120 results about "Tissue skin" patented technology

The invention discloses a skin targeted therapy laser control method and system based on a dual-wavelength synergistic effect, and the method comprises the steps: collecting the real-time morphological characteristics and pigment distribution data of skin tissues through a multispectral imaging unit, and recognizing the optical characteristic parameters of a target treatment region; generating a dual-wavelength combination scheme through a dynamic wavelength selection algorithm based on the optical characteristic parameters and the tissue structure characteristics of the target treatment area; according to a dual-wavelength combination scheme, generating a synergistic laser sequence with a specific pulse interval and energy ratio; the synergistic laser sequence is converted into a driving signal, and a dual-wavelength laser is controlled to output composite laser; and laser output parameters are dynamically adjusted through real-time thermal diffusion monitoring and an optical feedback mechanism. By utilizing the embodiment of the invention, accurate and selective heat dissipation of skin target tissues can be realized, surrounding normal tissues are effectively protected, the treatment safety and effectiveness are improved, and side effects are reduced.

The invention relates to a skin tissue layering evaluation method, device and equipment, a medium and a program product. The method comprises the following steps: acquiring an original gray-scale ultrasonic image of skin tissue layering, and preprocessing the original gray-scale ultrasonic image to obtain a preprocessed ultrasonic image; performing elastic image generation on the preprocessed ultrasonic image through an elastic imaging generation network to obtain an elastic modulus diagram; performing super-resolution image reconstruction on the preprocessed ultrasonic image through a super-resolution reconstruction network to obtain a high-resolution image; performing feature extraction on the preprocessed ultrasonic image, the elastic modulus diagram and the high-resolution diagram to obtain a multi-modal hierarchical feature map; performing cross-modal attention fusion on the multi-modal hierarchical features to obtain a fusion feature map; and according to the fusion feature map, performing layering evaluation on the skin tissue layering to obtain a multi-skin tissue probability map. By adopting the method, the integrated skin tissue layering evaluation of the whole body skin, fascia and muscular tissues can be realized under the limitation of insufficient resolution.

The present invention relates to an RF application apparatus comprising a composite electrode that induces surface thermal stimulation and deep thermal stimulation. The RF application apparatus according to an embodiment of the present invention comprises: a first treatment electrode that applies RF energy through skin tissue of a first layer which is a skin surface; a second treatment electrode that includes a plurality of needle electrodes and applies RF energy through skin tissue of a second layer located deeper than the first layer; and at least one return electrode configured to allow returning of RF energy applied from the first treatment electrode or the second treatment electrode, wherein the second treatment electrode is configured to be drawn out and drawn in through the first treatment electrode, and the first treatment electrode and the second treatment electrode are configured to operate simultaneously or selectively.

The invention belongs to the technical field of nutritional compositions and cosmetics, and particularly relates to an anti-aging composition and application and a product thereof. The composition provided by the invention is composed of L-ergothioneine and alpha-ketoglutaric acid, or L-ergothioneine and alpha-ketoglutaric acid salt, or L-ergothioneine and alpha-ketoglutaric acid salt. Through the synergistic effect of the L-ergothioneine and the alpha-ketoglutaric acid or the alpha-ketoglutarate, the contents of Col I and hydroxyproline in skin tissues can be remarkably increased, the expression of TGF-beta1 is up-regulated and converted, the activity of MMP-1 is inhibited, meanwhile, the malondialdehyde level is reduced to enhance the oxidation resistance, the synthesis of hyaluronic acid is promoted, and the water content of the skin is increased. The composition is simple in component and simple and convenient in preparation process, can be prepared into various products such as cosmetics, health care products or medicines, is used for achieving the effects of resisting aging, moisturizing, resisting inflammation or resisting oxidation, particularly has an excellent improvement effect on skin photoaging induced by ultraviolet rays, and is wide in application prospect.

The present invention relates to a hybrid exosome formed by the fusion of a human cell-derived exosome and an artificial exosome. When an active ingredient labeled with a fluorescent material was attached or encapsulated in the hybrid exosome of the present invention and applied to cells, the active ingredient was observed in the cells. In addition, when the exosome was applied to skin tissue, fluorescence expression could also be observed in the dermal layer. Therefore, the hybrid exosome according to the present invention can be used as a novel drug delivery system.

