91 results about "Tissue skin" patented technology

The invention discloses a skin targeted therapy laser control method and system based on a dual-wavelength synergistic effect, and the method comprises the steps: collecting the real-time morphological characteristics and pigment distribution data of skin tissues through a multispectral imaging unit, and recognizing the optical characteristic parameters of a target treatment region; generating a dual-wavelength combination scheme through a dynamic wavelength selection algorithm based on the optical characteristic parameters and the tissue structure characteristics of the target treatment area; according to a dual-wavelength combination scheme, generating a synergistic laser sequence with a specific pulse interval and energy ratio; the synergistic laser sequence is converted into a driving signal, and a dual-wavelength laser is controlled to output composite laser; and laser output parameters are dynamically adjusted through real-time thermal diffusion monitoring and an optical feedback mechanism. By utilizing the embodiment of the invention, accurate and selective heat dissipation of skin target tissues can be realized, surrounding normal tissues are effectively protected, the treatment safety and effectiveness are improved, and side effects are reduced.

The invention relates to a skin tissue layering evaluation method, device and equipment, a medium and a program product. The method comprises the following steps: acquiring an original gray-scale ultrasonic image of skin tissue layering, and preprocessing the original gray-scale ultrasonic image to obtain a preprocessed ultrasonic image; performing elastic image generation on the preprocessed ultrasonic image through an elastic imaging generation network to obtain an elastic modulus diagram; performing super-resolution image reconstruction on the preprocessed ultrasonic image through a super-resolution reconstruction network to obtain a high-resolution image; performing feature extraction on the preprocessed ultrasonic image, the elastic modulus diagram and the high-resolution diagram to obtain a multi-modal hierarchical feature map; performing cross-modal attention fusion on the multi-modal hierarchical features to obtain a fusion feature map; and according to the fusion feature map, performing layering evaluation on the skin tissue layering to obtain a multi-skin tissue probability map. By adopting the method, the integrated skin tissue layering evaluation of the whole body skin, fascia and muscular tissues can be realized under the limitation of insufficient resolution.

The present invention relates to an RF application apparatus comprising a composite electrode that induces surface thermal stimulation and deep thermal stimulation. The RF application apparatus according to an embodiment of the present invention comprises: a first treatment electrode that applies RF energy through skin tissue of a first layer which is a skin surface; a second treatment electrode that includes a plurality of needle electrodes and applies RF energy through skin tissue of a second layer located deeper than the first layer; and at least one return electrode configured to allow returning of RF energy applied from the first treatment electrode or the second treatment electrode, wherein the second treatment electrode is configured to be drawn out and drawn in through the first treatment electrode, and the first treatment electrode and the second treatment electrode are configured to operate simultaneously or selectively.

The invention belongs to the technical field of nutritional compositions and cosmetics, and particularly relates to an anti-aging composition and application and a product thereof. The composition provided by the invention is composed of L-ergothioneine and alpha-ketoglutaric acid, or L-ergothioneine and alpha-ketoglutaric acid salt, or L-ergothioneine and alpha-ketoglutaric acid salt. Through the synergistic effect of the L-ergothioneine and the alpha-ketoglutaric acid or the alpha-ketoglutarate, the contents of Col I and hydroxyproline in skin tissues can be remarkably increased, the expression of TGF-beta1 is up-regulated and converted, the activity of MMP-1 is inhibited, meanwhile, the malondialdehyde level is reduced to enhance the oxidation resistance, the synthesis of hyaluronic acid is promoted, and the water content of the skin is increased. The composition is simple in component and simple and convenient in preparation process, can be prepared into various products such as cosmetics, health care products or medicines, is used for achieving the effects of resisting aging, moisturizing, resisting inflammation or resisting oxidation, particularly has an excellent improvement effect on skin photoaging induced by ultraviolet rays, and is wide in application prospect.

The present invention relates to a hybrid exosome formed by the fusion of a human cell-derived exosome and an artificial exosome. When an active ingredient labeled with a fluorescent material was attached or encapsulated in the hybrid exosome of the present invention and applied to cells, the active ingredient was observed in the cells. In addition, when the exosome was applied to skin tissue, fluorescence expression could also be observed in the dermal layer. Therefore, the hybrid exosome according to the present invention can be used as a novel drug delivery system.

