99 results about "Bioactive glass" patented technology

The invention discloses a surface-modified bioactive glass oral cavity desensitization paste and a preparation method thereof, and relates to the technical field of oral cavity desensitization pastes. The surface-modified bioactive glass oral desensitization paste is prepared from the following raw materials in parts by weight: 5 to 15 parts of bioactive glass, 3 to 6 parts of modifier, 3 to 5 parts of silicon dioxide, 20 to 30 parts of humectant, 0.5 to 1 part of sweetening agent, 0.5 to 1.5 parts of foaming agent, 0.5 to 2 parts of thickening agent and 60 to 120 parts of deionized water. The surface modified bioactive glass oral cavity desensitization paste prepared by the invention has excellent antibacterial performance and dentinal tubule sealing effect.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

The invention discloses an antibacterial bioactive glass composite material for skull defect repair and a preparation method thereof, and relates to the technical field of bioactive glass materials. The antibacterial bioactive glass composite material for skull defect repair is prepared from the following raw materials in parts by weight: 8 to 15 parts of collagen, 45 to 55 parts of bioactive glass, 20 to 30 parts of hydroxyapatite, 5 to 8 parts of a toughening agent, 1 to 2 parts of an antibacterial agent and 150 to 250 parts of deionized water. The antibacterial bioactive glass composite material for skull defect repair prepared by the invention has excellent bending strength and antibacterial property.

The invention relates to the technical field of biological ceramic materials, in particular to a zirconium oxide bone repair scaffold material with a porous interconnection structure and a preparation method of the zirconium oxide bone repair scaffold material. The invention aims to solve the problems of poor mechanical property and fragile interconnection structure of the existing stent under high porosity. The core preparation process comprises the following steps of: performing acetone steam annealing and pre-fusion on a double-particle-size microsphere template to form a stable interconnection window prototype; then, a continuous hole wall main body is constructed through vacuum impregnation of high-viscosity zirconium oxide slurry, and then secondary positioning reinforcement is conducted on the interconnected neck parts through low-viscosity nano zirconium oxide sol; finally, diluted bioactive glass sol is introduced to endow the surface with biological activity, and a final product is obtained through temperature-controlled degreasing and sintering. According to the method, the pore connectivity, the mechanical strength and the biological activity of the scaffold are synergistically optimized through template pre-fusion and partition sequential processes, and the method is suitable for repairing load-bearing bone defects.

The invention discloses an absorbable soft artificial bone material and a preparation method thereof, and relates to the technical field of medical materials. The absorbable soft artificial bone material comprises the following raw materials in parts by weight: 30-60 parts of bioactive glass, 20-50 parts of collagen, 10-30 parts of a reinforcing agent, 1-3 parts of an antibacterial agent, 5-10 parts of a pore forming agent and 100-180 parts of deionized water. The absorbable soft artificial bone material prepared by the invention has good compressive strength and fracture toughness and excellent antibacterial performance.

The invention relates to the technical field of oral care and anhydrous toothpaste, in particular to bioactive glass-containing anhydrous toothpaste based on rheological property regulation and control and a preparation method and application thereof.The anhydrous toothpaste adopts glycerin and polyethylene glycol as a humectant compound system to construct an anhydrous system, and the situation that active ingredients of bioactive glass lose efficacy when meeting water is avoided; and the chemical activity and the structural stability can be kept during long-term storage. A thickening agent compound system composed of carbomer, quaternary ammonium salt-22 and hydroxypropyl gelatin is cooperatively adopted, so that a rigid-soft, compact and firm spatial network structure can be formed, an abrasive and bioactive glass particles can be stably suspended for a long time, the high activity of bioactive glass is kept, and the bioactivity of the bioactive glass is improved. And in the aspect of rheological properties, the composite material shows excellent thixotropy, relatively high structure recovery rate and appropriate yield stress, and has a remarkable remineralization repair effect and an excellent sensory effect. And the preparation process is simple, low in cost and suitable for large-scale industrial production.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

