The invention discloses a
nickel-based monatomic catalyst suitable for a glucose electrochemical sensor and preparation and application of the
nickel-based monatomic catalyst. Bis (
cyclopentadiene)
nickel (II),
melamine and a carbon-based nano material are mixed and ground uniformly, the mixture is dissolved in an
organic solvent and magnetically stirred, and suspension passes through a
rotary evaporator to obtain
powder; and putting the obtained
powder into a tubular furnace, calcining in non-
reactive gas, acidizing and
etching the obtained product by using an acid solution, and then centrifuging, washing and
drying in vacuum to obtain the nickel-based monatomic catalyst. According to the nickel-based monatomic catalyst, nickel monatomic is attached to a carbon tube through the synergistic effect of nickel and
nitrogen-
doped carbon, the nickel-based monatomic catalyst has rich
redox active sites, and reaction
kinetics and electrocatalytic activity are enhanced. In
glucose detection, the nickel-based monatomic catalyst material shows the sensitivity of 546.86 [mu] A / (mM.cm < 2 >), the
detection limit of 0.24 [mu] M and the linear response range of 0.1-10 mM. The nickel-based monatomic catalyst provided by the invention has relatively high electrocatalytic activity, excellent selectivity, simple preparation method and low cost, and is suitable for large-scale production.