intermediate 1, and reacting the intermediate 1 with dopamine to prepare the modified toughening agent. The bone cement for orthopedic repair prepared by the invention has good mechanical, self-repairing and antibacterial properties.

The present invention uses commercially available 3-aminopropylsilane coupling agent, diallylamino polyether acrylate, and an alkylating agent, or γ-propanesultone, or γ-butyrolactone as raw materials, and through an aza-Michael addition reaction and a quaternization reaction, a multifunctional silane coupling agent containing one or more quaternary ammonium cations, or sulfobetaine, or carboxybetaine in its molecular structure is prepared, which is used for the surface modification of bioactive glass, and the bioactivity, antibacterial and antifungal properties, and hydrophilicity enhancement effects after the surface modification of bioactive glass are obtained.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention discloses an oral care desensitization paste and a preparation method thereof, and mainly relates to the technical field of dental medicines. The oral care desensitization cream is prepared from the following components: bioactive glass, strontium chloride, sodium chloride, silicon dioxide, sodium carboxymethyl cellulose, polyethylene glycol 400, a xanthan gum solution, sodium lauryl sulfate, sodium lauroyl sarcosinate, titanium dioxide, beta-glucan, saccharin sodium salt, sorbitol, methylparaben, propyl hydroxybenzoate, edible essence and water. Compared with the prior art, the oral care desensitization paste disclosed by the invention can be used for sealing dentinal tubules and treating hemodia; the traditional Chinese medicine composition can also be used for treating plaque gingivitis, relieving and reducing gingival bleeding and inhibiting and reducing dental plaque; and meanwhile, the condition of mistakenly swallowing and eating in the using process is reduced.

The invention discloses a preparation method and application of a BG (at) ZIF-8 organic-inorganic nanofiber membrane, and belongs to the field of biomedical composite materials. The method comprises the following steps: preparing BG through high-temperature calcination, wrapping the BG in ZIF-8 by using a wrapping technology to form BG-coated ZIF-8, and then carrying out microfluidic electrostatic spinning on the BG-coated ZIF-8, PCL and PVA to obtain a nanofiber membrane containing Zn < 2 + >, Ca < 2 + > and Si < 4 + > for diabetes wound healing. The ions can be slowly released to promote growth factor expression and revascularization. Experiments prove that BG (at) ZIF-8 / PCL-PVA can inhibit diabetes mellitus wound inflammation and accelerate healing. The composite fiber membrane using the micro-fluidic electrostatic spinning technology provides a new view angle for wound healing of diabetes, and is a potential efficient treatment strategy.

The invention discloses a surface-modified bioactive glass oral cavity desensitization paste and a preparation method thereof, and relates to the technical field of oral cavity desensitization pastes. The surface-modified bioactive glass oral desensitization paste is prepared from the following raw materials in parts by weight: 5 to 15 parts of bioactive glass, 3 to 6 parts of modifier, 3 to 5 parts of silicon dioxide, 20 to 30 parts of humectant, 0.5 to 1 part of sweetening agent, 0.5 to 1.5 parts of foaming agent, 0.5 to 2 parts of thickening agent and 60 to 120 parts of deionized water. The surface modified bioactive glass oral cavity desensitization paste prepared by the invention has excellent antibacterial performance and dentinal tubule sealing effect.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

The invention relates to a soft tissue incremental scaffold material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the soft tissue incremental scaffold material comprises the following steps that S1, a collagen solution and bioactive glass are evenly mixed, and a mixture is obtained; the mass ratio of collagen to the bioactive glass in the collagen solution is (4-19): 1; s2, carrying out freeze drying and crosslinking on the mixed solution to obtain a crosslinked material; s3, placing the cross-linking material in a hydrogen peroxide solution for modification treatment; the mass fraction of hydrogen peroxide in the hydrogen peroxide solution is 2-6%; and S4, repeating the step S3 until the sodium content and the crosslinking agent residue in the modified material meet the requirements, thereby obtaining the soft tissue incremental scaffold material. The soft tissue increment scaffold material prepared by the invention has proper pore structure and pH, lower cytotoxicity, higher recovery rate after compression and lower thickness increase rate after water absorption, and is beneficial to regeneration of soft tissues.

