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Functional dressing, and preparation method and application thereof

A functional and raw material technology, applied in the field of medical materials, can solve problems such as the complexity of the low-temperature quenching process, and achieve the effects of reducing scar formation, wide application range, and good curative effect

Active Publication Date: 2014-01-22
成都迪康中科生物医学材料有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding a chemical cross-linking agent in this method has certain biological toxicity, and requires a complex low-temperature quenching process

Method used

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  • Functional dressing, and preparation method and application thereof
  • Functional dressing, and preparation method and application thereof
  • Functional dressing, and preparation method and application thereof

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Experimental program
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Effect test

Embodiment Construction

[0058] The functional dressing of the present invention adopts the mixture of alginate and chitosan as the carrier of bioactive glass; bioactive glass is hereinafter referred to as BG: it is based on CaSiO 3 , CaHPO 4 、Na 2 SiO 3 As a raw material, it is mixed according to the following weight percentage (wt%): CaSiO 3 40.5%~45.0%, CaHPO 4 10%~11.5%,Na 2 SiO 3 45% to 48%, melted at 1350-1460°C to form a uniform high-temperature melt, rapidly quenched, and ground to a particle size of 0.038-0.08mm with an agate ball mill to make powdered bioactive glass.

[0059] The following is the functional dressing film-forming and related performance formula screening experiments of the present invention.

[0060] Table 1 Formulation design table of alginate / chitosan / bioactive glass (BG)

[0061] Sample serial number

Alginate mass (parts)

Chitosan (parts)

BG (parts)

water (parts)

1#

24

0

0

240

2#

20

4

2

200

...

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Abstract

The invention relates to an active wound repair material, specifically to a functional dressing and a preparation method and application thereof, belonging to the field of medical materials. To overcome a technical problem, the invention provides the functional dressing, which belongs to biologically active wound repair materials. The functional dressing is prepared from the following raw materials by weight: 2 to 6 parts of biologically active glass, 12 to 20 parts of alginate, 4 to 12 parts of chitosan and 100 to 200 parts of water. Multiple dosage forms can be prepared from the above-mentioned raw materials, mainly comprising a gel, a dressing, etc. The functional dressing provided by the invention has the advantages of bacteriostatic action on a wound, promotion of wound healing and growth, adsorption of a small amount of tissue exudates, good biosecurity, waterproof performance, a bacterium blocking effect, etc. The functional dressing has a wide application scope, is applicable to mechanical trauma and operative incision (wound) and exerts a good therapeutic effect on hard-healing wounds like burns and scalds, diabetic foot, ulcer and pressure sores and a good curative effect on an infectious wound and a delayed union wound.

Description

technical field [0001] The invention belongs to the field of medical materials and relates to active wound repair materials, in particular to a functional dressing and its preparation method and application. Background technique [0002] Wound active repair materials can stimulate the migration of epidermal cells and fibroblasts, reduce the circulatory resistance of newly repaired blood vessels, hinder the deposition of granulocytes, inhibit the swelling of vascular endothelium, reduce the accumulation of cell debris in blood vessels, and greatly reduce the blood resistance of microvascular and the incidence of embolism, thereby improving local microcirculation, tissue repair, and promoting blood vessel growth. It can be used to treat wounds with a small amount of exudate, mechanical trauma, contusion, diabetic ulcers, decubitus ulcers, pressure ulcers, skin and mucous membranes Ulcers and erosive lesions, localized burns, wounds caused by various operations and trauma, surg...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/44
Inventor 高海利张凯李晓萍
Owner 成都迪康中科生物医学材料有限公司
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