A computer-implemented method is for calibrating a digital image of skin tissue. The digital image includes a calibration marker located on or near the skin tissue. The calibration marker has benchmark elements wherein at least one benchmark attribute value of at least one attribute type. The computer-implemented method detects the calibration marker within the digital image; and detects the benchmark elements within a cropped portion of the digital image that includes the calibration marker. The computer-implemented method further includes, for the respective benchmark elements, determining at least one depicted attribute value of the at least one attribute type based on pixels of the digital image located within the respective benchmark elements; and calibrating the digital image by correcting deviations between the depicted attribute values and the benchmark attribute values associated with the respective benchmark elements.

The invention discloses a preparation method and application of cubilose peptide. The amino acid sequence of the cubilose peptide is KPAPPKPEPK. The cubilose peptide prepared by the invention has strong ultraviolet damage resistance, and can improve the cell survival rate, improve the antioxidant enzyme level in serum, scavenge free radicals and reduce the inflammatory factor level in skin tissues. When the cubilose peptide is used for developing anti-ultraviolet damage products, the efficacy of cubilose can be deeply excavated, and the quality and economic value of cubilose products are improved.

Aspects relate to mechanisms to control the effective optical path length through skin tissue for non-invasive optical spectroscopy measurements. An apparatus can include a path length control part configured to control the effective optical path length of diffusely scattered light transmitted through skin tissue to produce a target effective optical path length. The apparatus may further include a spectral sensor, a detector, and a light source configured to produce input light directed towards the path length control part or the spectral sensor. The detector is configured to obtain a spectrum of an analyte under test based on the diffusely scattered light. The spectral sensor is configured to either receive the input light, produce modulated light based on the input light, and direct the modulated light to the skin tissue, or to receive the diffusely scattered light from the skin tissue and obtain the spectrum using the detector.

The invention relates to the technical field of functional nutritious food, in particular to multi-layer skin nutrition powder with a whole-spectrum skin growth and repair promoting effect and a preparation method and application thereof, the core of the multi-layer skin nutrition powder is composed of a collagen peptide system (60-62%), a proteoglycan system (20-22%) and the like, collagen peptide is compounded with three sources of cattle, fish and chicken, and the multi-layer skin nutrition powder has the advantages that the multi-layer skin nutrition powder is prepared; according to the present invention, with the combination of the following components, the skin structure and activity are jointly promoted by using the synergistic effect of the functional polypeptide compound (2.5-3.5%) and the plant active component (3.5-4.5%) rich in asiaticoside and procyanidine, and the nutrition enhancers (4-5%) such as L-ascorbic acid and amino acid chelated zinc and the food-grade auxiliary materials (8-10%) such as microcrystalline cellulose are integrated in the formula, such that the various systems achieve the synergistic effect so as to achieve the effect of nourishing the skin; through the synergistic compatibility of the three-source collagen peptide, the comprehensive supplement of various types of collagen in skin tissues is realized.

The application discloses a method for breeding Ptereleotris radiata by using siRNA molecules interfering with melanin tyr gene expression, wherein the sequence of the siRNA molecules is shown as SEQ ID NO. 6-35, and the siRNA molecules can interfere with the expression of melanin tyr gene in the skin tissue of Ptereleotris radiata. The siRNA sequence is designed and synthesized by using the melanin gene of Ptereleotris radiata, and a powder injection preparation containing the siRNA is obtained. The powder injection preparation is dissolved and injected into the body of Ptereleotris radiata. The individuals with faded melanin in the skin tissue of Ptereleotris radiata are screened out for breeding of parent fish and cross breeding, and the offspring of Ptereleotris radiata is obtained, wherein the skin tissue traits of the offspring are the same as those of the parent fish. By using the breeding method provided by the application, the melanin in the skin tissue of Ptereleotris radiata can be reduced and stably inherited, a foundation for obtaining Ptereleotris radiata varieties is laid, and the economic value of Ptereleotris radiata is improved.

