1594results about "Antiseptics" patented technology

The invention provides an antibacterial peptide cAMP048 sourced from microorganisms in a deep sea environment and application of the antibacterial peptide cAMP048, and belongs to the technical field of peptide inhibitors. The antibacterial peptide cAMP048 has an amino acid sequence as shown in SEQ ID NO: 1 (Sequence Identity Number 1). The antibacterial peptide can inhibit the growth of acinetobacter baumannii at 64 mu M, inhibit the growth of multi-drug-resistant acinetobacter baumannii and multi-drug-resistant enterococcus faecium at 128 mu M and inhibit the growth of escherichia coli, staphylococcus aureus and multi-drug-resistant klebsiella pneumoniae at 256 mu M. The antibacterial peptide can be used for preparing products with antibacterial and / or bactericidal performance, and can be applied to preparation of antibacterial and / or bactericidal products. Such as food, skin care products or medical supplies.

The invention discloses a gynecological antibacterial gel containing a carbomer component, and belongs to the technical field of gynecological nursing materials. The gel is prepared from 0.5 to 5 percent of plant extract microcapsules, 0.5 to 3 percent of carbomer, 2 to 10 percent of glycerol, 0.1 to 1.5 percent of triethanol and the balance of purified water. The plant extract microcapsule is prepared by compounding methacrylated silk fibroin and a caffeic acid hyaluronic acid graft, has temperature responsiveness, can improve the adhesive force on the surface of vaginal mucosa, and realizes slow release of the plant extract; the caffeic acid catechol hydroxyl is chelated with silver ions, a nano-silver monodisperse layer is formed on the surface of the microcapsule, and the antibacterial activity is improved. The composite plant extract can inhibit bacteria, repair mucous membranes and maintain the acidic microenvironment of the vagina. When the gel is prepared, the problem that the swelling efficiency of carbomer is low is solved through glycerol pre-grinding, and triethanolamine is added in three times to form a gradient cross-linked network. The problems that traditional gel is unstable in viscosity, poor in mucous membrane adhesiveness and prone to damaging vagina micro-ecology are solved, the antibacterial effect is good, and preservation is stable.

The invention provides an antibacterial synergy-mineralization regulation difunctional nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: mixing a disodium hydrogen phosphate solution and a calcium chloride solution to obtain an amorphous calcium phosphate suspension; mixing the amorphous calcium phosphate suspension with a tannic acid solution to obtain an ACP-TA suspension; and finally, mixing the ACP (at) TA suspension and the hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain the bifunctional nano material. A cross-linked shell is formed through the electrostatic adsorption effect of tannic acid and hydroxypropyl trimethyl ammonium chloride chitosan of the antibacterial layer, amorphous calcium phosphate is effectively wrapped, the crystallization process of amorphous calcium phosphate can be remarkably delayed, long-acting release of calcium and phosphorus ions is ensured, the antibacterial function can be effectively achieved, and the service life of the coating is prolonged. An ideal local microenvironment is provided for remineralization of tooth hard tissue, and finally biomimetic mineralization of enamel and deep mineralization plugging of dentinal tubules are achieved.

The invention discloses an oral care desensitization paste and a preparation method thereof, and mainly relates to the technical field of dental medicines. The oral care desensitization cream is prepared from the following components: bioactive glass, strontium chloride, sodium chloride, silicon dioxide, sodium carboxymethyl cellulose, polyethylene glycol 400, a xanthan gum solution, sodium lauryl sulfate, sodium lauroyl sarcosinate, titanium dioxide, beta-glucan, saccharin sodium salt, sorbitol, methylparaben, propyl hydroxybenzoate, edible essence and water. Compared with the prior art, the oral care desensitization paste disclosed by the invention can be used for sealing dentinal tubules and treating hemodia; the traditional Chinese medicine composition can also be used for treating plaque gingivitis, relieving and reducing gingival bleeding and inhibiting and reducing dental plaque; and meanwhile, the condition of mistakenly swallowing and eating in the using process is reduced.

