182 results about "Aerosol composition" patented technology

Sterile compositions for administration as aerosols are described. They contain an active agent which is poorly water-soluble, a non-ionic surfactant acomponent and a phospholipid component. The compositions are suitable for oral or nasal inhalation, but also for topical or oromucosal administration. They are particulary useful for the efficient pulmonary administration of poorly soluble corticosteroids and can be aerosolized with common nebulizers.

A pressure resistant plastic bottle for containing and dispensing an aerosol composition. The plastic bottle is comprised of a hollow elongate body having a central portion, a top portion and an opposite bottom portion with the central portion having an inwardly concave configuration extending along its longitudinal direction. The bottom portion of the elongate body is integral with the central portion and defines an outwardly projecting convexly shaped configuration. The top portion of the bottle is integral with the central portion and has an outwardly convex configuration extending along its longitudinal direction and defines a neck having an opening for receiving and dispensing the aerosol composition. A closure covers the opening and is sealingly attached to the neck to contain the aerosol within the plastic bottle.

A pressure resistant plastic bottle for containing and dispensing an aerosol composition. The plastic bottle is designed to reduce deformation by a local reinforcement to the neck and shoulder regions. The reinforcement preferably comprises the provision of a wall thickness for a lower portion of the neck as compared to the wall thickness of the upper portion of the neck to be increased by a ratio of from about 1.25:1 to about 2.5:1.

This invention relates to a “high lower alcohol content” (>40% v / v of a C1-4 alcohol) liquid composition able to be either dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers or as an alcohol gel composition which does not use thickener and gelling agents that leave undesirable deposits or a sticky after-feel and that has a final viscosity less than 4,000 cps. The liquid compositions comprise an alcohol, C1-4 (>40% v / v), a fluorosurfactant of at least 0.001% by weight to prepare a foamable composition or from 0-2.0% to prepare a gel-like composition of a final viscosity less than 4,000 cps, 0-10% w / w of additional minor components added to obtain the desired performance (a foamable composition or a gel-like composition with a viscosity less than 4,000 cps), and the balance being purified water. The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

The present invention provides a pharmaceutical composition for transdermal delivery comprising: one or more physiologically active agents; one or more dermal penetration enhancers; a pharmaceutically acceptable carrier comprising a volatile solvent; and a hydrofluorocarbon propellent; wherein the carrier and penetration enhancers combine to provide a single-phase solution of the one or more physiologically active agents.

This invention relates to a “high lower alcohol content” (>40% v / v of a C1-4 alcohol) liquid composition able to be dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers The liquid compositions comprise an alcohol, C1-4 (>40% v / v), a silicone-based surfactant of at least 0.001% by weight to prepare a foamable composition, 0-10% w / w of additional minor components added to obtain the desired performance (a foamable composition), and the balance being purified water. The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

Disclosed is an aerosol insect repellent composition. The composition has (a) an amount of an insect repellent effective to repel insects when applied to the skin and (b) a cosmetically-acceptable vehicle in which to disperse and deliver the insect repellent active. The vehicle has (i) a VOC component capable of volatilizing upon exposure to a reduction in pressure for delivering the composition in an aerosol form, and (ii) a non-VOC component. The aerosol composition has a VOC content of not greater than about 55 wt. % based upon the weight of the aerosol composition. Further disclosed is a method of repelling insects from skin wherein the aerosol composition is applied to or sprayed on the skin.

A composition for use in an aerosol inhaler, the composition comprising an active material, a propellant containing a hydrofluoroalkane (HFA), a cosolvent and further comprising a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler, filling of an aerosol container and use of the composition for the administration of active materials by inhalation.

The present invention provides stable aerosol cream mousse composition, preferably hair care composition, that can provide enhanced touch, combability, alignment and volume reduction to the hair, with low or reduced greasy, oily hair feel, while being formulated having a thick, rich, creamy, mousse-type rheology with excellent spreading, perception of spreading, and feel. The aerosol composition is based on the combination of component (A) a cationic surfactant, which is generally a quaternary ammonium compound such as e.g., ditallow dimethyl ammonium chloride; (B) a fatty alcohol, such as cetyl and stearyl alcohol; and (C) carbon dioxide.

