The invention relates to a manufacturing process of a novel embedded metal tube die-casting cooling cavity. The manufacturing cost comprises the following steps of S1, tube selecting, wherein the thicknesses of selected metal tubes are within the range of 1-4 mm, and burrs at end openings are removed; S2, bent forming, wherein heated parts of the metal tubes are placed on a bend-forming die or a bender and are bent according to a machining drawing, and the heated parts are cooled to be at the normal temperature; S3, water nozzle welding; S4, placing and locating the metal tubes and the water nozzles in a die-casting die; S5, die closing and die-casting, wherein after the die-casting die is closed, aluminum alloy solution is poured to a melting cup of a die-casting machine and is injected to the die through injection force of the die-casting machine, and the metal tubes are wrapped by the aluminum alloy solution; S6, die-casting pieces are taken out after the die is opened; S7, washing, drying, deburring, and local CNC machining, wherein finished products are finally obtained. The manufacturing process has the advantages that the die-casting piece and the metal tube are integrally formed in one time, raw material cost is low, machining cost is low, machining cycle is short, the production process is simple, and the cooling effect is improved.