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention relates to the field of biotechnology and female health care, in particular to a stachyose composition for promoting micro-ecological regulation of lactobacillus and application of the stachyose composition, and the composition comprises stachyose and pharmaceutically acceptable auxiliary materials. The stachyose is used as prebiotics to selectively promote proliferation and colonization of the lactobacillus crispatus, the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can promote proliferation of the lactobacillus crispatus, the lactobacillus crispatus is one or more of the lactobacillus crispatus, the lactobacillus plantarum and the lactobacillus acidophilus, and the combination of 1%-5% of the stachyose and 0.1%-0.5% of the lactic acid can inhibit gardnerella and candida albicans. The stachyose composition disclosed by the invention is in the form of slow-release gel and bath foam; the composition can be used for treating or preventing bacterial vaginitis, colpitis mycotica and related symptoms, has the advantages of no antibiotics, no drug resistance, high safety and the like, and is suitable for the fields of vagina local nursing and micro-ecological regulation.

The invention provides an additive composition containing a bioactive enzyme and a preparation method of the additive composition, and belongs to the technical field of biological enzymes. The preparation method comprises the following steps: fixing phytic acid and cyclodextrin on hydroxyapatite, modifying with tannic acid, reacting with dithiothreitol modified lysozyme to prepare an immobilized compound, adding 2, 2-dimethoxy-2-phenylacetophenone and methyl methacrylate, and carrying out irradiation reaction with an ultraviolet lamp to prepare the additive composition containing the bioactive enzyme. The broad-spectrum antibacterial property and the antiviral property of the lysozyme are greatly improved, the sterilization effect on gram negative bacteria is obviously improved, meanwhile, the stability of enzyme is greatly improved, the enzyme is not prone to inactivation, the preservation time of the enzyme is prolonged, the application effect of the enzyme is widened, meanwhile, the lysozyme has good killing capacity on oral bacteria and viruses, the addition of preservatives is reduced, and the cost is reduced. The cleaning effect and stability of the product are improved, tooth demineralization can be prevented, decayed teeth can be prevented, and wide application prospects are achieved.

The invention relates to the technical field of biological materials, in particular to silver nano-chlorogenic acid composite hydrogel as well as preparation and application thereof. According to the invention, the CGA and the silver nitrate are used for green synthesis of the nano-particles CGA-AgNPs, and the nano-particles have peroxide nano-enzyme activity and antibacterial activity; and the CGA-AgNPs and chitosan (CS) are cross-linked to form the silver nano-chlorogenic acid composite hydrogel CGA-AgNPs-CS, so that the uniform distribution of nano-particles in the hydrogel can be promoted. According to the invention, multi-functionalization is taken as a target, a novel hydrogel composition system is designed from the source, the provided preparation method is green, simple, rapid and environment-friendly, the obtained composite hydrogel has multiple functions, and a good foundation is laid for expansion and application of the composite hydrogel in the biomedical fields of wound repair, wearable equipment, nano antibacterial drugs and the like.

The invention discloses an oral care composition and a preparation method thereof, the oral care composition comprises a friction agent, a periodontal repair agent, a thickening agent, a humectant and a foaming agent, the friction agent comprises a dental plaque release agent, and the dental plaque release agent is configured to destroy a bacterial extracellular polysaccharide matrix in dental plaque; the periodontal repair agent comprises at least one of the following components: an inflammation inhibitor, a tissue repair promoter, a mucous membrane stimulation alleviator and a bacteriostatic agent. The oral care composition contains the dental plaque release agent and the periodontal repair agent, and can synergistically improve periodontal health.

The invention belongs to the technical field of skin care products, and particularly relates to a composition for treating acne and a preparation method thereof. The composition comprises the following components: 1-2% of a lactobacillus fermentation product and 5-8% of a plant extract component, the plant extraction component consists of a Pinus densiflora leaf extract, a celery root extract and an aster extract. The mass ratio of the Pinus densiflora leaf extract to the apium graveolens root extract to the aster extract is 1: (1-3): (5-10). Wherein the apium graveolens root extract, the Pinus densiflora leaf extract and the aster extract have a certain synergistic effect in the formula of the composition, so that the composition for treating acne provided by the invention can effectively inhibit the growth of propionibacterium acnes, reduce the occurrence of skin inflammation and effectively treat acne, and has a relatively good market application prospect.