The invention discloses spirulina extracellular vesicle hydrogel as well as a preparation method and application thereof. The spirulina extracellular vesicle hydrogel is prepared by separating spirulina extracellular vesicles and loading the spirulina extracellular vesicles on sodium alginate / carboxymethyl chitosan hydrogel, and the method is low in cost, simple, feasible, green and safe. Skin tissue lesions caused by ultraviolet radiation can be effectively prevented and treated by externally applying the hydrogel, and the skin tissue lesions comprise abnormal epidermis thickening, collagenous fiber loss and disorder and the like; skin oxidative stress caused by ultraviolet is inhibited, and the anti-oxidation effect is achieved; the skin inflammation caused by ultraviolet is relieved by inhibiting the generation of proinflammatory factors; as a skin dressing, transdermal noninvasive administration can be realized; good biological safety is shown. The method has a wide application prospect in prevention and treatment of skin ultraviolet injury related diseases by using bioactive materials.

A computer-implemented method is for calibrating a digital image of skin tissue. The digital image includes a calibration marker located on or near the skin tissue. The calibration marker has benchmark elements wherein at least one benchmark attribute value of at least one attribute type. The computer-implemented method detects the calibration marker within the digital image; and detects the benchmark elements within a cropped portion of the digital image that includes the calibration marker. The computer-implemented method further includes, for the respective benchmark elements, determining at least one depicted attribute value of the at least one attribute type based on pixels of the digital image located within the respective benchmark elements; and calibrating the digital image by correcting deviations between the depicted attribute values and the benchmark attribute values associated with the respective benchmark elements.

The invention relates to the technical field of biomedical engineering, and discloses a blood oxygen saturation degree detection method which comprises the following steps: S1, a multi-wavelength light source is utilized to irradiate a target area, and the light source comprises light with different wavelengths in a visible spectrum range; s2, collecting intensity information of light reflected or transmitted by the tissue; s3, constructing an oxyhemoglobin saturation model according to the received light intensity ratios under different wavelengths, and further provides an oxyhemoglobin saturation detection device which comprises a multi-wavelength light source module used for emitting light with different wavelengths in a visible spectrum range; and the optical sensor array is used for collecting the intensity information of the light reflected or transmitted by the skin tissue. By means of the multi-wavelength light source, machine learning optimization, personalized calibration and the environment sensing module, the accuracy and stability of blood oxygen measurement are remarkably improved, different individual differences and complex environment conditions can be adapted, and accurate blood oxygen saturation monitoring is ensured.

The invention discloses a preparation method and application of cubilose peptide. The amino acid sequence of the cubilose peptide is KPAPPKPEPK. The cubilose peptide prepared by the invention has strong ultraviolet damage resistance, and can improve the cell survival rate, improve the antioxidant enzyme level in serum, scavenge free radicals and reduce the inflammatory factor level in skin tissues. When the cubilose peptide is used for developing anti-ultraviolet damage products, the efficacy of cubilose can be deeply excavated, and the quality and economic value of cubilose products are improved.

Aspects relate to mechanisms to control the effective optical path length through skin tissue for non-invasive optical spectroscopy measurements. An apparatus can include a path length control part configured to control the effective optical path length of diffusely scattered light transmitted through skin tissue to produce a target effective optical path length. The apparatus may further include a spectral sensor, a detector, and a light source configured to produce input light directed towards the path length control part or the spectral sensor. The detector is configured to obtain a spectrum of an analyte under test based on the diffusely scattered light. The spectral sensor is configured to either receive the input light, produce modulated light based on the input light, and direct the modulated light to the skin tissue, or to receive the diffusely scattered light from the skin tissue and obtain the spectrum using the detector.

The invention belongs to the technical field of biomedical materials, and particularly relates to a high-stability injectable soft tissue filling material and a preparation method and application thereof. The soft tissue filling material disclosed by the invention is prepared by mixing an amphiphilic degradable polyether-polyester copolymer with water and annealing; the annealing process conditions are as follows: under the protection of inert gas, pressurizing to 1.0-5.0 bar, heating to 110-158 DEG C, slowly cooling to room temperature under the condition of maintaining the pressure, and finally reducing the pressure to standard atmospheric pressure. Through experimental tests, the soft tissue filling material has the excellent properties of high concentration, high particle size and viscosity, good preparation stability, good stability among process batches, good needle passing property, no need of a sterilization process, good safety, long-term retention effect in vivo, capability of promoting collagen generation of skin tissues and the like; good application effects are realized in the fields of wound healing, tissue filling and / or repairing, wrinkle removal, anti-aging and the like.