The application discloses an oat protein-based edible preservative film and a preparation method thereof. The edible preservative film is prepared from the following raw materials: oat protein aggregates, carboxymethyl cellulose, water, glycerol and bioactive glass. The preparation method comprises the following steps: oat protein aggregates are added into water and stirred uniformly to obtain a first mixed solution; carboxymethyl cellulose is added into water and stirred uniformly to obtain a second mixed solution; the first mixed solution and the second mixed solution are mixed, then glycerol and copper-doped mesoporous bioactive glass are added in sequence, and stirred for a period of time to obtain a film-forming solution; the film-forming solution is poured into a plane substrate, and then dried to obtain the oat protein-based edible preservative film. The oat protein is modified by heat treatment to obtain oat protein aggregates, the obtained oat protein aggregates are used for film preparation, a composite film is obtained, and the transparency, flexibility and barrier property of the composite film are significantly improved.

The present invention relates to the technical field of biodegradable materials. Disclosed is a preparation method for a bioactive glass fiber reinforced polylactic acid composite material. The preparation method comprises the following steps: (1) subjecting bioactive glass fibers to a plasma treatment; (2) dissolving chitosan in an aqueous acetic acid solution, and then adding the treated bioactive glass fibers thereto, so as to obtain a mixed solution I; (3) adding a bioactive glass powder to an aqueous sodium tripolyphosphate solution, and then subjecting same to ball milling, so as to obtain a mixed solution II; (4) gradually adding the mixed solution II to the mixed solution I while stirring same, continuously stirring same overnight after the addition is finished, and then conducting filtering and drying, so as to obtain modified glass fibers; and (5) mixing the modified glass fibers with polylactic acid particles, and then subjecting the resulting mixture to melt extrusion, so as to obtain a polylactic acid composite material. In the present invention, by compounding modified bioactive glass fibers with a polylactic acid material, the mechanical strength of the composite material can be significantly improved.

A dentifrice composition, comprising: sodium monofluorophosphate; a bioactive glass, comprising: 10-60 wt.% SiO2; 0.1-15 wt.% ZrO2; 10-60 wt.% CaO; and 1-30 wt.% P2O5; based on total weight of the bioactive glass; and water in an amount of at least 20 wt.%, based on total weight of the dentifrice composition.

The invention discloses a wound repair material and a preparation method thereof, and relates to the technical field of medical materials. The wound repair material is prepared from the following raw materials in parts by weight: 50 to 60 parts of bioactive glass, 15 to 30 parts of chitosan, 10 to 20 parts of functional materials and 300 to 450 parts of deionized water. The preparation method comprises the following steps: reacting oleamide propyl dimethylamine with 4-chlorobutanol to generate an intermediate 1, reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate an intermediate 2, and reacting the intermediate 2 with 4, 4 '-{[6-((1-carboxyl-2-mercaptoethyl) amino)-1, 3, 5-triazine-2, 4-diyl] bis (nitrounit)} bis [4-(2-carboxyethyl) pimelic acid] under the action of a photoinitiator to generate the functional material. The wound repair material prepared by the invention has excellent antibacterial property and hemostatic property.

The invention discloses a medical-grade PEEK composite material for 3D printing and a preparation method of the medical-grade PEEK composite material, relates to the technical field of 3D printing, and solves the problem of low biological activity of an existing PEEK material. The medical-grade PEEK composite material is prepared from the following raw materials in parts by weight: 80-95 parts of a polyether-ether-ketone matrix, 5-15 parts of a bioactive filler, 0.5-5 parts of an interface modifier and 0.1-3 parts of a heat conduction and nucleation enhancer, the bioactive filler comprises nano-hydroxyapatite and bioactive glass in a weight ratio of (1-5): (5-1). The natural bone environment can be effectively simulated, the biological activity of the composite material is improved, and cell adhesion and proliferation are promoted, so that the cell proliferation rate is increased, and the antibacterial effect and the mechanical property of the composite material can be effectively improved.

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.

A dentifrice formulation includes a solvent, a humectant, and a bioactive glass. The bioactive glass includes greater than or equal to 15 wt % and less than or equal to 45 wt % SiO2, greater than or equal to 30 wt % and less than or equal to 60 wt % CaO, greater than or equal to 8 wt % and less than or equal to 30 wt % P2O5, and greater than or equal to 2 wt % and less than or equal to 15 wt % ZrO2.

