566results about "Antiseptics" patented technology

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

The invention relates to a composition with functions of protecting gingiva and repairing enamel and a preparation method of the composition, and belongs to the technical field of oral care. The composition contains a functional additive, a plant compound fermentation extract and the like, the functional additive is a mixture of corn starch, calcium phosphosilicate, hydroxyapatite, ubiquinone, sodium guaiazulene sulfonate, menthol and vitamin E, and the plant compound fermentation extract is obtained by fermenting and purifying honeysuckle flowers, radix polygonati officinalis and dandelions according to a specific proportion. Through the synergistic effect of the fermentation extract and the functional components, the problems that an existing toothpaste body is hardened, the storage stability is poor, the gingival protecting effect is short, and the enamel repairing persistence is insufficient are solved, the gingival protecting effect can be enhanced, the enamel repairing effect can be improved, the stability of the toothpaste body can be optimized, the antibacterial property and the oral mucosa relieving effect are achieved, and the oral cavity repairing effect is achieved. And the preparation process is scientific and reasonable, and is suitable for daily oral care.

The invention relates to a medicine for skin regeneration and repair and a preparation method thereof, and belongs to the technical field of biological medicine, the medicine comprises cyperus esculentus extract peptide, brooklet anemone root tremella extract, rhodomyrtus tomentosa root-suberect spatholobus stem-radix cyathulae composite extract, pomegranate peel polyphenol and the like. The cyperus esculentus extracted peptide is a product which is more than 1kDa and is obtained by performing enzymolysis on cyperus esculentus through cellulase, alpha-chymotrypsin and ficin protease in sequence and then performing purification through a G-50 sephadex column; the tremellodon gelatinosum tremella extract is a product which is less than 3kDa and is obtained by performing common enzymolysis on tremellodon gelatinosum tremella sporocarp through cellulase and bromelain; the rhodomyrtus tomentosa root-suberect spatholobus stem-radix cyathulae composite extract is a product obtained by performing gradient extraction on rhodomyrtus tomentosa root, suberect spatholobus stem and radix cyathulae through an ethanol water solution to obtain an extract, and performing polyamide resin column adsorption and LH-60 sephadex column purification in sequence. A good repairing system is constructed by multiple components, and wound repairing and healing are accelerated.

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The invention discloses a degradable slow-release drug delivery device aiming at gynecological chronic inflammation and application, the degradable slow-release drug delivery device is of a hollow column-shaped or uterus-like structure matched with a gynecological physiological structure, the diameter of a hollow cavity of the hollow column-shaped structure is 2-5mm, and an arc-shaped bulge is arranged at the top end of the uterus-like structure; by replacing the drug delivery main body structure and adjusting the length of the catheter, treatment of various chronic inflammations such as cervicitis, endometritis and annexitis can be achieved, various devices do not need to be developed, the clinical use cost is reduced, the preparation process of each component of the device is the existing mature technology, the equipment investment cost is low, and the device is suitable for large-scale industrial production.

This invention relates to the field of nursing gel technology, and discloses a moisturizing nursing gel and its preparation method. The nursing gel is prepared from deionized water, poloxamer 407 powder, β-glucan, an antibacterial composite particle dispersion, and an aqueous lactic acid solution. The antibacterial composite particle dispersion is prepared from chitosan, an aqueous acetic acid solution, an antibacterial moisturizer, a modified sodium alginate solution, and deionized water. The modified sodium alginate solution is prepared from an aqueous sodium alginate solution, an aqueous sodium hydroxide solution, dopamine hydrochloride, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and deionized water. The antibacterial moisturizer is prepared from sodium hyaluronate, fructooligosaccharides, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and an aqueous solution of 1,4-butanediol diglycidyl ether. This invention exhibits good antibacterial and moisturizing properties.