The various implementations described herein include adhesive compositions for high-voltage focused ultrasound applications. In one aspect, an ultrasound transducer comprises a plurality of tiles. Each tile includes a first electrically conductive layer, a second electrically conductive layer, a plurality of transducer elements disposed between the first electrically conductive layer and the second electrically conductive layer, and a composite structural adhesive (a) disposed between the first electrically conductive layer and the second electrically conductive layer and (b) disposed between respective adjacent transducer elements of the plurality of transducer elements. The composite structural adhesive includes an epoxy resin, fumed silica, and a powder selected from the group consisting of: (i) micronized mica, (ii) bioactive glass powder, and (iii) micronized mica and bioactive glass powder.

The invention relates to the technical field of medical materials, and discloses a preparation method of a bioactive glass fiber reinforced polylactic acid composite material, which comprises the following steps: (1) carrying out plasma treatment on bioactive glass fibers; (2) dissolving chitosan in an acetic acid aqueous solution, and then adding the treated bioactive glass fibers to obtain a mixed solution I; (3) adding the bioactive glass powder into a sodium tripolyphosphate aqueous solution, and then carrying out ball milling to obtain a mixed solution II; (4) gradually adding the mixed solution II into the mixed solution I, stirring at the same time, and continuously stirring overnight after the stirring is finished; then filtering and drying to obtain modified glass fibers; and (5) mixing the modified glass fiber and the polylactic acid particles, and performing melt extrusion to obtain the polylactic acid composite material. The modified bioactive glass fibers are compounded with the polylactic acid material, so that the mechanical strength of the composite material can be remarkably improved, and the composite material can be better used as an orthopedic implant material.

The invention discloses magnesium-containing mesoporous active bioglass with drug sustained release, immunoregulation and bone metabolism regulation effects and application thereof. The drug-loaded MBGN is prepared by doping Mg ions and loading drugs, and the drug-loaded MBGN has good biocompatibility and can be decomposed in an acid environment to achieve controllable slow release of the drugs; on the other hand, released ions such as Si, Ca and Mg have a certain immunoregulation function, polarization of macrophages from M1 type to M2 type is promoted, inflammatory response is reduced, differentiation and maturation of osteoclasts are inhibited, and meanwhile, the released ions and drugs carried in mesopores play a synergistic effect, so that a good treatment effect is achieved. The drug-loaded MBGN provided by the invention has various biological properties, can overcome the defects of low drug loading rate, insufficient anti-inflammatory effect and the like when the existing mesoporous bioactive glass material is applied clinically, and has a good application prospect.

The invention discloses an antibacterial bioactive glass composite material for skull defect repair and a preparation method thereof, and relates to the technical field of bioactive glass materials. The antibacterial bioactive glass composite material for skull defect repair is prepared from the following raw materials in parts by weight: 8 to 15 parts of collagen, 45 to 55 parts of bioactive glass, 20 to 30 parts of hydroxyapatite, 5 to 8 parts of a toughening agent, 1 to 2 parts of an antibacterial agent and 150 to 250 parts of deionized water. The antibacterial bioactive glass composite material for skull defect repair prepared by the invention has excellent bending strength and antibacterial property.

The invention belongs to the technical field of medical materials, and relates to a bioactive glass composition as well as a preparation method and application thereof. The present invention provides a bioactive glass composition, which comprises: a base material, which is a bioactive glass; the surface of the base material is modified by a polyphenol compound. According to the invention, after being subjected to polyphenol compound surface modification, the bioactive glass shows a better sealing effect when being used for dentin exposure sensitive sealing, so that the drug loading rate, the biocompatibility, the water solubility, the biological activity and the antibacterial effect of the bioactive glass are improved; moreover, the acid-resistant stability and the wear-resistant stability of the sealing effect can also be improved when the sealing agent is used for repairing the dentin exposure sensitivity.