This invention relates to a “high lower alcohol content” (>40% v / v of a C1-4 alcohol) liquid composition able to be dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers. The liquid compositions comprise a C1-4 alcohol, (>40% v / v), a silicone-based surfactant of at least 0.001% by weight for foaming to prepare a foamable composition, 0-10% w / w of additional minor components added to obtain the desired performance (a foamable composition), and the balance being purified water. The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

Sterile compositions for administration as aerosols are described. They contain an active agent which is poorly water-soluble, a non-ionic surfactant acomponent and a phospholipid component. The compositions are suitable for oral or nasal inhalation, but also for topical or oromucosal administration. They are particulary useful for the efficient pulmonary administration of poorly soluble corticosteroids and can be aerosolized with common nebulizers.

The present invention pertains to aerosols which comprise a first compound which is physiologically active and a second compound which is different from the first compound. Such aerosols may be produced “on demand” and can be used to control drug release, to improve vaporizability, or to reduce, modify or eliminate undesirable taste associated with a drug aerosol. The present invention also pertains to methods for producing such aerosols.

Described herein are high oil-content emulsions and compositions for the treatment of inflammatory skin disorders. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. The emulsions or compositions may comprise active agents, such as corticosteroids. Also described are methods of treating inflammatory skin disorders, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition.

Spray compositions and particularly anhydrous aerosol compositions containing particulate antiperspirant actives exhibit a tendency for nozzle blockage, impeding discharge of the contents when a polyol humectant, such as glycerol, is blended into its base composition. The problem is overcome or at least ameliorated by preparation of a base composition, suitable for employment in conjunction with a propellant, that contains a low molecular weight (liquid) polyethylene glycol (PEG) as humectant, and particularly a PEG of molecular weight 150 to 500.

Described herein are emulsions and compositions for the treatment of acne vulgaris. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. The emulsions or compositions may comprise clindamycin phosphate and a buffer salt, and may exhibit decreased rates of clindamycin phosphate hydrolysis. Also described are methods of treating acne vulgaris, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition.

Described herein are high oil-content emulsions and compositions for the treatment of inflammatory skin disorders. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. The emulsions or compositions may comprise active agents, such as corticosteroids. Also described are methods of treating inflammatory skin disorders, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition.

A composition for solvating one or more active agents in an aqueous solution which is suitable for dispensing as a compressed gas aerosol composition is disclosed. The composition includes at least one surfactant, at least one active agent (such as a fragrance or an insecticide), and a compressed gas propellant. The at least one surfactant is preferably present in an amount from about 0.1 wt. % to about 3 wt. %. The at least one active agent is preferably present in an amount from about 0.1 wt. % to about 2 wt. %. The compressed gas propellant is preferably present in an amount from about 0.1 wt. % to about 1 wt. %. The total surfactant weight to active agent weight ratio for the composition is preferably about 1:3 to 5:1. The composition uses a reduced amount of surfactant and active agent thereby allowing for a more efficient active agent loading and a reduced stickiness or tackiness on surfaces contacted during use.

Non-foaming aqueous emulsion compositions; methylparaben-based preservative systems for aqueous aerosol compositions having a pH at or above a pH where methylparaben begins to hydrolyze; cosmetic, household, and human and veterinary pharmaceutical products containing these compositions.

Various compositions, including particularly aerosol compositions containing fluorinated olefins, including particularly 2,3,3,3-tetraluorpropene (HFO-1234yf), in a variety of applications are disclosed.

A method of achieving improved hair feel. The method includes applying an aerosol composition to the hair with an apparatus at a spray rate from about 0.4 g / sec to about 0.8 g / sec, wherein the aerosol composition comprises: (a) from about 5% to about 12% particulate tapioca starch; (b) from about 30% to about 50% alcohol; (c) from about 0.1% to about 0.3% redispersing agent; (d) from about 40% to about 60% propellant; and (e) less than about 1% nonvolatile oil; and depositing from about 0.15 g to about 0.35 g of nonvolatile material from the aerosol composition to the hair when the apparatus is sprayed for about 5 sec from about a 15 cm distance.