The invention relates to the technical field of biological medicine, in particular to an external bacteriostatic anti-inflammatory anti-oxidation traditional Chinese medicine microecological preparation for vagina as well as a preparation method and application of the external bacteriostatic anti-inflammatory anti-oxidation traditional Chinese medicine microecological preparation. A preparation method of an external antibacterial, anti-inflammatory and antioxidant traditional Chinese medicine microecological preparation for vagina comprises the following steps: mixing traditional Chinese medicine powder, adding water and a nutrient substrate as a fermentation substrate, uniformly mixing, performing autoclaved sterilization, cooling, adding probiotic powder into the fermentation substrate, fermenting, air-drying and crushing, thereby obtaining the antibacterial, anti-inflammatory and antioxidant traditional Chinese medicine microecological preparation, the probiotics are lactobacillus plantarum; the traditional Chinese medicine is composed of cortex phellodendri, fructus cnidii, folium artemisiae argyi and liquorice. The traditional Chinese medicine composition can play a significant role in inhibiting bacteria, resisting inflammation, resisting oxidation and regulating flora, improves the vagina environment, and can be used for sterilizing, relieving itching, eliminating vagina inflammation, relieving skin oxidative injury and maintaining female vagina health.

This invention belongs to the fields of biomedicine, beauty, and personal care health technology, and discloses a dual-target oil-controlling peptide co-amorphous assembly, its preparation method, and its application. The method involves adding capryloylglycine and acetyl tetrapeptide-5 to an alcohol solution, heating to dissolve, rotary evaporating, and drying to obtain a co-amorphous compound. This compound is then mixed with a cyclodextrin compound and water, rotary evaporating, and drying to obtain the dual-target oil-controlling peptide co-amorphous assembly. This invention employs a co-amorphous combination with cyclodextrin inclusion to assemble acetyl tetrapeptide-5 and capryloylglycine, solving the problem of their large solubility differences and difficulty in coexistence, and significantly improving the solubility of capryloylglycine. This assembly enables simultaneous transdermal delivery of the two active components through nano-assembly, helping to enhance the stability of acetyl tetrapeptide-5 and reduce its oxidative degradation. The two components synergistically control oil through a dual pathway of inhibiting 5α-reductase and targeting the MC5R receptor, respectively, exhibiting superior bioavailability and efficacy compared to a single component.

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

The invention discloses a photosensitizer, dynamic antibacterial hydrogel containing lipidosome wrapping the photosensitizer and a preparation method and application of the dynamic antibacterial hydrogel, and belongs to the technical field of biological materials. The invention provides a novel D-A-D type photosensitizer TPT which is simple in structure and simple in synthetic route, and from the angles of safety, practicability and use specificity of hydrogel dressing, modified hyaluronic acid and modified carboxymethyl chitosan are used as raw materials, cationic liposome wrapping the novel photosensitizer TPT is carried, and the hydrogel dressing is prepared. The efficient antibacterial dynamic cross-linked hydrogel material is prepared. The hydrogel disclosed by the invention has two pH response bonds, namely an imine bond and a boric acid ester bond, and has good moisture retention and biocompatibility; meanwhile, the hydrogel is loaded with the cationic liposome wrapping the novel photosensitizer TPT, so that the hydrogel has excellent active oxygen yield. The hydrogel disclosed by the invention aims to quickly resist bacteria, promote wound healing, reduce infection risk and improve the success rate of treatment through the targeted drug release function of the intelligent hydrogel.

The present application belongs to the technical field of oral care, and particularly relates to an oral care composition and a preparation method thereof. The oral care composition comprises, by mass percentage, chitosan oligosaccharide 0.1-0.3%, sea hao polysaccharide 0.08-0.14%, forskolin 0.07-0.12%, corn sprout extract 0.05-0.09%, thickening agent 1-3%, humectant 40-50%, and the balance being water. The oral care composition of the present application can effectively inhibit the activity of glucosyltransferase, inhibit the production of dextran, interfere with the formation process of dental plaque, and reduce the adhesion sites of pathogenic bacteria in the oral cavity. In addition, the composition of the present application can promote the proliferation and repair of oral mucosa epithelial cells, and help repair oral mucosa damage. Furthermore, the use of each component in the composition of the present application can balance the oral microbial flora, while achieving the effect of inhibiting pathogenic bacteria and improving the oral environment.