The invention focuses on the fields of biotechnology and sanitary disinfection, and successfully separates five brand-new small molecule peptides (small molecule peptides K, L, M, N and O) from herba violae and spica prunellae. According to the innovative extraction method from raw material pretreatment, mixed extraction to multi-step purification, a disinfection action mechanism of destroying pathogen cell membranes, interfering energy metabolism and inhibiting biosynthesis by small molecular peptides is defined. The small molecule peptides show the advantages of efficient disinfection activity, high safety, good stability and difficult generation of drug resistance. On the basis, a series of products such as hygienic disinfection spray, wet tissues and hand sanitizer are developed, the market application prospect is wide, remarkable economic and social benefits can be brought, and a brand-new and high-quality solution is provided for the field of hygienic disinfection.

The present invention relates to a pet sterilizer and deodorizer, which belongs to the technical field of pet deodorization. The present invention promotes the long-term expression of hop extract and enhances the sterilization and deodorization effect through the synergistic effect of hop extract, persimmon tannin, and lysozyme. Furthermore, the composition is stable, natural, and pollution-free, and can be used in the oral cavity and in vitro of animals. The present invention also provides zinc ricinoleate and an antibacterial agent. Through the three-phase interaction of zinc ricinoleate, hop extract, and antibacterial agent, the overall stability is enhanced and the antibacterial time of the complex is prolonged while ensuring antibacterial and deodorizing effects. The present invention also provides a modified quaternary ammonium salt antibacterial liquid. The modified quaternary ammonium salt has enhanced stability and, when present together with zinc ricinoleate, promotes an enhanced deodorizing effect. The present invention also provides an Artemisia annua extract, a Gentiana root extract, and an Artemisia argyi extract, which can eliminate odor sources and significantly inhibit bacterial growth, thereby having significant antibacterial, deodorizing, and odor-removing effects.

The invention relates to whitening and stain-removing toothpaste and a preparation method thereof, and belongs to the technical field of oral care. The toothpaste contains 1.5-2.5 parts of plant zymolyte, 15-25 parts of composite abrasive and the like, and the plant zymolyte is obtained by grinding walnut shell powder, beech, oyster shell and Manny root ice river mud into powder according to the mass ratio of 3: 3: 2: 1 and mixing the powder with compound enzyme liquid for enzymolysis; the composite friction agent and the chelating agent are respectively prepared by mixing substances with specific particle sizes / molecular weights according to a ratio, and also contain a film-forming agent, an enamel repairing component and the like. The preparation method comprises the following steps: preparing plant zymolyte; preparing a mixed solution; and subsequently stirring, degassing and filling. Through cooperation of multiple components, the toothpaste achieves efficient whitening, stain removal and bacteriostasis, has the effects of long-acting stain prevention, enamel repair and oxidation resistance, and solves the problems that traditional toothpaste is not thorough in stain removal, damages enamel and the like.

The invention relates to the technical field of toothpaste preparation, in particular to hydrolyzed procyanidine-containing Chinese herbal medicine nursing toothpaste as well as a preparation method and application thereof.The preparation method of the hydrolyzed procyanidine-containing Chinese herbal medicine nursing toothpaste comprises the following preparation steps: adding a humectant, a thickening agent, a surfactant, a sweetening agent and a preservative into deionized water, and uniformly stirring; uniformly stirring to obtain a mixed solution; adding the abrasive into the mixed solution, and uniformly stirring to obtain paste; and adding the active microcapsules into the paste, uniformly stirring, carrying out vacuum degassing, and filling to obtain the Chinese herbal medicine nursing toothpaste containing hydrolyzed procyanidine. The Chinese herbal medicine care toothpaste is fused with hydrolyzed procyanidine, and shows excellent oral care performance. The oral care solution has obvious inhibition capability on a plurality of common oral pathogenic bacteria, has extremely high bacteriostasis rate, and can effectively block bacterial breeding and maintain oral health from the source. Meanwhile, the toothpaste is excellent in deodorization effect and capable of rapidly decomposing oral cavity peculiar smell molecules and remarkably improving oral cavity freshness.