A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer / hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water. A method of application of a transdermal delivery composition to skin tissue includes applying the transdermal delivery composition to skin tissue and spreading the composition to form a film on the skin tissue. A method for formulating a transdermal delivery composition based on a desired penetration weight ratio of CBD to THC through skin tissue includes selecting a formulation weight ratio of CBD to THC for formulating the composition, wherein the weight ratio is determined by multiplying the desired penetration weight ratio of CBD to THC by a CBD / THC delivery factor, wherein the CBD / THC delivery factor.

The invention relates to the technical field of biological medicine, in particular to mussel mucin and hyaluronic acid cross-linked self-repairing eye health care cream and a 4D forming method thereof. The composition comprises stearic acid, cetostearyl alcohol and the like, a lactic acid bacteria fermentation extract, a jasmine flower extract, a wolfberry extract, a pseudo-ginseng extract, a cassia seed extract, a polygonum cuspidatum extract, a chrysanthemum extract, a leontopodium leontopodum extract, ethylparaben, methylparaben and the like, decapeptide-4, mussel mucin, proteoglycan protein and modified graphene. Modified graphene in the self-repairing eye health care cream can effectively promote crosslinking of mussel mucin and hyaluronic acid and improve the repairing effect, the micro-current effect of graphene can also promote skin tissue to absorb traditional Chinese medicine components and deeply repair eyes, the effect can be more obvious according to personal eye conditions and requirements, and the self-repairing eye health care cream has a good application prospect. The composition has the effects of relieving asthenopia, dryness and soreness, effectively delaying excessive growth of an ocular axis, relieving temporary myopia drift, relieving asthenopia and protecting near vision.

The application belongs to the technical field of biomedical optical imaging, and more particularly relates to a biosafe skin optical clearing agent and method based on a lysine synergistic system. The biosafe skin optical clearing agent provided in the application contains lysine or a salt thereof as an active ingredient, can effectively reduce the light scattering of skin tissue, and thus realizes the optical clearing of skin, and meanwhile, the morphology of the skin tissue is well maintained during the treatment. The skin optical clearing agent has the advantages of simple active ingredient, high biosafety, remarkable skin optical clearing effect, convenient preparation, simple application operation and the like, and is suitable for the optical clearing treatment of ex vivo skin and in vivo skin.

The invention provides a preparation process of melaleuca leucas essential oil. The preparation process comprises the following steps: picking melaleuca leucas leaves, cleaning, shredding, carrying out ultrasonic treatment, carrying out molecular force gradient separation and carrying out component analysis. The molecular force gradient separation is that volatile compounds in the cajeput virens are sequentially separated for 2-100 gradients according to the molecular force from weak to strong by utilizing the molecular force intensity difference of essential oil compounds, and the essential oil of each gradient is obtained. According to the method, efficient separation of chemical components of the melaleuca leucas essential oil is achieved, and the biological activity of the essential oil can be improved and the components irritating to the skin or the tissue can be removed by enriching bioactive components and components irritating to the skin or the tissue. The essential oil with different chemical components and contents can be prepared according to actual requirements.

This application belongs to the field of image processing and relates to a skin extraction method and system. The method includes: performing nonlinear regression fitting on the prior anatomical features of skin tissue in historical oral images to obtain a skin cutting threshold; acquiring a CBCT image of the oral cavity to be processed; extracting boundary features from the cross-sectional image layers of the CBCT image to be processed based on the skin cutting threshold to obtain a dynamic candidate masking region feature map; applying inter-layer geometric consistency constraints to the dynamic candidate masking region feature map to generate a target skin masking region; extracting the original pixel values ​​within the target skin masking region and suppressing their background values; performing isosurface evolution processing on the suppressed original pixel values ​​to generate an isosurface grid; and performing patch validity screening on the isosurface grid to generate the skin extraction result. This application can reduce the interference of irrelevant data on the extraction result during the skin extraction process and ensure the quality of skin tissue extraction as much as possible.