The invention provides a spraying film agent and a preparation method thereof. The spraying film agent comprises a phase A and a phase B, wherein the phase A is uniformly dispersed in the phase B; wherein the phase A is a water-in-oil structure microsphere, and the water-in-oil structure microsphere is formed by wrapping a water-soluble active substance with a surfactant; and the phase B comprises a low-polarity organic solvent and a film-forming agent. On the basis of a reverse micelle technology, a water-soluble active substance is wrapped by a surfactant to form a water-in-oil structure microsphere, in the structure, the hydrophilic end of the surfactant inwards forms a water pool for accommodating the water-soluble active substance, and the hydrophobic end of the surfactant outwards enables the water-soluble active substance to be uniformly dispersed in a low-polarity solvent; therefore, the uniform and stable dispersion of the water-soluble active substance in the low-polarity solvent phase is realized. The contradictions that a traditional water-soluble polymer matrix is slow in film forming and water-soluble active ingredients cannot be stably dispersed in a low-polarity quick-drying solvent are solved.

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

The invention discloses a polygala tenuifolia aqueous extract as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) removing impurities from a polygala tenuifolia medicinal material, and crushing to obtain polygala tenuifolia coarse powder for later use; (2) putting the polygala tenuifolia coarse powder obtained in the step (1) and pure water into an extraction device according to a solid-liquid ratio of 1: (10-15) (g / mL), and extracting for 2-3 times while keeping a slight boiling state; (3) after each time of extraction in the step (2) is finished, filtering, and collecting filtrate of each time to obtain a polygala tenuifolia water extract; and (4) concentrating and drying the polygala tenuifolia water extract in the step (3) to obtain polygala tenuifolia water extract dry powder. The polygala tenuifolia aqueous extract is used as an effective component to prepare the external medicament for treating the red and swollen skin, so that the limitation of dosage forms such as original water decoction or medicine residue external application is broken through, the transdermal absorption and the curative effect are remarkably improved, the efficient local treatment of the skin abscess is realized, and the problems of systemic side effects and drug resistance of antibiotics caused by oral medicines are avoided; the applicable crowd is expanded.

This invention belongs to the technical field of medical disinfectant products, specifically relating to a medical agarwood extract disinfectant, its preparation method, and its application. The disinfectant is an oil-in-water microemulsion comprising agarwood supercritical CO2 extract (total sesquiterpenes mass fraction not less than 35%), a nonionic surfactant, a pH buffer, and water for injection. The pH value is 6.5-7.0, and the total sesquiterpenes concentration is not less than 5 mg / mL. The preparation method involves supercritical CO2 extraction of agarwood to obtain a lipid-soluble extract rich in sesquiterpenes, followed by high-pressure homogenization with a nonionic surfactant in a pH buffer to form a microemulsion. This invention achieves sterilization through membrane perturbation mechanisms using agarwood sesquiterpenes, without involving protein denaturation or strong oxidation, resulting in zero irritation to wounds. Its antibacterial efficacy is comparable to 75% ethanol. Sodium hyaluronate provides sustained-release protection and promotes healing, making it suitable for disinfection of surgical incisions, burns, and chronic ulcers.

The invention discloses bacteriostatic gel for gynecology and a preparation method thereof, and relates to the technical field of bacteriostatic gel. The antibacterial gel is prepared from a gel matrix, a plant extracting solution, antibacterial peptide, a humectant, astaxanthin microcapsules and a specific buffer solution. The buffer solution contains sodium citrate, hyaluronic acid and citric acid, and intelligent regulation and control of the drug release behavior of the astaxanthin microcapsule are realized by utilizing the synergistic effect of a hyaluronic acid and citric acid buffer system and preferably adopting hyaluronic acid compounded or modified with different molecular weights. The gel can maintain stable drug release in a normal vagina and pathological fluctuation pH environment, and trigger accelerated release in a high active oxygen inflammation environment, so that the problems that the release behavior is greatly influenced by environmental fluctuation and cannot adapt to different disease stages in the prior art are effectively solved, accurate and personalized drug delivery is realized, and the drug delivery efficiency is improved. The antibacterial agent has the advantages of good antibacterial effect and high environmental adaptability.