The invention relates to the technical field of functional nutritious food, in particular to multi-layer skin nutrition powder with a whole-spectrum skin growth and repair promoting effect and a preparation method and application thereof, the core of the multi-layer skin nutrition powder is composed of a collagen peptide system (60-62%), a proteoglycan system (20-22%) and the like, collagen peptide is compounded with three sources of cattle, fish and chicken, and the multi-layer skin nutrition powder has the advantages that the multi-layer skin nutrition powder is prepared; according to the present invention, with the combination of the following components, the skin structure and activity are jointly promoted by using the synergistic effect of the functional polypeptide compound (2.5-3.5%) and the plant active component (3.5-4.5%) rich in asiaticoside and procyanidine, and the nutrition enhancers (4-5%) such as L-ascorbic acid and amino acid chelated zinc and the food-grade auxiliary materials (8-10%) such as microcrystalline cellulose are integrated in the formula, such that the various systems achieve the synergistic effect so as to achieve the effect of nourishing the skin; through the synergistic compatibility of the three-source collagen peptide, the comprehensive supplement of various types of collagen in skin tissues is realized.

The application discloses a method for breeding Ptereleotris radiata by using siRNA molecules interfering with melanin tyr gene expression, wherein the sequence of the siRNA molecules is shown as SEQ ID NO. 6-35, and the siRNA molecules can interfere with the expression of melanin tyr gene in the skin tissue of Ptereleotris radiata. The siRNA sequence is designed and synthesized by using the melanin gene of Ptereleotris radiata, and a powder injection preparation containing the siRNA is obtained. The powder injection preparation is dissolved and injected into the body of Ptereleotris radiata. The individuals with faded melanin in the skin tissue of Ptereleotris radiata are screened out for breeding of parent fish and cross breeding, and the offspring of Ptereleotris radiata is obtained, wherein the skin tissue traits of the offspring are the same as those of the parent fish. By using the breeding method provided by the application, the melanin in the skin tissue of Ptereleotris radiata can be reduced and stably inherited, a foundation for obtaining Ptereleotris radiata varieties is laid, and the economic value of Ptereleotris radiata is improved.

A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer / hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water. A method of application of a transdermal delivery composition to skin tissue includes applying the transdermal delivery composition to skin tissue and spreading the composition to form a film on the skin tissue. A method for formulating a transdermal delivery composition based on a desired penetration weight ratio of CBD to THC through skin tissue includes selecting a formulation weight ratio of CBD to THC for formulating the composition, wherein the weight ratio is determined by multiplying the desired penetration weight ratio of CBD to THC by a CBD / THC delivery factor, wherein the CBD / THC delivery factor.

The invention relates to the technical field of biological medicine, in particular to mussel mucin and hyaluronic acid cross-linked self-repairing eye health care cream and a 4D forming method thereof. The composition comprises stearic acid, cetostearyl alcohol and the like, a lactic acid bacteria fermentation extract, a jasmine flower extract, a wolfberry extract, a pseudo-ginseng extract, a cassia seed extract, a polygonum cuspidatum extract, a chrysanthemum extract, a leontopodium leontopodum extract, ethylparaben, methylparaben and the like, decapeptide-4, mussel mucin, proteoglycan protein and modified graphene. Modified graphene in the self-repairing eye health care cream can effectively promote crosslinking of mussel mucin and hyaluronic acid and improve the repairing effect, the micro-current effect of graphene can also promote skin tissue to absorb traditional Chinese medicine components and deeply repair eyes, the effect can be more obvious according to personal eye conditions and requirements, and the self-repairing eye health care cream has a good application prospect. The composition has the effects of relieving asthenopia, dryness and soreness, effectively delaying excessive growth of an ocular axis, relieving temporary myopia drift, relieving asthenopia and protecting near vision.

The invention relates to the technical field of feeding colorants, in particular to a feeding colorant composition and application thereof in improving the skin color of aquatic animals. The feed colorant composition provided by the invention has the efficacy of improving the skin coloring effect of the aquatic animals, and when the feed colorant composition is used for feeding the aquatic animals, the yellow chromaticity of skin tissues of the aquatic animals can be remarkably improved, and particularly, the feed colorant composition has an excellent yellow coloring effect on back and abdomen skins. The feeding colorant composition can be used as a feed additive, can be added into a daily feed for aquatic animals such as cultured fishes for feeding, realizes simultaneous improvement of skin color and brightness, has an effect obviously better than that of an existing colorant, and has a relatively good application prospect in aquatic animal culture.