The invention provides a composite nanoparticle with active substance sequential release capability, a multifunctional microneedle patch based on curcumin-loaded ZIF-67 nanoparticles, preparation methods of the composite nanoparticle and the multifunctional microneedle patch and application of the multifunctional microneedle patch, and belongs to the technical field of biology. The composite nano-particles with the active substance sequential release capability are CurZIF-67NPs, the average particle size is 403 + / -7 nm, the microstructure is dodecahedral structure particles with rough textures on the surface, and the composite nano-particles have the effects of slowly releasing bioactive substances, improving the inflammatory microenvironment and regulating and controlling osteogenesis under certain conditions. The composite nano-particle comprises curcumin powder and a ZIF-67 nano-material, the ZIF-67 nano-material can be decomposed to quickly release Co < 2 + >, macrophages are regulated and controlled to be polarized to an M2 type, and excessive immune inflammation reaction is improved; the curcumin powder is slowly released, so that the periodontal ligament stem cells can be regulated and controlled to be differentiated into osteoblasts, and the osteogenic activity is enhanced.

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

The invention relates to a near-infrared light response in-situ gelling and synergistic photo-thermal-photodynamic gel delivery system and a preparation method and application thereof, a mesoporous silicon coated up-conversion nano-carrier and an efficient photosensitizer are compounded to form a photo-response core unit, and then the photo-response core unit is intelligently integrated with photo-curing hydrogel to form the near-infrared light response in-situ gelling and synergistic photo-thermal-photodynamic gel delivery system. The general problem of aggregation and quenching of photosensitive molecules is relieved by utilizing the unique space confinement effect of the mesoporous structure, the ICG photo-thermal efficiency and photodynamic performance are enhanced, under precise excitation of a near-infrared light source, the system can activate a photo-crosslinking reaction through an up-conversion luminescence process, in-situ conversion from a liquid eye drop preparation to a stable gel state is achieved, and the stability of the eye drop preparation is improved. A lasting drug reservoir is formed on the surface of the cornea; synchronously excited photodynamic and photo-thermal dual-mode treatment generates a remarkable synergistic antibacterial effect, and shows an excellent removal capability on pathogens including highly drug-resistant bacteria; meanwhile, an ideal microenvironment is created for tissue repair through high biocompatibility and a stable mechanical matrix, and integrity recovery of cornea structures and functions is promoted.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The present invention relates to a new isolated antibacterial protein that specifically targets Cutibacterium acnes and thus is able to prevent and / or inhibit the infection by C. acnes. Advantageously, very low concentrations (in the range of ng / ml) of the newly isolated antibacterial protein are able to prevent and / or inhibit the growth of C. acnes. Accordingly, an isolated antibacterial protein is provided, as well as a composition for targeting Cutibacterium acnes comprising said antibacterial protein. The antibacterial protein or the composition comprising the isolated antibacterial protein of the present invention for use in a method of treating or preventing infection with Cutibacterium acnes are provided, as well as a method for inhibiting or preventing the growth of Cutibacterium acnes comprising the step of contacting the bacteria with the antibacterial protein of the present invention.

The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a compound external ointment for treating parasites of dogs and cats and skin tinea and a preparation method, the compound external ointment comprises the following components by mass percent: 2%-12% of selamectin, 3%-20% of imidacloprid, 0.5%-2% of terbinafine hydrochloride, 2%-12% of dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of polyethylene glycol 400 and the balance of water. The adhesive is prepared from, by weight, 9%-45% of polyethylene glycol 3350, 5%-15% of caprylic / capric polyethylene glycol glyceride, 1%-8% of oleyl alcohol, 0.5%-5% of dimeticone, 0.01%-0.1% of butylated hydroxytoluene and 1%-5% of cassava starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the imidacloprid, the terbinafine hydrochloride and the mixed solvent, then mixing with the matrix (the polyethylene glycol 400 and the polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the auricle of an animal, and not only can ensure that the medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a broad spectrum, but also has broad-spectrum antifungal activity, and can prevent and treat a plurality of skin diseases of pets.