The invention relates to the technical field of biological material manufacturing, in particular to vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds and a preparation method of the vanadium-doped mesoporous bioactive glass powder. Adding an ammonia solution into the template agent solution to obtain a mixed solution; adding a silicon source, a phosphorus source, a calcium source and a vanadium source into the mixed solution in batches according to a preset interval time under a continuous stirring condition, continuously stirring and reacting for 5.5-24 hours, and centrifuging and collecting a precipitation product; and washing, roasting and grinding the obtained precipitation product to obtain the vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds.

The invention relates to the technical field of medical composite materials, in particular to a high-compatibility bioactive glass composite material and a preparation method thereof. The preparation method comprises the following steps: synthesizing Mg / Sr-doped hydroxyapatite nano-powder and Zn / Li-doped bioactive glass microspheres, blending the Mg / Sr-doped hydroxyapatite nano-powder and the Zn / Li-doped bioactive glass microspheres with polycaprolactone, and preparing a stent primary blank with gradient pores which are dense outside and sparse inside through a low-temperature deposition 3D printing technology; and by taking the primary blank as a receiving device and adopting a coaxial electrostatic spinning technology, constructing a core-shell structure nanofiber functional layer loaded with the BMP-2 growth factor on the surface and in internal pores of the primary blank in situ. By regulating and controlling the composition of the bioactive glass and introducing functional metal ions, local alkaline stimulation caused by rapid release of ions after the material is implanted is reduced, and meanwhile, by combining a multi-gradient composite structure design and controllable loading of growth factors, synergistic improvement of biocompatibility, bioactivity and mechanical support performance of the composite material is realized; the bone regeneration can be effectively promoted, the stress damage is reduced, and the method is suitable for bone defect repair.

The application discloses a customizable biphasic hydrogel scaffold, which comprises a transparent cartilage layer and a subchondral bone layer, the transparent cartilage layer comprises methacrylated type I recombinant collagen and bone marrow mesenchymal stem cells, and the subchondral bone layer comprises methacrylated type I recombinant collagen and resveratrol-loaded bioactive glass. The application further provides a preparation method and application of the biphasic hydrogel scaffold. The biphasic hydrogel scaffold has the advantages of customization, antioxidation, anti-inflammation, high biocompatibility, promotion of wound healing and bone repair and the like.

The present application relates to a kind of zinc-doped antibacterial carbon dots and its preparation method and application, the preparation method of the zinc-doped antibacterial carbon dots is that biomass, anhydrous zinc acetate is dispersed in deionized water according to mass ratio, after ultrasonic stirring, mixed solution is obtained, after hydrothermal reaction, mixed solution is obtained after natural cooling, centrifugal, filtration treatment, carbon dot solution is obtained, carbon dot solution is obtained after freeze-drying treatment, and powder zinc-doped antibacterial carbon dots are obtained.Then zinc-doped antibacterial carbon dots are dissolved in double distilled water with carboxymethyl chitosan, bioactive glass according to proportion, stirring is obtained at room temperature, and composite hydrogel is obtained.The zinc-doped antibacterial carbon dots and composite hydrogel prepared in the present application have good antibacterial effect, the preparation process of composite hydrogel is simple, low in cost, low in cytotoxicity, and zinc-doped antibacterial carbon dots have wide application prospect in the preparation of antibacterial material and the treatment of skin deep lesions, diabetic wound and burn wound dressing material.

A composition, comprising: a bioactive glass, comprising: 10-60 wt.% SiO2; 0-15 wt.% ZrO2; 10-60 wt.% CaO; and 1-30 wt.% P2O5; based on total weight of the bioactive glass; at least one first amino acid comprising a side chain, the side chain having a functional group having a pKa of 7 or less; and at least one second amino acid different from the first amino acid, the at least one second amino acid having an isoelectric point of 5-8; wherein the composition has a pH of 5-9.