The application belongs to the technical field of biomedical optical imaging, and more particularly relates to a biosafe skin optical clearing agent and method based on a lysine synergistic system. The biosafe skin optical clearing agent provided in the application contains lysine or a salt thereof as an active ingredient, can effectively reduce the light scattering of skin tissue, and thus realizes the optical clearing of skin, and meanwhile, the morphology of the skin tissue is well maintained during the treatment. The skin optical clearing agent has the advantages of simple active ingredient, high biosafety, remarkable skin optical clearing effect, convenient preparation, simple application operation and the like, and is suitable for the optical clearing treatment of ex vivo skin and in vivo skin.

Disclosed in the present invention are a non-contact blood oxygen monitoring device and method improved using a notch filter. The device is used for real-time, non-contact blood oxygen saturation monitoring of a human skin tissue. The device is composed of an optical imaging module, an image analysis module, a blood oxygen calibration module, and a UI interface module. The optical imaging module obtains a video of consecutive image frames of the human skin tissue; the image analysis module receives and analyzes the video of the consecutive image frames of the human skin tissue in real time, and extracts pulse wave relative amplitude characteristics; the blood oxygen calibration module calibrates blood oxygen saturation on the basis of the pulse wave relative amplitude characteristics extracted by the image analysis module and a calibration model to obtain a blood oxygen value monitoring result; and the video of the consecutive image frames of the human skin tissue and the blood oxygen value monitoring result are displayed on a UI interface.

The invention provides an alcohol extraction method of cortex phellodendri and application of the cortex phellodendri alcohol extract as a liniment.The invention relates to the technical field of medicine.The alcohol extraction method of cortex phellodendri is provided, the alcohol extract of cortex phellodendri is obtained through the extraction method, the bacteriostatic activity of the alcohol extract of cortex phellodendri on propionibacterium acnes is 1.56 mg / mL, and the bacteriostatic activity of the alcohol extract of cortex phellodendri is remarkably superior to that of other existing traditional Chinese medicine extraction bacteriostatic schemes; meanwhile, the invention provides the golden cypress alcohol extract liniment for inhibiting acnes, propionibacterium acnes are synergistically inhibited by reducing the protein expression levels of Src, Akt and mTOR in skin tissues and destroying the completeness of cell walls and cell membranes of the propionibacterium acnes, and the liniment is not added with a penetration enhancer, does not irritate the skin, is safer to use, and has a good application prospect. The formed medicine film reduces evaporation of moisture on the skin surface, the medicine is promoted to be slowly released through cuticle, an animal model verifies that acnes rapidly fade after 4 days, a non-antibiotic treatment scheme is provided for light and moderate acnes, and a better treatment effect is achieved.

The invention provides a preparation process of melaleuca leucas essential oil. The preparation process comprises the following steps: picking melaleuca leucas leaves, cleaning, shredding, carrying out ultrasonic treatment, carrying out molecular force gradient separation and carrying out component analysis. The molecular force gradient separation is that volatile compounds in the cajeput virens are sequentially separated for 2-100 gradients according to the molecular force from weak to strong by utilizing the molecular force intensity difference of essential oil compounds, and the essential oil of each gradient is obtained. According to the method, efficient separation of chemical components of the melaleuca leucas essential oil is achieved, and the biological activity of the essential oil can be improved and the components irritating to the skin or the tissue can be removed by enriching bioactive components and components irritating to the skin or the tissue. The essential oil with different chemical components and contents can be prepared according to actual requirements.

This application belongs to the field of image processing and relates to a skin extraction method and system. The method includes: performing nonlinear regression fitting on the prior anatomical features of skin tissue in historical oral images to obtain a skin cutting threshold; acquiring a CBCT image of the oral cavity to be processed; extracting boundary features from the cross-sectional image layers of the CBCT image to be processed based on the skin cutting threshold to obtain a dynamic candidate masking region feature map; applying inter-layer geometric consistency constraints to the dynamic candidate masking region feature map to generate a target skin masking region; extracting the original pixel values ​​within the target skin masking region and suppressing their background values; performing isosurface evolution processing on the suppressed original pixel values ​​to generate an isosurface grid; and performing patch validity screening on the isosurface grid to generate the skin extraction result. This application can reduce the interference of irrelevant data on the extraction result during the skin extraction process and ensure the quality of skin tissue extraction as much as possible.