The invention discloses an infrared photothermal collaborative beauty / medical beauty roller capable of replacing microneedles and a using method thereof, and belongs to the technical field of beauty / medical beauty instruments. The roller comprises a handle, a roller body and a replaceable microneedle assembly. The roller main body is provided with a hollow frame, and an infrared light source is arranged in the hollow frame; the replaceable microneedle assembly comprises a light-transmitting microneedle patch and a mounting seat, and is detachably mounted on the roller main body; a light-transmitting area is arranged on a frame of the roller main body, and the microneedle patch is made of a light-transmitting high-molecular polymer, so that infrared light can penetrate through the light-transmitting area and the microneedle patch to irradiate the skin. Infrared light is converted into heat energy in skin tissue, traditional contact type electric heating is replaced, and the risk of scalding is fundamentally avoided; meanwhile, the high-light-transmittance microneedle structure is combined with the roller hollowed-out design, efficient cooperation of microneedle transdermal, infrared phototherapy and endothermic heat is achieved, and the device is suitable for skin care. The microneedle assembly can be replaced and is safe and sanitary.

The invention discloses a biological index data processing method and device, a storage medium and computer equipment, relates to the technical field of information processing, and mainly aims to improve the determination efficiency and the determination accuracy of radiation response characteristics of a biological index data set. The method comprises the following steps: acquiring a biological index data set of a skin tissue sample in a non-radiation exposure state; determining the degree of influence of each piece of biological index data in the biological index data set on radiation response characteristic prediction, and screening out core biological index data related to radiation response characteristics from the biological index data set based on the degree of influence; and analyzing the core biological index data by using a preset radiation response characteristic prediction model, and determining radiation response characteristics of the biological index data set based on an analysis result. The method is suitable for processing scenes of the biological index data.

The invention discloses application of a rhizoma dioscoreae nipponicae saponin extract in preparation of medicines or cosmetics for preventing or treating skin photoaging, and belongs to the technical field of medicines. The rhizoma dioscoreae nipponicae saponin extract is extracted from rhizoma dioscoreae nipponicae by utilizing an alcohol extraction and water precipitation method, skin light aging is UVB-induced skin exogenous aging and skin injury, and experimental research proves that the rhizoma dioscoreae nipponicae saponin extract can relieve UVB-induced HaCaT cell viability and mitochondrial membrane potential drop and reduce SA-beta-Gal accumulation; meanwhile, the rhizoma dioscoreae nipponicae saponin extract can relieve UVB-induced content reduction of hyaluronic acid and hydroxyproline in C57BL / 6 mice and improve the pathological structure of skin tissues, so that the rhizoma dioscoreae nipponicae saponin extract can be used for preparing the medicines or cosmetics for preventing or treating skin photoaging, and has a very good application prospect.

This invention discloses a mitochondrial-targeted nanomaterial for senescent cells and its application in anti-aging. The material is a nucleic acid aptamer-tetrahedral DNA, mainly assembled from four single-stranded DNA sequences, SEQ ID Nos. 1-4. Preparation involves first hybridizing the four single-stranded DNA sequences, then concentrating them to obtain aptamer-modified tetrahedra, which are then coupled with tannic acid (TA) via a Mann reaction in the presence of formaldehyde to obtain the Apt-tFNAs-TA complex. Finally, it is incubated with excess catechins to obtain the final delivery material, Apt-tFNAs@catechin-TA. This invention's material exhibits good biocompatibility and skin tissue compatibility, significantly improving uptake efficiency and mitochondrial localization ability in senescent cells. It can effectively deliver polyphenolic compounds such as catechins and protocatechuic acid, improving mitochondrial function and addressing the technical problems of low delivery efficiency of active ingredients and insufficient targeted enrichment in senescent cells.

The application discloses a micro wearable blood glucose monitoring device. The device comprises a first part and a second part which are connected in series to form a ring; the first part comprises an integrated Raman probe, the integrated Raman probe comprises two light sources for generating a line spot and a slit; the two light sources are arranged on the two sides of the slit respectively, and the slit emits excitation light to the skin tissue to generate a Raman signal, the slit is provided with a long-pass filter film for filtering Rayleigh scattering, other stray light and spontaneous fluorescence; the device further comprises a miniature spectrometer for performing light splitting and detection of the Raman signal; the second part comprises an information processing unit for driving control of the light source and the miniature spectrometer and micro blood glucose online analysis, a touch display screen for reading and displaying blood glucose values, and a battery module for supplying power to the integrated Raman probe, the information processing unit and the touch display screen; the watchband is provided with a data line for transmitting data and a power line for power supply.