The invention discloses functional bioactive glass as well as a preparation method and application thereof, and relates to the technical field of regenerative medical materials.The functional bioactive glass provided by the invention takes silicon, calcium, phosphorus and sodium as basic components, a porous structure is constructed by introducing nano zinc oxide (ZnO), and hydrophilicity and dispersity are improved by utilizing short amylose surface grafting. The nano zinc oxide is used as a pore-forming template and is selectively dissolved out in the subsequent steps to form sphere-like pores with the pore diameter of 1-30nm and the porosity of 30-70%, so that physical support is provided for cell adhesion and bone tissue ingrowth. The short amylose is grafted on the surface of the glass through a covalent bond of an amino silane coupling agent, and hydroxyl (-OH) on a molecular chain of the short amylose and water molecules form a hydrogen bond, so that the contact angle of the material is obviously reduced, and particle aggregation is effectively inhibited.

The invention belongs to the technical field of bioactive glass, and particularly relates to bioactive glass and a multi-process synergistic preparation method thereof.The method comprises the following steps that silicon dioxide, calcium oxide, sodium oxide and phosphorus pentoxide are selected as basic raw materials; putting into a reaction container, adding a silane coupling agent solution, and mixing with calcium oxide, sodium oxide and phosphorus pentoxide; putting into a crucible, and putting into a high-temperature smelting furnace; the temperature is raised to 800-1000 DEG C in the first stage, and the temperature is raised to 1300-1500 DEG C in the second stage, so that molten glass is obtained; pouring into a mold, transferring into supercritical fluid equipment, quenching and reducing pressure, and recovering gaseous supercritical carbon dioxide, thereby obtaining the bioactive glass at the same time. The affinity is enhanced, the uniformity and consistency are improved, the quality stability is improved, the energy consumption is reduced, and the production cost is saved. The microstructure can be controlled, the cracking risk is reduced, meanwhile, a nanoscale pore structure is formed, the compressive strength and toughness are enhanced, and environmental pollution is reduced.

This invention discloses a tooth powder with whitening, stain removal, and anti-inflammatory effects, and its preparation method. The tooth powder is a compound of a whitening system, an antibacterial and anti-inflammatory system and a microbiome regulation system, a repair and abrasion system, and a taste-correcting and preservative system. Its core utilizes a specifically formulated biofilm complex enzyme, which can efficiently decompose dental plaque biofilm. Combined with sodium phytate and niacinamide, it achieves gentle whitening and stain removal; with epigallocatechin gallate and baicalin, it achieves targeted antibacterial and anti-inflammatory effects; with probiotic components, it regulates the oral microbiome; and with hydroxyapatite and 45S5 bioactive glass, it repairs tooth enamel. This invention employs customized embedding technology and a graded low-temperature preparation process, significantly improving the storage stability of the active ingredients. The tooth powder of this invention is gentle and non-irritating, does not damage tooth enamel, does not disrupt the oral microecological balance, and has multiple oral care effects with long-lasting and non-rebounding results, making it suitable for large-scale industrial production and long-term use by various population groups.

The invention provides a bioactive glass collagen composite material and a preparation method thereof. The composite material comprises bioactive glass and collagen, and the bioactive glass and the collagen are mixed together. The method comprises the following steps: 1) taking a collagen solution; 2) taking bioactive glass, and uniformly mixing the bioactive glass with neutral salt to obtain a mixture; 3) adding the mixture into a collagen solution in a stirring state to obtain a precipitate which contains bioactive glass, collagen and residual neutral salt; and 4) filtering out the precipitate, and fully washing to remove neutral salt to obtain the bioactive glass collagen composite material. The design is reasonable, the conception is ingenious, the composite material can form a structure similar to a natural bone tissue in a human body, and the bioactive glass and the collagen of the composite material prepared by the method are uniformly mixed.

A dentifrice composition comprises a tubule blocking agent, wherein the tubule blocking agent comprises a bioactive glass, and wherein the tubule blocking agent has an average particle size of less than 4 µm.