Nanoparticles are prepared from a colloidal system comprising a continuous phase and micelles, the micelles comprising surfactant material. A microemulsion is formed by admixing the colloidal system with a solution of an active material, such as a medicament, dissolved in a solvent wherein the solution forms a disperse phase with the micelles of surfactant material. At least the dispersed phase is quenched to a solid state and the continuous phase and solvent are removed to produce the nanoparticles. The nanoparticles can be incorporated in an aerosol composition suitable for deep lung delivery by means of a metered dose inhaler.

An aerosol paint composition includes an alkyd resin; one or more solvents; an organoclay; an anti-settling wax; a dispersing agent; one or more pigments; a drying agent; an anti-skinning agent; a fragrance; and a fungicide.

The present invention provides stable aerosol cream mousse composition, preferably hair care composition, that can provide enhanced touch, combability, alignment and volume reduction to the hair, with low or reduced greasy, oily hair feel, while being formulated having a thick, rich, creamy, mousse-type rheology with excellent spreading, perception of spreading, and feel. The aerosol composition is based on the combination of component (A) a cationic surfactant, which is generally a quaternary ammonium compound such as e.g., ditallow dimethyl ammonium chloride; (B) a fatty alcohol, such as cetyl and stearyl alcohol; and (C) carbon dioxide.

Disclosed is an aerosol composition that includes water, an organic propellant, molasses components, and a surfactant. The composition preferably further includes an anti-agglomeration agent to inhibit agglomeration of insoluble materials and a sugar stabilizer to inhibit crystallization of sugar in the composition. Also disclosed are methods for feeding an animal by dispensing an aqueous solution of a sugar from an aerosol device, preferably an aerosol device that includes an aerosol composition as described above.

Described herein are emulsions and compositions for the treatment of acne vulgaris. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. The emulsions or compositions may comprise clindamycin phosphate and a buffer salt, and may exhibit decreased rates of clindamycin phosphate hydrolysis. Also described are methods of treating acne vulgaris, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition.

An aerosol composition includes at least one setting active substance, and at least one propellant having at least one compound having 3 to 10 carbon atoms in accordance with formula (I), in which the residues R1, R2, R3, and R4 signify, mutually independently, a hydrogen atom, a bromine atom, a fluorine atom, or a (C1 to C6) alkyl group substituted with at least one fluorine atom, or two of the residues R1, R2, R3, and R4 form a five- or six-membered ring, with the provision that: at least one of the residues R1, R2, R3, or R4 denotes a hydrogen atom or a fluorine atom, and at least one of the residues R1, R2, R3, or R4 denotes a (C1 to C6) alkyl group substituted with at least one fluorine atom, or at least two of the residues R1, R2, R3, and R4 form a five- or six-membered ring.

The present invention relates to methods and compositions for treating lymphangioleiomyomatosis in a human subject in need of such treatment. The methods comprise administering to the subject via inhalation an aerosol composition comprising rapamycin or a prodrug or derivative (including analog) thereof.

Certain surfactants suitable for use alone to dissolve a water-insoluble component in compositions is described for providing VOC-free compressed gas aerosol compositions. The compositions include water-insoluble component(s), a surfactant and water. The water-insoluble component(s) can be active agent(s), such as fragrance(s) and / or an insecticide(s). The surfactant is present as a single surfactant which, in the absence of a solvent, dissolves or disperses the water-insoluble component(s) and provides a homogenous blend in water which provides a stable compressed gas emulsion. The surfactant is an anionic surfactant or a nonionic surfactant, in particular nonionic alkylpolyglycosides; nonionic cocoglucoside; nonionic alkylene oxide extended chain alkylpolyglycosides; anionic sodium lauryl ether sulfate (SLES), nonionic C13-C15 oxoalcohol ethoxylate with 8 ethylene oxides (EO), nonionic C12-C14 secondary alcohol ethoxylate with 7EO or 12EO, polyethylene glycol (PEG) hydrogenated castor oil wherein the PEG is PEG-60 or PEG-40, polyglyceryl-10 laurate and polyglyceryl-6 caprylate.