The invention relates to the technical field of biomedical materials, and discloses an antioxidant nano double-response drug delivery system and a preparation method and application thereof.The preparation method comprises the steps that mesoporous bioactive glass nano-particles with the particle size being 100-400 nm, the aperture being 2-10 nm and the specific surface area being 200-800 m < 2 > / g are adopted, amino functionalization is conducted on the surfaces, and the mesoporous bioactive glass nano-particles are prepared; the preparation method comprises the following steps: adsorbing a micromolecular antioxidant drug to mesoporous channels and surfaces of nanoparticles by using a rotary evaporation method, and finally grafting a pH-sensitive and ROS-responsive gated polymer by adopting an amide reaction to construct a nano drug delivery system capable of releasing the antioxidant drug in a pH-ROS dual-response manner, and the nano drug delivery system has good biocompatibility, and can be used for preparing a drug delivery system for the antioxidant drug in a pH-ROS dual-response manner. Antioxidant drugs can be released by intelligently responding to low pH and high ROS; by releasing small-molecule antioxidant drugs, free radicals are eliminated, oxidative stress is relieved, inflammatory response is inhibited, and the hydrogel has good application prospects in the fields of diabetes mellitus chronic wound healing, tissue engineering drug release, cancer treatment, tumor resistance and the like.

The invention relates to injectable high-strength hydrogel for bone tissue repair and a preparation method of the injectable high-strength hydrogel, a poly (hydroxyethyl acrylate-methyl acrylate) random copolymer is prepared through solution polymerization, the copolymer is fully swelled in water to obtain physical cross-linked hydrogel, and the injectable high-strength hydrogel is injectable and gelling in vivo under the action of shear thinning. And the water spitting of the gel is enhanced under physiological conditions. And mixing bioactive glass capable of forming hydrogen bond crosslinking with the copolymer to prepare the injectable high-strength hydrogel. The hydrogel not only can provide good support for a bone defect part, but also can promote proliferation and differentiation of internal cells of the bone defect part. The hydrogel disclosed by the invention is simple to prepare, convenient to operate, rapid in response, good in biocompatibility, relatively good in self-repairing capability, injectable and small in minimally invasive injury, and has a good application prospect in the field of irregular bone defect repairing.

The invention relates to a method for forming fluorite from a fluid containing fluoride ions by using bioactive glass and a filter medium containing bioactive glass. A method of forming fluorite from an F-containing aqueous fluid, the method comprising: contacting a bioactive glass comprising calcium with an F-containing aqueous fluid; and forming fluorite. A filter medium for forming fluorite from an F-containing aqueous fluid and a filter comprising the filter medium, the filter medium comprising: a bioactive glass comprising calcium; and at least one of sand, gravel, charcoal, polymer particles, and ceramic particles.

The invention discloses a surface-modified bioactive glass tooth desensitizer as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: sequentially adding prepared MBG nanoparticles and dopamine hydrochloride into a Tris-HCI buffer solution, stirring at room temperature, centrifuging, collecting a product, washing, taking precipitate, adding deionized water, carrying out ultrasonic dispersion, dissolving gelatin into the deionized water, mixing with an MBG (at) PDA solution, stirring, centrifuging, collecting a product, washing, and carrying out vacuum freeze drying to obtain MBG (at) PDA (at) Gel powder. The medicine provided by the invention is a medicine for treating dentin hypersensitivity more safely and lastingly, so that generated mineral substances are tightly combined with dentin tubule walls, and long-acting dentin desensitization is realized by resisting a complex oral environment.

The invention relates to the technical field of biological ceramic materials, in particular to a zirconium oxide bone repair scaffold material with a porous interconnection structure and a preparation method of the zirconium oxide bone repair scaffold material. The invention aims to solve the problems of poor mechanical property and fragile interconnection structure of the existing stent under high porosity. The core preparation process comprises the following steps of: performing acetone steam annealing and pre-fusion on a double-particle-size microsphere template to form a stable interconnection window prototype; then, a continuous hole wall main body is constructed through vacuum impregnation of high-viscosity zirconium oxide slurry, and then secondary positioning reinforcement is conducted on the interconnected neck parts through low-viscosity nano zirconium oxide sol; finally, diluted bioactive glass sol is introduced to endow the surface with biological activity, and a final product is obtained through temperature-controlled degreasing and sintering. According to the method, the pore connectivity, the mechanical strength and the biological activity of the scaffold are synergistically optimized through template pre-fusion and partition sequential processes, and the method is suitable for repairing load-bearing bone defects.