The invention belongs to the field of multifunctional wound dressings, and provides preparation of a high-strength and high-toughness natural polymer hydrogel wound dressing with excellent photo-thermal performance. The preparation method comprises the following steps: firstly, separating cuttlefish element nanoparticles from ink sacs of cuttlefishes, then oxidizing sodium alginate by sodium periodate to generate oxidized sodium alginate with aldehyde groups, and grafting dopamine onto the oxidized sodium alginate at the same time; the preparation method comprises the following steps: preparing a polydopamine-oxidized sodium alginate network, polymerizing polyvinyl alcohol and polyvinylpyrrolidone, adding the polydopamine-oxidized sodium alginate network while polymerizing polyvinyl alcohol and polyvinylpyrrolidone, and finally doping cuttlefish element nanoparticles into the polymer network to obtain the natural polymer-based multifunctional hydrogel wound dressing wrapping the cuttlefish element nanoparticles. The dressing disclosed by the invention is prepared from all-natural high polymer materials, is environment-friendly and excellent in biocompatibility, and can perfectly accord with the physiological characteristics of human skin; in addition, the hydrogel also has good photo-thermal performance, oxidation resistance, strength and toughness, and can effectively inhibit the growth of bacteria at the wound to ensure that the hydrogel is not damaged during wound healing and does not cause damage to skin tissues.

The invention discloses an ultrasonic treatment auxiliary film and a use method thereof, relates to the technical field of ultrasonic treatment, and discloses the ultrasonic treatment auxiliary film which is a film with non-uniform thickness, and the thickness of the ultrasonic treatment auxiliary film is complementary with that of target skin tissue. Compared with the prior art that the treatment depth of each treatment head of an ultrasonic treatment instrument is fixed, so that the specific layer of the human tissue cannot be accurately treated, the thickness of the ultrasonic treatment auxiliary film is not uniform and is complementary with the thickness of the target skin tissue, so that the depth of the skin tissue of the user can be compensated, and the treatment accuracy is improved. Therefore, the ultrasonic therapeutic apparatus can accurately treat the specific layer of the human tissue based on the compensated skin depth, and the technical problem that the specific layer of the human tissue cannot be accurately treated due to the fact that the treatment depth of the treatment head of the ultrasonic therapeutic apparatus is fixed and the depths of the human tissue are different in the prior art is solved.

To provide a mesh assembly having improved fixing force and pulling force for biological tissues and having an excellent effect of coming in close contact with skin tissues and maintaining and fixing the skin tissues.SOLUTION: There may be provided a mesh assembly having improved fixing force and pulling force for biological tissues and having an excellent effect of coming in close contact with skin tissues and maintaining and fixing the skin tissues. The mesh assembly is inserted in skin tissues of a human body, and may include a mesh member in which a plurality of linear members crossing each other are formed in a cylindrical shape.SELECTED DRAWING: Figure 2

According to the isolated culture identification and key marker detection method for the down producing goat hair follicle stem cells, trypsin and EDTA are used for jointly digesting skin tissue, and high-activity cells are efficiently obtained; a culture medium containing various growth factors is adopted for culture, and cell proliferation and stemness maintenance are promoted. And identifying and integrating morphological observation, growth curve determination and clone formation experiment to accurately judge the characteristics of the cells. Immunofluorescent staining and real-time fluorescent quantitative PCR are applied to key marker detection, and expression of markers such as CK15, CD34 and beta1 integrin is detected with high sensitivity. The method is high in separation efficiency, accurate in identification and sensitive in marker detection, can provide sufficient high-quality cells for the research on the hair follicle stem cells of the cashmere goat, assists in deeply understanding the biological characteristics and the regulation mechanism of the cells, and is of great significance for improving the yield and quality of cashmere and promoting the development of related biotechnologies.