The utility model belongs to the technical field of mesoporous bioactive glass preparation, and discloses a stirring device with a homogenizing function for mesoporous bioactive glass preparation, which comprises a stirring tank, a sealing cover is arranged at the top of the stirring tank, and a stirring shaft penetrates through the sealing cover. The stirring shaft in the stirring tank is respectively provided with a frame type paddle and a turbine type paddle, the stirring shaft above the sealing cover is connected with a stirring driving assembly, the stirring shaft is connected with a shaft body cooling assembly, the shaft body cooling assembly comprises a cooling channel formed in the stirring shaft, and the cooling channel is communicated with the stirring driving assembly. The two ends of the cooling channel are connected with a top rotating joint and a bottom rotating joint respectively, and the top rotating joint is connected with a water guide pump through a pipeline, so that cold water penetrates through the cooling channel in the stirring shaft to absorb heat generated by long-time high rotation of the stirring shaft, and deformation of the stirring shaft due to overheating is avoided; the stability of the stirring system is ensured.

This invention relates to the field of bioceramic materials technology, specifically to a porous interconnected zirconia bone repair scaffold material and its preparation method. This invention aims to address the problems of poor mechanical properties and fragile interconnected structures in existing scaffolds under high porosity. The core preparation process includes: using a dual-size microsphere template, pre-fusion via acetone vapor annealing to form a stable interconnected window prototype; subsequently, constructing a continuous pore wall body by vacuum impregnation with high-viscosity zirconia slurry; then, using low-viscosity nano-zirconia sol for secondary positioning and reinforcement of the interconnected necks; finally, introducing diluted bioactive glass sol to impart surface bioactivity, followed by temperature-controlled degreasing and sintering to obtain the final product. This method, through template pre-fusion and a zoned sequential process, synergistically optimizes the scaffold's pore connectivity, mechanical strength, and bioactivity, making it suitable for the repair of weight-bearing bone defects.

The invention provides an injectable porous microsphere mesenchymal stem cell compound as well as a preparation method and application thereof, and relates to the field of biomedical materials and regenerative medicine. The injectable porous microsphere mesenchymal stem cell compound comprises a carrier and mesenchymal stem cells loaded on the carrier, the carrier is dMBG / PLGA porous microspheres, the dMBG / PLGA porous microspheres are prepared from dMBG and PLGA, the dMBG is dendritic mesoporous bioactive glass, and the PLGA is a polylactic acid-glycolic acid copolymer; the mesenchymal stem cells enter the three-dimensional through hole channels of the carrier and are planted in the three-dimensional through hole channels. According to the injectable porous microsphere mesenchymal stem cell compound, efficient planting and local retention of MSC can be achieved, high activity of cells after injection and cryopreservation resuscitation is guaranteed, and endogenous osteogenesis can be promoted without exogenous factors; meanwhile, the system has the functions of promoting angiogenesis, regulating immunity and repairing nerves, can fill irregular defects in a minimally invasive mode, can be applied in a large scale, is adaptive to various repairing scenes, and meets the clinical application requirements.

The application discloses a wound repairing material and a preparation method thereof, and relates to the technical field of medical materials. The wound repairing material comprises the following raw materials in parts by weight: 50-60 parts of bioactive glass, 15-30 parts of chitosan, 10-20 parts of functional material, and 300-450 parts of deionized water. The intermediate 1 is generated by the reaction of oleamide propyl dimethylamine and 4-chlorobutanol, the intermediate 2 is generated by the reaction of the intermediate 1 and 5,10,15,20-tetra(4-carboxyphenyl)porphyrin, and the functional material is generated by the reaction of the intermediate 2 and 4,4'-{[6-((1-carboxyl-2-mercaptoethyl)amino)-1,3,5-triazine-2,4-diyl]bis(nitrene)}bis[4-(2-carboxyethyl)heptanedioic acid] under the action of a photoinitiator. The wound repairing material prepared by the application has excellent antibacterial performance and hemostatic performance.

This application provides a toothpaste with antibacterial, anti-cavity, and teeth-strengthening effects, and its preparation method, relating to the field of daily chemical products technology. The toothpaste provided by this invention includes an antibacterial repair agent, which, by weight, comprises: 5-15 parts β-glucan, 2-8 parts mannoerythritol ester, and 2-8 parts Hedychium spirica extract. This invention combines β-glucan, mannoerythritol ester, and Hedychium spirica extract in a combination added to the toothpaste, which can reduce the amount of strontium fluoride and / or sodium fluoride, bioactive glass, etc., effectively achieving long-lasting protection and strengthening teeth.