The application discloses a light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme, a preparation method and application, and belongs to the technical field of biomedical materials. In the application, spherical silica nanoparticles are used as a template, and a structure of copper ion-polydopamine coated silica nanoparticles is formed on the surface of the silica nanoparticles through self-polymerization of dopamine and chelation of copper ions, and the spherical structure is maintained with the support of the silica nanoparticles. The copper ion-polydopamine coated silica nanoparticles are pyrolyzed to obtain a copper-based single-atom nanoscale enzyme with a carbon skeleton, and a hollow spherical single-atom nanoscale enzyme is obtained after etching. Nitric oxide donor molecules are loaded into the hollow of the hollow spherical single-atom nanoscale enzyme to obtain the light-controlled nitric oxide releasing hollow single-atom nanoscale enzyme. The application can realize the synergistic treatment effect of photothermal therapy, nitric oxide gas therapy and biological catalytic therapy, is used for efficiently removing bacteria and biofilms at an infected wound site, and effectively promotes the healing of the bacteria-infected wound.

The invention relates to the technical field of composite antibacterial materials, in particular to a preparation method and application of a spike rod-shaped nano composite material Cu-Fe-MOF (at) Ag. Rod-shaped Fe-MOF with biocompatibility is used as a carrier, Cu < 2 + > is introduced, and the appearance of the Fe-MOF is adjusted into a spike type, so that the antibacterial activity of the Fe-MOF is enhanced. On the basis of a soft and hard acid-base theory, by utilizing the principle that a d electron orbit of nano Ag is full electrons and is easy to coordinate with O and N atoms in Cu-Fe-MOF, the rodlike spike Cu-Fe-MOF (at) Ag composite nano material which can be adaptive to infected wound healing and intelligently adjust antibacterial activity and ROS (reactive oxygen species) removal capability is prepared through dual effects of adsorption and coordination. According to the material, the antibacterial activity of nano Ag can be improved, due to existence of coordinate bonds, the problem that Ag NPs are difficult to agglomerate and recycle can be solved, the problem of toxicity caused by accumulation of nano Ag on infected wounds is solved, and meanwhile, under the alkaline condition, conjugated bonds in MOF can cooperate with Ag to improve the ROS removal capacity.

The invention discloses sustained-release gynecological gel containing recombinant human collagen peptide and a preparation method of the sustained-release gynecological gel, and belongs to the field of biological medicines. The preparation method comprises the following steps: stirring and mixing a collagen peptide compound, carbomer, cuba balsam oil and purified water to obtain a mixed emulsion, then adding sodium alginate, and stirring for reaction to obtain the sustained-release gynecological gel containing the recombinant human collagen peptide. According to the sustained-release gynecological gel containing the recombinant human collagen peptide provided by the invention, the occurrence of adhesion is prevented by utilizing the physical isolation of the gel, so that the stability of the collagen and the cuba balsam oil is favorably maintained; the sustained release preparation has the advantages of slow and long-acting release, good stability, high bioavailability, effective reduction of postoperative recurrence rate, good biocompatibility, excellent biodegradability, good tolerance, safety, effectiveness, convenience in use and the like.

The embodiment of the invention provides nano-enzyme hydrogel for promoting scar-free wound repair through inflammation regulation and c-Jun gene silencing and a preparation method of the nano-enzyme hydrogel. The nano-enzyme hydrogel is prepared from the following components in parts by mass: synthesized epsilon-polylysine modified CeO2 nano-enzyme particles and aldehyde hyaluronic acid, an instant Schiff base reaction between epsilon PL-CeO2 surface amino groups and HA-CHO molecule aldehyde groups is utilized, in-situ mixing is performed to form a hydrogel network, in addition, bFGF and siRNA are loaded into PLGA microspheres, and the hydrogel network is formed through in-situ mixing. And further embedding into the hydrogel to obtain the nano-enzyme hydrogel. The obtained nano-enzyme hydrogel has the functions of inflammation regulation, cell proliferation promotion, vascular regeneration promotion, c-Jun gene silencing and the like, and scar-free healing of skin wounds is remarkably promoted.