The invention discloses an absorbable soft artificial bone material and a preparation method thereof, and relates to the technical field of medical materials. The absorbable soft artificial bone material comprises the following raw materials in parts by weight: 30-60 parts of bioactive glass, 20-50 parts of collagen, 10-30 parts of a reinforcing agent, 1-3 parts of an antibacterial agent, 5-10 parts of a pore forming agent and 100-180 parts of deionized water. The absorbable soft artificial bone material prepared by the invention has good compressive strength and fracture toughness and excellent antibacterial performance.

The invention relates to the technical field of oral care and anhydrous toothpaste, in particular to bioactive glass-containing anhydrous toothpaste based on rheological property regulation and control and a preparation method and application thereof.The anhydrous toothpaste adopts glycerin and polyethylene glycol as a humectant compound system to construct an anhydrous system, and the situation that active ingredients of bioactive glass lose efficacy when meeting water is avoided; and the chemical activity and the structural stability can be kept during long-term storage. A thickening agent compound system composed of carbomer, quaternary ammonium salt-22 and hydroxypropyl gelatin is cooperatively adopted, so that a rigid-soft, compact and firm spatial network structure can be formed, an abrasive and bioactive glass particles can be stably suspended for a long time, the high activity of bioactive glass is kept, and the bioactivity of the bioactive glass is improved. And in the aspect of rheological properties, the composite material shows excellent thixotropy, relatively high structure recovery rate and appropriate yield stress, and has a remarkable remineralization repair effect and an excellent sensory effect. And the preparation process is simple, low in cost and suitable for large-scale industrial production.

The invention relates to a bioactive glass material, an oral care composition, toothpaste and a preparation method thereof. The bioactive glass material belongs to a Na2O-CaO-SiO2-P2O5 system and is prepared from the following components in percentage by weight: 40 to 60 percent of SiO2, 1 to 10 percent of P2O5, 18 to 30 percent of CaO and 10 to 30 percent of Na2O. An X-ray diffraction pattern of the bioactive glass material comprises diffraction peaks with the following 2 theta angle values: 33.6 + / -0.2 degrees and 34.2 + / -0.2 degrees. The bioactive glass material provided by the invention has a special crystal structure, elements such as calcium, phosphorus, silicon and the like can be dissolved out more quickly, a silica glass network and hydroxyapatite are generated, the bioactive glass material can react with the tooth surface more quickly, remineralization of the dentin surface is realized, and the effect of relieving or treating dentin hypersensitivity is achieved.

The invention provides a mesoporous bioactive glass hybrid material and a preparation method and application thereof, and relates to the technical field of biomedical materials.According to the method, through a multi-step reaction method, a silane coupling agent and epsilon-polylysine are used as connecting molecules, and the mesoporous bioactive glass hybrid material is prepared. A mesoporous bioactive glass hybrid material with macrophage targeting, immunoregulation and bone regeneration functions is prepared, and the hybrid material can target macrophages, regulate and control the polarization state of the macrophages to be converted from a proinflammatory phenotype to an anti-inflammatory phenotype, enhance the bone immunoregulation ability and improve the bone regeneration effect. And the material shows excellent osteogenic induction performance in an in-vitro experiment, and a new thought is provided for research and development of bone repair materials. The method adopted by the invention is simple and easy to implement, and the prepared mesoporous bioglass hybrid material has good application potential in bone immunoregulation and bone tissue repair.

An article and a method of making the article. The article can include a conformable matrix comprising a mixture of collagen, bioactive glass, and an additive selected from cellulose and / or alginate; wherein the article is a conformable wound dressing. Methods of making articles and methods of using articles to treat wounds are described.

The invention relates to the technical field of biomedical materials, in particular to medical bioglass wound repair gel and a preparation method and application thereof, and the preparation method comprises the following steps: mixing sodium carboxymethyl cellulose or a substitute thereof with glycerol or a substitute thereof to form a pre-dispersion system; adding water to dissolve and homogenize the pre-dispersed system; dissolving sodium dihydrogen phosphate or a substitute thereof in water to ensure that the electrolyte is completely dissolved; pouring an electrolyte solution into the pre-dispersion system to form a gel matrix; adding the bioactive glass into the gel matrix, so that the bioactive glass is dispersed in the gel; transferring the gel into a homogenizer, so that the gel is uniformly ground; and putting the gel into a vacuum degasser, removing bubbles, and finally filling and sterilizing to obtain the gel. In the nursing of various non-chronic wounds and surrounding skin, an effective physical barrier is formed, a suitable microenvironment is created for wound healing, wound healing is accelerated, scar formation is reduced, and the rehabilitation experience of a patient is improved.