The invention discloses an infrared photothermal collaborative beauty / medical beauty roller capable of replacing microneedles and a using method thereof, and belongs to the technical field of beauty / medical beauty instruments. The roller comprises a handle, a roller body and a replaceable microneedle assembly. The roller main body is provided with a hollow frame, and an infrared light source is arranged in the hollow frame; the replaceable microneedle assembly comprises a light-transmitting microneedle patch and a mounting seat, and is detachably mounted on the roller main body; a light-transmitting area is arranged on a frame of the roller main body, and the microneedle patch is made of a light-transmitting high-molecular polymer, so that infrared light can penetrate through the light-transmitting area and the microneedle patch to irradiate the skin. Infrared light is converted into heat energy in skin tissue, traditional contact type electric heating is replaced, and the risk of scalding is fundamentally avoided; meanwhile, the high-light-transmittance microneedle structure is combined with the roller hollowed-out design, efficient cooperation of microneedle transdermal, infrared phototherapy and endothermic heat is achieved, and the device is suitable for skin care. The microneedle assembly can be replaced and is safe and sanitary.

The invention discloses a biological index data processing method and device, a storage medium and computer equipment, relates to the technical field of information processing, and mainly aims to improve the determination efficiency and the determination accuracy of radiation response characteristics of a biological index data set. The method comprises the following steps: acquiring a biological index data set of a skin tissue sample in a non-radiation exposure state; determining the degree of influence of each piece of biological index data in the biological index data set on radiation response characteristic prediction, and screening out core biological index data related to radiation response characteristics from the biological index data set based on the degree of influence; and analyzing the core biological index data by using a preset radiation response characteristic prediction model, and determining radiation response characteristics of the biological index data set based on an analysis result. The method is suitable for processing scenes of the biological index data.

The invention relates to the technical field of medicines, in particular to skin antibacterial transdermal liquid and a preparation method thereof. The traditional Chinese medicine composition is prepared by mixing the following raw materials in percentage by weight: 0.1%-0.4% of radix euphorbiae lantu, 0.25%-0.75% of rhizoma smilacis glabrae, 0.15%-0.55% of honeysuckle flower, 0.08%-0.38% of radix salviae miltiorrhizae, 0.2%-0.8% of flos chrysanthemi indici, 0.05%-0.55% of spina gleditsiae, 0.05%-0.45% of typhonium giganteum, 3%-8% of borneol, 0.25%-0.6% of radix sophorae flavescentis, 0.2%-0.65% of fructus cnidii, 0.15%-0.45% of fructus kochiae, 0.01%-0.45% of radix stemonae and 0.02%-0.55% of chlorhexidine acetate. The skin antibacterial transdermal liquid has the beneficial effects that through the synergistic interaction of various natural traditional Chinese medicine components and the combination of a modern extraction process, effective components are fully reserved, the skin antibacterial transdermal liquid has a remarkable inhibition effect on various skin pathogenic bacteria such as staphylococcus aureus, escherichia coli and candida albicans, and the antibacterial rate can reach 90% or above; meanwhile, the traditional Chinese medicine is used for improving skin microcirculation, and penetration promoting components such as borneol are used, so that the medicine can quickly penetrate through the skin cuticle and penetrate into the skin tissue to exert the medicine effect, the symptoms such as skin itch and inflammation are effectively relieved, the preparation process is relatively simple, and industrial production is easy.

The invention discloses application of a rhizoma dioscoreae nipponicae saponin extract in preparation of medicines or cosmetics for preventing or treating skin photoaging, and belongs to the technical field of medicines. The rhizoma dioscoreae nipponicae saponin extract is extracted from rhizoma dioscoreae nipponicae by utilizing an alcohol extraction and water precipitation method, skin light aging is UVB-induced skin exogenous aging and skin injury, and experimental research proves that the rhizoma dioscoreae nipponicae saponin extract can relieve UVB-induced HaCaT cell viability and mitochondrial membrane potential drop and reduce SA-beta-Gal accumulation; meanwhile, the rhizoma dioscoreae nipponicae saponin extract can relieve UVB-induced content reduction of hyaluronic acid and hydroxyproline in C57BL / 6 mice and improve the pathological structure of skin tissues, so that the rhizoma dioscoreae nipponicae saponin extract can be used for preparing the medicines or cosmetics for preventing or treating skin photoaging, and has a very good application prospect.