The invention is suitable for the technical field of gynecological gels, and provides a gynecological gel with a repairing effect. Comprising the following components in percentage by weight: 0.1%-0.5% of recombinant III type human collagen, 0.05%-0.2% of mussel mucin, 1%-3% of chitosan, 0.2%-1% of sodium hyaluronate, 2%-5% of lactobacillus fermentation product filtrate, 0.05%-0.2% of tea tree essential oil, 0.2%-0.5% of carbomer, 0.1%-0.4% of triethanolamine, 0.1%-0.2% of sodium methylparaben and the balance of purified water. The gynecological gel with the repairing effect has the excellent repairing effect, integrates multiple effects of effectively resisting bacteria and diminishing inflammation, promoting repairing of damaged vaginal mucosa, adjusting vaginal micro-ecological balance and the like, not only can efficiently inhibit growth of various pathogens, but also can remarkably promote proliferation and repairing of vaginal mucosa cells, and has the advantages that the repairing effect is good, and the repairing effect is good. The vaginal micro-ecological balance can be accurately adjusted, no stimulation is caused to vaginal mucosa, safety and reliability are achieved, and long-term use can be achieved.

The invention relates to the field of cosmetics, in particular to an oil-controlling and acne-removing composition and application thereof. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are compounded and have a synergistic effect after being combined, a stronger oil control network is formed, and the oil control effect is greatly improved compared with that when a single component is used; a multi-channel and multi-target acne removal path is formed, and the acne removal effect is multi-dimensionally improved compared with that when a single component is used; the skin barrier function can be further enhanced, the water loss is reduced, and the acne skin damaged skin can be recovered more quickly. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are all natural plant extracts, are high in safety and are suitable for sensitive skin. After the three components are compounded, the safety is high, the oil-controlling and acne-removing effects of the oil-controlling and acne-removing composition are remarkably improved through the synergistic effect, and the acne problem can be more comprehensively solved.

The invention relates to a composition with functions of protecting gingiva and repairing enamel and a preparation method of the composition, and belongs to the technical field of oral care. The composition contains a functional additive, a plant compound fermentation extract and the like, the functional additive is a mixture of corn starch, calcium phosphosilicate, hydroxyapatite, ubiquinone, sodium guaiazulene sulfonate, menthol and vitamin E, and the plant compound fermentation extract is obtained by fermenting and purifying honeysuckle flowers, radix polygonati officinalis and dandelions according to a specific proportion. Through the synergistic effect of the fermentation extract and the functional components, the problems that an existing toothpaste body is hardened, the storage stability is poor, the gingival protecting effect is short, and the enamel repairing persistence is insufficient are solved, the gingival protecting effect can be enhanced, the enamel repairing effect can be improved, the stability of the toothpaste body can be optimized, the antibacterial property and the oral mucosa relieving effect are achieved, and the oral cavity repairing effect is achieved. And the preparation process is scientific and reasonable, and is suitable for daily oral care.

The invention relates to the technical field of plant essential oil, in particular to natural acne removing and repairing plant essential oil and a preparation method and application thereof. The natural acne removing and repairing plant essential oil is prepared from, by weight, 40-60 parts of mixed oil, 40-60 parts of lavender essential oil, 20-30 parts of tea tree essential oil, 20-30 parts of chamomile essential oil, 20-30 parts of additive liquid, 10-20 parts of grape seed oil, 6-10 parts of pomelo essential oil, 2-4 parts of solubilizer and 0.8-0.12 part of dispersing agent. According to the preparation method, mesophyll tissues in the tea leaves can be separated through enzymolysis, rough vein components in the tea leaves are removed, so that the extract is finer, the smearing comfort of essential oil is improved, the tannic acid component rich in the tea leaves is utilized, and tannic acid can inhibit growth and reproduction of bacteria in acne, so that the skin is kept in a clean state; the acne symptom is improved, and meanwhile, the recurrence rate of the acne is effectively reduced.

The invention relates to the technical field of medicines, and discloses a medicine for treating helicobacter pylori infection, which comprises the following raw materials: a substance a and pharmaceutically acceptable auxiliary materials, the structural formula of the substance a is shown as a formula (I). The substance a has a good bactericidal effect on helicobacter pylori and can be used for treating and preventing helicobacter pylori infection; and the substance a has a specific structure, can realize efficient sterilization in vivo and can be rapidly degraded at the same time, the degradation product is rapidly discharged out of the body, the substance a and the common degradation product thereof are actually nontoxic and very high in safety, and the substance a cannot be absorbed by the human body, has no side effect and cannot cause the helicobacter pylori to generate drug resistance.