The application discloses a temperature-sensitive
phase change one-way water guide paste dry base material and a preparation method thereof, and relates to the technical fields of
skin care patches and flexible
drug-loaded base materials. The method comprises the following steps: step 1, uniformly spraying a
polylactic acid solution on one side of a non-
woven fabric base material to obtain a hydrophobic closed layer after volatilizing the
solvent; step 2, preparing a mixture containing
lauric acid,
myristic acid and Tween 20, heating and melting the mixture into a transparent liquid to obtain an
oil phase of a temperature-sensitive layer, weighing a set amount of an
efficacy component, stirring the
efficacy component in a
beaker containing a high-molecular-weight hydrogel solution to obtain an aqueous phase of the temperature-sensitive layer; step 3, stirring the
oil phase of the temperature-sensitive layer into the aqueous phase of the temperature-sensitive layer until uniform to prepare a temperature-sensitive
phase change microemulsion; step 4, quantitatively
coating the temperature-sensitive
phase change microemulsion on the other side of the non-
woven fabric base material to obtain a hydrophilic layer of the temperature-sensitive layer; and step 5, low-temperature
dehydration and
drying to obtain the temperature-sensitive phase change one-way water guide paste dry base material. The binary
eutectic system of
lauric acid and
myristic acid is used to keep the base material in a physical
closed state at
room temperature, when the microenvironment of
human skin is heated to about 35 DEG C-37 DEG C, the phase change lipid is melted to realize the temperature-controlled intelligent release of the
efficacy component; meanwhile, the one-way water guide structure is constructed in combination with the hydrophobic layer, the
transdermal absorption effect is improved, and the dry entity is beneficial to non-preserved packaging,
environmental protection and weight reduction.