The invention discloses a construction method of a jellyfish toxin metalloproteinase substrate peptide library, and relates to the technical field of biology. The construction method comprises the following steps: inducing mice with different dermatitis degrees by using a metalloproteinase inhibitor and jellyfish toxin; skin tissues with different dermatitis degrees are collected for proteome identification, and substrate membrane proteins of jellyfish toxin metalloproteinase are analyzed and screened through bioinformatics; screening by utilizing a protein database to obtain a potential substrate sequence in the substrate membrane protein; and screening sequences from the potential substrate sequences according to application conditions to construct a peptide library, and synthesizing the jellyfish toxin metalloproteinase substrate peptide library. The sequence contained in the jellyfish toxin metalloproteinase substrate peptide library constructed by the method is clear, the effect that the prepared polypeptide is hydrolyzed by toxin is remarkable, and the application prospect of the peptide library in jellyfish stings research is further guaranteed.

The application discloses a tripeptide with the effects of promoting HaCaT cell migration and barrier repair and application of the tripeptide, and the amino acid sequence of the tripeptide is glycine-methionine-hydroxyproline. The tripeptide has the effects of promoting HaCaT cell migration and barrier repair, and can be applied to the preparation of cosmetics with the effects of skin tissue repair and / or skin barrier repair.

The application discloses a jaundice meter based on programmable digital LED microarray, which comprises three parts of digital LED microarray, photoelectric conversion module and main control chip. The measurement comprises the following steps: the light emitting units in the digital LED microarray are controlled by a preset program to emit light in a combined form in sequence, the light beams are collected by a light trapping window after being reflected and absorbed by skin tissue, and are transmitted to the photoelectric conversion module through an optical fiber to be converted into digital electrical signals; the measurement signals obtained each time contain multi-dimensional information such as epidermis thickness, pigment distribution and blood vessel depth; and the accurate transcutaneous jaundice value is obtained by analyzing and calculating the comprehensive differentiated measurement results. The application can solve the inaccurate measurement problem caused by system errors such as environmental light brightness, interfering molecule distribution and individual skin differentiation based on the time and space controllable excitation mode.

The invention belongs to the technical field of biology, and particularly relates to application of DPP4 in treatment or diagnosis of inflammatory skin diseases characterized by skin barrier injury. According to the application disclosed by the invention, key effects of dipeptidyl peptidase-4 (DPP4) in regulating and controlling keratinocyte differentiation and maintaining normal skin barrier structures and functions are analyzed, and on the basis of AAV-mediated skin tissue keratinocyte DPP4 gene therapy, the conditions of abnormal epidermis thickening and abnormal differentiation caused by skin damage can be relieved by inducing normal differentiation of keratinocytes, so that the curative effect of the skin tissue keratinocyte DPP4 is improved, and the curative effect of the skin tissue keratinocyte DPP4 is improved. The traditional Chinese medicine composition provided by the invention can be used for promoting the repair of an epidermal barrier and improving and maintaining the steady state of the skin barrier so as to effectively improve psoriasis-like dermatitis, and a new scheme is provided for treating inflammatory dermatosis characterized by skin barrier injury. In addition, the expression level of DPP4 can be used as a diagnostic marker for inflammatory skin diseases characterized by skin barrier injury.

The invention discloses a soft tissue filling material, an injectable soft tissue filling agent and application of the injectable soft tissue filling agent, and belongs to the technical field of biomedical materials. The soft tissue filling material mainly comprises polymers of formulas i to vii. The soft tissue filling material disclosed by the invention can generate conformational change under the action of active oxygen, can effectively enhance the filling effect through reconstruction of a multi-layer structure, can be retained in skin tissues for a long time and stably maintain the volume shape and position, and has an excellent instant and lasting filling effect; meanwhile, the long-acting anti-inflammatory and anti-oxidation functions, collagen generation promoting, water locking and moisturizing functions and the like are achieved, and the composition can be used for wound healing, tissue filling and repairing, skin moisturizing and water locking, anti-aging and anti-oxidation treatment, skin barrier repairing and the like.