The invention relates to the technical field of oral biomedical materials, and particularly discloses a nanoscale calcium sodium phosphosilicate material composition and a preparation method thereof. The nanoscale calcium sodium phosphosilicate material composition is prepared from bioactive glass, glass silica gel, calcium salt and phosphate, and the oxide composition of the bioactive glass is limited. The nano-scale sodium calcium phosphate silicate material composition has high biological activity and can fully play a mineralization role in a saliva environment, and hydroxyapatite newly formed in the mineralization process can fully fill defects and holes in the tooth surface, so that the microhardness of the tooth surface is effectively improved within a short time, and the tooth quality is improved. The repair of damaged teeth is effectively realized.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The present application relates to the field of biological glass, in particular to a kind of composite biological glass and its preparation method and application.The present application uses rhBMP-2, doped antibacterial ion 45S5 bioactive glass and polyethylene glycol-lactide-glycolide polymer compound preparation slow-release antibacterial biological glass, the rhBMP-2 can occur synergistic effect with doped antibacterial ion 45S5 bioactive glass, compared with homologous growth factor can play more optimal synergy with antibacterial ion, so as to have higher antibacterial property and osteogenesis, while having longer slow-release effect in polyethylene glycol-lactide-glycolide polymer.The composite biological glass provided by the present application overcomes the pain points of the prior art for the treatment of oral bone defect, improves the treatment effect, reduces the amount of antibiotic use, and reduces the risk of infection.

The present invention belongs to the field of preparation of diabetes complication remission agents, and particularly relates to a combined preparation for improving microcirculation of diabetic foot and a preparation method thereof. Starting from platelet-rich plasma, the present invention obtains exosomes containing rich active substances such as growth factors through stimulation with calcium gluconate and the like, and loads protamine nanoparticles to obtain bioactive substances with strong antibacterial ability, which can resist the development process of diabetic foot ulcers. The present invention uses bioactive glass, hydroxyethyl cellulose and the like to stabilize the bioactive substances, prolong the in vitro lifespan of the bioactive substances, and modified carboxymethyl cellulose provides better biodegradation effect. The combined preparation prepared by the present invention has less cytotoxicity, better antibacterial effect, can promote wound healing quickly, and the microcirculation index shows that it can stimulate the change of foot blood flow and improve the condition of foot artery blockage, etc.

The application discloses a bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement.The bone cement for orthopedic repair comprises solid-phase powder and liquid-phase components; the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate salt, 10-15 parts of bioactive glass, 2-3 parts of developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of modified toughening agent and 2-3 parts of nanocellulose fiber; and the liquid-phase components comprise the following components in parts by weight: 40-50 parts of sodium alginate solution, 10-20 parts of methacrylated gelatin, 0.5-1 part of transglutaminase, 30-60 parts of citric acid buffer and 1-2 parts of antibacterial agent. The intermediate 1 is obtained by the reaction of pentaerythritol and 12-oxododecanoic acid, and the modified toughening agent is prepared by the reaction of the intermediate 1 and dopamine. The bone cement for orthopedic repair prepared by the application has good mechanical properties, self-repairing performance and antibacterial performance.

An aqueous dentifrice formulation, comprising: a bioactive glass exhibiting at least one of: a hydrolytic resistance of glass grains (HGB) of at most 4, when measured by International Organization for Standardization section 719 (ISO 719); a weight loss of 5 wt. % or less after soaking 5 g of the bioactive glass in powder form in 100 mL of deionized water for 7 days at 37° C.; an XRD spectrum substantially free of crystalline phase after soaking 5 g of the bioactive glass in powder form in 100 mL of deionized water for 7 days at 37° C.; or any combination thereof; wherein, when the bioactive glass is contacted with artificial saliva, the bioactive glass forms a bioactive crystalline phase. A method of using the aqueous dentifrice formulation to remineralize enamel of the tooth, treat caries of the tooth, treat dentin hypersensitivity of the tooth, or any combination thereof.