This invention discloses a mitochondrial-targeted nanomaterial for senescent cells and its application in anti-aging. The material is a nucleic acid aptamer-tetrahedral DNA, mainly assembled from four single-stranded DNA sequences, SEQ ID Nos. 1-4. Preparation involves first hybridizing the four single-stranded DNA sequences, then concentrating them to obtain aptamer-modified tetrahedra, which are then coupled with tannic acid (TA) via a Mann reaction in the presence of formaldehyde to obtain the Apt-tFNAs-TA complex. Finally, it is incubated with excess catechins to obtain the final delivery material, Apt-tFNAs@catechin-TA. This invention's material exhibits good biocompatibility and skin tissue compatibility, significantly improving uptake efficiency and mitochondrial localization ability in senescent cells. It can effectively deliver polyphenolic compounds such as catechins and protocatechuic acid, improving mitochondrial function and addressing the technical problems of low delivery efficiency of active ingredients and insufficient targeted enrichment in senescent cells.

The application discloses a micro wearable blood glucose monitoring device. The device comprises a first part and a second part which are connected in series to form a ring; the first part comprises an integrated Raman probe, the integrated Raman probe comprises two light sources for generating a line spot and a slit; the two light sources are arranged on the two sides of the slit respectively, and the slit emits excitation light to the skin tissue to generate a Raman signal, the slit is provided with a long-pass filter film for filtering Rayleigh scattering, other stray light and spontaneous fluorescence; the device further comprises a miniature spectrometer for performing light splitting and detection of the Raman signal; the second part comprises an information processing unit for driving control of the light source and the miniature spectrometer and micro blood glucose online analysis, a touch display screen for reading and displaying blood glucose values, and a battery module for supplying power to the integrated Raman probe, the information processing unit and the touch display screen; the watchband is provided with a data line for transmitting data and a power line for power supply.

The invention belongs to the technical field of biomedical materials, and particularly relates to a high-concentration and high-viscosity injectable soft tissue filling material as well as a preparation method and application thereof. The soft tissue filling material disclosed by the invention is prepared by mixing an amphiphilic degradable polyether-polyester copolymer with water and annealing; the annealing process conditions are as follows: under the protection of inert gas, pressurizing by 1-3 bar, heating to 110-130 DEG C, slowly cooling to room temperature, and reducing the pressure to standard atmospheric pressure while cooling. Through experimental tests, the soft tissue filling material has the excellent properties of high concentration, high particle size and viscosity, good preparation stability, good stability among process batches, good needle passing property, no need of a sterilization process, good safety, long-term retention effect in vivo, capability of promoting collagen generation of skin tissues and the like; good application effects are realized in the fields of wound healing, tissue filling and / or repairing, wrinkle removal, anti-aging and the like.

The invention belongs to the field of multifunctional wound dressings, and provides preparation of a high-strength and high-toughness natural polymer hydrogel wound dressing with excellent photo-thermal performance. The preparation method comprises the following steps: firstly, separating cuttlefish element nanoparticles from ink sacs of cuttlefishes, then oxidizing sodium alginate by sodium periodate to generate oxidized sodium alginate with aldehyde groups, and grafting dopamine onto the oxidized sodium alginate at the same time; the preparation method comprises the following steps: preparing a polydopamine-oxidized sodium alginate network, polymerizing polyvinyl alcohol and polyvinylpyrrolidone, adding the polydopamine-oxidized sodium alginate network while polymerizing polyvinyl alcohol and polyvinylpyrrolidone, and finally doping cuttlefish element nanoparticles into the polymer network to obtain the natural polymer-based multifunctional hydrogel wound dressing wrapping the cuttlefish element nanoparticles. The dressing disclosed by the invention is prepared from all-natural high polymer materials, is environment-friendly and excellent in biocompatibility, and can perfectly accord with the physiological characteristics of human skin; in addition, the hydrogel also has good photo-thermal performance, oxidation resistance, strength and toughness, and can effectively inhibit the growth of bacteria at the wound to ensure that the hydrogel is not damaged during wound healing and does not cause damage to skin tissues.