The invention belongs to the technical field of oral care, and discloses a rhodiola rosea-containing composite antibacterial oral bacteriostatic paste, which is prepared by compounding rhodiola rosea, tea polyphenol and other five-compound antibacterial components with sorbitol and other auxiliary materials according to an accurate proportion. According to the invention, a triple system of'instant sterilization-lasting bacteriostasis-ecological restoration 'is constructed, third-party detection shows that the inhibition rate on oral pathogens such as escherichia coli, staphylococcus aureus and the like reaches 99.9% or above, and multiple effects of resisting bacteria, diminishing inflammation, protecting gingiva, preventing caries and the like are achieved. The problems that an existing product is single in antibacterial effect, narrow in antibacterial spectrum and low in rhodiola rosea utilization rate are solved, no heavy metal is detected, stability is excellent, irritation is low, and the rhodiola rosea antibacterial agent is suitable for long-term use and has remarkable innovativeness and industrial value.

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The invention belongs to the technical field of biological medicine, and particularly relates to a sophora flower extract for inhibiting formation of an oral biofilm and application thereof. According to the method, the sophora flower extract obtained after alcohol extraction is subjected to specific macroporous resin column elution conditions, the sophora flower extract obtained through enrichment has a very excellent effect of inhibiting oral biofilm formation, and further elution is carried out under specific silica gel column conditions, so that the effect of the obtained sophora flower extract is further improved. The inhibition rate of the obtained sophora flower extract is obviously higher than that of sophora flower extracts prepared by traditional alcohol extraction or other processes, and the sophora flower extract has important application value in preparation of products for inhibiting and / or killing oral microorganisms or biological membranes thereof, and can be used for preventing and / or treating dental bacterial diseases including decayed teeth.

The invention discloses a freckle-removing and whitening mask which is prepared from the following raw materials: chrysanthemum, pearl, radix angelicae, almond, poria cocos, rhizoma atractylodis macrocephalae, peach kernel, ginseng, mung bean, bletilla striata, cortex moutan, rhodiola rosea, silkworm larva, Chinese yam, honeysuckle and the like. The facial mask is a pure traditional Chinese medicine facial mask, has remarkable curative effects on whitening, removing freckles, removing acnes and minimizing pores, and can effectively reduce facial skin damage, effectively inhibit growth of facial germs, promote vigor of subcutaneous capillaries of the damaged face, improve metabolism of the skin and enable the facial skin to reappear in a compact and refined state. In addition, the facial mask can enhance the ability of facial skin to resist invasion and stimulation of external germs, form a natural protective barrier for the facial skin, well repair, moisten and care the facial skin, and keep the facial skin comfortable, beautiful and healthy for a long time. Pure traditional Chinese medicine raw materials are selected, chemical components are not added, and harm to facial skin and the body is avoided.

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

The application belongs to the field of hydrogel biological medicine, and more particularly discloses a kind of supramolecular hydrogel based on natural plant ingredients, preparation and application thereof.The hydrogel only contains polyphenol, polysaccharide and solvent, and the hydrogel is in-situ gelled only by supramolecular interaction between polyphenol and polysaccharide.The hydrogel of the application can be prepared by simple mixing, and can also be in-situ injected by a syringe.The hydrogel preparation process is simple, the raw material cost is low, and the gelation speed is fast;the hydrogel can effectively adhere to the skin, isolate the contact between the wound and the external environment, avoid the invasion of pathogens, at the same time, it is breathable and moisturizing, can provide a suitable moist environment for wound healing, and can completely and quickly release polyphenol.The hydrogel also has excellent antibacterial, antioxidant, anti-inflammatory and pro-angiogenic functions, so it can accelerate wound healing and accelerate bacterial infection wound healing.

The present disclosure relates to micellar compositions conformed by biomimetic phospholipids and nonionic surfactants, among other ingredients, for eliminating one or more types of microorganisms including mycobacteria, bacteria, fungi, and viruses from a surface within a contact time on the surface of less than about 1 minutes and having pH of from about 0.3 to 8. The present invention aims on using 100% bio-based (renewable) biodegradable, non-toxic ingredients to be applied not only to hard inanimate surfaces but also on tissue for endodontic applications.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

The present invention relates to the field of biological fermentation application technology, and in particular, to use of a milk peptide fermentation product in regulating skin microecological balance. The milk peptide fermentation product selectively regulates the growth of Staphylococcus epidermidis and inhibits the growth of Staphylococcus aureus and Escherichia coli. It was discovered for the first time that the milk peptide fermentation product has a selective bacteriostatic effect on skin microorganisms. The experimental results show that the milk peptide fermentation product has an inhibitory effect on Escherichia coli and Staphylococcus aureus, but has no effect on the normal growth of Staphylococcus epidermidis. This characteristic is obviously different from common broad-spectrum chemical bacteriostatic agents, and the use of the milk peptide fermentation product is more conducive to maintaining the balance of skin microbiota.

The invention discloses composite hydrogel for wound repair as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of medical materials. The preparation method comprises the following steps: mixing methylacryloylated gelatin, hydroxyethyl methylacrylate and oxidized dextran, adding copper sulfide nanoparticles, a cross-linking agent and a photoinitiator, uniformly stirring, placing in a mold, irradiating by adopting ultraviolet light, carrying out Schiff base reaction on an aldehyde group on an ODex chain and an amino group on a GelMA chain to form a dynamic covalent bond, and forming a reversible cross-linking point, so as to obtain the copper sulfide nanoparticle / GelMA composite hydrogel. The preparation method comprises the following steps: carrying out a copolymerization reaction on HEMA and methacryloyl on a GelMA molecular chain to form a stable covalent cross-linked network, effectively capturing CuS NPs through a physical effect and stably dispersing the CuS NPs in the network in the process, and soaking the cross-linked hydrogel in deionized water for balancing to obtain the target composite hydrogel. The composite hydrogel has excellent mechanical strength, pH response swelling property and biocompatibility, can realize efficient antibacterial and endogenous immune regulation by combining near-infrared photothermal therapy, and effectively promotes wound repair.

The present application belongs to the technical field of daily chemical preparation, and particularly relates to a gynecological gel for inhibiting bacteria, regulating microecological balance and tightening vagina and a preparation method thereof. The gynecological gel comprises the following raw materials in mass fractions: 0.5-1 parts of carbomer, 0.04-0.09 parts of sodium hydroxide, 1-3 parts of collagen, 0.01-0.06 parts of sodium hyaluronate, 0.5-1.5 parts of isomaltooligosaccharide, 2-5 parts of propylene glycol, 0.05-0.3 parts of hydroxybenzoic acid methyl ester, 0.02-0.15 parts of hydroxyphenyl ethyl ester, 0.1-1.5 parts of hydrogenated lecithin, 1-6 parts of 1,3-butanediol, 3-5 parts of glycerol, 0.5-1 part of xanthan gum and 70-90 parts of water. The present application uses buckwheat filtrate to prepare collagen, and the active ingredients in the buckwheat filtrate can penetrate the cell membrane of pathogenic bacteria to play an antibacterial role; the collagen can repair the vaginal mucosa barrier and reduce the adhesion and invasion of pathogenic bacteria; therefore, after being compounded with the raw materials such as carbomer, sodium hydroxide, sodium hyaluronate, isomaltooligosaccharide and propylene glycol, the multiple components can synergistically promote the synthesis and repair of collagen fibers and improve the elasticity of tissues.

This invention discloses a bioactive glass oral desensitizing ointment and its preparation method, belonging to the technical field of oral desensitizing ointments. The oral desensitizing ointment comprises the following raw materials in parts by weight: 5-15 parts bioactive glass, 2-4 parts silica, 0.5-2 parts antibacterial and anti-inflammatory agent, 10-25 parts glycerin, 20-30 parts humectant, 2-4 parts surfactant, 0.5-1.5 parts fragrance, 0.5-2 parts gelling agent, and 30-50 parts purified water. The oral desensitizing ointment prepared by this invention exhibits good antibacterial properties and dentinal tubule sealing rate.